Transport mechanism of the α1-antagonist alfuzosin and its enantiomers in rat intestine: In vitro studies

European Journal of Pharmaceutical Sciences

Volumn 4, Issue 5, 1996, Pages 259-266

  Haddouche, Abdenour ^a   Boisset, Michel ^b   Thénot, Jean Paul ^a   Desjeux, Jehan François ^b  

^a SANOFI   (France)

^b University of Paris Cité   (France)

Author keywords

Alfuzosin; Enantiomers; Intestine; Permeability; Rat; Transport

Indexed keywords

ALFUZOSIN; MANNITOL; TAUROCHOLIC ACID;

ANIMAL TISSUE; ARTICLE; COLON; CONTROLLED STUDY; DRUG TRANSPORT; DUODENUM; ENANTIOMER; ILEUM; INTESTINE MUCOSA PERMEABILITY; ION TRANSPORT; JEJUNUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCINTILLATION;

EID: 0029858129     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/0928-0987(96)00161-3     Document Type: Article

References (4)

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2. Artursson, P., Ungell, A.L. and Löfroth, J.E. (1993) Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cell lines and rat intestinal segments. Pharm. Res. 10, 1123-1129.
3. Boisset, M., Billaud, C. and Desjeux, J.-F. (1994) Studies on the mechanism of intestinal passage of the food comutagen Harman, in the rabbit. Fed. Chem. Toxicol. 32, 349-356.
4. Brodie, B.B. and Hogben, C.A.M. (1957) Some physico-chemical factors in drug action. J. Pharm. Pharmacol. 9, 345-380.