Modulation of in vitro and in vivo T-cell responses by transferrin- gallium and gallium nitrate

Blood

Volumn 88, Issue 8, 1996, Pages 3056-3064

  Drobyski, William R ^a,b   Ui Haq, Riaz ^a   Majewski, David ^a   Chitambar, Christopher R ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b FROEDTERT MEMORIAL LUTHERAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD3 ANTIGEN; GALLIUM NITRATE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; LYMPHOKINE; MITOGENIC AGENT; PHYTOHEMAGGLUTININ; RNA; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MIXTURE; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0029859282     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.8.3056.bloodjournal8883056     Document Type: Article

References (36)

1. Harris WR, Pecoraro VL: Thermodynamic binding constants for gallium transferrin. Biochemistry 22:292, 1983
2. Larson SM, Rasey JS, Allen DR, Nelson NJ, Grunbaum Z, Harp GD, Williams DL: Common pathway for tumor cell uptake of gallium-67 and Iron-59 via a transferrin receptor. J Natl Cancer Inst 64:41, 1980
3. Chitambar CR, Zivkovic Z: Uptake of gallium-67 by human leukemic cells: Demonstration of transferrin-receptor dependent and transferrin-receptor independent mechanisms. Cancer Res 47:3929, 1987
4. Hegge FN, Mahler DJ, Larson SM: The incorporation of Ga67 into the ferritin fraction of rabbit hepatocytes in vivo. J Nucleic Med 18:937, 1977
5. Chitambar CR, Seligman PA: Effects of different transferrin forms of transferrin expression, iron uptake, and cellular proliferation of human leukemic HL60 cells. Mechanisms responsible for the specific cytotoxicity of transferrin-gallium. J Clin Invest 78:1538, 1986
6. Chitambar CR, Narasimhan J, Guy J, Sem DS, O'Brien WJ: Inhibition of ribonucleotide reductase by gallium in murine leukemic L1210 cells. Cancer Res 51:6199, 1991
7. Narasimhan J, Antholine WE, Chitambar CR: Effect of gallium on the tyrosyl radical of the iron-dependent M2 subunit of ribonucleotide reductase. Biochem Pharmacol 44:2403, 1992
8. Chitambar CR, Matthaeus WG, Antholine WE, Graff K, O'Brien WJ: Inhibition of leukemic HL60 cell growth by transferrin-gallium: Effects on ribonucleotide reductase and demonstration of drug synergy with hydroxyurea. Blood 72:1930, 1988
9. Cheson BD: New chemotherapeutic agents for the treatment of low grade non-Hodgkin's lymphoma. Semin Oncol 20:96, 1993 (suppl 5)
10. Chitambar CR, Zahir SA, Ritch PS, Anderson T: Evaluation of continuous infusion gallium nitrate and hydroxyurea in combination for the treatment of refractory non-Hodgkin's lymphoma. Am J Clin Oncol (in press)
11. Seidman AD,Scher HI, Heinemann MH, Bajorin DF, Sternberg CN, Dershaw DD, Silverberg M, Bosl GL: Continuous infusion gallium nitrate for patients with advanced refractory urothelial tract tumors. Cancer 60:2561, 1991
12. Einhorn LH, Roth BJ, Ansari R, Dreicer R, Gonin R, Loehrer PJ: Phase II trial of vinblastine, ifosfamide, and gallium combination chemotherapy in metastatic urothelial carcinoma. J Clin Oncol 12:2271, 1994
13. Crawford ED, Saiers JH, Baker LH, Costanzi JH, Bukowski BM: Gallium nitrate in advanced bladder carcinoma: Southwest Oncology Group Study. Urology 38:355, 1991
14. Warrell RP: Clinical trials of gallium nitrate in patients with cancer-related hypercalcemia. Semin Oncol 18:26, 1991
15. Matkovic V, Balboa A, Clinchot D, Whitacre C, Zwilling B, Brown D, Weisbrode SE, Apseloff G, Gerber N: Gallium prevents adjuvant arthritis in rats and interferes with macrophage/T cell function in the immune response. Curr Ther Res 50:255, 1991
16. Whitacre C, Apseloff G, Cox K, Matkovic V, Jewell S, Gerber N: Suppression of experimental autoimmune encephalomyelitis by gallium nitrate. J Neuroimmunol 39:175, 1992
17. Chitambar CR, Seigneuret MC, Matthaeus WG, Lum LG: Modulation of lymphocyte proliferation and immunoglobulin production by transferrin-gallium. Cancer Res 49:1125, 1989
18. Huang EH, Gabler DM, Krecic ME, Gerber N, Ferguson RM, Orosz CG: Differential effects of gallium nitrate on T lymphocyte and endothelial cell activation. Transplantation 58:1216, 1994
19. LeFever A, Truitt R, Shin C: Reactivity of in vitro-expanded alloimmune cytotoxic T lymphocytes and Qa-1 specific cytotoxic lymphocytes against AKR leukemia in vitro. Transplantation 40:531, 1985
20. Chirgwin JM, Pryzbyla AE, MacDonald RJ, Rutter WJ: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294, 1979
21. Hart MM, Smith CF, Yancey ST, Adamson RH: Toxicity and antitumor activity of gallium nitrate and periodically related metal salts. J Natl Cancer Inst 47:1121, 1971
22. Larrick JW, Cresswell P: Modulation of cell surface iron transferrin receptors by cellular density and state of activation. J Supramol Struct 11:279, 1979
23. Chitambar CR, Masseq EJ, Seligman PA: Regulation of transferrin receptor expression on human leukemic cells during proliferation and induction of differentiation. J Clin Invest 72:1314, 1983
24. Truitt RL, Atasoylu AA: Impact of pretransplant conditioning and donor T cells on chimerism, graft-versus-host disease, graft-versus-leukemia reactivity and tolerance after bone marrow transplantation. Blood 97:2515, 1991
25. Neckers LM, Cossman J: Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2. Proc Natl Acad Sci USA 80:3494, 1983
26. Kumagai N, Benedict SH, Mills GB, Gelfand EW: Comparison of phorbol ester/calcium ionophore and phytohemagglutinininduced signaling in human T lymphocytes. Demonstration of interleukin 2-independent transferrin receptor gene expression. J Immunol 140:37, 1988
27. Carotenuto P, Pontesilli O, Cambier JC, Hayward AR: Desferoxarnine blocks IL2 receptor expression on human T lymphocytes. J Immunol 136:2342, 1986
28. Pelosi E, Testa U, Louache F, Thomopoulos P, Salvo P, Samoggia P, Peschle C: Expression of transferrin receptors in phytohemagglutinin-stimulated human T lymphocytes. J Biol Chem 261:3036, 1986
29. Mattia E, Rao K, Shapiro DS, Sussman HH, Klausner RD: Biosynthetic regulation of the human transferrin receptor by desferrioxamine in K562 cells. J Biol Chem 259:2689, 1984
30. Theil EC: Iron regulatory elements (IREs): A family of mRNA non-coding sequences. Biochem J 304:1, 1994
31. Samaniego F, Chin J, Iwai K, Rouault TA, Klausner RD. Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. J Biol Chem 269:30904, 1994
32. Haq R, Chitambar CR. Modulation of transferrin receptor mRNA by transferrin-gallium in human myeloid HL60 and lymphoid CCRF-CEM leukemic cells. Biochem J 294:873, 1993
33. Foster BJ, Claggett-Carr K, Hoth D, Leyland-Jones B. Gallium nitrate: The second metal with clinical activity. Cancer Treat Rep 70:1311, 1986
34. Newman RA, Brody AR, Krakoff IH: Gallium nitrate (NSC-15200) induced toxicity in the rat. Cancer 44:1728, 1979
35. Whelan HT, Williams MB, Bajic DM, Segura AD, McAuliffe TL, Chitambar CR: Prevention of gallium toxicity by hyperhydration in treatment of medulloblastoma. Pediatr Neurol 10:217, 1994
36. Krakoff IH, Newman RA, Goldberg RS: Clinical, toxicologic, and pharmacologic studies of gallium nitrate. Cancer 44:1722, 1979