Intrathecal infusion of the nitric oxide synthase inhibitor N-methyl L- arginine after experimental spinal cord injury in guinea pigs

Journal of Neurotrauma

Volumn 13, Issue 7, 1996, Pages 361-369

  Cohen, Timothy I ^a   Weinberg, Richard J ^b   Blight, Andrew R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

inflammation; macrophage; nitric oxide; spinal cord trauma

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED SOMATOSENSORY RESPONSE; FEMALE; GUINEA PIG; INFLAMMATION; MACROPHAGE; NONHUMAN; OSMOTIC PUMP; SPINAL CORD FUNCTION; SPINAL CORD INJURY; STEREOISOMERISM; WHITE MATTER;

EID: 0029854453     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1996.13.361     Document Type: Article

References (66)

1. G-Methylarginine, an inhibitor of endothelium derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo? Biochem. Biophys. Res. Commun. 160, 881-886.
2. BALENTINE, J.D. (1978). Pathology of experimental spinal cord trauma I. The necrotic lesion as a function of vascular injury. Lab. Invest. 39, 263-253.
3. BARNEWALL, R.E., and RIKIHISA, Y. (1994). Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin. Infect. Immun. 62, 4804-4810.
4. BECKMAN, J.S., BECKMAN, T.W., CHEN, J., MARSHALL, P.A. and FREEMAN, B.A. (1990). Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U.S.A. 87, 1620-1624.
5. BELENKY, S.N., ROBBINS, R.A., and RUBINSTEIN, I. (1993). Nitric oxide synthase inhibitors attenuate human monocyte chemotaxis in vitro. J. Leukocyte Biol. 53, 498-503.
6. BLIGHT, A.R. (1991a). Morphometric analysis of a model of spinal cord injury in guinea pigs, with behavioral evidence of delayed secondary pathology. J. Neurol. Sci. 103, 156-171.
7. BLIGHT, A.R. (1991b). Morphometric analysis of blood vessels in chronic experimental spinal cord injury: Hypervascularity and recovery of function. J. Neurol. Sci. 106, 158-174.
8. BLIGHT, A.R. (1992). Macrophages and inflammatory damage in spinal cord injury. J. Neurotrauma 9, S83-S91.
9. BLIGHT, A.R. (1993). Remyelination, revascularization and recovery of function in experimental spinal cord injury, in Advances in Neurology, Vol. 59. Neural Injury and Regeneration. F.J. Seil (ed.). Raven Press: New York, pp. 91-104.
10. BLIGHT, A.R. (1994). Effects of silica on the outcome from experimental spinal cord injury: Implication of macrophages in secondary tissue damage. Neuroscience 60, 263-273.
11. BLIGHT, A.R., MCGINNIS, M.E., and BORGENS, R.B. (1990). Cutaneus trunci muscle reflex of the guinea pig. J. Comp. Neurol. 296, 614-633.
12. BLIGHT. A.R., SAITO, K., and HEYES, M.P. (1993). Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury. Brain Res. 632, 314-316.
13. BLIGHT, A.R., COHEN, T.I,. SAITO, K., and HEYES, M.P. (1995). Quinolinic acid accumulation and functional deficits following experimental spinal cord injury. Brain 118, 735-752.
14. BRACKEN, M.B., SHEPARD, M.J., COLLINS, W.F. et al. (1990). A randomized, control led trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. New Engl. J. Med. 322, 1405-1461.
15. BRACKEN, M.B., SHEPARD, M.J., COLLINS, W.F. et al. (1992). Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. J. Neurosurg. 76, 23-31.
16. BRAUGHLER, J.M., and HALL, E.D. (1992). Involvement of lipid peroxidation in CNS injury. J. Neurotrauma 9, S1-S8.
17. BREDT, D.S., and SNYDER, S.H. (1992). Nitric oxide, a novel neuronal messenger. Neuron 8, 3-11.
18. BREDT, D.S., GLATT, C.E., HWANG, P.M., FOUHI, M., DAWSON, T.M., and SNYDER, S.H. (1991). Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of mammalian central nervous system together with NADPH diaphorase. Neuron 7, 615-624.
19. BRESNAHAN, J.C., BEATTIE, M.S., STOKES, B.T., and CONWAY, K.M. (1991). Three-dimensional computer-assisted analysis of graded contusion lesions in the spinal cord of the rat. J. Neurotrauma 8, 91-101.
20. CHURCH, J. and LODGE, D. (1990). N-Methyl-D-aspartate (NMDA) antagonism is central to the actions of ketamine and other phencyclidine receptor ligands, in Status of Ketamine in Anesthesiology. E.F. Domino (ed). NPP Books: Ann Arbor, pp. 501-519.
21. DAWSON, V.L., DAWSON, T.M., LONDON, E.D., BREDT, D.S., and SNYDER, S.H. (1991). Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. U.S.A. 88, 6368-6371.
22. DAWSON, V.L., DAWSON, T.M., BARTLEY, D.A., UHL, G.R., and SNYDER, S.H. (1993). Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J. Neurosci. 13, 2651-2661.
23. DI ROSA, M., RADOMSKI, M., CARNUCCIO, R., and MONCADA, S. (1990). Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem. Biophys. Res. Commun. 172, 1246-1252.
24. DUMAREY, C.H., LABROUSSE, V., RASTOGI, N., VARGAFTIG, B.B., and BACHELET, M. (1994). Selective Mycobacterium avium-induced production of nitric oxide by human monocyte-derived macrophages. J. Leukoc. Biol. 56, 36-40.
25. DUN, N.J., DUN, S.L., WU, S.Y., FÖRSTERMANN, U., SCHMIDT, H., and TSENG, L.F. (1993). Nitric oxide synthase immunoreactivity in the rat, mouse, cat and squirrel monkey spinal cord. Neuroscience 54, 845-857.
26. FADEN, A.I., and SIMON, R.P. (1988). A potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann. Neurol. 23, 623-626.
27. FADEN, A.I., ELLISON, J.A., and NOBLE, L.J. (1990). Effects of competitive and non-competitive NMDA receptor antagonists in spinal cord injury. Eur. J. Pharmacol. 175, 165-174.
28. FELDMAN, P.L., and GRIFFITH, O.W. (1993). Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation. J. Med. Chem. 36, 491-496.
29. GARTHWAITE, J. (1991). Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci. 14, 60-68.
30. GROSS, S.S., JAFFE, E.A., LEVI, M., and KILBOURN, R.G. (1991). Cytokine-activated endothelial cells express an iso-type of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages. Biochem. Biophys. Res. Commun. 178, 823-829.
31. HALL, E.D. (1992). The neuroprotective pharmacology of methylprednisolone. J. Neurosurg. 76, 13-22.
32. HALLIWELL, B. (1992). Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623.
33. HASAN, K., HEESEN, B.J., CORBETT, J.A., et al. (1993). Inhibition of nitric oxide formation by guanidines. Eur. J. Pharmacol. 249, 101-106.
34. HEYES, M.P., SAITO, K., CROWLEY, J., et al. (1992a). Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurologic disease. Brain 115, 1249-1273.
35. HEYES, M.P., SAITO, K., and MARKEY, S.P. (1992b). Human macrophages convert L-tryptophan to the neurotoxin quinolinic acid. Biochem. J. 283, 633-635.
36. HOGG, N., DARLEY-USMAR, V.M., WILSON, M.T., and MONCADA, S. (1992). Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem. J. 281, 419-424.
37. IADECOLA, C. (1992). Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia? Proc. Natl. Acad. Sci. U.S.A. 89, 3913-3916.
38. KLOSTERGAARD, J., LEROUX, M.E., and HUNG, M.-C. (1991). Cellular models of macrophage tumoricidal effector mechanisms in vitro: characterization of cytolytic reponses to tumor necrosis factor and nitric oxide pathways in vitro. J. Immunol. 147, 2802-2808.
39. KUBES, P., SUZUKI, M., and GRAEGER, D.N. (1991). Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. U.S.A. 88, 4651-4655.
40. KUBES, P., KANWAR, S., NIU, X.F., and GABOURY, J.P. (1993). Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells. FASEB J. 7, 1293-1299.
41. LIU, D., THANGNIPON, W., and MCADOO, D.J. (1991). Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord. Brain Res. 547, 344-348.
42. LYONS, C.R., ORLOFF, G.J., and CUNNINGHAM, J.M. (1992). Molecular cloning and functional expression of an inducible nitric oxide synthase from a marine macrophage cell line. J. Biol. Chem. 267, 6370-6374.
43. MCCALL, T., WHITTLE, B.J.R., BRUGHTON-SMITH, N.K., and MONCADA, S. (1988). Inhibition of fMLP induced aggregation of rabbit neutrophils by nitric oxide. Br. J. Pharmacol. 95, 517P.
44. MELLER, S.T., DYKSTRA, C., GRZYBYCKI, D., MURPHY, S., and GEBHART, G.F. (1994). The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacology 33, 1471-1478.
45. MOILANEN, E., VUORINEN, P., KANKAANRANTA, H., METSÄ-KETELÄ. T., and VAPAATALO, H. (1993). Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions. Br. J. Pharmacol. 109, 852-858.
46. MONCADA, S. (1992). The L-arginine:nitric oxide pathway. Acta Physiol. Scand. 145, 201-227.
47. MONCADA, S., PALMER, R.M.J., and HIGGS, E.A. (1991). Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142.
48. MURRAY, H.W., and TEITELBAUM, R.F. (1992). L-Arginine-dependent reactive nitrogen intermediates and the antimicrobial effect of activated human mononuclear phagocytes. J. Infect. Dis. 165, 515-517.
49. NAGRA, R.M., HEYES, M.P., and WILEY, C.A. (1994). Viral load and its relationship to quinolinic acid, TNF-α and IL-6 levels in the CNS of retrovirus infected mice. Mol. Chem. Neuropathol. 22, 143-160.
50. PANTER, S.S., YUM, S.W., and FADEN, A.I. (1990). Alteration in extracellular amino acids after traumatic spinal cord injury. Ann. Neurol. 27, 96-99.
51. PETERSON, P.K., HU, S., ANDERSON, W.R., and CHAO, C.C. (1994). Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain. J. Infect. Dis. 170, 457-460.
52. RADOMSKI, M.W., PALMER, R.M.J., and MONCADA, S. (1990). Glucocorticoids inhibit the expression of an inducible but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 87, 10043-10047.
53. SAITO, K., NOWAK, T.S., Jr., MARKEY, S.P., and HEYES, M.P. (1993). Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia. J. Neurochem. 60, 180-192.
54. SAKAI, N., and MILSTEIN, S. (1993). Availability of tetrahydrobiopterin is not a factor in the inability to detect nitric oxide production by human macrophages. Biochem. Biophys. Res. Commun. 193, 378-383.
55. SAKUMA, I., STUEHR, D.J., GROSS, S.S., NATHAN, C., and LEVI, R. (1988). Identification of arginine as a precursor of endothelium derived relaxing factor. Proc. Natl. Acad. Sci. U.S.A. 85, 8664-8667.
56. 2+/calmodulin-regulated nitric oxide synthases. Cell Calcium 13, 427-134.
57. SCHNEEMANN, M., SCHOEDON, G., HOFER, S., BLAU, N., GUERRERO, L., and SCHAFFNER, A. (1993). Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes. J. Infect. Dis. 167, 1358-1363.
58. SIMMONS, M.L., and MURPHY, S. (1992). Induction of nitric oxide synthase in glial cells. J. Neurochem. 59, 897-905.
59. TATOR, C.H., and FEHLINGS, M.G. (1991). Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J. Neurosurg. 75, 15-26.
60. THOMAS, S.R., MOHR, D., and STOCKER, R. (1994). Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes. J. Biol. Chem. 269, 14457-14464.
61. VALTSCHANOFF, J.G., WEINBERG, R.J., and RUSTIONI, A. (1992). NADPH diaphorase in the spinal cord of rats. J. Comp. Neurol. 321, 209-222.
62. XIE, Q.-W., CHO, H.J., CALAYCAY, J., et al. (1992). Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256, 225-228.
63. YAMAMOTO, T., SHIMOYAMA, N., and MIZUGUCHI, T. (1993). Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw. Anesth. Analg. 77, 886-890.
64. YOUNG, W. (1985). Blood flow, metabolic and neurophysioiogical mechanisms in spinal cord injury, in Central Nervous System Trauma Status Report. D.P. Becker, and J.T. Povlishock, (eds.). NTH, NINCDS: Bethesda, MD, pp. 463-473.
65. YOUNG, W. (1993). Secondary injury mechanisms in acute spinal cord injury. J. Emergency Med. 11, 13-22.
66. ZEELASEK, J., TAUSCH, M., TOYKA, K.V., and HARTUNG, H.-P. (1992). Production of nitrite by neonatal rat microglial cells/brain macrophages. Cell. Immunol. 141, 111-120.