Biomimetic modeling of the decomposition of 2'-chloro-2'-deoxynucleotides by ribonucleotide reductases to give 3(2H)-furanones which can effect mechanism-based inactivation by Michael-type alkylation

Journal of the American Chemical Society

Volumn 118, Issue 45, 1996, Pages 11317-11318

  Robins, Morris J ^a   Guo, Zhiqiang ^a   Samano, Mirna C ^a,b   Wnuk, Stanislaw F ^a  

^a Brigham Young University   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FURANONE DERIVATIVE; RIBONUCLEOTIDE REDUCTASE;

ARTICLE; DRUG DEGRADATION; DRUG SYNTHESIS; ENZYME ACTIVITY; MODEL; REACTION ANALYSIS;

EID: 0029860477     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja962118e     Document Type: Article

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