Hemodynamic effects of carcinine in the anesthetized, instrumented, open-chest rat

Critical Care Medicine

Volumn 24, Issue 12, 1996, Pages 2042-2045

  Steinberg, Charlotte ^a   Notterman, Daniel A ^a,b  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

arteries; carcinine; cardiac output; contractility; electromagnetic flow meter; heart; hemodynamics; histamine; hypotension; left ventricular stroke work; systemic vascular resistance

Indexed keywords

CARCININE; HISTAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ELECTROMAGNETIC FLOWMETER; HEART INDEX; HEART OUTPUT; HEART STROKE VOLUME; HEMODYNAMICS; HYPOTENSION; INOTROPISM; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; SYSTEMIC VASCULAR RESISTANCE; VASODILATATION;

EID: 0029855861     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199612000-00018     Document Type: Article

References (12)

1. Arnoud JM, Frentz R: Mise en evidence, isolement et structure chimique d'une substance caracteristique du coeur de Carcinus maenas (L): La β-alanyl histamine. Comp Biochem Physiol C 1975; 50:59-66
2. Brotman DN, Flancbaum L, Fitzpatrick JC, et al: Presence of carcinine (β-alanylhistamine) in mammalian tissues. Abstr. FASEB J 1989; 3:A1028
3. Flancbaum L, Brotman DN, Fitzpatrick JC, et al: Existence of carcinine, a histamine related compound, in mammalian tissues. Life Sci 1990; 47:1587-1593
4. Fitzpatrick JC, Fisher H, Flancbaum L: Effect of histamine antagonists on myocardial carcinine metabolism during compound 48/80-induced shock. J Surg Res 1990; 49:293-297
5. Brotman DN, Flancbaum L, Young-Hee K, et al: Positive inotropic effect of carcinine in the isolated perfused guinea pig heart. Crit Care Med 1990; 18: 317-321
6. Arnould JM, Frentz R: La carcinine (β-alanyl-histamine): Synthèse rapide, action sur la pression sanguine des vertébrés. Arch Int Physiol Biochim 1977; 85:339-350
7. Katz RW, Pollack M, Weibley R: Pulmonary artery catheterization in pediatric intensive care. Adv Pediatr 1983; 30:169-190
8. Fitzpatrick JC, Brotman DN, Fisher H, et al: Involvement of carcinine (β-alanylhistamine) in the carnosine-histamine pathway. Abstr. FASEB J 1989; 3:A1028
9. Fisher DE, Amend JF, Strumeyer DH, et al: A role for carnosine and anserine in histamine metabolism of the traumatized rat. Proc Soc Exp Biol Med 1978; 158:402-405
10. Arnould JM: Mise en evidence de la carcinine synthetase, une nouvelle enzyme catalysant le metabolisme de l'histamine dans le systeme nerveux central de Carcinus maenas. J Neurochem 1987; 48:1316-1324
11. Levi R, Owen DAA, Trzeciakowski J: Actions of histamine on the heart and vasculature. In: Pharmacology of Histamine Receptors. Ganellin CR, Parsons M (Eds). London, J Wright & Sons, 1982, pp 236-297
12. Guo Z-G, Levi R, Graver LM, et al: Inotropic effects of histamine in human myocardium: Differentiation between positive and negative components. J Cardiovasc Pharmacol 1984; 6:1210-1215