Transformation of epithelial cells stably transfected with H2O2- generating peroxisomal urate oxidase

Cancer Research

Volumn 56, Issue 21, 1996, Pages 4846-4852

  Chu, Ruiyin ^a   Lin, Yulian ^a   Reddy, Kirthi C ^a   Pan, Jie ^a   Rao, M Sambasiva ^a   Reddy, Janardan K ^a   Yeldandi, Anjana V ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A OXIDASE; COMPLEMENTARY DNA; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; RECOMBINANT PROTEIN; URATE OXIDASE; URIC ACID;

ADENOCARCINOMA; ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; DNA DAMAGE; ENZYME ACTIVITY; ENZYME SUBSTRATE; EPITHELIUM CELL; FATTY ACID OXIDATION; GENE EXPRESSION; LIPID OXIDATION; LIVER CARCINOGENESIS; LIVER CARCINOMA; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PEROXISOME; PRIORITY JOURNAL; PROMOTER REGION; RAT; TRANSCRIPTION INITIATION;

ANIMALS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; HYDROGEN PEROXIDE; MALE; MICE; MICROBODIES; NEOPLASMS, EXPERIMENTAL; RATS; REACTIVE OXYGEN SPECIES; TRANSFECTION; URATE OXIDASE; URIC ACID;

EID: 0029854528     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. deDuve, C., and Baudhuin, P. Microbodies (peroxisomes) and related particles Physiol Rev 46 323-357, 1966
2. Tolbert, N. E Metabolic pathways in peroxisomes and glyoxysomes. Annu Rev. Biochem, 50: 133-157, 1981
3. Reddy, J K., and Mannaerts, G. P. Peroxisomal lipid metabolism. Annu Rev. Nutr., 14 343-370, 1994.
4. Lazarow, P. B., and deDuve, C. A fatty acyl-CoA oxidizing system in rat liver peroxisomes. enhancement by clofibrate, a hypolipidemic drug. Proc. Natl. Acad. Sci. USA, 73: 2043-2046, 1976.
5. Hashimoto, T Individual peroxisomal β-oxidation enzymes. Ann NY Acad. Sci, 386: 5-12, 1982.
6. Reddy, J. K., Goel, S. K., Nemali, M. R., Carrino, J. J, Laffler, T. G., Reddy, M. K., Sperbeck, S. J., Osumi, T. Hashimoto, T, Lalwani, N. D., and Rao, M S. Transcriptional regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators. Proc Natl. Acad. Sci. USA, 83: 1747-1751, 1986.
7. Rao, M S., and Reddy, J K Peroxisome proliferation and hepatocarcinogensis. Carcinogenesis (Lond), 8: 631-636, 1987.
8. Nemali, M. R., Reddy, M. K, Usuda, N, Reddy, P G., Comeau, L. D, Rao, M. S., and Reddy, J K Differential induction and regulation of peroxisomal enzymes, predictive value of peroxisomal proliferation in identifying certain nonmutagenic carcinogens. Toxicol. Appl. Pharmacol, 97: 72-87, 1989.
9. Reddy, J K., and Rao, M. S. Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis. Mutat. Res., 214: 63-68, 1989.
10. 2-generating peroxisomal fatty acyl-CoA oxidase. Proc. Natl. Acad. Sci. USA, 92: 7080-7084, 1995.
11. Varanasi, U., Chu, R., Huang, Q., Castellon, R., Yeldandi, A V., and Reddy, J. K. Identification of a human peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl-coenzyme A oxidase gene. J. Biol. Chem, 271: 2147-2155, 1996
12. Yeldandi, A. V., Chu, R., Reddy, S. K, Pan, J., Usuda, N., Lin, Y., Rao, M. S., and Reddy, J. K. Functional expression and peroxisomal targeting of rat urate oxidase in monkey kidney cells. Gene Expr, 5. 123-132, 1995
13. Pick, E., and Keisari, Y. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture J. Immunol Methods 38: 161-170, 1980
14. Alvares, K., Widrow, R J, Abu-Jawdeh, G. M . Schmidt, J. V., Yeldandi, A. V., Rao, M., and Reddy, J. K. Rat urate oxidase produced by recombinant baculovirus expression: Formation of peroxisome crystalloid core-like structures. Proc Natl. Acad. Sci. USA, 89: 4908-4912, 1992.
15. Rachubinski, R. A., and Subramani, S. How proteins penetrate peroxisomes Cell, 83: 525-528, 1995
16. Yeldandi, A., and Yeldandi, V Molecular evolution of the urate oxidase-encoding gene and its functional significance. In: G. G. Gibson and B. Lake (eds.), Peroxisome Proliferation, pp. 205-215. London: Taylor & Francis, 1993.
17. Ames, B. N., Gold, L S., and Willet, W. C. The causes and prevention of cancer. Proc Natl Acad. Sci. USA, 92: 5258-5265, 1995.
18. Issemann, I., and Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (Lond.), 347: 645-650, 1990
19. Youngman, L D., Shigenaga, M., Motchnik, P., and Ames, B. N. Effects of a peroxisomal proliferator (PP) on plasma and tissue levels of coenzyme Q9 (COQ) other antioxidants, and oxidative damage to DNA (OXO8DG): evidence that PPS depletes antioxidants and increase oxidative damage to DNA. Mol. Aspects Med., 15: S131-141, 1994.
20. κB in the immune system. Annu. Rev. Immunol, 12: 141-179, 1994.
21. Costa, M. Molecular mechanisms of nickel carcinogenesis. Annu Rev. Pharmacol Toxicol, 31: 321-337, 1991.
22. 2 is directly related to increased proliferation and transformation of tracheal epithelial cells. Cancer Res, 55, 2723-2726, 1995.
23. Busciglio, J., and Yankner, B. A. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature (Lond), 378; 776-779, 1995