Neurohumoral, peptidergic and biochemical responses to supine exercise in two groups with primary autonomic failure: Shy-Drager syndrome/multiple system atrophy and pure autonomic failure

Clinical Autonomic Research

Volumn 6, Issue 5, 1996, Pages 255-262

  Smith, G D P ^a   Watson, L P ^b   Mathias, C J ^b  

^a ST MARY S HOSPITAL   (United Kingdom)

^b NONE

Author keywords

Autonomic failure; Catecholamines; Exercise; Glucose; Hormones; Plasma renin activity

Indexed keywords

ADRENALIN; C PEPTIDE; DOPAMINE; GLUCOSE; GROWTH HORMONE; INSULIN; NEUROHORMONE; NORADRENALIN; RENIN;

ADRENALIN BLOOD LEVEL; ADULT; AGED; ARTICLE; AUTONOMIC DYSFUNCTION; BIOCHEMISTRY; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; DOPAMINE BLOOD LEVEL; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HUMAN; HYPOTENSION; INSULIN BLOOD LEVEL; LEG EXERCISE; MALE; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; PEPTIDERGIC NERVOUS SYSTEM; PLASMA RENIN ACTIVITY; SHY DRAGER SYNDROME; SUPINE POSITION;

AUTONOMIC NERVOUS SYSTEM DISEASES; BLOOD PRESSURE; CATECHOLAMINES; EXERCISE; FEMALE; HEART RATE; HEMODYNAMIC PROCESSES; HUMANS; MALE; MIDDLE AGED; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; SHY-DRAGER SYNDROME; SUPINE POSITION; SWEATING;

EID: 0029860606     PISSN: 09599851     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02556296     Document Type: Article

References (45)

1. Mathias CJ. Orthostatic hypotension - causes, mechanisms and influencing factors. Neurology 1995; 45 (suppl. 5): s6-s11 .
2. Smith GDP, Watson LP, Pavitt DV, Mathias CJ. Abnormal cardiovascular and catecholamine responses to supine exercise in human subjects with sympathetic dysfunction. J Physiol (Lond) 1995; 484: 255-265.
3. Marshall RJ, Schirger A, Shepherd JT. Blood pressure during supine exercise in idiopathic orthostatic hypotension. Circulation 1961; 24: 76-81.
4. Bevegard S, Jonsson B, Karlof I. Circulatory response to recumbent exercise and head-up tilting in patients with disturbed sympathetic cardiovascular control (postural hypotension). Acta Med Scand 1962; 172: 623-636.
5. Mathias CJ, Bannister R. Investigation of autonomic disorders. In: Bannister R, Mathias CJ, eds. Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System, 3rd edn. Oxford: Oxford University Press, 1992; 255-290.
6. May C, Ham IW, Heslop K, Stone FA, Mathias CJ. Intravenous morphine causes hypotension, hypoglycaemia and increases sympatho-adrenal activity in the conscious rat. Clin Sci 1988; 75: 71-77.
7. Polinsky RJ. Neuropharmacological investigation of autonomic failure. In: Bannister R, Mathias CJ, eds. Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System, 3rd edn. Oxford: Oxford University Press, 1992; 334-358.
8. Gray I, Beetham WP. Changes in plasma concentration of epinephrine and norepinephrine with muscular work. Proc Soc Exp Med 1957; 96: 636-638.
9. Kotchen TA, Hartley LH, Rice TW, Moughey EH, Jones LG, Mason JW. Renin, norepinephrine, and epinephrine responses to graded exercise. J Appl Physiol 1971; 31: 178-184.
10. Ziegler MG, Lake CR, Kopin IJ. The sympathetic-nervous-system defect in primary orthostatic hypotension. New Engl J Med 1977; 296: 293-297.
11. Mathias CJ, Matthews WB, Spalding JMK. Postural changes in plasma renin activity and responses to vasoactive drugs in a case of Shy-Drager syndrome. J Neurol Neurosurg and Psychiatry 1977; 40: 138-143.
12. Bannister R, Davies IB, Holly E, Rosenthal T, Sever PS. Defective cardiovascular reflexes and supersensitivity to sympathomimetic drugs in autonomic failure. Brain 1979; 10: 163-176.
13. Polinsky RJ, Kopin IJ, Ebert MH, Weise V. Pharmacological distinction of different orthostatic hypotension syndromes. Neurology 1981; 31: 1-7.
14. Jensen EB, Espersen K, Kanstrup I-L, Christensen NJ. Exercise-induced changes in plasma catecholamines and neuropeptide Y: relation to age and sampling time. J Appl Physiol 1994; 76: 1269-1273.
15. Bannister R, Sever PS, Gross M. Cardiovascular reflexes and biochemical responses in progressive autonomic failure. Brain 1977; 100: 327-344.
16. Wilcox CS, Aminoff MJ, Slater JDH. Sodium homoeostasis in patients with autonomic failure. Clin Sci 1977: 53; 321-328.
17. Gordon RD, Kuchel O, Island DP, Liddle GW. Role of sympathetic nervous system in mediating renal and adrenocortical secretory responses to upright posture. J Clin Invest 1966; 45: 1016.
18. Love DR, Brown JJ, Chinn RH et al. Plasma renin in idiopathic orthostatic hypotension: differential response in subjects with probable afferent and efferent autonomic failure. Clin Sci 1971; 41: 289-299.
19. DiBona GF, Wilcox CS. The kidney and the sympathetic nervous system. In: Bannister R, Mathias CJ, eds. Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System, 3rd edn. Oxford: Oxford University Press, 1992; 178-196.
20. Helmer OM. Renin activity in blood from patients with hypertension. Can Med Assoc J 1964; 90: 221-225.
21. Convertino VA, Keil LC, Bernauer EM, Greenleaf JE. Plasma volume, osmolarity, vasopressin, and renin activity during graded exercise in man. J Appl Physiol 1981; 50: 123-128.
22. Conn JW, Rovner DR, Cohen EL. Normal and altered function of the renin-angiotensin-aldosterone system in man: applications in clinical and research medicine. Ann Intern Med 1965; 63: 266-284.
23. Polonsky KS, Rubestein AH. C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations. Diabetes 1984; 33: 486-494.
24. Mathias CJ. Post-prandial hypotension. Pathophysiological mechanisms and clinical implications, in different disorders. Hypertension 1991; 18: 694-704.
25. Mathias CJ, Holly E, Armstrong E, Shareef M, Bannister R. The influence of food on postural hypotension in three groups with chronic autonomic failure - clinical and therapeutic implications. J Neurol Neurosurg Psychiatry 1991; 54: 726-730.
26. Mathias CJ, Da Costa DF, Fosbraey P, Christensen NJ, Bannister R. Hypotensive and sedative effect of insulin in autonomic failure. Br Med J 1987; 295: 161-163.
27. Brown RT, Polinsky RJ, Lee GK, Deeter JA. Insulin-induced hypotension and neurogenic orthostatic hypotension. Neurology 1986; 36: 1402-1406.
28. Hartley LH, Mason JW, Hogan RP et al. Multiple hormonal responses to prolonged exercise in relation to physical training. J Appl Physiol 1972; 33: 607-610.
29. Galbo H, Holst JJ, Christensen NJ. Glucagon and plasma catecholamine responses to graded and prolonged exercise in man. J Appl Physiol 1975; 38: 70-76.
30. Sutton JR. Effect of acute hypoxia on the hormonal response to exercise. J Appl Physiol 1977; 42: 587-592.
31. Galbo H. Hormonal and Metabolic Adaptations to Exercise. Stuggart: George Thieme Verlag, 1983.
32. Macdonald IA. The sympathetic nervous system and its influence on metabolic function. In: Bannister R, Mathias CJ, eds. Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System, 3rd edn. Oxford: Oxford University Press, 1992; 197-211.
33. McGuffin WL, Sherman BM, Roth J et al. Acromegaly and cardiovascular disorders. A prospective study. Ann Intern Med 1974; 81: 11-18.
34. Thomaides TN, Chaudhuri KR, Maule S, Watson L, Marsden CD, Mathias CJ. Growth hormone response to clonidine in central and peripheral primary autonomic failure. Lancet 1992; 340: 263-266.
35. Polinsky RJ, Kopin IJ, Ebert MH, Weise V, Recant L. Hormonal response to hypoglycaemia in orthostatic hypotension patients with adrenergic insufficiency. Life Sci 1981; 29: 417-425.
36. Lightman SL, Williams TDM. Hypothalamic and pituitary function in autonomic failure. In: Bannister R, Mathias CJ, eds. Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System, 3rd edn. Oxford: Oxford University Press, 1992; 378-390.
37. Mathias CJ, da Costa DF, McIntosh CM et al. Differential blood pressure and hormonal effects after glucose and xylose ingestion in chronic autonomic failure. Clin Sci 1989; 77: 85-92.
38. Mathias CJ, Bannister R. Postcibal hypotension in autonomic disorders. In: Bannister R, Mathias CJ, eds. Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System, 3rd edn. Oxford: Oxford University Press, 1992; 489-509.
39. Mathias CJ, Frankel HL, Turner RC, Christensen NJ. Physiological responses to insulin hypoglycaemia in spinal man. Paraplegia 1979; 17: 319-326.
40. Kjaer M, Kiens B, Hargreaves M, Richter EA. Influence of active muscle mass on glucose homoeostasis during exercise in humans. J Appl Physiol 1991; 71: 552-557.
41. Calles JJJ, Cunningham L, Nelson N et al. Glucose turnover during recovery from intensive exercise. Diabetes 1983; 32: 734-738.
42. Kjaer M, Farrell NJ, Christensen NJ, Galbo H. Increased epinephrine response and inaccurate glucoregulation in exercising athletes. J Appl Physiol 1986; 61: 1693-1700.
43. Hoelzer DR, Dalsky GP, Clutter WE, Shah SD, Holloszy JO, Cryer PE. Glucoregulation during exercise hypoglycaemia is prevented by redundant glucoregulatory systems, sympathochromaffin activation, and changes in islet hormone secretion. J Clin Invest 1986; 77: 212-221.
44. Kjaer M, Secher NH, Bach FW, Galbo H. Role of motor centre activity for hormonal changes and substrate mobilisation in humans. Am J Physiol 1987; 253: R687-R695.
45. Polinsky RJ, Kopin IJ, Ebert MH, Weise V. The adrenal medullary response to hypoglycaemia in patients with orthostatic hypotension. J Clin Endocrinol Metab 1980; 51: 1401-1406.