Dissecting processing and apoptotic activity of a cysteine protease by mutant analysis

Journal of Cell Biology

Volumn 135, Issue 2, 1996, Pages 479-486

  Allet, Bernard ^a   Hochmann, Alena ^a   Martinou, Isabelle ^a   Berger, Anouk ^a   Missotten, Marc ^a   Antonsson, Bruno ^a   Sadoul, Rémy ^a   Martinou, Jean Claude ^a   Bernasconi, Lilia ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CYSTEINE PROTEINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ETIOLOGY; GENE MUTATION; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; APOPTOSIS; CASPASE 2; CASPASES; CELL LINE; CELL SURVIVAL; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CYSTEINE; CYSTEINE ENDOPEPTIDASES; GENE EXPRESSION; MICE; MUTAGENESIS, SITE-DIRECTED; NEURONS; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN BIOSYNTHESIS; PROTEINS; RABBITS; RECOMBINANT PROTEINS; RETICULOCYTES; SEMLIKI FOREST VIRUS; SYMPATHETIC NERVOUS SYSTEM; TRANSFECTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS; SEMLIKI FOREST VIRUS;

EID: 0029862249     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.135.2.479     Document Type: Article

References (34)

1. Allet, B., M. Payton, R.J. Mattaliano, A.M. Gronenborn, G.M. Clore, and P.T. Wingfield. 1988. Purification and characterization of the DNA-binding protein Ner of bacteriophage Mu. Gene (Amst.). 65:259-268.
2. Ausubel, F.M., R. Brent, R.E. Kingston, J.G. Seidman, J.A. Smith, and K. Struhl. 1992. Short Protocols in Molecular Biology. Second edition. Harvard Medical School. Greene Publishing Associates and John Wiley & Sons, New York.
3. Banks, M., P. Graber, A.E.I. Proudfoot, C.Y. Arod, B. Allet, A.R. Bernard, E. Sebille, M. McKinnon, T.N.C. Wells, and R. Solari. 1995. Soluble interleukin 5 receptor alpha-chain binding assays: use for screening and analysis of ILS mutants. Anal. Biochem. 230:321-328.
4. Bebington, C.R., and C.C.G. Hentschel. 1987. The use of vectors based on gene amplification for the expression of cloned genes in mammalian cells. In DNA Cloning. Volume III. D.M. Glover, editor. IRL Press, Oxford/Washington, DC. 163-189.
5. Bump, N.J., M. Hackett, M. Huguenin, S. Seshagiri, K. Brady, P. Chen, C. Ferenz, S. Franklin, T. Ghayur, P. Li et al. 1995. Inhibition of ICE family proteases by baculovirus antiapoptotic protein P35. Science (Wash. DC). 269: 1885-1888.
6. Ceretti, D.P., C.J. Kozloski, B. Mosley, N. Nelson, K.V. Ness, T.A. Greenstreet, C.J. March, S.R. Kronheim, T. Druck, L.A. Cannizaro et al. 1992. Molecular cloning of the interleukin-1β converting enzyme. Science (Wash. DC). 256: 97-100.
7. Duan, H., M. Chinnaiyan, P.L. Hudson, J.P. Wing, W.W. He, and V.M. Dixit. 1996. ICE-LAP-3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. J. Biol. Chem. 271:1621-1625.
8. Faucheu, C., A. Diu, A.W.E. Chan, A.M. Blanchet, C. Miossec, F. Hervé, V. Collard-Dutilleul, Y. Gu, R.A. Aldape, J.A. Lippke et al. 1995. A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells. EMBO (Eur. Mol. Biol. Organ.) J. 14:1914-1922.
9. Fernandes-Alnemri, T., G. Litwack, and E.S. Alnemri. 1994. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin 1β-converting enzyme. J. Biol. Chem. 269:30761-30764.
10. Fernandes-Alnemri, T., G. Litwack, and E.S. Alnemri. 1995a. Mch 2, a new member of the apoptotic Ced-3/ICE cysteine protease gene family. Cancer Res. 55:2737-2742.
11. Fernandes-Alnemri, T., A. Takahashi, R. Armstrong, J. Krebs, L. Fritz, K.J. Tomaselli, L. Wang, Z. Yu, C.M. Croce, G. Salveson et al. 1995b. Mch 3, a novel human apoptotic cysteine protease highly related to CPP 32. Cancer Res. 55:6045-6052.
12. Gagliardini, V., P.A. Fernandez, R.K.K. Lee, H.C.A. Drechsler, R.J. Rotello, M.C. Fishman, and J. Yuan. 1994. Prevention of vertebrate neuronal death by the crmA gene. Science (Wash. DC). 263:826-828.
13. Garcia, I., I Martinou, Y. Tsujimoto, and J.C. Martinou. 1992. Prevention of programmed cell death of sympathetic neurons by the bcl-2 protooncogene. Science (Wash. DC). 258:302-304.
14. Gu, Y., J. Wu, C. Faucheu, J.L. Lalanne, A. Diu, D.J. Livingston, and M.S.S. Su. 1995. Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo. EMBO (Eur. Mol. Biol. Organ.) J. 14: 1923-1931.
15. Kamens, J., M. Paskind, M. Huguenin, R.V. Talanian, H. Allen, D. Banach, N. Bump, M. Hackett, C.G. Johnston, P. Li et al. 1995. Identification and characterization of ICH-2, a novel member of the interleukin-1-beta-converting enzyme family of cysteine proteases. J. Biol. Chem. 270:15250-15256.
16. Kumar, S., Y. Tomooka, and M. Noda. 1992. Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem. Biophys. Res. Commun. 185:1155-1161.
17. Kumar, S., M. Kinoshita, M. Noda, N.G. Copeland, and N.A. Jenkins. 1994. Induction of apoptosis by the mouse Nedd-2 gene which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene Ced-3 and the mammalian IL-1β converting enzyme. Genes & Dev. 8:1613-1626.
18. Liljestrom, P., and H. Garoff. 1991. A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. Biotechnology (NY). 9: 1356-1361.
19. Lundstrom, K., A. Mills, G. Buell, E. Allet, N. Adami, and P. Liljestrom. 1994. High-level expression of the human neurokinin-1 receptor in mammalian cell lines using the Semliki Forest virus expression system. Eur. J. Biochem. 224:917-921.
20. Lundstrom, K., A. Vargas, and B. Allet. 1995. Functional activity of a biotinylated human neurokinin-1 receptor fusion expressed in the Semliki Forest virus system. Biochem. Biophys. Res. Commun. 208:260-266.
21. Maniatis, T., E.F. Fritsch, and J. Sambrook. 1982. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 545 pp.
22. Martin, S.J., and D.R. Green. 1995. Protease activation during apoptosis: death by a thousand cuts? Cell. 82:349-352.
23. Martinou, I., P.A. Fernandez, M. Missoten, E. White, B. Allet, R. Sadoul, and J.C. Martinou. 1995. Viral proteins E1b19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation. J. Cell Biol. 128:201-208.
24. Munday, N.A., J.P. Vaillancourt, A. Ali, F.J. Casano, D.K. Miller, S.M. Molineaux, T.T. Yamin, V.L. Yu, and D.N. Nicholson. 1995. Molecular cloning and pro-apoptotic activity of ICE rel II and ICE rel III, members of the ICE/Ced-3 family of cysteine proteases. J. Biol. Chem. 270:15870-15876.
25. Nicholson, D.N., A. Ali, N.A. Thornberry, J.P. Vaillancourt, C.K. Ding, M. Gallant, Y. Gareau, P.R. Griffin, M. Labelle, Y.A. Iazebnik et al. 1995. Identification and inhibition of the ICE/Ced-3 protease necessary for mammalian apoptosis. Nature (Lond.). 376:37-43.
26. Ramage, P., D. Cheneval, M. Chvei, P. Graff, R. Hemmig, R. Heng, H.P. Kocher, A. Mackenzie, K. Memmert, L. Revesz et al. 1995. Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1 beta converting enzyme precursor. J. Biol. Chem. 270:9378-9383.
27. Tewari, M., L.T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D.R. Beidler, G.G. Poirier, G.S. Slavesen, and V.M. Dixit. 1995. Yama/CPP32 beta, a mammalian homologue of Ced-3, is a Crm A-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 81:801-809.
28. Thornberry, N.A., H.G. Bull, J.R. Calaycay, K.T. Chapman, A.D. Howard, M.J. Kostura, D.K. Miller, S.M. Molineaux, J.R. Weidner, J. Aunins et al. 1992. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature (Lond.). 356:768-774.
29. Walker, N.P., R.V. Talanian, K.D. Brady, L.C. Dang, N.J. Bump, C.R. Ferenz, S. Franklin, T. Ghayur, M.C. Hackett, L.D. Hammill et al. 1994. Cristal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. Cell. 78:343-352.
30. Wang, L., M. Miura, L. Bergeron, H. Zhu, and J. Yuan. 1994. Ich-1, an ICE/Ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell. 78:739-750.
31. Wilson, K.P., J.A.F. Black, J.A. Thomson, E.E. Kim, J.P. Griffith, M.A. Navia, M.A. Murcko, S.P. Chambers, R.A. Aldape, S.A. Raybuck et al. 1994. Structure and mechanism of interleukin-1β converting enzyme. Nature (Lond.). 370:270-274.
32. Xue, D., and H.R. Horvitz. 1995. Inhibition of the Caenorhabditis elegans cell-death protease Ced-3 by a Ced-3 cleavage site in baculovirus p35 protein. Nature (Lond.). 377:248-251.
33. Yuan, J. 1995. Molecular control of life and death. Curr. Opin. Cell Biol. 7:211-214.
34. Yuan, J., S. Shaham, S. Ledoux, H.M. Ellis, and H.R. Horvitz. 1993. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell. 75:641-652.