메뉴 건너뛰기




Volumn 7, Issue 15, 1996, Pages 1883-1893

Regulatable promoters for use in gene therapy applications: Modification of the 5'-flanking region of the CFTR gene with multiple cAMP response elements to support basal, low-level gene expression that can be upregulated by exogenous agents that raise intracellular levels of cAMP

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; DNA FRAGMENT; FORSKOLIN; LUCIFERASE; PHOSPHODIESTERASE INHIBITOR; TRANSMEMBRANE CONDUCTANCE REGULATOR;

EID: 0029858012     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.15-1883     Document Type: Article
Times cited : (29)

References (44)
  • 2
    • 0028559768 scopus 로고
    • An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3
    • BETT, A.J., HADDARA, W., PREVEC, L., and GRAHAM, F.L. (1994). An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA 91, 8802-8806.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8802-8806
    • Bett, A.J.1    Haddara, W.2    Prevec, L.3    Graham, F.L.4
  • 5
    • 0027155874 scopus 로고
    • In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment
    • CHENG, L., ZIEGELHOFFER, P.R., and YANG, N.S. (1993). In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc. Natl. Acad. Sci. USA 90, 4455-4459.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4455-4459
    • Cheng, L.1    Ziegelhoffer, P.R.2    Yang, N.S.3
  • 6
    • 0026327058 scopus 로고
    • Characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene
    • CHOU, J., ROZMAHEL, R., and TSUI, L. (1991). Characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene. J. Biol. Chem. 266, 24471-24476.
    • (1991) J. Biol. Chem. , vol.266 , pp. 24471-24476
    • Chou, J.1    Rozmahel, R.2    Tsui, L.3
  • 7
    • 0028875936 scopus 로고
    • Transfer of genes to humans: Early lessons and obstacles to success
    • CRYSTAL, R.G. (1995). Transfer of genes to humans: Early lessons and obstacles to success. Science 270, 404-410.
    • (1995) Science , vol.270 , pp. 404-410
    • Crystal, R.G.1
  • 9
    • 0029102198 scopus 로고
    • A phase I study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung
    • CRYSTAL, R.G., JAFFE, A., BRODY, S., MASTRANGELI, A., McELVANEY, N.G., ROSENFELD, M., CHU, C., DANEL, C., HAY, J., and EISSA, T. (1995). A phase I study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung. Hum. Gene Ther. 6, 643-666.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 643-666
    • Crystal, R.G.1    Jaffe, A.2    Brody, S.3    Mastrangeli, A.4    McElvaney, N.G.5    Rosenfeld, M.6    Chu, C.7    Danel, C.8    Hay, J.9    Eissa, T.10
  • 12
    • 0028959499 scopus 로고
    • Use of the stress-inducible grp78/bip promoter in targeting high level gene expression in fibrosarcoma in vivo
    • GAZIT, G., KANE, S.E., NICHOLS, P., and LEE, A.S. (1995). Use of the stress-inducible grp78/bip promoter in targeting high level gene expression in fibrosarcoma in vivo. Cancer Res. 55, 1660-1663.
    • (1995) Cancer Res. , vol.55 , pp. 1660-1663
    • Gazit, G.1    Kane, S.E.2    Nichols, P.3    Lee, A.S.4
  • 13
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • GRAHAM, F.L., and VAN DER EB, A.J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, F.L.1    Van Der Eb, A.J.2
  • 14
    • 0017710978 scopus 로고
    • Characteristics of a human cell line transformed by DNA from human adenovirus type 5
    • GRAHAM, F.L., SMILEY, J., RUSSELL, W.C., and NAIRN, R. (1977). Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36, 59-72.
    • (1977) J. Gen. Virol. , vol.36 , pp. 59-72
    • Graham, F.L.1    Smiley, J.2    Russell, W.C.3    Nairn, R.4
  • 15
    • 0028802876 scopus 로고
    • Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector
    • HAY, J.G., McELVANEY, N.G., HERENA, J., and CRYSTAL, R.G. (1995). Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector. Hum. Gene Ther. 6, 1487-1496.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 1487-1496
    • Hay, J.G.1    McElvaney, N.G.2    Herena, J.3    Crystal, R.G.4
  • 16
    • 0028124788 scopus 로고
    • Expression of a thyroid hormone-responsive recombinant gene introduced into adult mice livers by replication-defective adenovirus can be regulated by endogenous thyroid hormone receptor
    • HAYASHI, Y., DE PAOLI, A.M., BURANT, C.F., and REFETOFF, S. (1994). Expression of a thyroid hormone-responsive recombinant gene introduced into adult mice livers by replication-defective adenovirus can be regulated by endogenous thyroid hormone receptor. J. Biol. Chem. 269, 23872-23875.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23872-23875
    • Hayashi, Y.1    De Paoli, A.M.2    Burant, C.F.3    Refetoff, S.4
  • 19
    • 0027185802 scopus 로고
    • Characterization of the cystic fibrosis transmembrane conductance regulator promoter region; Chromatin context and tissue-specificity
    • KOH, J., SFERRA, T.J., and COLLINS, F.S. (1993). Characterization of the cystic fibrosis transmembrane conductance regulator promoter region; Chromatin context and tissue-specificity. J. Biol. Chem. 268, 15912-15921.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15912-15921
    • Koh, J.1    Sferra, T.J.2    Collins, F.S.3
  • 21
    • 0028609837 scopus 로고
    • Dopaminergic regulation of a transfected preproenkephalin promoter in primary rat astrocytes in vitro and in vivo
    • LA GAMMA, E.F., STRECKER, R.E., LENN, N.J., DE CRISTOFARO, J.D., and WEISINGER, G. (1994). Dopaminergic regulation of a transfected preproenkephalin promoter in primary rat astrocytes in vitro and in vivo. Exp. Neurol. 130, 304-310.
    • (1994) Exp. Neurol. , vol.130 , pp. 304-310
    • La Gamma, E.F.1    Strecker, R.E.2    Lenn, N.J.3    De Cristofaro, J.D.4    Weisinger, G.5
  • 22
    • 0025796875 scopus 로고
    • Indiscriminate activity from the B19 parvovirus P6 promoter in nonpermissive cells
    • LIU, J.M., FUJII, H., GREEN, S.W., KOMATSU, N., YOUNG, N.S., and SHIMADA, T. (1991). Indiscriminate activity from the B19 parvovirus P6 promoter in nonpermissive cells. Virology 182, 361-364.
    • (1991) Virology , vol.182 , pp. 361-364
    • Liu, J.M.1    Fujii, H.2    Green, S.W.3    Komatsu, N.4    Young, N.S.5    Shimada, T.6
  • 24
    • 0026516574 scopus 로고
    • Metabolic control of gene expression: In vivo studies with transgenic mice
    • McGRANE, M.M., YUN, J.S., PATEL, Y.M., and HANSON, R.W. (1992). Metabolic control of gene expression: in vivo studies with transgenic mice. Trends Biochem. Sci. 17, 40-44.
    • (1992) Trends Biochem. Sci. , vol.17 , pp. 40-44
    • McGrane, M.M.1    Yun, J.S.2    Patel, Y.M.3    Hanson, R.W.4
  • 25
    • 0023883716 scopus 로고
    • A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5
    • McGRORY, W.J., BAUTISTA, D.S., and GRAHAM, F.L. (1988). A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology 163, 614-617.
    • (1988) Virology , vol.163 , pp. 614-617
    • McGrory, W.J.1    Bautista, D.S.2    Graham, F.L.3
  • 26
    • 0016374484 scopus 로고
    • Analogs of cyclic AMP and cyclic GMP: General methods of synthesis and the relationship of structure to enzymic activity
    • MEYER, R.B., JR., and MILLER, J.P. (1974). Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity. Life Sci. 14, 1019-1040.
    • (1974) Life Sci. , vol.14 , pp. 1019-1040
    • Meyer Jr., R.B.1    Miller, J.P.2
  • 27
    • 0026457204 scopus 로고
    • Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection
    • MULLER, M., BRENIG, B., WINNACKER, E.L., and BREM, G. (1992). Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection. Gene 121, 263-270.
    • (1992) Gene , vol.121 , pp. 263-270
    • Muller, M.1    Brenig, B.2    Winnacker, E.L.3    Brem, G.4
  • 28
    • 0026230417 scopus 로고
    • Guidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute. National Asthma Education Program. Expert Panel Report
    • NATIONAL HEART, LUNG, AND BLOOD INSTITUTE. (1991). Guidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute. National Asthma Education Program. Expert Panel Report. J. Allergy Clin. Immunol. 88, 425-534.
    • (1991) J. Allergy Clin. Immunol. , vol.88 , pp. 425-534
  • 29
    • 0023553666 scopus 로고
    • A novel rapid assay for chloramphenicol acetyltransferase gene expression
    • NEUMANN, J.R., MORENCY, C.A., and RUSSIAN, K.O. (1987). A novel rapid assay for chloramphenicol acetyltransferase gene expression. Biotechniques 5, 444-447.
    • (1987) Biotechniques , vol.5 , pp. 444-447
    • Neumann, J.R.1    Morency, C.A.2    Russian, K.O.3
  • 30
    • 0019971764 scopus 로고
    • Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring
    • PALMITER, R.D., CHEN, H.Y., and BRINSTER, R.L. (1982). Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell 29, 701-710.
    • (1982) Cell , vol.29 , pp. 701-710
    • Palmiter, R.D.1    Chen, H.Y.2    Brinster, R.L.3
  • 31
    • 0023888280 scopus 로고
    • Cyclic AMP and the induction of eukaryotic gene transcription
    • ROESLER, W.J., VANDENBARK, G.R., and HANSON, R.W. (1988). Cyclic AMP and the induction of eukaryotic gene transcription. J. Biol. Chem. 263, 9063-9066.
    • (1988) J. Biol. Chem. , vol.263 , pp. 9063-9066
    • Roesler, W.J.1    Vandenbark, G.R.2    Hanson, R.W.3
  • 32
    • 0023556383 scopus 로고
    • Proteolytic activity of human tumor cell lines deriving from bronchial squamous cell carcinoma, pulmonary metastasis of rhabdomyosarcoma and pleural metastasis of mesothelioma
    • SCHOENBERGER, O.L., BEIKIRCH, S., TREFZ, G., DRINGS, P., and EBERT, W. (1987). Proteolytic activity of human tumor cell lines deriving from bronchial squamous cell carcinoma, pulmonary metastasis of rhabdomyosarcoma and pleural metastasis of mesothelioma. Eur. J. Respir. Dis. 71, 434-443.
    • (1987) Eur. J. Respir. Dis. , vol.71 , pp. 434-443
    • Schoenberger, O.L.1    Beikirch, S.2    Trefz, G.3    Drings, P.4    Ebert, W.5
  • 33
    • 0023024937 scopus 로고
    • Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains
    • SHORT, J.M., WYNSHAW-BORIS, A., SHORT, H.P., and HANSON, R.W. (1986). Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains. J. Biol. Chem. 261, 9721-9726.
    • (1986) J. Biol. Chem. , vol.261 , pp. 9721-9726
    • Short, J.M.1    Wynshaw-Boris, A.2    Short, H.P.3    Hanson, R.W.4
  • 34
    • 0025156930 scopus 로고
    • Cell type-specific induction of the major immediate early enhancer of human cytomegalovirus by cyclic AMP
    • STAMMINGER, T., FICKENSCHER, H., and FLECKENSTEIN, B. (1990). Cell type-specific induction of the major immediate early enhancer of human cytomegalovirus by cyclic AMP. J. Gen. Virol. 71, 105-113.
    • (1990) J. Gen. Virol. , vol.71 , pp. 105-113
    • Stamminger, T.1    Fickenscher, H.2    Fleckenstein, B.3
  • 35
    • 0025083185 scopus 로고
    • IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice
    • TEPPER, R.I., LEVINSON, D.A., STANGER, B.Z., CAMPOS-TORRES, J., ABBAS, A.K., and LEDER, P. (1990). IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 62, 457-467.
    • (1990) Cell , vol.62 , pp. 457-467
    • Tepper, R.I.1    Levinson, D.A.2    Stanger, B.Z.3    Campos-Torres, J.4    Abbas, A.K.5    Leder, P.6
  • 36
    • 0026043883 scopus 로고
    • Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis
    • TRAPNELL, B.C., CHU, C., PAAKKO, P.K., BANKS, T.C., YOSHIMURA, K., FERRANS, V.J., CHERNICK, M.S., and CRYSTAL, R.G. (1991). Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. Proc. Natl. Acad. Sci. USA 88, 6565-6569.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6565-6569
    • Trapnell, B.C.1    Chu, C.2    Paakko, P.K.3    Banks, T.C.4    Yoshimura, K.5    Ferrans, V.J.6    Chernick, M.S.7    Crystal, R.G.8
  • 37
    • 0029013217 scopus 로고
    • Inflammation-induced recombinant protein expression in vivo using promoters from acute-phase protein genes
    • VARLEY, A.W., COULTHARD, M.G., MEIDELL, R.S., GERARD, R.D., and MUNFORD, R.S. (1995). Inflammation-induced recombinant protein expression in vivo using promoters from acute-phase protein genes. Proc. Natl. Acad. Sci. USA 92, 5346-5350.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5346-5350
    • Varley, A.W.1    Coulthard, M.G.2    Meidell, R.S.3    Gerard, R.D.4    Munford, R.S.5
  • 39
    • 0023025504 scopus 로고
    • Cystic fibrosis and beta-adrenergic response of airway epithelial cell cultures
    • WIDDICOMBE, J.H. (1986). Cystic fibrosis and beta-adrenergic response of airway epithelial cell cultures. Am. J. Physiol. 251, R818-R822.
    • (1986) Am. J. Physiol. , vol.251
    • Widdicombe, J.H.1
  • 40
    • 0001244722 scopus 로고
    • A phase I study of gene therapy of cystic fibrosis utilizing a replication deficient recombinant adenovirus vector to deliver the human cystic fibrosis transmembrane conductance regulator cDNA to the airways
    • WILMOTT, R.W., WHITSETT, J., and TRAPNELL, B. (1993). A phase I study of gene therapy of cystic fibrosis utilizing a replication deficient recombinant adenovirus vector to deliver the human cystic fibrosis transmembrane conductance regulator cDNA to the airways. Fed. Register 58, 21739.
    • (1993) Fed. Register , vol.58 , pp. 21739
    • Wilmott, R.W.1    Whitsett, J.2    Trapnell, B.3
  • 41
    • 0027933841 scopus 로고
    • Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: A phase I trial
    • WILSON, J.M., ENGELHARDT, J.F., GROSSMAN, M., SIMON, R.H., and YANG, Y. (1994). Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: A phase I trial. Hum. Gene Ther. 5, 501-519.
    • (1994) Hum. Gene Ther. , vol.5 , pp. 501-519
    • Wilson, J.M.1    Engelhardt, J.F.2    Grossman, M.3    Simon, R.H.4    Yang, Y.5
  • 42
    • 0025776409 scopus 로고
    • The cystic fibrosis gene has a "housekeeping"-type promoter and is expressed at low levels in cells of epithelial origin
    • YOSHIMURA, K., NAKAMURA, H., TRAPNELL, B.C., DALEMANS, W., PAVIRANI, A., LECOCQ, J., and CRYSTAL, R.G. (1991). The cystic fibrosis gene has a "housekeeping"-type promoter and is expressed at low levels in cells of epithelial origin. J. Biol. Chem. 266, 9140-9144.
    • (1991) J. Biol. Chem. , vol.266 , pp. 9140-9144
    • Yoshimura, K.1    Nakamura, H.2    Trapnell, B.C.3    Dalemans, W.4    Pavirani, A.5    Lecocq, J.6    Crystal, R.G.7
  • 43
    • 0027377523 scopus 로고
    • Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis
    • ZABNER, J., COUTURE, L.A., GREGORY, R.J., GRAHAM, S.M., SMITH, A.E., and WELSH, M.J. (1993). Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75, 207-216.
    • (1993) Cell , vol.75 , pp. 207-216
    • Zabner, J.1    Couture, L.A.2    Gregory, R.J.3    Graham, S.M.4    Smith, A.E.5    Welsh, M.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.