Variability in loss of constitutional heterozygosity across loci and among individuals: Association with candidate genes in ductal breast carcinoma

Molecular Carcinogenesis

Volumn 17, Issue 3, 1996, Pages 117-125

  Rebbeck, Timothy R ^a   Godwin, Andrew K ^b   Buetow, Kenneth H ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

Breast neoplasms; Carcinogen metabolism; Genetic susceptibility; Somatic mutation

Indexed keywords

CARCINOGEN;

BREAST CARCINOMA; BREAST DUCT; CLINICAL ARTICLE; CONFERENCE PAPER; DRUG METABOLISM; FEMALE; GENETIC POLYMORPHISM; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SOMATIC MUTATION;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2D6; EPOXIDE HYDROLASES; FEMALE; GENE DELETION; GENOTYPE; GLUTATHIONE TRANSFERASE; HETEROZYGOTE; HUMANS; INDIVIDUALITY; MIDDLE AGED; POLYMORPHISM, GENETIC; QUINONE REDUCTASES;

EID: 0029856249     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199611)17:3<117::AID-MC3>3.0.CO;2-C     Document Type: Conference Paper

References (29)

1. Nebert DW, Gonzalez FJ. P450 genes: Structure evolution and regulation. Ann Rev Biochem 56:945-993, 1987.
2. Omenn GS. Future research in cancer ecogenetics. Mutat Res 247:291-293, 1991.
3. Board PG, Coggan M, Johnston P, Ross V, Suzuki T, Webb G. Genetic heterogeneity of the human glutathione transferases: A complex of gene families. Pharmacol Ther 48:357-369, 1990.
4. Gruis NA, Abalone ECA, Bardoel AFJ, Devilee P, Frants RR, Cornelisse CJ. PCR-based microsatellite polymorphisms in the detection of loss of heterozygosity in fresh and archival tumor tissue. Br J Cancer 68:308-313, 1993.
5. Hayashi SI, Watanabe J, Kawajiri K. Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P-450IIE1 gene. J Biochem 110:559-565, 1991.
6. Peterson DD, McKinney CE, Ikeya K, et al. Human CYPIAI gene: Cosegregation of the enzyme inducibility phenotype and RFLP. Am J Hum Genet 48:720-725, 1991.
7. Rebbeck TM, Rosvold EA, Duggan DJ, Zhang J, Buetow KH. Genetics of CYP1A1: Coamplification of specific alleles by polymerase chain reaction and association with breast cancer. Cancer Epidemiol Biomarkers Prev 3:511-514, 1994.
8. Gough AC, Miles JS, Spurr NK, et al. Identification of the primary gene defect at the cytochrome P450 CYP2D locus. Nature 347:773-776, 1990.
9. Comstock KE, Sanderson BJ, Claglin G, Henner WD. GST1 gene deletion determined by polymerase chain reaction. Nucleic Acids Res 18:3670, 1990.
10. Jaiswal AK, McBride OW, Adesnik M, Nebert DW. Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. J Biol Chem 263:13572-13578, 1988.
11. Traveler RD, Tetsuro H, Danenberg KD, et al. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: Characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity. Cancer Res 52:797-802, 1992.
12. Rosvold EA, McGlynn KA, Lustbader ED, Buetow KH. Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking. Pharmacogenetics 5(4):199-206, 1995.
13. Daniel WW. Applied Nonparametric Statistics, 2nd ed. PWS-KENT Publishing Co., Boston, 1990.
14. Draper N, Smith H. Applied Regression Analysis, 2nd ed. John Wiley & Sons, New York, 1981.
15. SAS Institute, Inc. SAS User's Guide, Version 6, First Edition. SAS Institute, Inc., Cary, NC, 1990.
16. Chen LC, Kurisu W, Ljung B-M, Goldman ES, Morre D, Smith HS. Heterogeneity for allelic loss in human breast cancer. J Natl Cancer Inst 84:506-510, 1992.
17. Merlo GR, Venesio T, Bernardi A, et al. Loss of heterozygosity on chromosome 17p13 in breast carcinomas identifies tumors with high proliferation index. Am J Pathol 140(1):215-223, 1992.
18. Devilee P, van Vliet M, van Sloun P, et al. Allelotype of human breast carcinoma: A second major site for loss of heterozygosity is on chromosome 6q. Oncogene 6:1705-1711, 1991.
19. Børreson AL, Ottestad L, Gaustad A, et al. Amplification and protein over-expression of the neu/HER-2/c-erb-2 protooncogene in human breast carcinomas: Relationship to the loss of gene sequences on chromosome 17, family history and prognosis. Br J Cancer 62:585-590, 1990.
20. Cropp CS, Lidereau R, Campbell G, Champene MH, Callahan R, Loss of heterozygosity on chromosomes 17 and 18 breast carcinoma: Two additional regions identified. Proc Natl Acad Sci USA 87:7737-7741, 1990.
21. Malkin D, Li FP, Strong L, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250:1233-1238, 1990.
22. Thomas AM, Steel CM, Chetty U, et al. p53 gene mRNA expression and chromosome 17p allele loss in breast cancer. Br J Cancer 61:74-78, 1990.
23. MacKay J, Elder PA, Steel CM, Dorrest APM, Evans HJ. Allele loss on short arm of chromosome 17 in breast cancers. Lancet 2(8625): 1384-1385, 1988.
24. Devilee P, van den Broek M, Kuipers-Dijkshorn N, et al. At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma. Genomics 5:554-560, 1989.
25. Nigro JM, Baker SJ, Preisinger AC, et al. Mutations in the p53 gene occur in diverse human tumor types. Nature 342:705- 708, 1989.
26. Sato T, Tanigami A, Yamakawa K, et al. Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res 50:7184-7189, 1990.
27. Callahan R, Cropp C, Merlo GR, et al. Genetic and molecular heterogeneity of breast cancer cells. Clin Chim Acta 217(1):63- 73, 1993.
28. Bieche I, Champeme M-H, Matifas F, Cropp CS, Callahan R, Lidereau R. Two distinct regions involved in 1p deletion in human primary breast cancer. Cancer Res 53:1990-1994, 1993.
29. Metzler M, McLachlan JA. Oxidative metabolism of diethylstil- bestrol and steroidal estrogens as a potential factor in their fetotoxicity. In: Neubert D, Merker HJ, Nau H, Langman J (eds), Role of Pharmacokinetics in Prenatal and Perinatal Pharmacology. Georg Thieme, Stuttgart, 1978, pp. 157-163.