Chemosensitivity of head and neck squamous carcinoma cell lines is not primarily correlated with glutathione level but is modified by glutathione depletion

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 11, 1996, Pages 653-658

  Bier, Henning ^a   Hoffmann, Thomas ^a   Eickelmann, Peter ^b   Hafner, Dieter ^b  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Buthionine sulfoximine; Drug resistance; Glutathione; Glutathione S transferase

Indexed keywords

BLEOMYCIN; BUTHIONINE SULFOXIMINE; CARBOPLATIN; CISPLATIN; FLUOROURACIL; GLUTATHIONE; GLUTATHIONE TRANSFERASE;

ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE;

CARBOPLATIN; CARCINOMA, SQUAMOUS CELL; CELL SURVIVAL; CISPLATIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEAD AND NECK NEOPLASMS; HUMANS; TUMOR CELLS, CULTURED;

EID: 0029862340     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01209027     Document Type: Article

References (32)

1. Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbot BJ, Mayo JG, Shoemaker RH, Boyd MR (1988) Feasability of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48:589-601
2. Arrick BA, Nathan CF (1984) Glutathione metabolism as a determinant of therapeutic efficacy. Cancer Res 44:4224-4232
3. Bier H (1991) Circumvention of drug resistance in cisplatin-resistant sublines of the human squamous carcinoma cell line HLac 79 in vitro and in vivo. Acta Otolaryngol 111:797-806
4. Bier H (1993) Chemotherapeutic drug resistance in the management of head and neck cancer. Eur Arch Otorhinolaryngol 250:200-208
5. Bier H, Bergler W, Mickisch G, Wesch H, Ganzer U (1990) Establishment and characterisation of cisplatin-resistant sublines of the human squamous carcinoma cell line HLac 79. Acta Otolaryngol 110:466-473
6. Carey TE (1985) Establishment of epidermoid carcinoma cell lines. In: Wittes RE (ed) Head and neck cancer. Wiley, Chichester. pp 287-314
7. Carey TE (1994) Head and neck tumor cell lines. In: Hay RJ (ed) Atlas of human tumor cell lines. Academic Press, San Diego, pp 79-120
8. Chabner BA (1986) The oncologic end game. J Clin Oncol 4:625-638
9. Chasseaud LF (1979) The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents. Adv Cancer Res 29:175-274
10. Gallo JM, Brennan J, Hamilton TC, Halbherr T, Laub PB, Ozols RF, O'Dwyer PJ (1995) Time-dependent pharmacodynamic models in cancer chemotherapy: population pharmacodynamic model for glutathione depletion following modulation by buthionine sulfoximine (BSO) in a phase I trial of melphalan and BSO. Cancer Res 55:4507-4511
11. Habig WH, Jakoby WB (1981) Gluthathione S-transferase (rat and human). Methods Enzymol 77:218-230
12. Hafner D, Heinen E, Noack E (1977) Mathematical analysis of concentration-response-relationships: method for the evaluation of the ED50 and the number of receptor binding sites using a logit transformation. Drag Res 27:1871-1873
13. Hill BT, Deuchars KL, Hosking LK, Ling V, Whelan RD (1990)Overexpression of P-glycoprotein in mammalian tumor cell lines after fractionated irradiation. J Natl Cancer Inst 82:607-612
14. Ishikawa T, Ali-Osman F (1993) Glutathione-associated cis-diammmedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. J Biol Chem 268:1-10
15. Jacobs C (1991) Adjuvant and neoadjuvant treatment of head and neck cancers. Semin Oncol 18:504-514
16. Janot F, Massaad L, Ribrag V, Waziers I de, Beaune PH, Luboinski B, Parise O, Gouyette A, Chabot GG (1993) Principal xenobioticmetabolizing enzyme systems in human head and neck squamous cell carcinoma. Carcinogenesis 4:1279-1283
17. Meister A (1983) Selective modification of glutathione metabolism. Science 220:472-477
18. Meister A, Anderson ME (1983) Glutathione. Annu Rev Biochem 52:711-760
19. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
20. Mulcahy RT, Tutsch KD, Pomplun M, Arzoomanian RZ, Alberti D, Feierabend C, Bailey HH (1994) The pharmacodynamics of L-S,R-buthionine-sulfoximine (BSO) given as a 24-48 hour continuous infusion in patients undergoing phase I treatment with i.v. melphalan and BSO. Proc Am Assoc Cancer Res 35:377
21. Nathan CF, Arrick BA, Murray HW, Santis NM de, Cohn ZA (1980) Tumor cell anti-oxidant defenses. J Exp Med 153:766-782
22. Orrenius S, Moldeus P (1984) The multiple role of glutathione in drug metabolism. Trends Pharmacol Sci 5:432-435
23. Ozols RF (1991) Molecular and clinical advances in anticancer drug resistance. Kluwer, Boston
24. Pinedo HM, Peters GF (1988) Fluorouracil: biochemistry and pharmacology. J Clin Oncol 6:1653-1664
25. Ripple GH, Mulcahy RT, Tutsch KD, Arzoomanian RZ, Alberti D, Feierabend C, Mahvi D, Schink J, Pomplun M, Wilding G, Bailey HH (1995) Tumor glutathione depletion to < 10% of baseline observed during a phase I trial of continuous infusion L-S,R-buthionine sulfoximine. Proc Am Assoc Cancer Res 36:238
26. Russo A, Mitchell JB, Me Pherson S, Friedman N (1984) Alteration of bleomycin cytotoxicity by glutathione depletion or elevation. Int J Radiat Oncol Biol Phys 10:1675-1678
27. Snow GB, Clark JR (1992) Multimodality therapy for head and neck cancer. Thieme, Stuttgart
28. Talmadge JE, Wohman SR, Fidler U (1982) Evidence for the clonal origin of spontaneous metastatis. Science 217:361-363
29. Teicher BA, Holden SA, Kelley M J, Shea TC, Cucchi CA, Rosowsky A, Henner WD, Frei E (1987) Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloro-platinum (II). Cancer Res 47:388-393
30. Tew KD (1994) Glutathione-associated enzymes in anticancer drug resistance. Cancer Res 54:4313-4320
31. Tsuruo Z, Fidler IJ (1981) Differences in drug senstivity among tumor cells from parental tumors, selected variants and spontaneous metastases. Cancer Res 41:3058-3064
32. Zenner HP, Lehner W, Herrmann IF (1979) Establishment of cell lines from larynx and submandibular gland carcinoma. Arch Otorhinolaryngol 225:269-277