Fructose and tagatose protect against oxidative cell injury by iron chelation

Free Radical Biology and Medicine

Volumn 22, Issue 1-2, 1997, Pages 257-268

  Valeri, Fabio ^a   Boess, Franziska ^a   Wolf, Armin ^b   Göldlin, Christian ^a   Boelsterli, Urs A ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Sandoz Pharma Ltd   (Switzerland)

Author keywords

Cocaine; Cultured hepatocytes; Free radicals; Fructose; Iron chelators; Luminol chemiluminescence; Nitrofurantoin; Reactive oxygen species; Tagatose

Indexed keywords

COCAINE; FREE RADICAL; FRUCTOSE; NITROFURANTOIN; REACTIVE OXYGEN METABOLITE; TAGATOSE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL PROTECTION; CHEMOLUMINESCENCE; ENZYME ACTIVITY; ENZYME RELEASE; GLYCOLYSIS; IRON CHELATION; LIVER CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0029860108     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(96)00331-0     Document Type: Article

References (61)

1. Anundi I., King J., Owens D. A., Schneider H., Lemasters J. J., Thurman R. G. Total protection from hypoxic liver damage by fructose. Res. Commun. Chem. Pathol. Pharmacol. 55:1987;111-116.
2. Brass C. A., Crawford J. M., Narciso J., Gollan J. L. Hypoxic liver injury and the ameliorating effects of fructose - The glucose paradox revisited. Am. J. Physiol. 263:1992;G293-G300.
3. Okabe H., Kurosawa K., Hatanaka N., Yoshitake J.-I., Tagawa K. Protection of cellular and mitochondrial functions against anoxic damage by fructose in perfused liver. Biochim. Biophys. Acta. 1098:1991;41-48.
4. i. J. Biol. Chem. 267:1992;7545-7552.
5. Brass C. A., Crawford J. M., Narciso J. P., Gollan J. L. Evaluation of University of Wisconsin cold-storage solution in warm hypoxic perfusion of rat liver - The addition of fructose reduces injury. Gastroenterology. 105:1993;1455-1463.
6. Nieminen A.-L., Dawson T. L., Gores G. J., Kawanishi T., Herman B., Lemasters J. J. Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals. Biochem. Biophys. Res. Commun. 167:1990;600-606.
7. Wu E. Y., Smith M. T., Bellomo G., DiMonte D. Relationships between the mitochondrial transmembrane potential, ATP concentration and cytotoxicty in isolated rat hepatocytes. Arch. Biochem. Biophys. 282:1990;358-362.
8. Cannon J. R., Harvison P. J., Rush G. F. The effects of fructose on adenosine triphosphate depletion following mitochondrial dysfunction and lethal cell injury in isolated rat hepatocytes. Toxicol. Appl. Pharmacol. 108:1991;407-416.
9. Mithöfer K., Sandy M. S., Smith M. T., Dimonte D. Mitochondrial poisons cause depletion of reduced glutathione in isolated hepatocytes. Arch. Biochem. Biophys. 295:1992;132-136.
10. Snyder J. W., Pastorino J. G., Thomas A. P., Hoek J. B., Farber J. L. ATP synthase activity is required for fructose to protect cultured hepatocytes from the toxicity of cyanide. Am. J. Physiol. 264:1993;C709-C714.
11. Nieminen A. L., Saylor A. K., Herman B., Lemasters J. J. ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition. Am. J. Physiol. 267:1994;C67-C74.
12. Niknahad H., Khan S., Sood C., O'Brien P. J. Prevention of cyanide-induced cytotoxicity by nutrients in isolated hepatocytes. Toxicol. Appl. Pharmacol. 128:1994;271-279.
13. Di Monte D., Sandy M. S., Blank L., Smith M. T. Fructose prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced ATP depletion and toxicity in isolated hepatocytes. Biochem. Biophys. Res. Commun. 153:1988;734-740.
14. Mourelle M., Beales D., McLean A. E. M. Prevention of paracetamol-induced liver injury by fructose. Biochem. Pharmacol. 41:1991;1831-1837.
15. Adamson G. M., Billings R. E. Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes. Arch. Biochem. Biophys. 294:1992;223-229.
16. Imberti R., Nieminen A. L., Herman B., Lemasters J. J. Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide - Protection by fructose, cyclosporin-A and trifluoperazine. J. Pharmacol. Exp. Ther. 265:1993;392-400.
17. Silva J. M., Khan S., O'Brien P. J. Molecular mechanisms of nitrofurantoin-induced hepatocyte toxicity in aerobic versus hypoxic conditions. Arch. Biochem. Biophys. 305:1993;362-369.
18. Martin F. L., McLean A. E. M. Cell protection by fructose is independent of adenosine triphosphate (ATP) levels in paracetamol injury to rat liver slices. Toxicology. 107:1996;177-187.
19. Van den Berghe G. Fructose: Metabolism and short-term effects on carbohydrate and purine metabolic pathways. Prog. Biochem. Pharmacol. 21:1986;1-32.
20. Mayes P. A. Intermediary metabolism of fructose. Am. J. Clin. Nutr. 58:(Suppl.):1993;754S-765S.
21. Gores G. J., Nieminen A. L., Fleishman K. E., Dawson T. L., Herman B., Lemasters J. J. Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes. Am. J. Physiol. (Cell Physiol.). 24:1988;C315-C322.
22. Herman B., Gores G. J., Nieminen A.-L., Kawanishi T., Harman A., Lemasters J. J. Calcium and pH in anoxic and toxic injury. Crit. Rev. Toxicol. 21:1991;127-148.
23. Bronk S. F., Gores G. J. pH-Dependent nonlysosomal proteolysis contributes to lethal anoxic injury of rat hepatocytes. Am. J. Physiol. 264:1993;G744-G751.
24. Kehrer J. P., Lund L. G. Cellular reducing equivalents and oxidative stress. Free Radic. Biol. Med. 17:1994;65-75.
25. Yamamoto K., Farber J. L. Metabolism of pyridine nucleotides in cultured rat hepatocytes intoxicated with tert-butyl hydroperoxide. Biochem. Pharmacol. 43:1992;1119-1126.
26. Charley P. J., Sarkar B., Stitt C. F., Saltman P. Chelation of iron by sugars. Biochim. Biophys. Acta. 69:1963;313-321.
27. Davis P. S., Deller D. J. Prediction and demonstration of iron chelating ability of sugars. Nature. 212:1966;404-405.
28. Tonkovic M. New approach to the complexation of iron(III) with fructose. Carbohydr. Res. 254:1994;277-280.
29. Göldlin C., Boelsterli U. A. Reactive oxygen species and non-peroxidative mechanisms of cocaine-induced cytotoxicity in rat hepatocyte cultures. Toxicology. 69:1991;79-91.
30. Boelsterli U. A., Wolf A., Göldlin C. Oxygen free radical production mediated by cocaine and its ethanol-derived metabolite, cocaethylene, in rat hepatocytes. Hepatology. 18:1993;1154-1161.
31. Klee S., Nurnberger M. C., Ungemach F. R. The consequences of nitrofurantoin-induced oxidative stress in isolated rat hepatocytes: Evaluation of pathobiochemical alterations. Chem. Biol. Interact. 93:1994;91-102.
32. Silva J. M., McGirr L., O'Brien P. J. Prevention of nitrofurantoin-induced cytotoxicity in isolated hepatocytes by fructose. Arch. Biochem. Biophys. 289:1991;313-318.
33. Berry M. N., Friend D. S. High-yield preparation of isolated rat liver parenchymal cells. A biochemical and fine structural study. J. Cell Biol. 43:1969;506-520.
34. Henley R., Worwood M. The enhancement of iron-dependent luminol peroxidation by 2,2′-dipyridyl and nitriloacetate. J. Biolumin. Chemilumin. 9:1994;245-250.
35. Kahl R., Weinmann A., Weinke S., Hildebrandt A. G. Detection of oxygen activation and determination of the activity of antioxidants towards reactive oxygen species by use of the chemiluminigenic probes luminol and lucigenin. Arch. Toxicol. 60:1987;158-162.
36. Wolf A., Broadhurst M., Tschopp M., Singer T. Protective effect of vitamin E-acetate against lipid peroxidation is higher in liver than in kidney. Nigam S., Honn K. V., Marnett L. I., Walden T. L. Eicosanoids and other bioactive lipids in cancer, inflammation and radiation injury. 1992;119-124 Kluwer Academic Publishers, Berlin.
37. Smith M. T., Thor H., Orrenius S. Detection and measurement of drug-induced oxygen radical formation. Packer L. P. Oxygen radicals in biological systems. Methods in enzymology. 105:1984;505-510 Academic Press, Orlando, FL.
38. Azzi A., Montecucco C., Richter C. The use of acetylated ferricytochrome c for the detection of superoxide radicals produced in biological membranes. Biochem. Biophys. Res. Commun. 65:1975;597-603.
39. Göldlin C., Boelsterli U. A. Dissociation of covalent protein adduct formation from oxidative injury in cultured hepatocytes exposed to cocaine. Xenobiotica. 24:1994;251-264.
40. Noack H., Kunz W. S., Augustin W. Evaluation of a procedure for the simultaneous determination of oxidized and reduced pyridine nucleotides and adenylates in organic phenol extracts from mitochondria. Anal. Biochem. 202:1992;162-165.
41. Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
42. Noll F. L-(+)-Lactate. Determination with LDH, GPT and NAD. Bergmeyer H. U. Methods of enzymatic analysis. 4:1974;1475-1477 Academic Press, New York.
43. Kloss M. W., Rosen G. M., Rauckman E. J. N-Demethylation of cocaine to norcocaine. Evidence for participation by cytochrome P-450 and FAD-containing monooxygenase. Mol. Pharmacol. 23:1983;482-485.
44. Boelsterli U. A., Göldlin C. Biomechanisms of cocaine-induced hepatocyte injury mediated by the formation of reactive metabolites. Arch. Toxicol. 6:1991;351-360.
45. Roberts S. M., James R. C., Harbison R. D. Cocaine-induced hepatotoxicity. Lakoski J. M., Galloway M. P., White F. J. Cocaine. Pharmacology, physiology, and clinical strategies. 1992;15-33 CRC Press, Boca Raton, FL.
46. Evans M. A. Role of protein binding in cocaine-induced hepatic necrosis. J. Pharmacol. Exp. Ther. 224:1983;73-79.
47. Martinez P., Carrascosa J. M., Nunez de Castro I. Ketose induced respiratory inhibition in isolated hepatocytes. Rev. Esp. Fisiol. 43:1987;163-172.
48. Nagelkerke J. F., Debont A., Debont H. J. G. M., Tijdens I. B., Mulder G. J., Meerman J. H. N. Fasting increases the susceptibility of rat hepatocytes to the cytotoxic effects of N-hydroxy-acetylaminofluorene - Effects on mitochondrial respiration and membrane potential. Biochem. Pharmacol. 44:1992;2339-2345.
49. O'Dell B. L. Fructose and mineral metabolism. Am. J. Clin. Nutr. 58:(Suppl.):1993;771S-778S.
50. Reiser S., Hallfrisch J. Metabolic effects of dietary fructose. 1987;CRC Press, Boca Raton, FL.
51. Nagy L., Ohtaki H. EXAFS study of iron(III) complexes of sugar-type ligands. Inorg. Chim. Acta. 159:1989;201-207.
52. Ryan T. P., Aust S. D. The role of iron in oxygen-mediated toxicities. Crit. Rev. Toxicol. 22:1992;119-141.
53. Kirschner R. E., Fantini G. A. Role of iron and oxygen-derived free radicals in ischemia-reperfusion injury. J. Am. Coll. Surgeons. 179:1994;103-117.
54. Boyer C. S., Petersen D. R. Hepatic biochemical changes as a result of acute cocaine administration in the mouse. Hepatology. 14:1991;1209-1216.
55. Lloyd R. V., Shuster L., Mason R. P. Reexamination of the microsomal transformation of N-hydroxynorcocaine to norcocaine nitroxide. Mol. Pharmacol. 43:1993;645-648.
56. Suntres Z. E., Shek P. N. Nitrofurantoin-induced pulmonary toxicity. Biochem. Pharmacol. 43:1992;1127-1135.
57. Hoener B., Noach A., Andrup M., Yen T. S. B. Nitrofurantoin produces oxidative stress and loss of glutathione and protein thiols in the isolated perfused rat liver. Pharmacology. 38:1988;363-373.
58. Jaeschke H. Reactive oxygen and ischemia/reperfusion injury of the liver. Chem.-Biol. Interact. 79:1991;115-136.
59. Omar R., Nomikos I., Piccorelli G., Savino J., Agarwal N. Prevention of postischaemic lipid peroxidation and liver cell injury by iron chelation. Gut. 30:1989;510-514.
60. Hider R. C. Potential protection from toxicity by oral iron chelators. Toxicol. Lett. 82/83:1995;961-967.
61. Hallfrisch J. Metabolic effects of dietary fructose. FASEB J. 4:1990;2652-2660.