Tacalcitol ointment in the treatment of psoriasis vulgaris: A multicentre, placebo-controlled, double-blind study on efficacy and safety

British Journal of Dermatology

Volumn 135, Issue 5, 1996, Pages 758-765

  Van De Kerkhof, P C M ^a   Werfel, T ^b   Haustein, U F ^c   Luger, T ^d   Czarnetzki, B M ^e   Niemann, R ^f   Planitz Stenzel V ^f  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f HERMAL Kurt Herrmann   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIFEDIOL; CALCITONIN; PARATHYROID HORMONE; PLACEBO; TACALCITOL;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ERYTHEMA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PSORIASIS VULGARIS; RANDOMIZED CONTROLLED TRIAL; TOPICAL DRUG ADMINISTRATION;

EID: 0029857629     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1996.d01-1075.x     Document Type: Article

References (24)

1. 3. Med J Osaka Univ 1985; 35: 51.
2. Norman AW, Bouillon R, Thomasset M (eds). Vitamin D: Gene Regulation Structure-Function Analysis, and Clinical Application: Proceedings of the Eight Workshop on Vitamin D. Berlin: de Gruyter, 1991.
3. Kragballe K, Iversen L. Calcipotriol: a new typical antipsoriatic. Dermatol Ther 1993; 11: 137-41.
4. 3 for the treatment of psoriasis. Review of the literature. Eur J Dermatol 1993; 3: 255-61.
5. 3 with high activity for inducing epidermal differentiation hut decreased hypercalcemic activity. J Dermatol 1990; 17: 135-42.
6. 3 on the growth of human keratinocytes. J Dermatol 1990; 17: 97-103.
7. 3 to induce keratinocyte differentiation. J Dermatol 1990; 17: 707-9.
8. 3: a multiparameter flowcytometrical analysis of epidermal growth, differentiation and inflammation. Acta Derm Venereol (Stockh) 1995; 75: 381-5.
9. Farkas B, Bonnekoh B, Mahrle G, Dobozy A. Regulatory effect of calcitriol, calcipotriol and tacalcitol: a direct comparison in the human keratinocyte line HACAT. Arch Dermatol Res (in press).
10. Kimura H, Nishiyama S, Nakamizo Y et al. Investigation of the usefulness of TV-02 ointment for patients with psoriasis - right and left comparison test with betamethasone valerate ointment. Western Jpn Dermatol 1989; 51: 963-9.
11. Kimura H, Nishiyama S, Nakamizo Y et al. Investigation of the clinical effects of TV-02 ointment on psoriasis. Western Jpn Dermatol 1989; 51: 970-9.
12. Eto M, Nishiyama S, Nakamizo Y et al. Study on the efficacy of TV-02 ointment for psoriasis - results of a double blind comparative clinical study of the left and right sides with a placebo (ointment base) as a control. Nishinihon J Dermatol 1991; 53: 1252-61.
13. Nishiyama S, Goto M, Ohkawara A et al. Study for setting optimal concentration of TV-02 ointment. Nishinihon J Dermatol 1989; 51: 310-16
14. 3, 1α,24-hydroxycholecalciferol ointment. Acta Dermatol (Kyoto) 1989; 84: 431-6.
15. Eto M, Nishiyama S, Nakamizo Y et al. Safety confirmation study on TV-02 ointment to patients with psoriasis. Nishinihon J Dermatol 1989; 51: 317-24.
16. Baadsgaard O, Traulsen J, Roed-Petersen J, Jakobsen HB. Optimal concentration of tacalcitol in once-daily treatment of psoriasis. J Dermatol Treat 1995; 6: 145-50.
17. Frederiksson T, Pettersson U. Severe psoriasis - oral therapy with a new retinoid. Dermatologica 1978; 157: 238-44.
18. Speight EL, Farr PM. Plaque area is a poor measure of response of psoriasis to treatment. Br J Dermatol 1994; 131: 443 (Abstract.).
19. Ramsay CA, Berth-Jones J, Brundin G et al. Long-term use of topical calcipotriol in chronic plaque psoriasis. Dermatology 1994; 189: 260-4.
20. Saurat J-H, Gumowski-Sunek D, Rizzoli R. Topical calcipotriol and hypercalcaemia. Lancet 1991; 337: 1287 (Letter).
21. Hardman KA, Heath DA, Nelson HM. Hypercalcaemia associated with calcipotriol (Dovonex) treatment. Br Med J 1993; 306: 896.
22. Hoeck HC, Laurberg G, Laurberg P. Hypercalcaemic crisis after excessive topical use of a vitamin D derivative. J Intern Med 1994; 235: 281-2.
23. Poyner T, Hughes IW, Dass BK, Adnitt PI. Long-term treatment of chronic plaque psoriasis with calcipotriol. J Dermatol Treat 1993; 4: 173-7.
24. 3 (calcitriol) ointment in psoriasis. J Dermatol Treat 1992; 3: 177-80.