Chelerythrine inhibits Na+-H+ exchange in platelets from spontaneously hypertensive rats

Hypertension

Volumn 28, Issue 6, 1996, Pages 1013-1017

  Gende, Oscar A ^a,b  

^a UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^b FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

Author keywords

blood platelets; chelerythrine; hydrogen ion concentration; ion exchange; protein kinases; rats, inbred SHR; sodium hydrogen antiporter

Indexed keywords

AMMONIUM CHLORIDE; CHELERYTHRINE; PROTEIN KINASE C; PROTON; SODIUM;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL PH; CONTROLLED STUDY; ENZYME INHIBITION; FLUORESCENCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; THROMBOCYTE;

EID: 0029851786     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.28.6.1013     Document Type: Article

References (39)

1. Kemp GJ, Thompson CH, Radda GK. Proton efflux from rat skeletal muscle in vivo: changes in hypertension. Clin Sci (Colch). 1992; 82:489-491.
2. + exchange. J Clin Invest. 1989;83:822-829.
3. + antiport activity in cultured skeletal muscle cells and vascular smooth muscle cells from the spontaneously hypertensive rat. Clin Sci (Colch). 1991;80:509-516.
4. Siczkowsky M, Davies JE, Ng LL. Sodium-hydrogen antiporter protein in normotensive Wistar-Kyoto rats and spontaneously hypertensive rats. J Hypertens. 1994;12:775-781.
5. + exchanger expression in vascular smooth muscle of spontaneously hypertensive and Wistar-Kyoto rats. Hypertension. 1994;24:734-738.
6. + exchanger, NHE-1, by phosphorylating a set of common sites. J Biol Chem. 1991;266:19166-19171.
7. + sensing. Proc Natl Acad Sci U S A. 1992;89:2424-2428.
8. Siczkowsky M, Davies JE, Ng LL. Increased phosphorylation and turnover of the sodium proton exchanger (NHE-1) in cultured vascular smooth muscle from insulin resistant spontaneously hypertensive rats. Diabet Med. 1994;1(suppl 1):P82. Abstract.
9. Murakawa K, Kohno M, Yasunari K, Yokokawa K, Horio T, Takeda T. Possible involvement of protein kinase C in the maintenance of hypertension in spontaneously hypertensive rats. J Hypertens. 1988; 6(suppl4):S157-S159.
10. Uehara Y, Ishii M, Ishimitsu T, Sugimoto T. Enhanced phospholipase C activity in the vascular wall of spontaneously hypertensive rats. Hypertension. 1988;11:28-33.
11. + antiport: an unifying factor for essential hypertension. J Hypertens. 1988; 6:685-691.
12. + antiport in the development of hypertension and insulin resistance. J Am Soc Nephrol. 1992;3:1049-1063.
13. Weinman EJ, Shenolikar S. Protein kinase C activates the renal apical membrane Na/H exchanger. J Membr Biol. 1986;93:133-139.
14. + exchange in vascular smooth muscle cells from WKY and SHR: effect of phorbol ester. Am J Physiol. 1995;268:C14-C20.
15. + exchanger is phosphorylated in human platelets in response to activating agents. FEBS Lett. 1991;284:219-222.
16. + exchange rate and more alkaline intracellular set point in essential hypertension: effects of protein kinase modulation in platelets. J Hypertens. 1991;9: 1013-1019.
17. Kimura M, Cho JH, Lasker N, Aviv A. Differences in platelet calcium regulation between African Americans and Caucasians. J Hypertens. 1994;12:199-208.
18. Oshima T, Young EW, Bukoski RD, McCarron DA. Abnormal calcium handling by platelets of spontaneously hypertensive rats. Hypertension. 1990;15:606-611.
19. Thomas JA, Buchsbaum RN, Zimniar A, Racker E. Intracellular pH measurements in Ehrich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry. 1979;18:2210-2218.
20. Rosskopf D, Dusing R, Siffert W. Membrane sodium-proton exchange and primary hypertension. Hypertension. 1993;21: 607-617.
21. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, Duhamel L, Charon D, Kirilovsky J. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem. 1991;266:15771-15781.
22. Herbert JM, Augereau JM, Gleye J, Maffrand JP. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990;172:993-999.
23. Ko FN, Chen IS, Lee LG, Haung TF, Teng CM. Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans. Biochim Biophys Acta. 1990;1052:360-365.
24. Takaori K, Itoh S, Kanayama Y, Takeda T. Protein kinase C activity in platelets from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Biochem Biophys Res Commun. 1986;141:769-773.
25. Feig PU. Increased platelet membrane sodium-proton exchange in spontaneously hypertensive rats. Am J Hypertens. 1990;3:927-932.
26. + exchange in spontaneously hypertensive rats. Hypertension. 1987;9:282-288.
27. + antiporter of lymphocytes from the spontaneously hypertensive rat: role of intracellular pH. J Clin Invest. 1990;85:1734-1739.
28. + exchanger. Circ Res. 1995;77:1192-1200.
29. + exchanger is stimulated and the cell volume increased in lymphocytes of patients with essential hypertension. J Hypertens. 1991;9:519-524.
30. + exchanger activity and NHE-1 mRNA expression in lymphocytes from patients with essential hypertension. Hypertension. 1995;25:356-364.
31. + exchange and intracellular pH by protein kinase C and protein phosphatase in blood platelets. Biochim Biophys Acta. 1991;1068:161-166.
32. Inariba H, Kanayama Y, Takaori K, Itoh S, Inoue T, Takeda T. Intracellular pH in platelets from spontaneously hypertensive rats and Wistar-Kyoto rats. J Hypertens Suppl. 1988;6:S252-S254.
33. 2+ response in human platelets. Am J Physiol. 1994; 267:C1543-C1552.
34. 2+] and pH in human platelets: cytoplasmic alkalinization is not a prerequisite for calcium mobilization. Biochim Biophys Acta. 1988;958:497-500.
35. + antiport activation in cultured rat aortic smooth muscle on calmodulin, calcium, and ATP. J Biol Chem. 1988;263:16780-16786.
36. Gardner JP, Cho JH, Skurnick JH, Award G, Gutkin M, Byrd LH, Lasker N, Aviv A. Blood pressure inversely correlates with thrombin-evoked calcium rise in platelets. Hypertension. 1994;23:703-709.
37. + exchange rates in essential hypertension: application of a novel test. Lancet. 1987;1:533-536.
38. Rinaldi GJ, Amado Cattaneo E, Cingolani HE. Interaction between calcium and hydrogen ions in canine coronary arteries. J Mol Cell Cardiol. 1987;19:773-784.
39. Thomas RC. Cell growth factors: bicarbonate and pHi response. Nature. 1989;337:601.