Dissecting the individuality of cancer cells: The morphological and molecular dynamics of single human glioma cells

Cell Motility and the Cytoskeleton

Volumn 35, Issue 3, 1996, Pages 237-253

  Giuliano, Kenneth A ^a,b  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

actin cytoskeleton; astrocytoma; glioma; living cells; multimode microscopy

Indexed keywords

ACTIN;

ACTIN FILAMENT; ARTICLE; CANCER CELL CULTURE; CELL SPREADING; CELL STRUCTURE; CYTOSKELETON; GLIOMA CELL; HUMAN; HUMAN CELL; IMAGE ANALYSIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL;

CELL LINE, TRANSFORMED; CELL MOVEMENT; GLIOMA; HUMANS; TUMOR CELLS, CULTURED;

EID: 0029855378     PISSN: 08861544     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0169(1996)35:3<237::AID-CM6>3.0.CO;2-5     Document Type: Article

References (62)

1. Aaronson, S.A. (1991): Growth factors and cancer. Science 254: 1146-1153.
2. Adams, S.R., and Tsien, R. Y. (1993): Controlling cell chemistry with caged compounds. Annu. Rev. Physiol. 55:755-784.
3. Ambrose, E.J. (1967): The role of the cell surface in tumour invasion. In Denoix, P. (ed.): "Mechanisms of Invasion in Cancer," Vol. 6. New York: Springer-Verlag, pp. 130-139.
4. Bigner, D.D. (1981): Biology of gliomas: Potential clinical implications of glioma cellular heterogeneity. Neurosurgery 9:320-326.
5. Bigner, D.D., Bigner, S.H. Pontén, J., Westermark, B., Mahaley, M.S., Jr., Ruoslahti, E., Herschman, H., Eng, L.F., and Wikstrand, C.J. (1981): Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas. J. Neuropath. Exp. Neurol. 40:201-229.
6. Cavenee, W.K., and White, R.L. (1995): The genetic basis of cancer. Sci. Am. March:72-79.
7. Cleveland, W.S. (1993): "Visualizing Data." Summit, NJ: Hobart Press.
8. Coons, S.W., Johnson, P.C., and Shapiro, J.R. (1995): Cytogenetic and flow cytometry DNA analysis of regional heterogeneity in a low grade human glioma. Cancer Res. 55:1569-1577.
9. Dalrymple, S.J., and Jenkins, R.B. (1994): Molecular genetics of astrocytomas and meningiomas. Curr. Op. Neurol. 7:477-483.
10. DeBiasio, R.L., Wang, L.L., Fisher, G.W., and Taylor, D.L. (1988): The dynamic distribution of fluorescent analogues of actin and myosin in protrusions at the leading edge of migrating Swiss 3T3 fibroblasts. J. Cell Biol. 107:2631-2645.
11. DeBiasio, R.L., LaRocca, G.M., Post, P.L., and Taylor, D.L. (1996): Myosin II transport, organization, and phosphorylation: Evidence for cortical flow/solation-contraction coupling during cytokinesis and cell locomotion. Mol. Biol. Cell 7:1259-1282.
12. Farkas, D.L., Baxter, G., DeBiasio, R.L., Gough, A., Nederlof, M.A., Pane, D., Pane, J., Patek, D.R., Ryan, K.W., and Taylor, D.L. (1993): Multimode light microscopy and the dynamics of molecules, cells, and tissues. Annu. Rev. Physiol. 55:785-817.
13. Feinberg, A.P., and Coffey, D.S. (1982): The concept of DNA rearrangement in carcinogenesis and development of tumor cell heterogeneity. In Owens, A.H., Jr., Coffey, D.S., and Baylin, S.B. (eds.): "Tumor Cell Heterogeneity: Origins and Implications." New York: Academic Press, pp. 469-494.
14. Fidler, I.J., and Ellis, L.M. (1994): The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79:185-188.
15. Fidler, I.J., and Post, G. (1982): The heterogeneity of metastatic properties in malignant tumor cells and regulation of the metastatic phenotype. In Owens, A.H., Jr., Coffey, D.S., and Baylin, S.B. (eds.): "Tumor Cell Heterogeneity: Origins and Implications." New York: Academic Press, pp. 127-145.
16. Folkman, J., and Moscona, A. (1978): Role of cell shape in growth control. Nature 273:345-349.
17. Forsby, N., Collins, V.P., and Westermark, B. (1985): The spreading of human normal glial and malignant glioma cells in culture. Acta Path. Microbiol. Immunol. Scand. Sect. A 93:235-249.
18. Forsby, N., Vollins, V.P., Brunk, U.T., Fredrikson, B.A., and Westermark, B. (1986): Translocation of human glial and glioma cells in culture. Virchows Arch. Cell Pathol. 51:3-15.
19. Fox, C.H., Caspersson, T., Kudynowski, J., Sanford, K.K., and Tarone, R.E. (1977): Morphometric analysis of neoplastic transformation in rodent fibroblast cell lines. Cancer Res. 37: 892-897.
20. Gatenby, R.A. (1995): The potential role of transformation-induced metabolic changes in tumor-host interaction. Cancer Res. 55: 4151-4156.
21. Gey, G.O. (1956): Some aspects of the constitution and behavior of normal and malignant cells maintained in continuous culture. In: "The Harvey Lectures." New York: Academic Press, pp. 154-229.
22. Gillaspy, G.E., Miller, R.H., Samols, D., and Goldthwait, D. A. (1993): Antigenic and differentiative heterogeneity among human glioblastomas. Cancer Lett. 68:215-224.
23. Giuliano, K.A. (1996): The actin-cytoskeleton and glial cell transformation: Dissecting the molecular dynamics of tumorigenesis. In Walker, M., and Kornblith, P. (eds.): "Advances in NeuroOncology." Armonk, NY: Futura Publishing (in press).
24. Giuliano, K.A., and Taylor, D.L. (1990): Formation, transport, contraction, and disassembly of stress fibers in fibroblasts. Cell Motil. Cytoskeleton 16:14-21.
25. Giuliano, K.A., and Taylor, D.L. (1994): Fluorescent actin analogs with a high affinity for profilin in vitro exhibit an enhanced gradient of assembly in living cells. J. Cell Biol. 124:971-983.
26. Giuliano, K.A., and Taylor, D.L. (1995a): Light-optical-based reagents for the measurement and manipulation of ions, metabolites, and macromolecules in living cells. Methods Neurosci 27:1-16.
27. Giuliano, K.A., and Taylor, D.L. (1995b): Measurement and manipulation of cytoskeletal dynamics in living cells. Curr. Opin. Cell Biol. 7:4-12.
28. Giuliano, K.A., Nederlof, M.A., DeBiasio, R., Lanni, F., Waggoner, A.S., and Taylor, D.L. (1990): Multi-mode light microscopy. In Herman, B., and Jacobson, K. (eds.): "Optical Microscopy for Biology." New York: Wiley-Liss, pp, 543-557.
29. Giuliano, K.A., Post, P.L., Hahn, K.M., and Taylor, D.L. (1995): Fluorescent protein biosensors: Measurement of molecular dynamics in living cells. Ann. Rev. Biophys. Biomol. Struct. 24:405-434.
30. Gough, A.H., and Taylor, D.L. (1993): Fluorescence anisotropy imaging microscopy maps calmodulin binding during cellular contraction and locomotion. J. Cell Biol. 121:1095-1107.
31. Hahn, K., DeBiasio, R., and Taylor, D.L. (1992): Patterns of elevated free calcium and calmodulin activation in living cells. Nature 359:736-738.
32. Janson, L.W., and Taylor, D.L. (1993): In vitro models of tail contraction and cytoplasmic streaming in amoeboid cells. J. Cell Biol. 123:345-356.
33. Kohn, E.C., and Liotta, L.A. (1995): Molecular insights into cancer invasion: Strategies for prevention and intervention. Cancer Res. 55:1856-1862.
34. Kolega, J., and Taylor, D.L. (1993): Gradients in the concentration and assembly of myosin II in living Fibroblasts during locomotion and fiber transport. Mol. Biol. Cell 4:819-836.
35. Kolega, J., Janson, L.W., and Taylor, D.L. (1991): The role of solation-contraction coupling in regulating stress fiber dynamics in nonmuscle cells. J. Cell Biol. 114:993-1003.
36. Lee, J., Ishihara, A., Theriot, J.A., and Jacobson, K. (1993): Principles of locomotion for simple-shaped cells. Nature 362:167-171.
37. Levine, A.J. (1993): The tumor suppressor genes. Annu. Rev. Biochem. 62:623-651.
38. Lewis, W.H. (1936): Malignant cells. In: "The Harvey Lectures," Vol. 31. Baltimore: Williams & Wilkins, pp. 214-234.
39. Lynch, R.G. (1995): Differentiation and cancer: The conditional autonomy of phenotype. Proc. Natl. Acad. Sci. 92:647-648.
40. Meixensberger, J., Herting, B., Roggendorf, W., and Reichmann, H. (1995): Metabolic patterns in malignant gliomas. J. Neurooncol. 24:153-161.
41. Owens, L.V., Xu, L.H., Craven, R.J., Dent, G.A., Weiner, T.M., Kornberg, L., Liu, E.T., and Cance, W.G. (1995): Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res. 55:2752-2755.
42. Pagliaro, L., and Taylor, D.L. (1988): Aldolase exists in both the fluid and solid phases of cytoplasm. J. Cell Biol. 107:981-991.
43. Pagliaro, L., and Taylor, D.L. (1992): 2-Deoxyglucose and cytochalasin D modulate aldolase mobility in living 3T3 cells. J. Cell Biol. 118:859-863.
44. Partin, A.W., Schoeniger, J.S., Mohler, J.L., and Coffey, D.S. (1989): Fourier analysis of cell motility: Correlation of motility with metastatic potential. Proc. Natl. Acad. Sci. 86:1254-1258.
45. Pokorná, E., Jordan, P.W., O'Neill, Zicha, D., Gilbert, C.S., and Vesely, P. (1994): Actin cytoskeleton and motility in rat sarcoma cell populations with different metastatic potential. Cell Motil. Cytoskeleton 28:25-33.
46. Post, P.L., DeBiasio, R.L., and Taylor, D.L. (1995): A fluorescent protein biosensor of myosin II regulatory light chain phosphorylation reports a gradient of phosphorylated myosin II in migrating cells. Mol. Biol. Cell 6:1755-1768.
47. Racker, E. (1972): Bioenergetics and the problem of tumor growth. Am. Sci. 60:56-63.
48. Racker, E. (1989): The search for oncogene targets. J. Natl. Can. Inst. 81:247-251.
49. Rong, S., Segal, S., Anver, M., Resau, J.H., and Vande Woude, G.F. (1994): Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation. Proc. Natl. Acad. Sci. 91:4731-4735.
50. Shapiro, W.R., Yung, W.A., Basler, G.A., and Shapiro, J.R. (1981): Heterogenous response to chemotherapy of human gliomas grown in nude mice and as clones in vitro. Cancer Treat. Rep. 65:55-59.
51. Souhami, R.L. (1993): Heterogeneity of tumors as a clinical problem. In D'Incalci, M., Mantovani, A., and Garattini, S. (eds.): "Heterogeneity of Cancer Cells," Vol. 95. New York: Raven Press, pp. 131-140.
52. Taylor, D.L., Nederlof, M.A., Lanni, F., and Waggoner, A.S. (1992): The new vision of light microscopy. Am. Sci. 80:322-335.
53. Taylor, D.L., DeBiasio, R., LaRocca, G., Pane, D., Post, P., Kolega, J., Giuliano, K., Burton, K., Gough, B., Dow, A., Yu, J., Waggoner, A.S., and Farkas, D.L. (1994): Potential of machine-vision light microscopy in toxicologic pathology. Toxicol. Pathol. 22:145-159.
54. Taylor, D.L., Harris, L.D., DeBiasio, R., Fahlman, S.E., Farkas, D.L., Lanni, F., Nederlof, M., and Gough, A.H. (1996): Automated interactive microscopy: Measuring and manipulating the chemical and molecular dynamics of cells and tissues. Soc. Phot. Opt. Instr. Eng. (SPIE) 2678:15-27.
55. Van Meir, E.G., Roemer, K., Diserens, A.C., Kikuchi, T., Rempel, S.A., Haas, M., Huang, H.J.S., Friedmann, T., De Tribolet, N., and Cavenee, W.K. (1995): Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells. Proc. Natl. Acad. Sci. 92:1008-1012.
56. Vasiliev, J.M., and Gelfand, I.M. (1981): Morphology and locomotion of transformed cells in culture. In: "Neoplastic and Normal Cells in Culture." Cambridge: Cambridge University Press, pp. 131-159.
57. Verschueren, H., De Baetselier, P., and Bereiter-Hahn, J. (1991): Dynamic morphology of metastatic mouse T-lymphoma cells invading through monolayers of 10T1/2 cells. Cell Motil. Cytoskeleton 20:203-214.
58. Warburg, O. (1956): On the origin of cancer cells. Science 123:309-314.
59. Welch, W.C., Morrison, R.S., Gross, J.L., Gollin, S.M., Kitson, R.B., Goldfarb, R.H., Giuliano, K.A., Bradley, M.K., and Kornblith, P.K. (1995): Morphologic, immunologic, biochemical, and cytogenetic characteristics of the human glioblastomaderived cell line, SNB-19. In Vitro Cell. Dev. Biol. 31:610-616.
60. Westermark, B., and Nistér, M. (1994): Molecular genetics of human glioma. Curr. Opin. Oncol. 7:220-225.
61. Wood, S., Jr., Baker, R.R., and Marzocchi, B. (1967): Locomotion of cancer cells in vivo compared with normal cells. In Denoix, P. (ed.): "Mechanisms of Invasion in Cancer," Vol. 6. New York: Springer-Verlag, pp. 26-30.
62. Yung, W.K.A. (1994): New approaches to molecular therapy of brain tumors. Curr. Opin. Neurol. 7:501-505.