A model of measles virus-induced immunosuppression: Enhanced susceptibility of neonatal human PBLs

Nature Medicine

Volumn 2, Issue 11, 1996, Pages 1250-1254

  Tishon, Antoinette ^a   Manchester, Marianne ^a   Scheiflinger, Friedrich ^a   Oldstone, Michael B A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; MEASLES VACCINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; IMMUNOSUPPRESSIVE TREATMENT; LEUKOCYTE; MEASLES; MEASLES VIRUS; MODEL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

ADULT; ANIMALS; ANTIGENS, CD; ANTIGENS, CD46; BASE SEQUENCE; CELL TRANSPLANTATION; DNA PRIMERS; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; INFANT, NEWBORN; LEUKOCYTES, MONONUCLEAR; MEASLES VIRUS; MEMBRANE GLYCOPROTEINS; MICE; MICE, SCID; MOLECULAR SEQUENCE DATA; RNA, VIRAL;

ANIMALIA; MEASLES VIRUS;

EID: 0029856069     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1196-1250     Document Type: Article

References (33)

1. Griffin, D.E. & Bellini, W.J. Measles virus, in Virology (eds. Fields, B.N., Knipe, D.M. & Howley, P.M.) 1267-1312 (Lippincott-Raven, Philadelphia, 1996).
2. Markowitz, L. & Katz, S. Measles vaccine, in Vaccines (eds. Plotkin, S. & Mortimer, S.) 229-276 (Saunders, Philadelphia, 1994).
3. Black, F.L. Measles active and passive immunity in a worldwide perspective. Prog. Med. Virol. 36, 1-33 (1989).
4. Hendrickson, E.A. The SCID mouse: Relevance as an animal model system for studying human disease. Am. J. Pathol. 143, 1511-1522 (1993).
5. Bosma, G.C., Custer, R.P. & Bosma, M.J. A severe combined immunodeficiency mutation in the mouse. Nature 301, 527-530 (1983).
6. Mosier, D., Gulizia, R., Baird, S. & Wilson, D. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335, 256-9 (1988).
7. Duchosal, M.A., Eming, S.A., McConahey, P.J. & Dixon, F.J. The hu-PBLS-SCID mouse model: Long-term human serologic evolution associated with the xenogeneic transfer of human peripheral blood leukocytes into SCID mice. Cell, Immunol. 139, 468-477 (1992).
8. Mosier, D.E. et al. Human immunodeficiency virus infection of human-PBLS-SCID mice. Science 251, 791-794 (1991).
9. + T cells in human-PBLS-SCID mice by noncytopathic HIV isolates. Science 260, 689-692 (1993).
10. Mosier, D.E., Gulizia, RJ., Maclsaac, P.D., Corey, L. & Greenberg, P.D. Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp 160 and recombinant gp160. Proc. Natl. Acad. Sci. USA 90, 2443-7 (1993).
11. Tyor, W., Power, C., Gendelman, H. & Markham, R. A model of human immunodeficiency virus encephalitis in scid mice. Proc. Natl. Acad. Sci. USA 90, 8658-8662 (1993).
12. Cannon, M.P., Pisa, P., Fox, R. & Cooper, N. Epstein-Barr virus induces aggressive lymphoproliferative disorders of human B cell origin in SCID/hu chimeric mice. J. Clin. Invest. 85, 1333-1337 (1990).
13. Mocarski, E., Bonyhadi, M., Salimi, S., McCune, J.M. & Kaneshima, H. Human cytomegalovirus in a SCID-hu mouse: Thymic epithelial cells are prominent targets of viral replication. Proc. Natl. Acad. Sci. USA 90, 104-108 (1993).
14. Naniche, D., et al. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J. Virol. 67, 6025-6032 (1993).
15. Dorig, R., Marcel, A., Chopra, A. & Richardson, C.D. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75, 295-305 (1993).
16. Manchester, M., Liszewski, M.K., Atkinson, J.P. & Oldstone, M.B.A. Multiple isoforms of CD46 (membrane cofactor protein) serve as receptors for measles virus. Proc. Natl. Acad. Sci. USA 91, 2161-2165 (1994).
17. Slifka, M.K., Matloubian, M. & Ahmed, R. Bone marrow is a major site of longterm antibody production after acute viral infection. J. Virol. 69, 1895-902 (1995).
18. Ahmed, R. & Gray, D. Immunologic memory and protective immunity: Understanding their relation. Science 272, 54-60 (1996).
19. Ueki, Y., et al. Clonal analysis of a human antibody response. Quantification of precursors and antibody producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus. J. Exp. Med. 171, 19-34 (1990).
20. McChesney, M.B. & Oldstone, M.B.A. Virus-induced immunosuppression: Infections with measles virus and human immunodeficiency virus. Adv. Immunol. 45, 335-380 (1989).
21. Yanagi, Y., Cubitt, B. & Oldstone, M.B.A. Measles virus inhibits mitogen-induced T cell proliferation but does not directly perturb the T cell activation process inside the cell. Virology 187, 280-289 (1992).
22. von Pirquet, C.E. Das Verhalten der kutanen Tuberkulin-reaktion wahrend der Masern. Deutsch Med. Wochenschr. 34, 1297-1300 (1908).
23. McChesney, M.B., Fujinami, R.S., Lampert, P.W. & Oldstone, M.B.A. Viruses disrupt functions of human T lymphocytes. II. Measles virus suppresses antibody production by acting on B lymphocytes. J. Exp. Med. 163, 1331-1336 (1986).
24. McChesney, M.B., Kehrl, J.H., Valsamakis, A., Fauci, A.S. & Oldstone, M.B.A. Measleï virus infection of B lymphocytes permits cellular activation but blocks progression through the cell cycle. J. Virol. 61, 3441-3447 (1987).
25. McChesney, M.B., Altman, A. & Oldstone, M.B.A. Suppression of T lymphocyte function by measles virus is due to cell cycle arrest in G1. J. Immunol. 140, 1269-1273 (1988).
26. Casali, P., Rice, G.P.A. & Oldstone, M.B.A. Viruses disrupt functions of human lymphocytes: Effects of measles virus and influenza virus on lymphocyte-mediated killing and antibody production. J. Exp. Med. 159, 1322-1337 (1984).
27. Fenner, F., McAuslan, B.R., Mims, C.A., Sambrook, J. & White, D. The Biology of Animal Viruses (Academic Press, New York, 1974).
28. McChesney, M.B., Fujinami, R.S., Lerche, N.W., Marx, P.A. & Oldstone, M.B.A. Virus induced immunosuppression: Infection of peripheral blood mononuclear cells and suppression of immunoglobulin synthesis during natural measles virus infection of rhesus monkeys. J. Infect. Dis. 159, 757-760 (1989).
29. Rebai, N. & Malissen, B. Structural and genetic analyses of HLA class 1 molecules using monoclonal xenoantibodies. Tissue Antigens 22, 107-117 (1983).
30. Meizlik, E.H. & Carpenter, A.M. Beneficial effect of measles on nephrosis: Report of 3 cases. Am. J. Dis. Child. 76, 83-90 (1948).
31. Gellen, B. & Katz, S. Putting a stop to a serial killer: Measles. J. Infect. Dis. 170, S1-S3 (1994).
32. Markowitz, L.E. & Bernier, R.H. Immunization of young infants with Edmonston-Zagreb measles vaccine. Pediatr. Infect. Dis. J. 6, 809-812 (1987).
33. Sambrook, J., Fritsch, E.F. & Maniatis, T. Molecular Cloning: A Laboratory Manual, edn. 2 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989).