메뉴 건너뛰기




Volumn 60, Issue 2, 1996, Pages 218-228

Relationship between pharmacodynamic activity and cognitive effects of eptastigmine in patients with Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE INHIBITOR; HEPTYLSTIGMINE TARTRATE; PLACEBO;

EID: 0029860968     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(96)90138-1     Document Type: Article
Times cited : (53)

References (41)
  • 1
    • 0023049733 scopus 로고
    • Anticholinesterase activity of a new carbamate, heptylphysostigmine, in view of its use in patients with Alzheimer-type dementia
    • Brufani M, Marta M, Pomponi M. Anticholinesterase activity of a new carbamate, heptylphysostigmine, in view of its use in patients with Alzheimer-type dementia. Eur J Biochem 1986;157:115-20.
    • (1986) Eur J Biochem , vol.157 , pp. 115-120
    • Brufani, M.1    Marta, M.2    Pomponi, M.3
  • 3
    • 0024329466 scopus 로고
    • The effect of heptylphysostigmine, a new cholinesterase inhibitor, on the central cholinergic system of the rat
    • De Sarno P, Pomponi M, Giacobini E, Tang XC, Williams E. The effect of heptylphysostigmine, a new cholinesterase inhibitor, on the central cholinergic system of the rat. Neurochem Res 1989;14:971-7.
    • (1989) Neurochem Res , vol.14 , pp. 971-977
    • De Sarno, P.1    Pomponi, M.2    Giacobini, E.3    Tang, X.C.4    Williams, E.5
  • 4
    • 0026005792 scopus 로고
    • The behavioural effects of heptyl-physostigmine, a new cholinesterase inhibitor, in tests of long-term and working memory in rodents
    • Dawson GR, Bentley G, Draper F, Rycroft W, Iversen SD, Pagella PG. The behavioural effects of heptyl-physostigmine, a new cholinesterase inhibitor, in tests of long-term and working memory in rodents. Pharmacol Biochem Behav 1991;39:865-71.
    • (1991) Pharmacol Biochem Behav , vol.39 , pp. 865-871
    • Dawson, G.R.1    Bentley, G.2    Draper, F.3    Rycroft, W.4    Iversen, S.D.5    Pagella, P.G.6
  • 5
    • 0026512632 scopus 로고
    • Reversal of cognitive impairment by heptylphisostigmine, a long lasting cholinesterase inhibitor, in primates
    • Rupniak NMJ, Tye SJ, Brazell C, Heald A, Iversen SD, Pagella PG. Reversal of cognitive impairment by heptylphisostigmine, a long lasting cholinesterase inhibitor, in primates. J Neurol Sci 1992;107:246-9.
    • (1992) J Neurol Sci , vol.107 , pp. 246-249
    • Rupniak, N.M.J.1    Tye, S.J.2    Brazell, C.3    Heald, A.4    Iversen, S.D.5    Pagella, P.G.6
  • 8
    • 0028963655 scopus 로고
    • Relationship between pharmacokinetics and pharmacodynamics of eptastigmine in young healthy volunteers
    • Imbimbo BP, Licini M, Schettino M, Mosca A, Zecca L, Radice D, et al. Relationship between pharmacokinetics and pharmacodynamics of eptastigmine in young healthy volunteers. J Clin Pharmacol 1995;35: 285-90.
    • (1995) J Clin Pharmacol , vol.35 , pp. 285-290
    • Imbimbo, B.P.1    Licini, M.2    Schettino, M.3    Mosca, A.4    Zecca, L.5    Radice, D.6
  • 9
    • 84896373034 scopus 로고
    • A study to investigate the safety, tolerance, and pharmacodynamics of single rising doses of L-693,487 (heptylphysostigmine tartrate) in healthy elderly volunteers
    • Southampton, England, Sept. 18-20
    • Swift RH, Mant TG, Heald A, Sciberras DG, Imbimbo B, Morrison PJ, et al. A study to investigate the safety, tolerance, and pharmacodynamics of single rising doses of L-693,487 (heptylphysostigmine tartrate) in healthy elderly volunteers. Presented at the Joint Meeting of the British Pharmacological Society with the Nordic Society, Southampton, England, Sept. 18-20, 1991.
    • (1991) Joint Meeting of the British Pharmacological Society with the Nordic Society
    • Swift, R.H.1    Mant, T.G.2    Heald, A.3    Sciberras, D.G.4    Imbimbo, B.5    Morrison, P.J.6
  • 10
    • 0028890937 scopus 로고
    • A multiple-dose safety trial of eptastigmine in Alzheimer's disease, with pharmacodynamic observations of red blood cell cholinesterase
    • Sramek JJ, Block GA, Reines SA, Sawin SF, Barchowsky A, Cutler NR. A multiple-dose safety trial of eptastigmine in Alzheimer's disease, with pharmacodynamic observations of red blood cell cholinesterase. Life Sci 1994;56:319-26.
    • (1994) Life Sci , vol.56 , pp. 319-326
    • Sramek, J.J.1    Block, G.A.2    Reines, S.A.3    Sawin, S.F.4    Barchowsky, A.5    Cutler, N.R.6
  • 11
    • 0023720774 scopus 로고
    • Acetylcholinesterase in the human erythron; II: Biochemical assay
    • Barr RD, Koekebakker M, Lawson AA. Acetylcholinesterase in the human erythron; II: biochemical assay. Am J Hematol 1988;28:260-5.
    • (1988) Am J Hematol , vol.28 , pp. 260-265
    • Barr, R.D.1    Koekebakker, M.2    Lawson, A.A.3
  • 12
    • 84945058027 scopus 로고
    • Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine
    • Thomsen T, Kaden B, Fischer JP, Bickel U, Barz H, Gusztony G, et al. Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine. Eur J Clin Chem Clin Biochem 1991;29:487-92.
    • (1991) Eur J Clin Chem Clin Biochem , vol.29 , pp. 487-492
    • Thomsen, T.1    Kaden, B.2    Fischer, J.P.3    Bickel, U.4    Barz, H.5    Gusztony, G.6
  • 13
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • Mckhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
    • (1984) Neurology , vol.34 , pp. 939-944
    • Mckhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 14
    • 0016823810 scopus 로고
    • Mini-mental state: A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SW, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.W.2    McHugh, P.R.3
  • 15
    • 0020638387 scopus 로고
    • Diagnostic evaluation of degenerative and vascular dementia
    • Loeb C, Gandolfo C. Diagnostic evaluation of degenerative and vascular dementia. Stroke 1983;14:399-401.
    • (1983) Stroke , vol.14 , pp. 399-401
    • Loeb, C.1    Gandolfo, C.2
  • 17
    • 0029004494 scopus 로고
    • A non-invasive technique for real-time measurements of acetylcholinesterase activity during monitoring of eptastigmine treatment
    • Mosca A, Onelli E, Rosti E, Paleari R, Luzzana M, Imbimbo BP. A non-invasive technique for real-time measurements of acetylcholinesterase activity during monitoring of eptastigmine treatment. Ther Drug Monit 1995;17:230-8.
    • (1995) Ther Drug Monit , vol.17 , pp. 230-238
    • Mosca, A.1    Onelli, E.2    Rosti, E.3    Paleari, R.4    Luzzana, M.5    Imbimbo, B.P.6
  • 18
    • 0027311066 scopus 로고
    • Determination of heptylphysostigmine in plasma by highperformance liquid chromatography with electrochemical detection
    • Zecca L, Radice D, Mosca A, Pagella PG. Determination of heptylphysostigmine in plasma by highperformance liquid chromatography with electrochemical detection. J Chromatogr 1993;615:169-73.
    • (1993) J Chromatogr , vol.615 , pp. 169-173
    • Zecca, L.1    Radice, D.2    Mosca, A.3    Pagella, P.G.4
  • 19
    • 1642572165 scopus 로고
    • Studies of illness in the aged. The index of ADL: A standardized measure of biological and psychological function
    • Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychological function. JAMA 1963;85:914-9.
    • (1963) JAMA , vol.85 , pp. 914-919
    • Katz, S.1    Ford, A.B.2    Moskowitz, R.W.3    Jackson, B.A.4    Jaffe, M.W.5
  • 20
    • 0014579432 scopus 로고
    • Assessment of older people: Self-maintaining and Instrumental Activities of Daily Living
    • Lawton MP, Brody EM. Assessment of older people: self-maintaining and Instrumental Activities of Daily Living. Gerontologist 1969;9:179-86.
    • (1969) Gerontologist , vol.9 , pp. 179-186
    • Lawton, M.P.1    Brody, E.M.2
  • 21
    • 0002603228 scopus 로고
    • Standardizzazione e Taratura Italiana di Test Neuropsicologici
    • Spinnler H, Tognoni G, editors. Standardizzazione e Taratura Italiana di Test Neuropsicologici. Ital J Neurol Sci 1987;6(suppl 8):8-120.
    • (1987) Ital J Neurol Sci , vol.6 , Issue.8 SUPPL. , pp. 8-120
    • Spinnler, H.1    Tognoni, G.2
  • 22
    • 0004143423 scopus 로고
    • Letter to the sponsors involved in clinical trials with drugs in Alzheimer's disease. Rockville, MD: US Food and Drug Administration, Nov. 8
    • Leber P. Guidelines for the clinical evaluation of antidementia drugs. Letter to the sponsors involved in clinical trials with drugs in Alzheimer's disease. Rockville, MD: US Food and Drug Administration, Nov. 8, 1990.
    • (1990) Guidelines for the Clinical Evaluation of Antidementia Drugs
    • Leber, P.1
  • 23
    • 0019255833 scopus 로고
    • Memory deficits in aged Cebus monkeys and facilitation with central cholinomimetics
    • Bartus RT, Dean RL, Beer B. Memory deficits in aged Cebus monkeys and facilitation with central cholinomimetics. Neurobiol Aging 1980;1:145-52.
    • (1980) Neurobiol Aging , vol.1 , pp. 145-152
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3
  • 24
    • 0022473115 scopus 로고
    • Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: Modification by cholinergic drugs
    • Ridley RM, Murray TK, Johnson JA, Baker HF. Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: modification by cholinergic drugs. Brain Res 1986;376:108-16.
    • (1986) Brain Res , vol.376 , pp. 108-116
    • Ridley, R.M.1    Murray, T.K.2    Johnson, J.A.3    Baker, H.F.4
  • 25
    • 0017091532 scopus 로고
    • Short-term memory in rhesus monkey: Disruption for the anticholinergic scopolamine
    • Bartus RT, Johnson HR. Short-term memory in rhesus monkey: disruption for the anticholinergic scopolamine. Pharmacol Biochem Behav 1976;5:39-46.
    • (1976) Pharmacol Biochem Behav , vol.5 , pp. 39-46
    • Bartus, R.T.1    Johnson, H.R.2
  • 26
    • 0025285346 scopus 로고
    • Effects of a novel CNS-selective cholinesterase inhibitor, SM-10888, on habituation and passive avoidance responses in mice
    • Okazaki Y, Natori K, Irie T, Katsube J. Effects of a novel CNS-selective cholinesterase inhibitor, SM-10888, on habituation and passive avoidance responses in mice. Jpn J Pharmacol 1990;53:211-20.
    • (1990) Jpn J Pharmacol , vol.53 , pp. 211-220
    • Okazaki, Y.1    Natori, K.2    Irie, T.3    Katsube, J.4
  • 27
    • 7144245404 scopus 로고
    • Determination of cholinesterase inhibition in erythrocytes, plasma and CSF following administration of eptastigmine and physostigmine at behaviourally active doses in rat
    • Freedman SB, Harley EA, Bentley G, Dawson GR. Determination of cholinesterase inhibition in erythrocytes, plasma and CSF following administration of eptastigmine and physostigmine at behaviourally active doses in rat [abstract]. Neurobiol Aging 1992; 13(suppl 1):S129.
    • (1992) Neurobiol Aging , vol.13 , Issue.1 SUPPL.
    • Freedman, S.B.1    Harley, E.A.2    Bentley, G.3    Dawson, G.R.4
  • 28
    • 0022501203 scopus 로고
    • Measurement of erythrocyte acetylcholinesterase and plasma cholinesterase activity by a differential pH technique
    • Barenghi L, Ceriotti F, Luzzana M, Ripamonti M, Mosca A, Bonini PA. Measurement of erythrocyte acetylcholinesterase and plasma cholinesterase activity by a differential pH technique. Ann Clin Biochem 1986;23:538-45.
    • (1986) Ann Clin Biochem , vol.23 , pp. 538-545
    • Barenghi, L.1    Ceriotti, F.2    Luzzana, M.3    Ripamonti, M.4    Mosca, A.5    Bonini, P.A.6
  • 29
    • 0027177781 scopus 로고
    • Rapid potentiometric determination of cholinesterases in plasma and red cells: Application to eptastigmine monitoring
    • Cazzola E, Lattuada N, Zecca L, Radice D, Luzzana M, Imbimbo BP, et al. Rapid potentiometric determination of cholinesterases in plasma and red cells: application to eptastigmine monitoring. Chem Biol Interact 1993;87:265-8.
    • (1993) Chem Biol Interact , vol.87 , pp. 265-268
    • Cazzola, E.1    Lattuada, N.2    Zecca, L.3    Radice, D.4    Luzzana, M.5    Imbimbo, B.P.6
  • 30
    • 0019505638 scopus 로고
    • Cholinergic receptor interactions and their effects on long-term memory processing
    • Flood JF, Landry DW, Jarvik ME. Cholinergic receptor interactions and their effects on long-term memory processing. Brain Res 1981;215:177-85.
    • (1981) Brain Res , vol.215 , pp. 177-185
    • Flood, J.F.1    Landry, D.W.2    Jarvik, M.E.3
  • 32
    • 0023721555 scopus 로고
    • Effects of the novel compound NIK-247 on impairment of passive avoidance response in mice
    • Nabeshima T, Yoshida S, Kameyama T. Effects of the novel compound NIK-247 on impairment of passive avoidance response in mice. Eur J Pharmacol 1988; 154:263-9.
    • (1988) Eur J Pharmacol , vol.154 , pp. 263-269
    • Nabeshima, T.1    Yoshida, S.2    Kameyama, T.3
  • 33
    • 0025978708 scopus 로고
    • Cholinergic drugs reverse AF64A-induced impairment of passive avoidance learning in rats
    • Yamazaki N, Kato K, Kurihara E, Nagaoka A. Cholinergic drugs reverse AF64A-induced impairment of passive avoidance learning in rats. Psychopharmacology 1991;103:215-22.
    • (1991) Psychopharmacology , vol.103 , pp. 215-222
    • Yamazaki, N.1    Kato, K.2    Kurihara, E.3    Nagaoka, A.4
  • 34
    • 0028062912 scopus 로고
    • Characterization of novel muscarinic receptor agonist, YM796: Comparison with cholinesterase inhibitors in in vivo pharmacological studies
    • Wanibuchi F, Nishida T, Yamashita H, Hidaka K, Koshiya K, Tsukamoto S, et al. Characterization of novel muscarinic receptor agonist, YM796: comparison with cholinesterase inhibitors in in vivo pharmacological studies. Eur J Pharmacol 1994;265:151-8.
    • (1994) Eur J Pharmacol , vol.265 , pp. 151-158
    • Wanibuchi, F.1    Nishida, T.2    Yamashita, H.3    Hidaka, K.4    Koshiya, K.5    Tsukamoto, S.6
  • 35
    • 0017575630 scopus 로고
    • Memory enhancement after physostigmine treatment in the amnesic syndrome
    • Peters BH, Levin HS. Memory enhancement after physostigmine treatment in the amnesic syndrome. Arch Neurol 1977;34:215-9.
    • (1977) Arch Neurol , vol.34 , pp. 215-219
    • Peters, B.H.1    Levin, H.S.2
  • 37
    • 0024253376 scopus 로고
    • Long-term administration of oral phsysotigmine in Alzheimer's disease
    • Stern Y, Sano M, Mayeux R. Long-term administration of oral phsysotigmine in Alzheimer's disease. Neurology 1988;38:1837-41.
    • (1988) Neurology , vol.38 , pp. 1837-1841
    • Stern, Y.1    Sano, M.2    Mayeux, R.3
  • 38
    • 0024561304 scopus 로고
    • Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease
    • Thal LJ, Masur DM, Blau AD, Fuld PA, Klauber MR. Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease. J Am Geriatr Soc 1989;37:42-8.
    • (1989) J Am Geriatr Soc , vol.37 , pp. 42-48
    • Thal, L.J.1    Masur, D.M.2    Blau, A.D.3    Fuld, P.A.4    Klauber, M.R.5
  • 39
    • 0019505981 scopus 로고
    • Autoregulation of acetylcholine release in isolated hippocampal nerve endings
    • Marchi M, Paudice P, Raiteri M. Autoregulation of acetylcholine release in isolated hippocampal nerve endings. Eur J Pharmacol 1981;73:75-9.
    • (1981) Eur J Pharmacol , vol.73 , pp. 75-79
    • Marchi, M.1    Paudice, P.2    Raiteri, M.3
  • 40
    • 0023280053 scopus 로고
    • An in vivo pharmacological study on muscarinic receptor subtypes regulating cholinergic neurotransmission in rat striatum
    • Consolo S, Ladinsky H, Vinci R, Palazzi E, Wang JX. An in vivo pharmacological study on muscarinic receptor subtypes regulating cholinergic neurotransmission in rat striatum. Biochem Pharmacol 1987;36: 3075-7.
    • (1987) Biochem Pharmacol , vol.36 , pp. 3075-3077
    • Consolo, S.1    Ladinsky, H.2    Vinci, R.3    Palazzi, E.4    Wang, J.X.5
  • 41
    • 0027291923 scopus 로고
    • Muscarinic receptors mediate attenuation of extracellular acetylcholine levels in rat cerebral cortex after cholinesterase inhibition
    • Messamore E, Warpman U, Williams E, Giacobini E. Muscarinic receptors mediate attenuation of extracellular acetylcholine levels in rat cerebral cortex after cholinesterase inhibition. Neurosci Lett 1993;158: 205-8.
    • (1993) Neurosci Lett , vol.158 , pp. 205-208
    • Messamore, E.1    Warpman, U.2    Williams, E.3    Giacobini, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.