Glucose is essential for the initiation of fatty acid oxidation in ATP-depleted cultured ventricular myocytes

Molecular and Cellular Biochemistry

Volumn 162, Issue 2, 1996, Pages 159-163

  Tirosh, Régine ^a   Mishor, Tehila ^a   Pinson, Arié ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

ATP depletion; Fatty acid oxidation; Glucose oxidation; Oligomycin; Ventricular cardiomyocytes

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; OLIGOMYCIN; PALMITIC ACID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FATTY ACID OXIDATION; HEART MUSCLE CELL; MITOCHONDRIAL RESPIRATION; NONHUMAN; RAT;

ANIMALIA;

EID: 0029853084     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00227544     Document Type: Article

References (24)

1. Neely JR, Morgan HE: Relationship between carbohydrate and lipid metabolism, and the energy balance of heart muscle. Ann Rev Physiol 36: 413-459, 1974
2. Frelin C, Pinson A, Athias P, Surville JM, Padien P: Glucose and palmitate metabolism by beating heart cells in culture. Pathol Biol 27: 45-50, 1979
3. Liedtke AJ: Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart. Prog Cardiovasc Dis 23: 321-336, 1981
4. Opie LH, Owen P, Riemersam RA: Relative rates of oxidation of glucose and FFA by ischaemic and nonischaemic myocardium after coronary artery ligation. Eur J Clin Invest 3: 419-435, 1973
5. Opie LH, Bricknell OL: Role of glycolytic flux in effect of glucose in decreasing fatty acid induced release of lactate dehydrogenase from isolated coronary ligated rat heart. Cardiovasc Res 13: 693-702, 1979
6. Opie LH: The Heart, Physiology and Metabolism (2nd ed). Raven Press, New York, 1991, p 430
7. Schwaiger M, Schelbert HR, Keen R, Vinten-Johansen J, Hansen H, Selin C, Bario G, Huang S-C, Phelps ME: Retention and clearance of C-11 palmitic acid in ischemic and reperfused canine myocardium. J Am Coll Card 6: 311-320, 1985
8. Myears DW, Sobel BE, Bergmann SR: Substrate use in ischemic and reperfused canine myocardium: Quantitative considerations. Am J Physiol 253: H107-H114, 1987
9. Liedke AJ, DeMaison L, Eggleston AM, Cohen LM, Nellis SH: Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium. Circ Res 62: 535-542, 1988
10. Lopaschuk GD, Spafford MA, Davies NJ, Wall SR: Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia. Circ Res 66: 546-553, 1990
11. Pinson A, Padieu P, Harary I: Techniques for culturing heart cells. In: A. Pinson (ed). The Heart Cell in Culture. CRC Press, Boca Raton, FL, 1987, p 7
12. Holmsen H, Storm E, Day HJ: Determination of ATP and ADP in blood platelets: A modification of the firefly luciferase assay for plasma. Anal Biochem 46: 489-502, 1972
13. Gorge G, Chatelain P, Schaper J, Lerch R: Effect of increasing degrees of ischemic injury on myocardial oxidative metabolism early after reperfusion in isolated rat hearts. Circ Res 68: 1681-1692, 1991
14. Teoh KH, Mickle DAG, Weisel RD, Fremes SE, Christakis GT, Romaschin AD, Harding RS, Madunick MM, Ivanov J: Decreased postoperative myocardial fatty acid oxidation. J Surg Res 44: 36-44, 1988
15. Stryer L: Biochemistry (2nd ed). WH Freeman and Co, New York, 1981, p 321
16. Fritz IB, Kaplan E, Lyn KTN: Specificity of carnitine action on fatty acid oxidation by heart muscle. Am J Physiol 202: 117-121, 1962
17. Saddik M, Lopaschuk GD: Myocardial triglyceride turnover during reperfusion of isolated rat hearts subjected to a transient period of global ischemia. J Biol Chem 267: 3825-3831, 1992
18. Trach V, Buschmans DE, Schaper W: Relation between lipolysis and glycolysis during ischemia in the isolated rat heart. Basic Res Cardiol 81: 454-464, 1986
19. Bricknell OL, Opie LH: Effect of various substrates on tissue metabolic changes in the isolated rat heart during underperfusion and on release of lactate dehydrogenase and arrythmias during reperfusion. Circ Res 43: 102-115, 1978
20. Apstein CS, Gravino FN, Haudenshild CC: Determinants of a protective effect of glucose and insulin on the myocardium. Effects on contractile function, diastolic compliance, metabolism and ultrastructure during ischemia and reperfusion. Circ Res 52: 515-526, 1983
21. McVeigh JJ, Lopaschuk GD: Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am J Physiol 259: H1079-H1085, 1990
22. Weiss SN, Lamp ST: Glycolysis preferentially inhibits ATP sensitive K{++} channels in isolated guinea pig cardiac myocytes. Science 238: 67-69, 1987
23. Owen P, Dennis S, Opie LH: Glucose flux rate regulates onset of ischemic contracture in globally underperfused rat hearts. Circ Res 66: 344-354, 1990
24. Ibel H, Zimmer HG: Metabolic recovery following temporary regional myocardial ischemia in the rat. J Mol Cell Cardiol 18 (Suppl 4): 61-65, 1986