Use of a μ-antisense oligodeoxynucleotide as a μ, opioid receptor noncompetitive antagonist in vivo

Neurochemical Research

Volumn 21, Issue 11, 1996, Pages 1363-1368

  Chen, Xiao Hong ^a   Liu Chen, Lee Yuan ^a   Tallarida, Ronald J ^a   Geller, Ellen B ^a   De Riel, J Kim ^b   Adler, Martin W ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY HEALTH SYSTEM   (United States)

Author keywords

Antisense; Cold water tail flick (CWT) test; Morphine; Oligodeoxynucleotide; Opioid receptor; funaltrexamine ( FNA)

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; BETA FUNALTREXAMINE; MORPHINE; MU OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; DOSE RESPONSE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TAIL FLICK TEST;

ANIMALS; BASE SEQUENCE; CEREBRAL VENTRICLES; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SUBCUTANEOUS; MALE; MOLECULAR SEQUENCE DATA; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; OLIGONUCLEOTIDES, ANTISENSE; PAIN; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, OPIOID, MU;

ANIMALIA;

EID: 0029859826     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02532377     Document Type: Article

References (46)

1. Adler, M. W., and Geller, E. B. 1993. Physiological functions of opioids: temperature regulation. Pages 205-238, in Herz, A. (ed), Handbook of Experimental Pharmacology, Vol. 104/11, Opioids II, Springer-Verlag, Berlin.
2. Chen, Y., Mestek, A., Liu, J., Hurley, J. A., and Yu, L. 1993. Molecular cloning and functional expression of a μ-opioid receptor from rat brain. Mol. Pharmacol. 44:8-12.
3. Evans, C. J., Keith, D. E., Jr., Morrison, H., Magendzo, K., and Edwards, R. H. 1992. Cloning of a delta opioid receptor by functional expression. Science 258:1952-1955.
4. Kieffer, B. L., Befort, K., Gaveriaux-Ruff, C., and Hirth, C. G. 1992. The δ-opioid receptor: Isolation of a cDNA by expression cloning and pharmacological characterization. Proc. Natl. Acad. Sci. USA. 89:12148-12152.
5. Li, S., Zhu, J., Chen, C., Chen, Y.-W., DeRiel, J. K., Ashby, B., and Liu-Chen, L.-Y. 1993. Molecular cloning and expression of a rat κ opioid receptor. Biochem. J. 295:629-633.
6. Yasuda, K., Raynor, K., Kong, J., Breder, C. D., Takeda, J., Reisine, T., and Bell, G. I. 1993. Cloning and functional comparison of κ and δ opioid receptors from mouse brain. Proc. Natl. Acad. Sci. USA. 90:6736-6740.
7. Wahlestedt, C., Pich, E. M., Koob, G. F., Yee, F., and Heilig, M. 1993. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259:528-531.
8. Wahlestedt, C., Golanov, E., Yamamoto, S., Yee, F., Ericson, H., Yoo, H. Inturrisi, C. E., and Reis, D. J. 1993. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature 363:260-263.
9. 2 dopamine receptors in mouse striatum. J. Pharmacol. Exp. Ther. 268:1015-1023.
10. Tseng, L. F., Collins, K. A., and Kampine, J. P. 1994. Antisense oligodeoxynucleotide to a δ-opioid receptor selectively blocks the spinal antinociception induced by δ-, but not μ- or κ-opioid receptor agonists in the mouse. Eur. J. Pharmacol. 258:R1-3.
11. 4]deltorphin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor. Life Sci. 55:PL 37-43.
12. Chien, C.-C., Brown, G., Pan, Y.-X., and Pasternak, G. W. 1994. Blockade of U50,488H analgesia by antisense oligodeoxynucleotides to a κ-opioid receptor. Eur. J. Pharmacol. 253:R7-8.
13. Standifer, K. M., Chien, C.-C., Wahlestedt, C., Brown, G. P., and Pasternak, G. W. 1994. Selective loss of δ opioid analgesia and binding by antisense oligodeoxynucleotides to a δ opioid receptor. Neuron. 12:805-810.
14. Adams, J. U., Chen, X. H., DeRiel, J. K., Adler, M. W., and LiuChen, L.-Y. 1994. Intraventricular treatment with an antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats. Brain Res. 667:129-132.
15. Chen, X. H., Geller, E. B., DeRiel, J. K., Liu-Chen, L.-Y., and Adler, M. W. 1995. Antisense oligodeoxynucleotides against μ-or κ-opioid receptors block agonist-induced body temperature changes in rats. Brain Res. 688:237-241.
16. Chen, X. H., Adams, J. U., Geller, E. B., DeRiel, J. K., Adler, M. W., and Liu-Chen, L.-Y. 1995. An antisense oligodeoxynucleotide to μ-opioid receptors inhibits μ-agonist-induced analgesia in rats. Eur. J. Pharmacol. 275:105-108.
17. Adams, J. U., Chen, X. H., DeRiel, J. K., Yin, J., Adler, M. W., and Liu-Chen, L.-Y. 1996. Functional effects of antisense oligodeoxynucleotides to opioid receptors in rats, pages 37-52, in R. B. Raffa and F. Porreca (eds), Application of antisense strategies for investigation of receptor mechanisms in vivo and in vitro, Landes Biomedical Publishers.
18. Wahlestedt, C. 1994. Antisense oligodeoxynucleotide strategies in neuropharmacology. Trends in Pharm. Sci. 15:42-46.
19. Furchgott, R. F., and Bursztyn, P. 1967. Comparison of dissociation constants and of relative efficacies of selected agonists acting on parasympathetic receptors. Ann. N.Y. Acad. Sci. 144:882-899.
20. Portoghese, P. S., Larson, D. L., Sayre, L. M., Fries, D. S., and Takemori, A. E. 1980. A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities. J. Med. Chem. 23:233-234.
21. Takemori, A. E., Larson, D. L., and Portoghese, P. S, 1981. The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone. Eur. J. Pharmacol. 70:445-451.
22. Ward, S. J., Portoghese, P. S., and Takemori, A. E. 1982. Pharmacological profiles of β-funaltrexamine (β-FNA) and β-chlornaltrexamine (β-CNA) on the mouse vas deferens preparation. Eur. J. Pharmacol. 80:377-384.
23. Ward, S. J., Portoghese, P. S., and Takemori, A. E. 1982. Pharmacological characterization in vivo of the novel opiate, β-funaltrexamine. J. Pharmacol. Exp. Ther. 220:494-498.
24. Adams, J. U., Paronis, C. A., and Holtzman, S. G. 1990. Assessment of relative intrinsic activity of mu-opioid analgesics in vivo by β-funaltrexamine. J. Pharmacol. Exp. Ther. 255:1027-1032.
25. Mjanger, E., and Yaksh, T. L. 1991. Characteristics of dose-dependent antagonism by β-funaltrexamine of the antinociceptive effects of intrathecal Mu agonists. J. Pharmacol. Exp. Ther. 258: 544-550.
26. Tam, S. W., and Liu-Chen, L.-Y. 1986. Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes. J. Pharmacol. Exp. Ther. 239:351-357.
27. Recht, L. D., and Pasternak. 1987. G. W., Effects of beta-funaltrexamine on radiolabeled opioid binding. Eur. J. Pharmacol. 140: 219-214.
28. 3H]β-funaltrexamine. Mol. Pharmacol. 32: 321-329.
29. 3H]β-funaltrexamine binding to μ opioid receptor. Mol. Pharmacol. 37:243-251.
30. 3H]β-funaltrexamine to opioid receptors in the rat forebrain: comparison with μ and δ receptor distribution. Brain Res., 544:235-242.
31. Martin, T. J., Dworkin, S. I., and Smith, J. E. 1995. Alkylation of mu opioid receptors by beta-funaltrexamine in vivo: comparison of the effects on in situ binding and heroin self-administration in rats. J. Pharmacol. Exp. Ther. 272:1135-1140.
32. Liu-Chen, L.-Y., Yang, H. H., Li, S., and Adams, J. U. 1995. Effect of intracerebroventricular β-funaltrexamine on μ opioid receptors in the rat brain: consideration of binding condition. J. Pharmacol. Exp. Ther. 273:1047-1056.
33. Pellegrino, L. J., and Cushman, A. J.: A Stereotaxic Atlas of the Rat Brain, pp. 1-81, Appleton-Century-Crofts, New York, 1967.
34. Lipman, D. J., and Pearson, W. R. 1985. Rapid and sensitive protein similarity searches. Science. 227:1435-1441.
35. Pizziketti, R. J., Pressman, N. S., Geller, E. B., Cowan A., and Adler, M. W. 1985. Rat cold water tail-flick: a novel analgesic test that distinguishes opioid agonists from mixed agonist-antagonists. Eur. J. Pharmacol. 119:23-29.
36. Tallarida, R. J., and Murray, R. B. 1987. Manual of Pharmacologic Calculation with Computer Program, Springer-Verlag, N.Y. (2nd edition)
37. Tallarida, R. J., and Cowan, A. 1982. The affinity of morphine for its pharmacologic receptor in vivo. J. Pharmacol. Exp. Ther. 222:198-211.
38. Tallarida, R. J. 1995. Receptor discrimination and control of agonist-antagonist binding. Am. J. Physiol. 269 (Endocrinol. and Metab. 32): E379-391.
39. Marquardt, D. W. 1963. An algorithm for least-squares estimation of nonlinear parameter. J. Soc. Ind. Appl. Math. Vol 11, p431-441.
40. Zimmerman, D. M., Leander, J. D., Reel, J. K., and Hynes, M. D. 1987. Use of β-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands. J. Pharmacol. Exp. Ther. 241:374-378.
41. Ward, S. J., Fries, D. S., Larson, D. L., Portoghese, P. S., and Takemori, A. E. 1985. Opioid receptor binding characteristics of the non-equilibrium μ antagonist, β-funaltrexamine (β-FNA). Eur. J. Pharmacol. 107:323-330.
42. Chen, X. H., Geller, E. B., and Adler, M. W. 1996. Electrical stimulation at traditional acupuncture sites in periphery produces brain opioid-receptor-mediated antinociception in rats. J. Pharmacol. Exp. Ther. 277:654-660.
43. Han, J.-S., and Xie, C.-W. 1982. Dynorphin: Potent antinociceptive effect in spinal cord of the rat. Life Sci 31:1781-1784.
44. Geller, E. B., Hawk, C., Keinath, S. H., Tallarida, R. J., and Adler, M. W. 1983. Subclasses of opioids based on body temperature change in rats: acute subcutaneous administration. J. Pharmacol. Exp. Ther. 225:391-398.
45. Geller, E. B., Rowan, C. H., and Adler, M. W. 1986. Body temperature effects of opioids in rats: Intracerebroventricular administration. Pharmacol. Biochem. Behav. 24:1761-1765.
46. 2 dopamine antisense oligodeoxynucleotide in mouse brain. J. Mol. Neurosci.