Neither the homeodomain nor the activation domain of Bicoid is specifically required for its down-regulation by the Torso receptor tyrosine kinase cascade

Development

Volumn 122, Issue 11, 1996, Pages 3499-3508

  Bellaïche, Yohanns ^a,b   Bandyopadhyay, Rupa ^a,d   Desplan, Claude ^a   Dostatni, Nathalie ^c  

^a ROCKEFELLER UNIVERSITY   (United States)

^b HHMI   (United States)

^c AIX MARSEILLE UNIVERSITÉ   (France)

^d SKI   (United States)

Author keywords

Bicoid; Drosophila; RTK signal transduction cascade; Transcription

Indexed keywords

CHIMERIC PROTEIN; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; MUTANT PROTEIN; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO PATTERN FORMATION; GENE ACTIVATION; GENE REPRESSION; HEAD; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; REPORTER GENE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

ANIMALS; BINDING, COMPETITIVE; BODY PATTERNING; DNA-BINDING PROTEINS; DOWN-REGULATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEAD; HOMEODOMAIN PROTEINS; INSECT HORMONES; RECEPTOR PROTEIN-TYROSINE KINASES; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0029855382     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Berleth, T., Burri, M., Thoma, G., Bopp, D., Richstein, S., Frigerio, G., Noll, M. and Nusslein-Volhard, C. (1988). The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo. EMBO J. 7, 1749-1756.
2. Blumberg, B., Wright, C. V. E., DeRobertis, E. M. and Cho, K. W. Y. (1991). Organizer-specific homeobox genes in Xemipus laevis embryos. Science 253, 194-196.
3. Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-15.
4. Brunner, D., Oellers, N., Szabad, J., Biggs, W. H., Zipursky, S. L. and Hafen, E. (1994). A gain-of-function mutation in Drosophila MAP kinase activates multiple ReceptorTyrosine Kinase signaling pathways. Cell 76, 875-888.
5. Carey, M., Kakidani, H., Leatherwood, J., Mostashari, F. and Ptashne, M. (1989). An amino-terminal fragment of GAL4 binds DNA as a dimer. J. Mol. Biol. 209, 423-432.
6. Cherry, J., Johnson, T., Dollard, C., Shuster, J. and Denis, C. (1989). Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR 1. Cell 56, 409-419.
7. Cheyette, B., Green, P., Martin, K., Garren, H., Hartenstein, V. and Zipursky, L. (1994). The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron 12, 977-996.
8. Cook, W. J., Chase, D., Audino, D. C. and Denis, C. L. (1994). Dissection of the ADRI protein reveals multiple, functionally redundant activation domains interspersed with inhibitory regions: evidence for a repressor binding to the ADRI c region. Malec. Cell. Biol. 14, 629-40.
9. Denis,C. L., Fontaine, S. C.,Chase, D., Kemp,B. E. and Bemis,L. T. (1992). ADRI c mutations enhance the ability of ADRI to activate transcription by a mechanism that is independent of effects on cyclic AMP-dependent protein kinase phosphorylation of Ser-230. Molec. Cell. Biol. 12, 1507-14.
10. Driever, W., Ma, J., Nüsslein-Volhard, C. and Ptashne, M. (1989a). Rescue of bicoid mutant drosophila embryos by bicoid fusion proteins containing heterologous activating sequences. Nature 342, 149-154.
11. Driever, W. and Nüsslein-Volhard, C. (1988a). The Bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner. Cell 54, 95-104.
12. Driever, W. and Nüsslein-Volhard, C. (1988b). A gradient of bicoid protein in Drosophila embryos. Cell 54, 83-93.
13. Driever, W. and Nüsslein-Volhard, C. (1989). The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo. Nature 337, 138-143.
14. Driever, W., Thoma, G. and Nüsslein-Volhard, C. (1989b). Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen. Nature 340, 363-367.
15. Driever, W., Siegel, V. and Nüsslein-Volhard, C. (1990). Autonomous determination of anterior structures in the early Drosophila embryo by the Bicoid morphogen. Development 109, 811-820.
16. Dubnau J. and Struhl G. (1996). RNA recognition and translational repression by a homeodomain protein. Nature 379, 694-699.
17. Finkelstein, R. and Perrimon, N. (1990). The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development. Nature 346, 485-488.
18. Finkelstein, R., Smouse, D., Capaci, T. M., Spradling, A. C. and Perrimon, N. (1990). The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures. Genes Dev. 4, 1516-1527.
19. Frigerio, G., Burri, M., Bopp, D., Baumgartner, S. and Noll, M. (1986). Structure of the segmentation of gene paired and the Drosophila PRO gene set as part of a gene network. Cell 47, 735-746.
20. Frohnhöfer, H. G. and Nüsslein-Volhard, C. (1986). Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid. Nature 324, 120-125.
21. Gao Q., Wang Y. and R. Finkelstein (1996). orthodenticle regulation during embryonic head development in Drosophila. Mech. Dev. 56, 3-15.
22. Goriely, A., Stella, M., Coffinier, C., Kessler, D., Mailhos, M., Dessain S. and Desplan C. (1996). A functional homologue of goosecoid in Drosophila. Development 122, 1641-1650.
23. Hahn, M. and Jäckle, H. (1996). Drosophila goosecoid participates in neural development but not in body axis formation. EMBO J. 15, 3077-3084.
24. Hanes, S. D. and Brent, R. (1989). DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9. Cell 57, 1275-1283.
25. Hanes, S. D., Riddihough, G., Ish-Horowicz, D. and Brent, R. (1994). pecific DNA recognition and intersite spacing are critical for action of the Bicoid morphogen. Mol. Cell. Biol. 14, 3364-3375.
26. Hill, C. S., Marais, R., John, S., Wynne, J., Daltion, S. and Treisman, R. (1993). Functional analysis of a growth factor-responsive transcription factor complex. Cell 73, 395-406.
27. Hunter, T. and Karin, M. (1992). The regulation of transcription by phosphorylation. Cell 70, 375-387.
28. Jaynes, J. B. and O'Farrell, A. P. H. (1988). Activation and repression of transcription by homeodomain-containing proteins that bind a common site. Nature 336, 744-749.
29. Klingler, M., Erdelyi, M., Szabad, J. and Nüsslein-Volhard, A. C. (1988). Function of Torso in determining the terminal anlagen of the Drosophila embryo. Nature 335, 275-277.
30. Karin, M. and Hunter, T. (1995). Transcriptional control by phosphorylation: signal transmission from the cell surface to the nucleus. Current Biology 5, 747-757.
31. Krasnow, M. A., Saffman, E. E., Kornfeld, K. and Hogness, A. D. S. (1989). Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells. Cell 57, 1031-1043.
32. Laski, F. A., Rio, D. C. and Rubin, G. M. (1986). Tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing. Cell 44, 7-19.
33. Ma, J. and Ptashne, M. (1987). Deletion analysis of GAL4 defines two transcriptional activating segments. Cell 48, 847-853.
34. Macdonald, P. M. and Struhl, G. (1988). Cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos. Nature 336, 595-598.
35. Marais, R., Wynne, J. and Treisman, R. (1993). The SRF accessory protein Elk-I contains a growth factor-regulated transcriptional activation domain. Cell 73, 381-393.
36. Marmorstein, R., Carey, M., Ptashne, M. and Harrison, S. C. (1992). DNA recognition by GAL4: structure of a protein-DNA complex. Nature 356, 408-414.
37. Miller J. H. ed. (1972). Experiments in Molecular Genetics. Cold Spring Harbor, New-York: Cold Spring Harbor Laboratory.
38. Müller M. M., Schreiber E, Schaffner W and Matthias P. (1989). Rapid test for in vivo stability and DNA binding of mutated octamer binding proteins with 'mini-extracts' prepared from transfected cells. Nucleic Acids Res 17, 6420.
39. Nüsslein-Volhard, C., Frohnhofer, H. G. and Lehmann, R. (1987). Determination of anteroposterior polarity in Drosophila. Science 238, 1675-1681.
40. O'Neill, E. M., Rebay, I., Tjian, R. and Rubin, G. M. (1994). The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78, 137-147.
41. Perrimon, N. and Desplan, C. (1994). Signal transduction in the early Drosophila embryo: When genetics meets biochemistry. Trends Biochem. Sci. 19, 509-513.
42. Picard, D., Salser, S. J. and Yamamoto, K. R. (1988). A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor. Cell 54, 1073-1080.
43. Pignoni, F., Baldarelli, R., Steingrimsson, E., Diaz, R., Patapoutian, A., Merriam, J. and Lengyel, J. (1990). The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily. Cell 62, 151-163.
44. Ptashne, M. (1988). How eukaryotic transcriptional activators work. Nature 335, 683-689.
45. Rivera-Pomar, R., Lu, X., Perrimon,N., Taubsrt, H. and Jäckle, H. (1995). Activation of posterior gap gene expression in the Drosophila blastoderm. Nature 376, 253-6.
46. Ronchi, E., Treisman, J., Dostatni, N., Struhl, G. and Desplan, C. (1993). Down-regulation of the Drosophila morphogen bicoid by the Torso receptor-mediated signal transduction cascade. Cell 74, 347-355.
47. Sauer F, Hansen S and Tjian R. (1996). Multiple TAFlls directing synergistic activation of transcription. Science 270, 1783-1788.
48. Segil, N., Roberts, S. B. and Heintz, N. (1991). Mitotic phosphorylation of the Oct-l homeodomain and regulation of Oct-l DNA hinding activity. Science 254, 1814-1816.
49. Simpson-Brose, M., Treisman, J. and Desplan, C. (1994). Synergy between the Hunchback and Bicoid morphogens is required for anterior patterning in Drosophila. Cell 78, 855-865.
50. Sprenger, F. and Nüsslein-Volhard, C. (1992). Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg. Cell 71, 987-1001.
51. StJohnston, D. and Nüsslein-Volhard, C. (1992). The origin of pattern and polarity in the Drosophila embryo. Cell 68, 201-219.
52. Struhl, G., Johnston, P. and Lawrence, P. A. (1992). Control of Drosophila body pattern by the hunchback morphogen gradient. Cell 69, 237-249.
53. Struhl, G., Struhl, K. and Macdonald, P. M. (1989). The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell 57, 1259-1273.
54. Tautz, D. (1988). Regulation of the Drosophila segmentation gene Hunchback by two maternal morphogenetic centres. Nature 332, 281-284.
55. Tautz, D. and Pfeifle, C. (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.
56. Taylor, W. E. and Young, E. T. (1990). cAMP-dependent phosphorylation and inactivation of yeast transcription factor ADR1 does not affect DNA binding. Proc. Natl. Acad. Sci. USA 87, 4098-4102.
57. Treisman, J. and Desplan, C. (1989). The products of the Drosophila gap genes hunchback and Kruppel bind to the hunchback promoters. Nature 341, 335-7.
58. Treisman, J., Harris, E., Wilson, D. and Desplan, C. (1992). The homeodomain: A new face for the helix-turn-helix? BioEssays 14, 145-150.
59. Weigel, D., Jürgens, G., Klingler, M. and Jäckle, H. (1990). Two gap genes mediate maternal terminal pattern information in Drosophila. Science 248, 495-498.
60. Wigler, M., Sweet, R., Sim, G. K., Wold, B., Pellicer, A., Lacy, E., Maniatis, T., Silverstein, S. and Axel, R. (1979). Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell 16, 777-85.