Circumvention of drug resistance in cancer cells by a new fluoropyrimidine analogue

Experimental and Molecular Medicine

Volumn 28, Issue 3, 1996, Pages 119-123

  Kim, Sun Hee ^a   Kang, Chi Dug ^a   Chung, Byung Seon ^a   Kim, Jack C ^b  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

5 fluorouracil; 5 fluorouracil 1 yl butanone; 5 FU resistance; MDR1 gene; Multidrug resistant cells

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; FLUOROURACIL DERIVATIVE; GLYCOPROTEIN P; TRITIUM; VINBLASTINE; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG POTENTIATION; GENE REPRESSION; GENETIC TRANSFORMATION; HUMAN; HUMAN CELL; ISOTOPE LABELING; MULTIDRUG RESISTANCE; NORTHERN BLOTTING; ONCOGENE H RAS;

TRITIUM;

EID: 0029851833     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.1996.18     Document Type: Article

References (19)

1. Akazawa, S., Kumai, R., Yoshida, K., Ayusawa, D., Shimizu, K. and Seono, T. (1986) The cytotoxicity of 5-fluorouracil is due to its incorporation into RNA not its inhibition of thymidylate synthase as evidanced by the use of mouse cell mutant in thymidylate synthetase. Jpn. J. Cancer Res. 77: 602-624
2. Chin, K.-V., Ueda, K., Pastan, I. and Gottesman, M. M. (1992) Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science 255:459-462
3. Cohen, M. B. and Glazer, R. I. (1985) Cytotoxicity and the inhibition of ribosomal RNA processing in human colon carcinoma cells. Mol. Pharmacol. 27: 308-313
4. Darnowski, J. W. and Handschumacher, R. E. (1985) Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine. Cancer Res. 45: 5364-5368
5. Fujii, S., Fukushima, M., Shimamoto, Y. and Shirasaka, T. (1989) Pharmacokinetic modulation of plasma 5-fluorouracil concentration to potentiate the antitumor activity of continuous venous infasion of 5-fluorouracil. Jpn. J. Cancer Res. 80: 509-512
6. Fujii, S., Fukushima, M., Shimamoto, Y., Ohshimo, H., Imaoka, T. and Shirasaka, T. (1989) Antitumor activity of BOF-A2, a new 5-fluorouracil derivative, Jpn. J. Cancer Res. 80: 173-181
7. Geng, Y., Gheuens, E. E. O. and De Bruijn, E. A. (1991) Activation and cytotoxicity of 5′-deoxy-5-fluorouridine in c-Ha-ras transformed NIH3T3 cells. Biochem. Pharmacol. 41: 301-303
8. Gorman, C. M., Moffat, L. F. and Howard, B. H. (1982) Recombinant genomes which express chloramphenicol acetyl transferase in mammalian cells. Mol. Cell. Biol. 2: 1044-1051
9. Graham, F. L. and Van der Eb., A. J. (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52: 456-467
10. Houghton, J. A., Weiss, K. D., William, L. G., Torrance, P. M. and Houghton, P. J. (1986) Binding of 5-fluorodeoxyuridylate to thymidylate synthase in human colon adenocarcinoma xenografts. Eur. J. Cancer Clin. Oncol. 22: 505-510
11. Kim, S. H., Park Y. H., Kim, D. W., Kang, C. D. and Chung, B. H. (1993) Oncogene and tumor suppressor genes regulate the human multidrug resistance gene(MDR1) expression. Mol. Cells 3: 13-16
12. Kim, J. C., Dong, E. S., Kim, J. A., Kim, S. H., Park J. I. and Kim, S. H. (1994) Synthesis and antitumor evaluation of acyclic 5-substituted pyrimidine nucleoside analogues. Korean J. Med. Chem. 4: 11-118
13. Kubota, T., Ishibiki, K. and Abe, O. (1988) The clinical usefulness of human xenografts. In Prediction of Response to Cancer Therapy (Hall, T. T., ed.), pp. 213-225, Alan R. Liss, New York
14. Matsuo, K., Kohno, K., Takano, H., Sato, S., Kiue, A. and Kuwano, M. (1990) Reduction of drug accumulation and DNA topoisomerase II activity in acquired teniposide-resistant human cancer KB cell lines. Cancer Res. 50: 5819-5824
15. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival; application to proliferation and cytotoxicity asay. J. Immounol. Methods 65: 55-63
16. Nishiyama, M., Takagami, S., Kim, R., Kiribara, Y., Saeki, T., Jinushi, K., Niimoto, M. and Hattori, T. (1988) Inhibition of thymidylate synthetase and antiproliferative effect by 1-hexylcarbamoyl-5-fluorouracil. Jpn. J. Cancer Chemother. 15: 3109-3113
17. Swayer, R. C., Stolfi, R. L., Martin, D. S. and Spiegelman, S. (1984) Incoporation of 5-fluorouracil into murine bone marrow DNA in vivo. Cancer Res. 44: 1847-1851
18. Ueda, K., Pastan, I. and Gottesman, M. M. (1987) Isolation and sequence of promoter region of the human multidrug resistance (P-glycoprotein) gene. J. Biol. Chem. 262: 17432-17436
19. Van Der Heyden, S., Gheuens, E., Van'De Vrie, W., Van Bockstaele, D., Van Dosterom, A., Eggermont, A. and De Brujjin, E. A. (1994) 5′-Deoxy-5′-fluoro uridine increase daunorubicin uptake in multidrug-resistant cells and its activity is related with P-gp170 expression. Jpn. J. Cancer Res. 85: 13-16