Apoptosis in renal cell carcinoma: Detection by in situ end-labeling of fragmented DNA and correlation with other prognostic factors

Human Pathology

Volumn 27, Issue 10, 1996, Pages 1012-1017

  Todd, David ^b   Yang, Guang ^b   Brown, Richard W ^b   Cao, James ^b   D'Agati, Vivette ^b   Thompson, Timothy S ^b   Truong, Luan D ^a  

^a HOUSTON METHODIST HOSPITAL   (United States)

^b NONE

Author keywords

apoptosis; in situ end labeling; prognostic factors; renal cell carcinoma

Indexed keywords

DNA FRAGMENT; MONOCLONAL ANTIBODY KI 67;

APOPTOSIS; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER SIZE; CANCER STAGING; CELL PROLIFERATION; CLINICAL ARTICLE; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PROGNOSIS;

EID: 0029859679     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(96)90276-2     Document Type: Article

References (29)

1. Stenzle A, deKernion JB: Pathology, biology and clinical staging of renal cell carcinoma. Semin Oncol 16:3-11, 1989
2. Takatera H, Maeda O, Oka T, et al: Solitary late recurrence of renal cell carcinoma. J Urol 136:799-800, 1986
3. Thrasher J, Paulson D: Prognostic factors in renal cancer. Urol Clin North Am 20:247-262, 1993
4. Fuhrman S, Lasky L, Lumas C: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6:655-663, 1982
5. Meduros LF, Gelb AB, Weiss LM: Renal cell carcinoma: Prognostic significance of morphologic parameters in 121 cases. Cancer 61:1639-1651, 1988
6. Golimbu M, Joshi P, Sperber A, et al: Renal cell carcinoma: Survival and prognostic factors. Urology 27:291-301, 1986
7. Cavayzcina AO, Prayer-Galetti T, Sangiorgio A, et al: DNA content, nuclear grading and early tumor progression in renal cell cancer: A prospective study on frozen specimens. Eur Urol 22:311-315, 1992
8. Murphy G, Partin A, Maygarden S, et al: Nuclear shape analysis for assessment of prognosis in renal adenocarcinoma. J Urol 143:1103-1107, 1990
9. deRiese W, Crabtree W, Allhoff E, et al: Prognostic significance of Ki-67 immunostaining in nonmetastatic renal cell carcinoma. J Clin Oncol 11:1804-1808, 1993
10. Marx J: Cell death studies yield cancer clues. Science 259:760-761, 1993
11. Herr JFR, Harmon BV: Definition and incidence of apoptosis: An historical perspective. Apoptosis: The Molecular Basis of Cell Death. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1991, pp 5-29
12. Bursch W, Leine L, Tenniswood M: The biochemistry of cell death by apoptosis. Biochem Cell Biol 68:1071-1074, 1990
13. Kerr JFR, Wyllie AH, Currie AR: Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257, 1972
14. Wyllie AH: Apoptosis: Cell death under homeostatic control. Arch Toxicol 11:3-10, 1987
15. Del Vecchio MT, Leoncini L, Buerki K, et al: Diffuse centrocytic and/or centroblastic malignant non-Hodgkin's lymphomas: Comparison of mitotic and pyknotic (apoptotic) indices. Int J Cancer 47:38-43, 1991
16. Leoncini L, Del Vecchio MT, Mehga T, et al: Correlation between apoptotic and proliferative indices in malignant non-Hodgkins lymphomas. Am J Pathol 142:755-763, 1993
17. Aihara M, Truong LD, Dunn JK, et al: Frequency of apoptotic bodies positively correlates with Gleason grade in prostatic cancer. HUM PATHOL 25:797-801, 1994
18. Aihara M, Scardino PT, Truong LD, et al: The frequency of apoptosis correlates with prognosis of Gleason grade 3+3 prostatic adenocarcinoma. Cancer 75:522-529, 1995
19. Sasano H, Imatani A, Shizawa S, et al: Cell proliferation and apoptosis in normal and pathologic human adrenal. Mod Pathol 8:11-17, 1995
20. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 119:493-501, 1992
21. Harman MH (ed): TNM Classification of Malignant Tumours. Geneva, Switzerland, Union Internationale Contre le Cancer, 1978
22. Wyllie AH, Kerr JFR, Currie AR: Cell death: The significance of apoptosis. Int Rev Cytol 68:251-306, 1980
23. Schiodt T: Breast carcinoma: A histological and prognostic study of 650 followed-up cases. Dan Med Bull 14:239-243, 1967
24. Cordon-Cardo C: Mutation of cell cycle regulators: Biological and clinical implications for human neoplasia. Am J Pathol 147:545-560, 1995
25. Evan GI, Wyllie AH, Gilbert CS, et al: Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119-128, 1992
26. Savill J: Apoptosis and the kidney. J Am Soc Nephrol 5:12-21, 1994
27. Ledda-Columbano GM, Columbano A, Coni P, et al: Cell deletion by apoptosis during regression of renal hyperplasia. Am J Pathol 135:657-662, 1989
28. Shimizu A, Yamanaka N: Apoptosis and cell desquamation in repair process of ischemic tubular necrosis. Mol Pathol 64:171-180, 1993
29. Gobe GC, Axelsen RA, Serle JW: Cellular events in experimental unilateral ischemic renal atrophy and in regeneration after contralateral nephrectomy. Lab Invest 63:770-779, 1990