Effects of PIXY321, a granulocyte-macrophage colony-stimulating factor/interleukin 3 fusion protein, on human tumor colony-forming units taken directly from patients

Clinical Cancer Research

Volumn 2, Issue 10, 1996, Pages 1713-1716

  Izquierdo, Miguel A ^a   Degen, Donna ^a   Raymond, Eric ^a   Caron, Dania ^c   Ortiz, Veronica ^a   Banks, Peter ^b   Von Hoff, Daniel D ^a,d  

^a CTRC Institute for Drug Development   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c AMGEN INC   (United States)

^d University of Texas Health Science Center at San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; MILODISTIM;

ARTICLE; BONE MARROW SUPPRESSION; BREAST CANCER; CLONOGENIC ASSAY; CONTROLLED STUDY; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; OVARY CANCER; PRIORITY JOURNAL; TUMOR CELL;

BREAST NEOPLASMS; CELL DIVISION; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-3; LUNG NEOPLASMS; LYMPHOMA; OVARIAN NEOPLASMS; RECOMBINANT FUSION PROTEINS; TUMOR STEM CELL ASSAY; TUMOR STEM CELLS;

EID: 0029856812     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Rowe, J. M., and Rapoport, A. P. Hematopoietic growth factors: a review. J. Clin. Pharmacol., 32: 486-501, 1992.
2. Gasson, J. C. Molecular physiology of granulocyte-macrophage colony-stimulating factor. Blood, 77: 1131-1145, 1991.
3. Oster, W., and Schulz, G. Interleukin 3: biological and clinical effects: Int. J. Cell Cloning, 9: 5-23, 1991.
4. Broxmeyer, H. E., Williams, D., Hangoc, G., Cooper, S., Gillis, S., Shadduck, R. K., and Bicknell, D. C. Synergistic myelopoietic actions in vivo after administration to mice of combinations of purified natural murine CSF-1, recombinant murine interleukin-3, and recombinant murine GM-CSF. Proc. Natl. Acad. Sci. USA, 84: 3871-3875, 1987.
5. Curtis, B. M., Williams, D. E., Broxmeyer, H. E., Dunn, J., Farrah, T., Jeffery, E., Clevenger, W., DeRoos, P., Martin, U., Friend, D., Craig, V., Gayle, R., Price, V., Cosman. D , March, C. J., and Parks, L. Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interieukin-3 fusion protein. Proc. Natl. Acad. Sci. USA, 88: 5809-5813, 1991.
6. Kitamura, T., Sato, N., Arai, K., and Miyajima, A. Expression cloning of the human interleukin-3 (hIL-3) receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell, 66: 1165-1174, 1991.
7. Ganser, A., Ottmann, O. G., and Hoelzer, D. Interleukin 3 and interleukin 3/GM-CSF combination therapy-clinical implications. Stem Cells, 11: 465-473, 1993.
8. Williams, D. E., and Park, L. S. Hematopoietic effects of a granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein. Cancer (Phila.), 67: 2705-2707, 1991.
9. McCrady, C. W., Li, F., Pettit, G. R., and Grant, S. Modulation of the activity of a human granulocyte-macrophage colony-stimulating factor/ interleukin-3 fusion protein (PIXY321) by the macrocyclic lactone protein kinase C activator bryostatin 1. Exp. Hematol., 21: 893-900, 1993.
10. Kanz, L., Brugger, W., and Mertelsmann, R. The use of hematopoietic growth factors for high-dose chemotherapy and peripheral blood progenitor cell transplantation. Semin. Oncol., 21: 10-18, 1994.
11. Berdel, W. E., Danhauser-Riedl, S., Steinhauser, G., and Winton, E. F. Various hematopoietic growth factors (interleukin-3, GM-CSF, G-CSF) stimulate clonal growth of non-hematopoietic tumor cells. Blood, 73: 80-83, 1989
12. Dippold, W. G., Klingel, R., Kerlin, M., Schwaeble, W., and Meyer zum Buschenfelde, K H. Stimulation of pancreas and gastric carcinoma cell growth by interleukin 3 and granulocyte-macrophage colony-stimulating factor. Gastroenterology, 100: 1338-1344, 1991.
13. Block, T., Schmid, F., Geffken, B., Treiber, U., Busch, R., and Hartung, R. Modulation of in vitro cell growth of human and murine urothelial tumor cell lines under the influence of interleukin-3. granulocyte, macrophage- and granulocyte-colony-stimulating factor. Urol. Res., 20: 289-292, 1992.
14. Vellenga, E., Biesma, B., Meyer, C., Wagteveld, L., Esselink, M., and deVrics, E. G. E. The effects of five hematopoietic growth factors on human small cell lung carcinoma cell lines: interleukin 3 enhances the proliferation in one of the eleven cell lines. Cancer Res., 51: 73-76, 1991
15. Guillaume, T., Sekhavat, M., Rubinstein, D. B., Hamdam, O., and Symman, M. L. Transcription of genes encoding granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin 6 receptors and lack of proliferative response to exogenous cytokines in nonhematopoietic human malignant cell lines. Cancer Res., 53: 3139-3144, 1993.
16. Anonymous. Human granulocyte-macrophage colony stimulating factor modulates in vitro growth in only a minority of continuous human tumor cell lines. EORTC Clonogenic Assay Screening Study Group. Eur. J. Cancer, 27: 231-235, 1991.
17. Salmon, S. E., and Liu, R. Effects of granulocyte-macrophage colony-stimulating factor on in vitro growth of human solid tumors. J. Clin. Oncol., 7: 1346, 1989.
18. Foulke, R S., Marshall, M. H., Trotta, P. P., and Von Hoff, D. D. In vitro assessment of the effects of granulocyte-macrophage colonystimulating factor on primary human tumors and derived lines. Cancer Res., 50: 6264-6267, 1990.
19. Von Hoff, D. D., Degen, D., Myers, L. A., and Levitt, D. Effect of hematopoietic growth factors GMCSF, IL-3 and IL-6 on colony-forming units of tumors taken directly from patients (Abstract). Blood, 80: 1676, 1992.
20. Joraschkewitz, M., Depenbrock, H., Freund, M., Erdmann, G., Meyer, H. J., De Riese, W., Neukam, D., Hanauske, U., Krumwieh, M., Poliwoda, H , and Hanauske, A. R. Effects of cytokines on in vitro colony formation of primary human tumour specimens. Eur. J Cancer, 26: 1070-1074, 1990.
21. Clay, C., Luna-Fineman, S., Lee, J. E., Pillai, A., Campbell, M., Levy, R., and Krensky, A. M. Interleukin-3 is a growth factor for human follicular B cell lymphoma. J. Exp. Med., 175: 371-376, 1992.
22. Fibbe, W. E., Raemaekers, J., Verdonck, L. F., Schouten, H. C., van Imhof, G., Tromp, B., Willemze, R , van Bree, J., Hessels, J. A., and Vellenga, E. Recombinant human interleukin-3 after autologous bone marrow transplantation for malignant lymphoma: a phase I/II multi-center study (Abstract). Blood, 78: 163, 1991
23. Raemaekers, J., Imhoff, G. V., Fibbe, W., Verdonck, L. F., Hessels, J., and Mull, R. A. Randomized, double-blinded, placebo-controlled, phase I/II study on human recombinant interleukin-3 after DHAP chemotherapy in patients with relapsed malignant lymphoma (Abstract). Blood, 78: 162, 1991.
24. Gerhartz, H. H., Walther, J., Bunica, O., Klener, P., Visani, G., Peschl, C., Huber, C., Wilmanns, W., Mull, R., and Sklenar, I. Clinical-hematological-and cytokine-response to interleukin-3 (IL-3) supported chemotherapy in resistant lymphomas: a phase II study (Abstract). Proc. Am. Soc. Clin. Oncol., 11: 329, 1992.
25. Ganser, H. H., Lindemann, A., Seipelt, G , Ottmann, O. G., Herrmann, F., Eder, M., Frisch, J., Schulz, G., Mertelsmann, R., and Hoelzer, D. Effects of recombinant human interleukin-3 in patients with normal hematopoiesis and in patients with bone marrow failure. Blood, 76: 666-676, 1990.
26. Fay, J. W., Lazarus, H., Herzig, R., Saez, R., Stevens, D. A., Collins, R. H., Pineiro, L. A., Cooper, B. W., DiCesare, J., Campion, Felser, J. M., Herzig, G., and Bernstein, S. H. Sequential administration of recombinant interleukin-3 and granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for malignant lymphoma: a phase I/II multicenter study. Blood, 84: 2151-2157, 1994.
27. Abboud, C. N., Liesveld, J. L., Belanger, T. J., Kempski, M. C., Frediani, K E., Reykdal, S., Flesher, W. R., Wedow, L. A., Kouides, P. A., Rapoport, A. P., Rowe, J. M., Packman, C. H., Duerst, R. E., and Dipersio, J F. Prospective randomized trial of four peripheral blood stem cell mobilization (PBSC) regimens in cancer patients undergoing autologous marrow transplantation (Abstract). Proc. Am. Soc. Clin. Oncol., 14: 259, 1995.
28. Raptis, G., Gilewski, T., Caron, D., and Jakubowski, A. PIXY321 (PIXY) abrogates cumulative myelosuppression - once (qd) vs. twice (bid) daily dosing (Abstract) Proc. Am. Soc. Clin Oncol., 14: 260, 1995.
29. Schwartz, G N., Warren, M. K., Szabo, J. M., Hakim, F., Sander, E , Riley, J., Riseberg, D., Setzer, A., Noone, M., Cowman, K., Gress, R. E., and O'Shaughnessy, J. Effect of GM-CSF and PIXY 321 on bone marrow recovery in breast cancer patients after first cycle of 5-fluorouracil, leucovorin, Adryamicin, and Cytoxan (FLAC) therapy. Proc. Am. Assoc. Cancer Res., 36: 221, 1995.
30. Cairo, M. S., Weinthal, J. A., Garrison, L., Krailo, M., Kao, W. W., Sender, L. S., Blazar, B., and Reaman, G. Results of a phase I trial of PIXY321 following ifosfamide, carboplatin, and etoposide (ICE) chemotherapy in children with recurrent solid tumors (RST): improved hematopoietic reconstitution (Abstract). Proc. Am. Soc. Clin. Oncol., 14: 255, 1995.
31. Vadhan-Raj, S., Papadopoulos, N. E., Burgess, M. A., Patel, S. R., Hays, C., Arcenas, A., Plager, C., Kudelka, A. P., Hittelman, W. N., Broxmeyer, H. E., Williams, D. E., Garrison, L., and Benjamin, R. S. Effects of PIXY321, a granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein, on chemotherapy-induced multilineage myelosuppression in patients with sarcoma. J. Clin. Oncol., 12: 715-724, 1994.
32. Hamburger, A. W., and Salmon, S. E. Primary assay of human tumor stem cells. Science (Washington DC), 197: 461-463, 1977.
33. Von Hoff, D. D., Clark, G. M., Stogdill, B. J., Sarosdy, M. F., O'Brien, M. T., Casper, J. T., Mattox, D. E., Page, C. P., Cruz, A. B., and Sandbach, J. F. Prospective clinical trial of a human tumor cloning system Cancer Res., 43: 1926-1931, 1983.
34. Hanauske, U., Hanauske, A. R., Marshall, M. H., Muggia, V. A., and Von Hoff, D. D. Biphasic effects of vanadium salts on in vitro tumor colony growth: Int. J. Cell Cloning, 5: 170-178, 1987.
35. Shoemaker, R. H., Wolpert-DeFilippes, M. K., Kern, D. H., Lieber, M. M., Makuch, R. W., MeInick, N. R., Miller, W. T., Salmon, S. E., Simon, R. M., Venditti, J. M., and Von Hoff, D. D. Application of a human tumor colony-forming assay to new drug screening. Cancer Res., 45: 2145-2153, 1985.