Effect of magnesium sulfate on calcium channels in isolated cardiomyocytes of guinea pig

Acta Pharmacologica Sinica

Volumn 17, Issue 6, 1996, Pages 550-552

  Fan, Ji Hai ^a,b   Yang, Jun Guo ^a   Tang, Ming ^a   Wang, Yang Gan ^a   Liu, Qing Hua ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b No 455 Hospital of PLA   (China)

Author keywords

calcium channels; cultured cells; magnesium sulfate; myocardium; patch clamp techniques

Indexed keywords

ANTIARRHYTHMIC AGENT; CALCIUM CHANNEL; EGTAZIC ACID; MAGNESIUM SULFATE; TETRYLAMMONIUM; VERAPAMIL;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ELECTRIC POTENTIAL; FEMALE; GUINEA PIG; HEART MUSCLE CELL; HEART VENTRICLE; MALE; NONHUMAN; PATCH CLAMP;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNELS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; MAGNESIUM SULFATE; MALE; MYOCARDIUM; PATCH-CLAMP TECHNIQUES;

EID: 0029851936     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Tzivoni D, keren A. Suppression of ventricular arrhythmias by magnesium. Am J Cardiol 1990; 65: 1397 - 9.
2. Thögersen AM, Johnson O, Wester PO. Effects of intravenous magnesium sulphate in suspected acute myocardial infarction on accute arrhythmias and long-term outcome. Int J Cardiol 1995; 49: 143 - 51.
3. Arsenian MA. Magnesium and cardiovascular disease. Prog cardiovasc disease 1993; 35: 271 - 310.
4. Kraft LF, Katholi RE, Woods WT, James TN. Attenuation by magnesium of the electrophysiologic effects of hyperkalemia on human and canine heart cells. Am J Cardiol 1980;45: 1189 - 95.
5. 2+ release in isolated triads. Am J Physiol 1995; 269 (1 Pt 1) : C85 - C95.
6. Beeler GW Jr, Reuter H. Voltage clamp experiments on ventricular myocardial fibres. J Physiol (Lond) 1970; 207: 165 - 90.
7. Belles B, Malécot CO, Hescheler J, Trautwein W. "Run-down" of the Ca current during long whole-cell recordings in guinea pig heart cells: role of phosphorylation and intracellular calcium. Pflügers Arch 1989; 411: 353 - 60.
8. Lee KS, Tsien RW. High selectivity of calcium channels in single dialysed heart cells of the guinea-pig. J Physiol (Lond) 1984; 354: 253 - 72.
9. Davidenko JM, Cohen L, Gooddrow R, Antzelevitch C. Quinidine-induced action potential prolongation, early after-depolarizations, and triggered activity in canine Purkinje fibers: Effects of stimulation rate, potassium, and magnesium. Circulation 1989; 79 : 674 - 86.
10. Bailie DS, Inoue H, Kaseda S, Ben-David J, Zipes DP. Magnesium suppression of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium in dogs. Circulation 1989; 77: 1395-402.