Classification and staging of Ph-negative myeloproliferative disorders by histopathology from bone marrow biopsies

Leukemia and Lymphoma

Volumn 22, Issue SUPPL. 1, 1996, Pages 15-29

  Georgii, A ^a   Buhr, T ^a   Buesche, G ^a   Kreft, A ^a   Choritz, H ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Essential thrombocythemia; Histopathology; Megakaryocytes; Myelofibrosis; Myeloproliferative diseases; Philadelphia negative; Polycythemia vera

Indexed keywords

ACUTE LEUKEMIA; ARTICLE; BONE MARROW BIOPSY; CANCER CLASSIFICATION; CANCER STAGING; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MEGAKARYOCYTE; MYELOFIBROSIS; MYELOPROLIFERATIVE DISORDER; POLYCYTHEMIA VERA; PRIORITY JOURNAL; THROMBOCYTHEMIA;

EID: 0029859112     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199609074357     Document Type: Article

References (79)

1. Rozman, C., Giralt, M., Feliu, E., Rubio, D. and Cortés, M.-T. (1991) Life expectancy of patients with chronic non-leukemic myeloproliferative disorders. Cancer, 67, 2658-2665.
2. Cortelazzo, S., Viero, P., Finazzi, G., D'Emilio, A., Rodeghiero, F. and Barbui, T. (1990) Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia. J. Clin. Oncol., 8, 556-562.
3. Van Genderen, P. J. and Michiels, J. J. (1993) Primary thrombocythemia: diagnosis, clinical manifestations and management. Ann. Hematol., 67, 57-62.
4. Pearson, T. C. and Messinezy, M. (1987) Polycythemia and thrombocythaemia in the elderly. Baillieres Clin. Hematol., 1, 355-387.
5. Landaw, S. A. (1990) Polycythemia vera and other polycythemic states. Clin. Lab. Med., 10, 857-871.
6. Murphy, S. (1992) Polycythemia vera. Disease-a-month, 38, 153-212.
7. Rain, J. D. (1994) Clinical and laboratory assessment and therapeutic problems in longstanding polycythemia vera. Nouv. Rev. Fr. Hematol., 36, 197-203
8. Barbui, T., De Gaetano, G., Finazzi, G., Landolfi, R., Marchioli, R., Patrono, C. and Tognoni, G. (1996) Clinical epidemiology in 1,213 patients with polycythemia vera. Ann. Int. Med., in press.
9. Visani, G., Finelli, C., Castelli V., et al (1990) Myelofibrosis with myeloid metaplasia: clinical and haematological parameters predicting survival in a series of 133 patients. Br. J. Haematol, 75, 4-9.
10. Weinstein, I. M. (1991) Idiopathic myelofibrosis: historical review, diagnosis, and management. Blood Rev., 5, 98-104.
11. Loewy, G., Mathew, A. and Distenfeld, A. (1994) Skin manifestation of agnogenic myeloid metaplasia. Am. J. Hematol., 45(2), 167-170.
12. Kaplan, K. R., Mitchell, D. G., Steiner, R. M., Murphy, S., Vinitski, S., Rao, V. M., Burk, D. L. and Rifkin, M. D. (1992) Polycythemia vera and myelofibrosis: correlation of MR imaging, clinical, and laboratory findings. Radiology, 183, 329-334.
13. Ellis, J. T., Peterson, P., Geller, St. A. et al (1986) Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and secondary hematologic malignancies. Semin. Hematol., 23, 144-155.
14. Lagier, R. and Baud, C. A. (1990) Osteomyelosclerosis following polycythaemia vera: radiological correlation in a femur. Eur. J. Radiol., 10, 15-18.
15. Thiele, J., Wagner, St., Degel, Ch., Dienemann, D., Wienhold, St., Zankovich, R., Fischer, R. and Stein, H. (1990) Megakaryocyte precursors (pro- and megakaryoblasts) in bone marrow tissue from patients with reactive thrombocytosis, polycythemia vera, and primary (essential) thrombocythemia. Virchows Arch. [B], 58, 295-302.
16. Thiele, J., Rompcik, V., Wagner, St. and Fischer, R. (1992) Vascular architecture and collagen type IV in primary myelofibrosis and polycythaemia vera: an immunomorphometric study on trephine biopsies of the bone marrow. Br. J. Haematol., 80, 227-334.
17. Dickstein, J. I. and Vardiman, J. W. (1995) Hematopathologic findings in myeloproliferative disorders. Semin. Oncol., 22, 355-373.
18. Tefferi, A. Silverstein, M. N. (1996) Agnogenic myeloid metaplasia. Leukemia & Lymphoma, in this issue.
19. Castro-Malaspina, H. (1984) Pathogenesis of myelofibrosis: role of in-effective megakaryopoiesis and megakaryocyte components. Prog. Clin. Biol. Res., 154, 427-451.
20. Thiele, J., Chen, Y. S., Kvasnicka, H. M., Diehl, V. and Fischer, R. (1994) Evolution of fibro-osteosclerotic bone marrow lesions in primary (idiopathic) osteomyelofibrosis - a histomorphometric study on sequential trephine biopsies. Leukemia & Lymphoma, 14, 163-169.
21. Yonemitsu, H. and Okuda, K. (1985) Essential thrombocythemia terminating in myelofibrosis and myeloblastic transformation. Jpn. J. Med., 24 (1), 57-61.
22. Georgii, A., Vykoupil, K.-R, Buhr, T., Choritz, H., Döhler, U., Kaloutsi, V. and Werner, M. (1990) Chronic myeloproliferative disorders in bone marrow biopsies. Path. Res. Pract., 186, 3-27.
23. Hernandez, J. M., Orfao, A., Gonzalez, M., Cuesta, B., Lopez-Berges, M. C., Canizo, M. C., Ciudad, J. and San Miguel, J. F. (1993) Immunophaenotypic characterisation of acute leukaemia after polycythaemia vera. J. Clin. Pathol., 46, 668-671.
24. Najfeld, V., Coyle, T. and Berk, P. D. (1988) Transformation of polycythemia vera to acute nonlymphocytic leukemia accompanied by t(1;3) (p36;q21) karyotype). Cancer Genet. Cytogenet., 33, 193-200.
25. Bartl, R., Frisch, B. and Wilmanns, W. (1993) Potential of bone marrow biopsy in chronic myeloproliferative disorders (MPD). Eur. J. Haematol., 40 (1), 41-52.
26. Hernandez, J. M., San Miguel, J. F., Gonzalez, M., Orfao, A., Canizo, M. C., Bascones, C., Hernandez, J., and Lopez Borrasca, A. (1992) Development of acute leukaemia after idiopathic myelofibrosis. J. Clin. Path., 45(5), 427-430.
27. Kurashima, K., Kawamura, Y., Ohka, T., Hayashi, M. and Matsuda, T. (1990) Primary myelofibrosis terminating in megakaryoblastic crisis. Jpn. J. Med., 29(2), 226-229.
28. Koza, I. and Babusikova, O. (1988) Sequential development of chronic lymphocytic leukemia in a patient with polycythemia vera. Neoplasma, 35, 77-80.
29. Roth, A. D., Oral, A., Przepiorka, D., Gollin, S. M. and Chervenick, P. A. (1993) Chronic myelogenous leukemia and acute lymphoblastic leukemia occurring in the course of polycythemia vera. Am. J. Hematol., 43, 123-128.
30. Hoffman, R., Estren, S., Kopel, S. et al (1978) Lymphoblastic-like leukemic transformation of polycythemia vera. Ann. Intern. Med., 89, 71.
31. Peterson, P., Ellis, J. T., Block, M. H. et al (1985) The occurrence of non-Hodgkin's lymphoma in polycythemia vera. Lab. Invest., 52, 51a.
32. Schlaifer, D., Dastugue, N., Brousset, P., Delsol, G., Muller, C., Rigal-Huguet, F., Attal, M., Laurent, G. and Pris, J. (1994) B-cell lymphoma following polycythemia vera: evidence for the involvement of two different clones. Leukemia, 8, 895-896.
33. Sedlacek, S. M., Curtis, J. L., Weintraub, J. and Levin, J. (1986) Essential thrombocythemia and leukemic transformation. Medicine, 65(6), 353-364.
34. Chen, Y. H., Mishoulam, H., Mir, J. A., Choi, Y. S. and Schade, S. G. (1987) Elastic transformation in a case of essential thrombocythemia. South. Med. J., 80(8), 1040-1043.
35. Emilia, G., Sacchi S., Temperani, P., Longo, R. and Vecchi, A. (1993) Progression of essential thrombocythemia to blastic crisis via idiopathic myelofibrosis. Leukemia and Lymphoma, 9, 423-426.
36. Kimura, A., Fujimoro, T., Inada, T., Imamura, N., Oguma, N., Kajihara, H., Mtasiwa, D. M., Katoh, O., Fujimura, K. and Kuramoto, A. (1990) Blastic transformation in essential thrombocythemia. In vitro differentiation of blast cells in granulocytic, erythroid, and megakaryocytic lineages. Cancer, 65(7), 1538-1544.
37. Vinti, H., Taillan, B., Pesce, A., Michiels, J. F., Bayle, J. and Cassuto, J. P. (1990) Megakaryoblastic transformation of essential thrombocythemia, hypercalcemia, and lytic bone lesions (letter). Acta Haematol. (Basel), 83(1), 53.
38. Honma, K., Moto, K., Ohnishi, Y. and Kimura, K. (1989) Blastic transformation of essential thrombocythemia. A case report. Acta. Pathol. Jpn., 39(10), 670-676.
39. Selleri, C., Alfinito, F., Del Vecchio, L., Luciano, L., De Renzo, A. and Rotoli, B. (1993) Cytoplasmic GPIIb-IIIa and cytokine secretion by blasts in a case of megakaryoblastic transformation of essential thrombocythemia. Leukemia and Lymphoma, 10, 497-500.
40. Shibata, K., Shimamoto, Y., Suga, K., Sano, M., Matsuzaki, M. and Yamaguchi, M. (1994) Essential thrombocythemia terminating in acute leukemia with minimal myeloid differentiation - a brief review of recent literature. Acta Haematol. (Basel), 91(2), 84-88.
41. Van De Pette, J. E. W., Prochazka, A. V., Pearson, T. C., Singh, A. K., Dickson, E. R. and Wetherley-Mein, G. (1986) Primary thrombocythemia treated with busulfan. Br. J. Haematol, 62, 229-237.
42. Cortelazzo, S., Viero, P., Finazzi, G., D'Emilio, A., Rodeghiero, F. and Barbui, T. (1995) Hydroxyurea in the treatment of patients with essential thrombocythemia to high risk of thrombosis: a prospective randomized trial. N. Engl. J. Med., 17, 1132-1136.
43. Lengfelder, E., Hochhaus, A., and Hehlmann R. (1995) Therapy of 143 essential thrombocythemia patients by interferon alpha versus hydroxyurea. (submitted).
44. 32P) in the treatment of polycythemia vera. Nouv. Rev. Fr. Hematol., 36, 189-192.
45. Messora, C., Bensi, L., Vecchi, A., Longo, R., Giacobbi, F., Temperani, P., Bevini, M., Emilia, G. and Sacchi, S. (1994) Cytogenetic conversion in a case of polycythaemia vera treated with interferon-alpha. Br. J. Haematol., 86, 402-404.
46. Peterson, P., Murphy, S., Hand, H. J., Geller, S. A. and Ellis, J. T. (1994) Occurrence of acute leukemia in treated essential thrombocythemia. Lab. Invest., 70, 118A.
47. Berk, P. D., Goldberg, J. D., Silverstein, M. N., Weinfeld, A., Donovan, P. B., Ellis, J. T., Landaw, S. A., Laszlo, J., Najean, Y., Psciotta, A. V. and Wasserman, L. R. (1981) Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy. N. Engl. J. Med., 34, 441-447.
48. Hawkins, T. E., Carter, J. M., Romeril, K. R., Jackson, S. R. and Green, G. J. (1993) Lymphoma transformation in polycythaemia vera treated with hydroxyurea (letter). Am. J. Hematol., 44, 290.
49. Weinfeld, A., Swolin, B. and Westin, J. (1994) Acute leukaemia after hydroxyurea therapy in polycythaemia vera and allied disorders: prospective study of efficency and leukaemogenicity with therapeutic implications. Eur. J. Haematol., 52, 134-139.
50. Brandt, L. and Anderson, H. (1995) Survival and risk of leukaemia in polycythaemia vera and essential thrombocythaemia treated with oral radiophosphorus: are safer drugs available? Eur. J. Haematol., 54(1), 21-26.
51. Silverstein, M. N., Petitt, R. M., Solberg, L. A. Jr., Fleming, J. St., Knight, R. C. and Schacter, L. P. (1988) Anagrelide: a new drug for treating thrombocytosis. W. Engl. J. Med., 318, 1292-1294.
52. Anagrelide Study Group (1992) Anagrelide - a therapy for thrombocythemic states: experience in 577 patients. Am. J. Med., 92, 69-76.
53. Landolfi, R., Ciabattoni, G., Patrignani, P., Castellana, M. A. L., Pogliani, E., Bizzi, B. and Patrono, C. (1992) Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo. Blood, 80, 1965-1971.
54. De Mascarel, A. (1994) Contribution of bone marrow biopsy in the diagnosis and prognosis of polycythemia vera. Nouv. Rev. Fr. Hematol., 36, 165-166.
55. Werner, M., Kaloutsi, V., Kausche, F., Buhr, T. and Georgii, A. (1993) Evidence from moleculargenetic and cytogenetic analyses that bone marrow histopathology gives reliable diagnoses in chronic myeloproliferative disorders. Virchows Arch. [B], 63, 199-204.
56. Werner, M., Nolte, M., Kaloutsi, V., Buhr, Th., Kausche, F. and Georgii, A. (1995) Karyotype findings and molecular analysis of the bcr gene rearrangement supplementing the histological classification of chronic myeloproliferative disorders. Lab. Invest., 72, 405-410.
57. Nolte, M., Werner, M., Ewig, M., von Wasielewski, R., Wilkens, L. and Georgii, A. (1995). Demonstration of the Philadelphia translocation by fluorescence in situ hybridization (FISH) in paraffin sections and identification of aberrant cells by a combined FISH/immunophenotyping approach. Histopathotogy, 26, 433-437.
58. Bernhards, J., Weitzel, B., Werner, M., Rimpler, M. and Georgii, A. (1992) A new histological embedding method by low-temperature polymerisation of methyl methacrylate allowing immuno- and enzyme histochemical studies on semi-thin sections of undecalcified bone marrow biopsies. Histochemistry, 98, 145-154.
59. Georgii, A., Bernhards, J. and Werner, M. (1995) Die neue Hannover-Methode zur Kunststoff-Einbettung vom Knochenmark: Kalt-Polymerisation von Methyl-Methacrylat. Pathologe, 16, 28-33.
60. Nafe, R., Georgii, A., Kaloutsi, V., Fritsch, R. S. and Choritz, H. (1991) Planimetric analysis of megakaryocytes and the four main groups of chronic myeloproliferative disorders. Virchows Arch. [B], 61, 111-116.
61. Nafe, R., Kaloutsi, V., Choritz, H. and Georgii, A. (1992) Elliptic fourier analysis of megakaryocyte nuclei in chronic myeloproliferative disorders. Anal. Quant. Cytol. Histol., 14, 391-397.
62. Nafe, R., Kaloutsi, V., Fritsch, R. S. and Georgii, A. (1991) Quantitative cytomorphology of megakaryocytes in chronic myeloproliferative disorders-Analysis of planimetric and numeric characteristics by means of a knowledge based system. Exp. Pathol., 40, 213-219.
63. Peterson, P., Ellis, J. T., Geller, S. A. et al (1986) Increased incidence of acute leukemia in spent polycythemia following myelosuppressive therapy. Lab. Invest., 54, 48a.
64. Najean, Y., Dresch, C. and Rain, J. D. (1994) The very-long-term course of polycythemia: a complement to the previously published data of the Polycythaemia Vera Study Group. Br. J. Haematol., 86, 233-235.
65. Anger, B., Haug, U., Seidler, R. and Heimpel, H. (1989) Polycythemia vera. A. clinical study of 141 patients. Blut, 59, 493-500.
66. Swolin, B., Weinfeld, A. and Westin, J. (1988) A prospective long-term cytogenetic study in polycythemia vera in relation to treatment and clinical course. Blood, 72, 386-395.
67. Hino, K., Sato, S., Sakashita, A., Tomoyasu, S., Tsuruoka, N. and Koike, T. (1992) Megakaryoblastic transformation associated with disseminated intravascular coagulation in the course of polycythemia vera: a case report. Rinsho Ketsueki (Jpn. J. Clin. Hematol), 33, 500-506.
68. Wong, K. F., Chan, J. K., Ma, S. K. and Chu, Y. C. (1993) Megakaryoblastic transformation of polycythemia vera associated with hypercalcemia. Am. J. Hematol., 43, 240-242.
69. Barosi, G., Ambrosetti, A., Burratti, A. et al. (1993) Splenectomy for patients with myelofibrosis with myeloid metaplasia; pretreatment variables and outcome prediction. Leukemia, 7, 200-206.
70. Georgii, A., Vykoupil, K. F. and Thiele, J. (1980) Chronic megakaryocytic granulocytic myelosis -CMGM -. A subtype of chronic myeloid leukemia. Virchows Arch. A (Path Anat and Histol), 389, 253-268.
71. Buhr, Th., Georgii, A. and Choritz, H. (1993) Myelofibrosis in chronic myeloproliferative disorders: Incidence among subtypes according to the Hannover classification. Path. Res. Pract., 189, 121-132.
72. Buhr, T., Choritz, H. and Georgii, A. (1992) The impact of megakaryocyte proliferation for the evolution of myelofibrosis. Histological follow-up study in 186 patients with chronic myeloid leukaemia. Virchows Arch. [A], 420, 473-478.
73. Lewis, S. M., Szur, L. (1963) Malignant myelosclerosis. Br. Med. J., 2, 472-477.
74. Amberger, D. M., Saleem, A., Kemp, B. L. and Truong, L. D. (1990) Acute myelofibrosis - a leukemia of pluripotent stem cell. A report of three cases and review of the literature. Ann. Clin. Lab. Sci., 20(6), 409-114.
75. Becher, R. (1988) Acute myelofibrosis in megakaryoblastic leukemia with translocation between chromosomes 8 and 14. Klin. Wschr., 66(12), 556.
76. Bullorsky, E. O., Shanley, C. M., Stemmelin, G., Venditti, J. and Lajous, J. R. (1990) Acute megakaryoblastic leukemia with massive myelofibrosis: complete remission and reversal of marrow fibrosis with allogeneic bone marrow transplantation as the only treatment. Bone Marrow Transplantation, 6(6), 449-452.
77. Marino, G. G. (1989) Acute myelofibrosis: report of a case and review of current literature. J. Am. Osteopath. Assoc., 89(10), 1323-1326.
78. Thiele, J., Krech, R., Vykoupil, K. F. and Georgii, A. (1984) Malignant (acute) myelosclerosis - a clinical pathological study in 6 patients. Scand. J. Haematol., 33, 95-105.
79. Hruban, R. H., Kukajda, F. P. and Mann, R. B. (1987) Acute myelofibrosis. Immunohistochemical study of four cases and comparison with acute megakaiyocytic leukemia. Am. J. Clin. Pathol., 88, 578-588.