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Systemic lupus erythematosus: Emerging concepts. Part 2: dermatologic and joint disease, the antiphospholipid antibody syndrome, pregnancy and hormonal therapy, morbidity and mortality, and pathogenesis
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Boumpas DT, Fessier BJ, Austin HA, Balow JE, Klippel JH, Lockshin MD: Systemic lupus erythematosus: emerging concepts. Part 2: dermatologic and joint disease, the antiphospholipid antibody syndrome, pregnancy and hormonal therapy, morbidity and mortality, and pathogenesis. Ann Intern Med 1995, 123:42-53.
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Bermas BL, Hill JA: Effects of immunosuppressive drugs during pregnancy. Arthritis Rheum 1995, 38:1722-1732. Excellent in-depth review of the use of immunosuppressive drugs in pregnancy.
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McDermott EM, Powell RJ: Incidence of ovarian failure in systemic lupus erythematosus after treatment with pulse cyclophosphamide. Ann Rheum Dis 1996, 55:224-229. This study confirmed previous studies showing that the risk of cyclophosphamide-induced menopause in women with SLE is considerable.
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McDermott, E.M.1
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8
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9
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Houssiau FA, D'Cruz DP, Haga HJ, Hughes GRV: Short course of weekly low-dose intravenous pulse cyclophosphamide in the treatment of lupus nephritis: a preliminary study. Lupus 1991, 1:31-35.
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Pulse cyclophosphamide in the treatment of neuropyschiatric systemic lupus erythematosus
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Infertility may sometimes be associated with NSAID consumption
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Akil M, Amos RS, Stewart P: Infertility may sometimes be associated with NSAID consumption. Br J Rheumatol 1996, 35:76-78.
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Julkunen HA: Oral contraceptives in systemic lupus erythematosus: side-effects and influence on the activity of SLE. Scand J Rheumatol 1991, 20:427-433.
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Julkunen HA, Kaaja R, Friman C: Contraceptive practice in women with systemic lupus erythematosus. Br J Rheumatol 1993, 32:227-230.
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Julkunen, H.A.1
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Hunt BJ, Khamashta MA: Management of the Hughes syndrome. Clin Exp Rheumatol 1996, 14:115-117. Succinct review of the treatment of major manifestations of APS.
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Hunt, B.J.1
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Ruiz-Irastorza G, Lima F, Alves J, Khamashta MA, Simpson J, Hughes GRV, Buchanan NMM: Increased rate of lupus flare during pregnancy and the puerperium: a prospective study of 78 pregnancies. Br J Rheumatol 1996, 35:133-138. This study suggests that SLE tends to flare during pregnancy. Flares are maximal during the second and third trimesters and the puerperium. However, flares are not more severe than in nonpregnant patients.
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Br J Rheumatol
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Ruiz-Irastorza, G.1
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Ramsey-Goldman R, Manzi S, Schilling EM, Kutzer JE, Medsger TA Jr: Lupus activity in pregnant and non-pregnant women [abstract]. Arthritis Rheum 1995, 38(Suppl1):S219.
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Lima F, Buchanan NMM, Khamashta MA, Kerslake S, Hughes GRV: Obstetric outcome in systemic lupus erythematosus. Semin Arthritis Rheum 1995, 25:184-192. This prospective study suggests that lupus patients should not be discourged from becoming pregnant despite the increased risk of obstetric complications, especially in renal and aPL-positive patients. The fetal loss risk can be reduced by close obstetric monitoring.
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Semin Arthritis Rheum
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Lima, F.1
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Johnson MJ, Petri M, Witter FR, Repke JT: Evaluation of preterm delivery In systemic lupus erythematosus pregnancy clinic. Obstet Gynecol 1995, 86:396-399.
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The Canadian Hydroxychloroquine Study Group: A randomized study of the effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus. N Engl J Med 1991, 324:150-154.
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Buchanan NMM, Khamashta MA, Kerslake S, Hunt BJ, Hughes GRV: Practical management of pregnancy in systemic lupus erythematosus. Fetal Mat Med Rev 1993, 5:223-230.
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Buchanan NMM, Toubi E, Khamashta MA, Lima F, Kerslake S, Hughes GRV: Hydroxychloroquine and lupus pregnancy: a review of a series of 36 cases. Ann Rheum Dis 1996, 55:486-488. Largest recorded series of the use of hydroxychloroquine in pregnancy. No ill effects were observed in mothers or babies.
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Buchanan, N.M.M.1
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Lima F, Khamashta MA, Buchanan NMM, Kerslake S, Hunt BJ, Hughes GRV: A study of sixty pregnancies in patients with the antiphospholipid syndrome. Clin Exp Rheumatol 1996, 1:131-136. Largest recorded experience of pregnancy in patients with APS. Antithrombotic therapy was effective in reducing fetal loss in these patients.
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Early Doppler studies in lupus pregnancy
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Kerslake S, Morton KE, Versi E, Buchanan NMM, Khamashta M, Baguley E, Braude P, Hughes GRV: Early Doppler studies in lupus pregnancy. Am J Reprod Immunol 1992, 28:172-175.
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Am J Reprod Immunol
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Pregnancy outcome in relation to uterine artery flow velocity waveforms and clinical characteristics in women with antiphospholipid syndrome
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Silver RM, Draper ML, Byme JLB, Ashwood EA, Lyon JL, Branch W: Unexplained elevations of maternal serum alpha-fetoproteln in women with antiphospholipid antibodies: a harbinger of fetal death. Obst Gyn 1994, 83:150-155.
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Lynch A, Marlar R, Murphy J, Davila G, Santos M, Rutledge J, Emlen W: Antiphospholipid antibodies in predicting adverse pregnancy outcome. Ann Intern Med 1994, 120:470-475.
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Lynch AM, Rutledge JH, Stephens JK, Murphy JR, Marlar RA, Davila GH, Santos ME, Emlen W: Longitudinal measurement of anticardiolipin antibodies during normal pregnancy: a prospective study. Lupus 1995, 4:365-369. This study assessed the variability of aPL levels in normal pregnancy and the association of aPL at different times in pregnancy with pregnancy complications.
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Lupus
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Lynch, A.M.1
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2-glycoprotein I-dependent anticardiolipin antibodies in the reproductive autoimmune failure syndrome: Correlation with conventional antiphospholipid antibody detection systems
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2-glycoprotein I-dependent anticardiolipin antibodies in the reproductive autoimmune failure syndrome: correlation with conventional antiphospholipid antibody detection systems. Am J Obset Gynecol 1995, 172:926-931.
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Shoenfeld Y, Blank M, Fisnman P: Antiphospholipid syndrome: from the laboratory bench to the patients' bedside. Lupus 1995, 4(suppl 1):33-36. Succint review of animal models of APS.
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