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Volumn 17, Issue 6, 1996, Pages 895-900

EM523L, a nonpeptide motilin agonist, stimulates gastric empyting and pancreatic polypeptide secretion

Author keywords

blood glucose; diabetic neuropathy; insulin; motilide; vagal cholinergic mechanisms

Indexed keywords

8,9 ANHYDRO N ETHYLNORERYTHROMYCIN A 6,9 HEMIACETAL; ERYTHROMYCIN DERIVATIVE; MACROLIDE;

EID: 0029855482     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/0196-9781(96)00143-X     Document Type: Article
Times cited : (18)

References (38)
  • 3
    • 0022413003 scopus 로고
    • Gastric acid and pancreatic polypeptide responses to sham feeding are impaired in diabetic subjects with autonomie neuropathy
    • 3. Buysschaert, M.; Donckier, J.; Dive, A.; Ketelslegers, J. M.; Lambert, A. E. Gastric acid and pancreatic polypeptide responses to sham feeding are impaired in diabetic subjects with autonomie neuropathy. Diabetes 34:1181-1186; 1985.
    • (1985) Diabetes , vol.34 , pp. 1181-1186
    • Buysschaert, M.1    Donckier, J.2    Dive, A.3    Ketelslegers, J.M.4    Lambert, A.E.5
  • 4
    • 0019144295 scopus 로고
    • Pancreatic polypeptide
    • 4. Floyd, J. C., Jr. Pancreatic polypeptide. Clin. Gastroenterol. 9:657-678; 1980.
    • (1980) Clin. Gastroenterol. , vol.9 , pp. 657-678
    • Floyd J.C., Jr.1
  • 5
    • 0025153742 scopus 로고
    • Hyperglycemia slows gastric emptying in type I (insulin-dependent) diabetes mellitus
    • 5. Fraser, R.; Horowitz, M.; Maddox, A.; Chatterton, B.; Harding, P.; Dent, J. Hyperglycemia slows gastric emptying in type I (insulin-dependent) diabetes mellitus. Diabetologia 33:675-680; 1990.
    • (1990) Diabetologia , vol.33 , pp. 675-680
    • Fraser, R.1    Horowitz, M.2    Maddox, A.3    Chatterton, B.4    Harding, P.5    Dent, J.6
  • 6
    • 0020371467 scopus 로고
    • Production of rabbit antibody specific for amino-terminal residues of cholecystokinin octapeptide (CCK-8) by selective suppression of cross-reactive antibody response
    • 6. Hashimura, E.; Shimizu, F.; Nishino, T.; Imagawa, K.; Tateishi, K.; Hamaoka, T. Production of rabbit antibody specific for amino-terminal residues of cholecystokinin octapeptide (CCK-8) by selective suppression of cross-reactive antibody response. J. Immunol. Methods 55:375-387; 1982.
    • (1982) J. Immunol. Methods , vol.55 , pp. 375-387
    • Hashimura, E.1    Shimizu, F.2    Nishino, T.3    Imagawa, K.4    Tateishi, K.5    Hamaoka, T.6
  • 7
    • 0023716064 scopus 로고
    • Pancreatic polypeptide (PP) response to food in type I diabetics with and without diabetic autonomic neuropathy
    • 7. Hossdorf, T.; Wagner, M.; Hoppe, H. W. Pancreatic polypeptide (PP) response to food in type I diabetics with and without diabetic autonomic neuropathy. Hepatogastroenterology 35:238-241; 1988.
    • (1988) Hepatogastroenterology , vol.35 , pp. 238-241
    • Hossdorf, T.1    Wagner, M.2    Hoppe, H.W.3
  • 8
    • 0011982649 scopus 로고
    • The effects of the physical state of food on postprandial pancreatic polypeptide release in canine
    • 8. Inui, A.; Mizuno, N.; Ogawa, T.; Ishida, M.; Baba, S. The effects of the physical state of food on postprandial pancreatic polypeptide release in canine. Biomed. Res. Suppl. 4:245-250; 1983.
    • (1983) Biomed. Res. Suppl. , vol.4 , pp. 245-250
    • Inui, A.1    Mizuno, N.2    Ogawa, T.3    Ishida, M.4    Baba, S.5
  • 9
    • 0021929780 scopus 로고
    • Cross-reactivities of neuropeptide Y and peptide YY with pancreatic polypeptide antisera: Evidence for the existence of pancreatic polypeptide in the brain
    • 9. Inui, A.; Mizuno, N.; Oya, M.; Suenaga, K.; Morioka, H.; Ogawa, T.; Ishida, M.; Baba, S. Cross-reactivities of neuropeptide Y and peptide YY with pancreatic polypeptide antisera: Evidence for the existence of pancreatic polypeptide in the brain. Brain Res. 330:386-389; 1985.
    • (1985) Brain Res. , vol.330 , pp. 386-389
    • Inui, A.1    Mizuno, N.2    Oya, M.3    Suenaga, K.4    Morioka, H.5    Ogawa, T.6    Ishida, M.7    Baba, S.8
  • 10
    • 0027410594 scopus 로고
    • Plasma and cerebroventricular fluid levels of pancreatic polypeptide in the dog: Effects of feeding, insulin-induced hypoglycemia and physical exercise
    • 10. Inui, A.; Okita, M.; Miura, M.; Hirosue, Y.; Mizuno, N.; Baba, S.; Kasuga, M. Plasma and cerebroventricular fluid levels of pancreatic polypeptide in the dog: effects of feeding, insulin-induced hypoglycemia and physical exercise. Endocrinology 132:1235-1239; 1993.
    • (1993) Endocrinology , vol.132 , pp. 1235-1239
    • Inui, A.1    Okita, M.2    Miura, M.3    Hirosue, Y.4    Mizuno, N.5    Baba, S.6    Kasuga, M.7
  • 11
    • 0021697495 scopus 로고
    • Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog
    • 11. Itoh, Z.; Nakaya, M.; Suzuki, T.; Arai, H.; Wakabayashi, K. Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog. Am. J. Physiol. 247:G688-694; 1984.
    • (1984) Am. J. Physiol. , vol.247
    • Itoh, Z.1    Nakaya, M.2    Suzuki, T.3    Arai, H.4    Wakabayashi, K.5
  • 12
    • 0029119926 scopus 로고
    • Rapid gastric emptying and pathological changes of vagus nerve in the spontaneously diabetic Chinese hamsters
    • 12. Itoh, H.; Yoneda, M.; Tamori, K.; Miyamoto, Y.; Morikawa, A.; Eto, M.; Makino, I. Rapid gastric emptying and pathological changes of vagus nerve in the spontaneously diabetic Chinese hamsters. Diabetes Res. Clin. Prac. 28:89-95; 1995.
    • (1995) Diabetes Res. Clin. Prac. , vol.28 , pp. 89-95
    • Itoh, H.1    Yoneda, M.2    Tamori, K.3    Miyamoto, Y.4    Morikawa, A.5    Eto, M.6    Makino, I.7
  • 13
    • 0022457812 scopus 로고
    • Elevation of plasma CCK concentrations after intestinal administration of a pancreatic enzyme secretion-stimulating peptide purified from rat bile-pancreatic juice: Analysis with N-terminal region specific radioimmunoassay
    • 13. Iwai, K.; Fukuoka, S.; Fushiki, T.; Kodaira, T.; Ikei, N. Elevation of plasma CCK concentrations after intestinal administration of a pancreatic enzyme secretion-stimulating peptide purified from rat bile-pancreatic juice: analysis with N-terminal region specific radioimmunoassay. Biochem. Biophys. Res. Commun. 136:701-706; 1986.
    • (1986) Biochem. Biophys. Res. Commun. , vol.136 , pp. 701-706
    • Iwai, K.1    Fukuoka, S.2    Fushiki, T.3    Kodaira, T.4    Ikei, N.5
  • 16
    • 0023863250 scopus 로고
    • Subnormal pancreatic polypeptide and epinephrine responses to insulin-induced hypoglycemia identify patients with insulin-dependent diabetes mellitus predisposed to develop overt autonomie neuropathy
    • 16. Kennedy, F. P.; Go, V. L. W.; Cryer, P. E.; Bolli, G. B.; Gerich, J. E. Subnormal pancreatic polypeptide and epinephrine responses to insulin-induced hypoglycemia identify patients with insulin-dependent diabetes mellitus predisposed to develop overt autonomie neuropathy. Ann. Int. Med. 108:54-58; 1988.
    • (1988) Ann. Int. Med. , vol.108 , pp. 54-58
    • Kennedy, F.P.1    Go, V.L.W.2    Cryer, P.E.3    Bolli, G.B.4    Gerich, J.E.5
  • 18
    • 0018630295 scopus 로고
    • Impaired response of pancreatic polypeptide to hypoglycemia: An early sign of autonomie neuropathy in diabetics
    • 18. Krarup, T.; Schwartz, T. W.; Hilsted, J.; Madsbad, S.; Verlaege, O.; Sestoft, L. Impaired response of pancreatic polypeptide to hypoglycemia: An early sign of autonomie neuropathy in diabetics. Br. Med. J. 15:1544-1546; 1979.
    • (1979) Br. Med. J. , vol.15 , pp. 1544-1546
    • Krarup, T.1    Schwartz, T.W.2    Hilsted, J.3    Madsbad, S.4    Verlaege, O.5    Sestoft, L.6
  • 19
    • 0018946563 scopus 로고
    • Impaired pancreatic polypeptide responses to insulin induced hypoglycemia in diabetic autonomic neuropathy
    • 19. Levitt, N. S.; Vinik, A. I.; Sive, A. A.; Tonder, S.; Lund, A. Impaired pancreatic polypeptide responses to insulin induced hypoglycemia in diabetic autonomic neuropathy. J. Clin. Endocrinol. Metab. 50:445-449; 1980.
    • (1980) J. Clin. Endocrinol. Metab. , vol.50 , pp. 445-449
    • Levitt, N.S.1    Vinik, A.I.2    Sive, A.A.3    Tonder, S.4    Lund, A.5
  • 21
    • 0028577279 scopus 로고
    • Effect of intravenous administration of EM523L on gastric emptying and plasma glucose levels after a meal in patients with diabetic gastroparesis: A pilot study
    • 21. Nakamura, T.; Ishii, M.; Arai, Y.; Tandoh, Y.; Terada, A.; Takebe, K. Effect of intravenous administration of EM523L on gastric emptying and plasma glucose levels after a meal in patients with diabetic gastroparesis: A pilot study. Clin. Ther. 16:989-999; 1994.
    • (1994) Clin. Ther. , vol.16 , pp. 989-999
    • Nakamura, T.1    Ishii, M.2    Arai, Y.3    Tandoh, Y.4    Terada, A.5    Takebe, K.6
  • 22
    • 0022537838 scopus 로고
    • High plasma cholecystokinin response following ingestion of test meal by patients with non-insulin dependent diabetes mellitus
    • 22. Nakano, I.; Funakoshi, A.; Shinozaki, H.; Miyazaki, K.; Ibayashi, H.; Tateishi, K.; Hamaoka, T. High plasma cholecystokinin response following ingestion of test meal by patients with non-insulin dependent diabetes mellitus. Regul. Pept. 14:229-236; 1986.
    • (1986) Regul. Pept. , vol.14 , pp. 229-236
    • Nakano, I.1    Funakoshi, A.2    Shinozaki, H.3    Miyazaki, K.4    Ibayashi, H.5    Tateishi, K.6    Hamaoka, T.7
  • 24
    • 0027302998 scopus 로고
    • Mechanism of gastroprokinetic effect of EM5231, an erythromycin derivative, in dogs
    • 24. Ohtawa, M.; Mizumoto, A.; Hayashi, N.; Yanagida, K.; Itoh, Z.; Omura, S. Mechanism of gastroprokinetic effect of EM5231, an erythromycin derivative, in dogs. Gastroenterology 104:1320-1327; 1993.
    • (1993) Gastroenterology , vol.104 , pp. 1320-1327
    • Ohtawa, M.1    Mizumoto, A.2    Hayashi, N.3    Yanagida, K.4    Itoh, Z.5    Omura, S.6
  • 27
    • 0027141042 scopus 로고
    • Erythromycin and other macrolides as prokinetic agents
    • 27. Peeters, T. L. Erythromycin and other macrolides as prokinetic agents. Gastroenterology 105:1886-1899; 1993.
    • (1993) Gastroenterology , vol.105 , pp. 1886-1899
    • Peeters, T.L.1
  • 31
    • 0021026804 scopus 로고
    • Pancreatic polypeptide: A hormone under vagal control
    • 31. Schwartz, T. W. Pancreatic polypeptide: A hormone under vagal control. Gastroenterology 85:1411-25; 1983.
    • (1983) Gastroenterology , vol.85 , pp. 1411-1425
    • Schwartz, T.W.1
  • 32
    • 0030054198 scopus 로고    scopus 로고
    • Effect of nonpeptide motilin agonist EM523 on release of gut and pancreatic hormones in conscious dogs
    • 32. Shiba, Y.; Mizumoto, A.; Satoh, M.; Inui, A.; Itoh, Z.; Omura, S. Effect of nonpeptide motilin agonist EM523 on release of gut and pancreatic hormones in conscious dogs. Gastroenterology 110:241-250, 1996.
    • (1996) Gastroenterology , vol.110 , pp. 241-250
    • Shiba, Y.1    Mizumoto, A.2    Satoh, M.3    Inui, A.4    Itoh, Z.5    Omura, S.6
  • 33
    • 0027463137 scopus 로고
    • Erythromycin effects on gastric emptying, antral motility and plasma motilin and pancreatic polypeptide concentrations in anorexia nervosa
    • 33. Stacher, G.; Peeters, T. L.; Bergmann, H.; Wiesnagrotzki, S.; Schneider, C.; Granser-Vacariu, G. V.; Gaupmann, G.; Kugi, A. Erythromycin effects on gastric emptying, antral motility and plasma motilin and pancreatic polypeptide concentrations in anorexia nervosa. Gut 34:166-172; 1993.
    • (1993) Gut , vol.34 , pp. 166-172
    • Stacher, G.1    Peeters, T.L.2    Bergmann, H.3    Wiesnagrotzki, S.4    Schneider, C.5    Granser-Vacariu, G.V.6    Gaupmann, G.7    Kugi, A.8
  • 34
    • 0029002623 scopus 로고
    • Motilin and the enteric nervous system in the control of interdigestive and postprandial gastric motility
    • 34. Tack, J. Motilin and the enteric nervous system in the control of interdigestive and postprandial gastric motility. Acta Gastroenterol. Bel. 58:21-30; 1995.
    • (1995) Acta Gastroenterol. Bel. , vol.58 , pp. 21-30
    • Tack, J.1
  • 35
    • 0001703812 scopus 로고
    • Pancreatic polypeptide family: Pancreatic polypeptide, neuropeptide Y, and peptide YY
    • Rauner, B. B.; Makhlouf, G. M.; Schultz, S. G., Eds. Bethesda: American Physiological Society
    • 35. Taylor, I. L. Pancreatic polypeptide family: Pancreatic polypeptide, neuropeptide Y, and peptide YY. In: Rauner, B. B.; Makhlouf, G. M.; Schultz, S. G., Eds. Handbook of physiology, Sect. 6, Vol 2. Bethesda: American Physiological Society; 1989:475-543.
    • (1989) Handbook of Physiology, Sect. 6 , vol.2 , pp. 475-543
    • Taylor, I.L.1
  • 36
    • 0026460797 scopus 로고
    • A new twist in the brain-gut axis
    • 36. Whitcomb, D. C.; Taylor, I. L. A new twist in the brain-gut axis. Am. J. Med. Sci. 304:334-338; 1992.
    • (1992) Am. J. Med. Sci. , vol.304 , pp. 334-338
    • Whitcomb, D.C.1    Taylor, I.L.2
  • 38
    • 0027212993 scopus 로고
    • Sensitive high performance liquid chromatographic determination of EM523, a new erythromycin derivative in human plasma and urine with ultraviolet detection using column switching
    • 38. Yamashita, K.; Motohashi, M.; Yashiki, T. Sensitive high performance liquid chromatographic determination of EM523, a new erythromycin derivative in human plasma and urine with ultraviolet detection using column switching. J. Chromatogr. 616:144-150; 1993.
    • (1993) J. Chromatogr. , vol.616 , pp. 144-150
    • Yamashita, K.1    Motohashi, M.2    Yashiki, T.3


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