A 'picture' is worth a thousand experiments

Nature Medicine

Volumn 2, Issue 11, 1996, Pages 1193-1194

  Gibson, Wade ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; PROTEIN; PROTEINASE;

CRYSTAL STRUCTURE; CYTOMEGALOVIRUS INFECTION; ENZYME STRUCTURE; NONHUMAN; NOTE; PRIORITY JOURNAL;

CRYSTALLOGRAPHY, X-RAY; CYTOMEGALOVIRUS; ENDOPEPTIDASES; HUMANS; MODELS, MOLECULAR; PROTEIN FOLDING; SERINE ENDOPEPTIDASES; VIRAL PROTEINS;

CYTOMEGALOVIRUS;

EID: 0029856311     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1196-1193     Document Type: Note

References (15)

1. Mocarski, E.S.J. in Virology (ed. Fields, B.N., Knipe, D.M. & Howley, P.M.) 2447-2492 (Lippincott-Raven, Philadelphia, 1996).
2. Britt, W.B. & Alford, C. in Virology (ed. Fields, B.N., Knipe, D.M. & Howley, P.M.) 2493-2523 (Lippincott-Raven, Philadelphia, 1996).
3. Welch, A.R., Woods, A.S., McNally, L.M., Cotter, RJ. & Gibson, W. A herpesvirus maturational protease, assemblin: Identification of its gene, putative active site domain, and cleavage site. Proc. Natl. Acad. Sci. USA 88, 10792-10796 (1991).
4. Preston, V.G., Rixon, F.J., McDougall, I.M., McGregor, M. & Al Kobaisi, M.F. Processing of the herpes simplex virus assembly protein ICP35 near its carboxy terminal end requires the product of the whole of the UL26 reading frame. Virology 186, 87-98 (1992).
5. Liu, F. & Roizman, B. The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate. J. Virol. 65, 5149-5156 (1991).
6. Gibson, W., Welch, A.R. & Hall, M.R.T. Assemblin, a herpes virus serine maturational proteinase and new molecular target for antivirals. Perspectives in Drug Discovery and Design 2, 413-426 (1995).
7. Chen, P. et al. Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad. Cell 86, 835-843 (1996).
8. Tong, L. et al. A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease. Nature 383, 272-275 (1996).
9. Shieh, H.-S. et al. Three-dimensional structure of human cytomegalovirus protease. Nature 383, 279-282 (1996).
10. Qiu, X. et al. Unique fold and active site in cytomegalovirus protease. Nature 383, 275-279 (1996).
11. Darke, P.L. et al. Active human cytomegalovirus protease is a dimer. J. biol. Chem. 271, 7445-7449 (1996).
12. Margosiak, S.A., Vanderpool, D.L., Sisson, W. Pinko, C. & Kan, C.C. Dimerization of the human cytomegalovirus protease - kinetic and biochemical characterization of the catalytic homodimer. Biochemistry 35, 5300-5307 (1996).
13. Welch, A.R., McNally, L.M., Hall, M.R.T. & Gibson, W. Herpesvirus proteinase: Site-directed mutagenesis used to study maturational, release, and inactivation cleavage sites of precursor and to identify a possible catalytic site serine and histidine. J. Virol. 67, 7360-7372 (1993).
14. Babe, LM., Rose, J. & Craik, C.S. Synthetic interface peptides alter dimeric assembly of the HIV-1 and HIV-2 proteases. Frotein Sci. 1, 1244-1253 (1992).
15. Gibson, W. Structure and assembly of the virion. in Cytomegaloviruses. (ed. Stinski, M.F.) (S. Karger, Basel, 1996).