Adrenal steroid precursors exert potent androgenic action in the hamster sebaceous glands of flank organs and ears

Endocrinology

Volumn 137, Issue 5, 1996, Pages 1752-1757

  Chen, Cailin ^a   Belanger, Alain ^a   Labrie, Fernand ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; ANDROSTENEDIONE; PRASTERONE; TESTOSTERONE; THYMIDINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EAR; HORMONE BLOOD LEVEL; MALE; NONHUMAN; ORCHIECTOMY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SEBACEOUS GLAND; SKIN; SYRIAN HAMSTER;

EID: 0029862625     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.5.8612511     Document Type: Article

References (35)

1. Ebling FJ 1948 Sebaceous glands. I. The effect of sex hormones on the sebaceous glands of the female albino rat. J Endocrinol 5:297-302
2. Ebling FJ 1963 Hormonal control of the sebaceous gland in experimental animals. In: Advances in Biology of Skin. The Sebaceous Glands. Pergamon Press, Oxford, vol 4:200-219
3. Hamilton JB, Montagna W 1950 The sebaceous glands of the hamster. Morphological effects of androgens on integumentary structure. Am J Anat 86:191-233
4. Plewig G, Luderschmidt C 1982 Hamster ear model for sebaceous glands. J Invest Dermatol 68:171-176
5. Goss GMAA, Wirtz P, Vormorken HJM 1982 An improved method for evaluating antiandrogens. Dermatol Res 273:333-341
6. Weissman A, Bowden J, Frank BL, Horwitz SN, Frost P 1984 Morphometric studies of the hamster flank organ: an important model to evaluate pharmacologie effects on sebaceous glands. J Invest Dermatol 82:522-525
7. Lutsky BN, Budak M, Koziol P, Monahan M, Neri RO 1975 The effects of a nonsteroid antiandrogen, flutamide, on sebaceous gland. J Invest Dermatol 64:412-417
8. Schröder HG, Ziegler M, Nickisch K, Kaufmann J, Etreby FE 1989 Effect of topically applied antiandrogenic compounds on sebaceous glands of hamster ears and flank organs. J Invest Dermatol 92:769-773
9. Luderschmidt C, Eiermann W, Jawny J, Bidlingmaier F, Ring J 1984 17α-Propylmesterolone (SH-434): an antiandrogenic sebosuppressive substance not influencing circulating testosterone concentrations. Experimental studies in Syrian hamsters. Nauynyn Schmiedeberg Arch Pharmacol 328:214-218
10. Brooks JR, Primka R, Berman C, Krupa DA, Reynolds GF, Rasmusson GH 1991 Topical anti-androgenicity of a new 4-azasteroid in the hamster. Steroids 56:428-433
11. Bouton MM, Lecaque D, Secchi J, Tournemine C 1986 Effect of a new topically active antiandrogen (RU38882) on the rat sebaceous gland: comparison with cyproterone acetate. J Invest Dermatol 86:163-167
12. Baillie AH, Thomson J, Milne JA 1966 The distribution of hydroxysteroid dehydrogenase in human sebaceous glands. Br J Dermatol 78:451-457
13. 4-androstenedione and dehydroisoandrosterone. J Invest Dermatol 52:32-36
14. 4 isomerase in human skin. J Invest Dermatol 99:415-421
15. Labrie F 1991 Intracrinology. Mol Cell Endocrinol 78:C113-C118
16. Labrie F, Dupont A, Bélanger A 1985 Complete androgen blockade for the treatment of prostate cancer. In: de Vita VT, Hellman S, Rosenberg SA (eds) Important Advances in Oncology. Lippincott, Philadelphia, 193-217
17. 3H]testosterone by skin from men. 101st Meeting of the Society for Endocrinology, London, UK, 1966, p 19 (Abstract)
18. Ellis RA 1958 Ageing of the human male scalp. In: Montagna W, Ellis RA (eds) The Biology of Hair Growth. Academic Press, New York, pp 469-485
19. Hay JB, Hodgins MB 1978 Distribution of androgen metabolizing enzymes in isolated tissues of human forehead and axillary skin. J Endocrinol 79:29-39
20. Bélanger A, Caron S, Picard V 1980 Simultaneous radioimmunoassay of progestins, androgens, and estrogens in adult rat testis. J Steroid Biochem 13:185-190
21. Kramer CY 1956 Extension of multiple range tests to group means with unique numbers of replications. Biometrics 12:307-310
22. Boring CC, Squire TS, Tong T 1993 Cancer statistics 1993. CA Cancer J Clin 43:7-26
23. Burton JL, Johnson G, Libman S, Shuster S 1972 Skin virilism in women with hirsutism. J Endocrinol 53:349-354
24. Plewig G 1974 Acne vulgaris, proliterative cells in sebaceous glands. Br J Dermatol 90:623-630
25. Labrie C, Bélanger A, Labrie F 1988 Androgenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate. Endocrinology 123:1412-1417
26. Sawaya ME, Penneys NS 1991 Immunohistochemical distribution of aromatase and 3β-hydroxysteroid dehydrogenase in human hair follicle and sebaceous gland. J Cutan Pathol 19:309-314
27. Martel C, Rhéaume E, Takahashi M, Trudel C, Couet J, Luu-The V, Simard J, Labrie F 1992 Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity and human tissues. J Steroid Biochem Mol Biol 41:597-603
28. Thériault C, Labrie F 1991 Multiple steroid metabolic pathways in ZR-75-1 human breast cancer cells. J Steroid Biochem Mol Biol 38:155-164
29. Couture P, Thériault C, Simard J, Labrie F 1993 Androgen receptor-mediated stimulation of 17β-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells. Endocrinology 132:179-185
30. Poyet P, Labrie F 1985 Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megestrol acetate. Mol Cell Endocrinol 42:283-288
31. Labrie C, Simard J, Zhao HF, Pelletier G, Labrie F 1990 Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate. Mol Cell Endocrinol 68:169-179
32. Labrie C, Cusan L, Plante M, Lapointe S, Labrie F 1989 Analysis of the androgenic activity of synthetic "progestins" currently used for the treatment of prostate cancer. J Steroid Biochem 28:379-384
33. Moghissi E, Ablan F, Horton R 1984 Origin of plasma androstanediol glucuronide in men. J Clin Endocrinol Metab 59:417-421
34. Bélanger A, Brochu M, Cliche J 1986 Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer. J Clin Endocrinol Metab 62:812-815
35. Bélanger A, Candas B, Dupont A, Cusan L, Diamond P, Gomez JL, Labrie F 1994 Changes in serum concentration of conjugated and unconjugated steroids in 40- to 80-year-old men. J Clin Endocrinol Metab 79:1086-1090