C-polymodal nociceptors activated by noxious low temperature in human skin

Journal of Physiology

Volumn 497, Issue 2, 1996, Pages 565-572

  Campero, Mario ^a,c   Serra, Jordi ^a,d   Ochoa, José L ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b LEGACY GOOD SAMARITAN HOSPITAL   (United States)

^c UNIVERSITY OF CHILE   (Chile)

^d HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR SUBTYPE;

ADULT; ARTICLE; CLINICAL ARTICLE; COLD SENSITIVITY; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; MUSCLE SPINDLE AFFERENT NERVE; NOCICEPTIVE RECEPTOR; NORMAL HUMAN; PRIORITY JOURNAL; SKIN RECEPTOR; TEMPERATURE SENSITIVITY;

EID: 0029854387     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021789     Document Type: Article

References (29)

1. ARNDT, J. O., KINDGEN-MILLES, D. & KLEMENT, W. (1993). Capsaicin did not evoke pain from human vein segments but did so after injections into the perivascular tissue. Journal of Physiology 463, 491-499.
2. ARNDT, J. O. & KLEMENT, W. (1991). Pain evoked by polymodal stimulation of hand veins in humans. Journal of Physiology 440, 467-478.
3. BEITEL, R. E. & DUBNER, R. (1976). Response of unmyelinated (C) polymodal nociceptors to thermal stimuli applied to the monkey's face. Journal of Neurophysiology 39, 1160-1175.
4. BESSOU, P. & PERL, E. R. (1969). Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. Journal of Neurophysiology 32, 1025-1043.
5. CAMPERO, M., SERRA, J. & OCHOA, J. L. (1994). Response of human cutaneous C-polymodal nociceptors elicited by low temperature stimulation. Journal of Neurology 241, suppl., 561.
6. CHÉRY-CROZE, S. (1983). Relationship between noxious cold stimuli and the magnitude of pain sensation in man. Pain 15, 265-269.
7. CROZE, S., DUCLAUX, R. & KENSHALO, D. R. (1976). The thermal sensitivity of the polymodal nociceptor in the monkey. Journal of Physiology 263, 539-562.
8. GEORGOPOULOS, A. P. (1976). Functional properties of primary afferent units probably related to pain mechanisms in primate glabrous skin. Journal of Neurophysiology 39, 71-83.
9. GEORGOPOULOS, A. P. (1977). Stimulus-response relations in high-threshold mechanothermal fibers innervating primate glabrous skin. Brain Research 128, 547-552.
10. HALLIN, R. G., TOREBJÖRK, H. E. & WIESENFELD, Z. (1981). Nociceptors and warm receptors innervated by C fibers in human hand. Journal of Neurology, Neurosurgery and Psychiatry 44, 313-319.
11. IGGO, A. & OGAWA, H. (1971). Primate cutaneous thermal nociceptors. Journal of Physiology 216, 77-78P.
12. KENSHALO, D. R. & DUCLAUX, R. (1977). Response characteristics of cutaneous cold receptors in the monkey. Journal of Neurophysiology 40, 319-332.
13. KUMAZAWA, T. & PERL, E. R. (1977). Primate cutaneous sensory units with unmyelinated (C) afferent fibers. Journal of Neurophysiology 40, 1325-1338.
14. LAMOTTE, R. H. & THALHAMMER, J. G. (1982). Response properties of high-threshold cutaneous cold receptors in the primate. Brain Research 244, 279-287.
15. LEWIS, T. & LOVE, W. S. (1926). Vascular reactions of the skin to injury. III. Some effects of freezing, of cooling and of warming. Heart 13, 27-60.
16. MACKENZIE, R. A., BURKE, D., SKUSE, N. P. & LETHLEAN, A. K. (1975). Fibre function and perception during cutaneous nerve block. Journal of Neurology, Neurosurgery and Psychiatry 38, 865-873.
17. OCHOA, J. & TOREBJÖRK, E. (1989). Sensations evoked by intraneural microstimulation of C nociceptor fibres in human skin nerves. Journal of Physiology 415, 583-599.
18. OCHOA, J. L. & YARNITSKY, D. (1994). The triple cold 'CCC': cold hyperalgesia, cold hypoesthesia and cold skin in peripheral nerve disease. Brain 117, 185-197.
19. PAINTAL, A. S. (1967). A comparison of the nerve impulses of mammalian non-medullated nerve fibres with those of the smallest diameter medullated fibres. Journal of Physiology 193, 523-533.
20. SAUMET, J. L., CHÉRY-CROZE, S. & DUCLAUX, R. (1985). Response of cat skin mechanothermal nociceptors to cold stimulation. Brain Research Bulletin 15, 529-532.
21. SIMONE, D. A., LI, J., STEVENS, E. R., ALLEN, B. & KAJANDER, K. C. (1995). Psychophysical measures of cold pain sensations in humans: comparison with evoked responses of primary afferent nociceptors. Society for Neuroscience Abstracts 21, 1161.
22. TOREBJÖRK, H. E. (1974). Single unit activity in afferent and sympathetic C fibres recorded from intact human skin nerves. Acta Universitatis is Upsaliensis 211, 1-23.
23. TOREBJÖRK, H. E. & HALLIN, R. G. (1974). Identification of afferent C units in intact human skin nerves. Brain Research 67, 387-403.
24. TOREBJÖRK, H. E. & HALLIN, R. G. (1976). Skin receptors supplied by unmyelinated (C) fibres in man. In Sensory Functions of the Skin in Primates with Special Reference to Man, ed. ZOTTERMAN, Y., pp. 475-485. Pergamon Press, Oxford.
25. TOREBJÖRK, E., LAMOTTE, R. H. & ROBINSON, C. J. (1984). Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers. Journal of Neurophysiology 51, 325-339.
26. VAN HEES, J. & GYBELS, J. (1981). C nociceptor activity in human nerve during painful and non painful skin stimulation. Journal of Neurology, Neurosurgery and Psychiatry 44, 600-607.
27. WAHRÉN, L. K., TOREBJÖRK, E. & JØRUM, E. (1989). Central suppression of cold-induced C fibre pain by myelinated fibre input. Pain 38, 313-319.
28. YARNITSKY, D. & OCHOA, J. L. (1990). Release of cold-induced burning pain by block of cold-specific afferent input. Brain 113, 893-902.
29. YARNITSKY, D., SIMONE, D., CLINE, M., DOTSON, R. & OCHOA, J. L. (1992). Single C nociceptor responses and psychophysical parameters of evoked pain: effect of rate of rise of heat stimuli in humans. Journal of Physiology 450, 581-592.