Diagnosis and classification of the acute leukemias: Recent advances and controversial issues

Hematopathology and Molecular Hematology

Volumn 10, Issue 1-2, 1996, Pages 1-38

  Taylor, Colin G ^a   Stasi, Roberte ^b   Bastianelli, Caria ^a   Venditti, Adriano ^b   Poeta, Giovanni Del ^a   Amadori, Sergio ^b   Sargent, Jean ^a  

^a Pembury Hospital   (United Kingdom)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MEGAKARYOCYTIC LEUKEMIA; BIOTECHNOLOGY; CANCER CLASSIFICATION; CELL CYCLE; CELL KINETICS; CHROMOSOME TRANSLOCATION 1; CHROMOSOME TRANSLOCATION 14; CHROMOSOME TRANSLOCATION 15; CHROMOSOME TRANSLOCATION 17; CHROMOSOME TRANSLOCATION 19; CHROMOSOME TRANSLOCATION 22; CHROMOSOME TRANSLOCATION 8; CHROMOSOME TRANSLOCATION 9; CYTOCHEMISTRY; CYTOGENETICS; DIFFERENTIATION; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; KARYOTYPE; MOLECULAR BIOLOGY; MORPHOLOGY; PRIORITY JOURNAL; REVIEW;

ACUTE DISEASE; BIOTECHNOLOGY; HISTOCYTOCHEMISTRY; HUMANS; IMMUNOPHENOTYPING; KARYOTYPING; LEUKEMIA; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOID; MICROSCOPY, ELECTRON;

EID: 0029851583     PISSN: 10828893     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (216)

1. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Proposals for the classification of the acute leukemias (FAB Coopérative Group). Br J Haematol 33:451, 1976.
2. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: A variant form of acute hypergranular promyelocytic leukemia (M3). Br J Haematol 44:169, 1980.
3. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: The morphological classification of acute lymphoblastic leukemia: concordance among observers and clinical correlations. Br J Haematol 47:553, 1981.
4. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Proposed revised criteria for the classification of acute myeloid leukemia. Ann Intern Med 103:620, 1985.
5. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). Ann Intern Med 103:460, 1985.
6. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Proposal for the recognition of minimally differentiated acute myeloid leukemia. Br J Haematol 78:325, 1991.
7. First MIC Cooperative Sludy Group. Morphologic, immunologie and cylogenetic (MIC) working classification of the acule lymphoblastic leukemias. Cancer Gen Cytogenet 23:189, 1986.
8. Second MIC Cooperative Study Group: Morphologie, immunologie and cytogenetic (MIC) working classification of the acute myeloid leukemias. Br J Haematol 68:487, 1988.
9. Cason JD, Trujillo JM, Estey EH, Huh Yo, Freireich EJ, Stass SA: Peripheral acute leukemia: high peripheral but low-marrow blast count. Blood 74:1758, 1989.
10. Dalton WT, Ahearn MJ, Cork O, Trujillo JM, Keating MJ, McCredie KB, Freireich EJ, Stass SA: Acute myelomonocytic leukemia associated with abnormalities of chromosome 16; a light and electron microscopic study. Hematol Pathol 1:105, 1987.
11. Cheson BD, Cassileth PA, Head DR, Schiffer CA, Bennet JM, Bloomfield CD, Brunning R, Gale RP, Grever MR, Keating MJ, Sawitsky A, Stass S, Weinstein H, Woods WG: Report of the National Cancer Institute-sponsored workshop on the definition of diagnosis and response in acute myeloid leukemia. J Clin Oncol 8:813, 1990.
12. Fradera J, Velez-Garcia E, White JG: Acute lymphoblastic leukemia with unusual cytoplasmic granulation: a morphologic, cytochemical, and ultrastructural study. Blood 68:406, 1986.
13. Smith H, Collins R: Peculiar cytoplasmic inclusions in cells of acute lymphoblastic leukemia. Am J Clin Pathol 86:261, 1986.
14. Cantu-Rajnoldi A, Invernizzi R, Biondi A, Banfi P, Zoia A, De Fazio P, Polli N: Biological and clinical features of acute lymphoblastic leukaemia with cytoplasmic granules or inclusions: description of 8 cases. Br J Haematol 73:309, 1989.
15. Penchansky L, Taylor SR, Krause JR: Three infants with acute megakaryoblastic leukemia simulating metastatic tumor. Cancer 64:1366, 1989.
16. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51:189, 1982.
17. Rosen NR, Di Fina S, Nelson DA: Acute leukemia with unusual cytoplasmic inclusions. Cancer 43:2405, 1979.
18. Djaldetti M, Perek J, Zahavi I. Two types of intracytoplasmic inclusions in the cells of a patient with acute lymphoblastic leukemia. Blut 47:13, 1983.
19. Yanagihara ET, Naheim F, Gale RP, Austin G, Weisman J: Acute lymphoblastic leukemia with giant intracytoplasmic inclusions. Am J Clin Pathol 74:345, 1980.
20. Cawley JC, Barker CR, Britchford RD, Smith JL: Intracellular IgA immunoglobulin crystals in chronic lymphocytic leukemia. Clin Exp Immunol 13:407, 1973.
21. Groom DA, Wong D, Brynes RK, Macaulay LK: Auer Rod-like inclusions in circulating lymphoma cells. Am J Clin Pathol 96:111, 1991.
22. Pearson EC: Crystal structure of Auer rods in acute myeloblastic leukemia. Clin Pathol 39:569, 1986.
23. Koeffler HP: Myelodysplastic syndromes (preleukemia). Semin Hematol 23:284, 1986.
24. Layton DM, Mufti GJ. Myelodysplastic syndromes: their history, evolution and relation to acute myeloid leukemia. Blut 53:423, 1986.
25. Brito-Babapulle F, Catovsky D, Galton DAG. Myelodysplastic relapse of de novo acute myeloid leukemia with trilineage myelodysplasia. Br J Haematol 66:445, 1988.
26. Rowley JD, Alimena G, Garson OM, Hagemeijer A, Mitelman F, Prigogina EL: A collaborative study of the relationship of the morphological type of acute nonlymphocytic leukemia with patient age and karyotype. Blood 59:1013, 1982.
27. Head DR, Downing JR: Pathology and immunology of leukemia. Curr Opin Oncol 4:14, 1992.
28. Pui C-H, Mirro J, Woodruff L: Phagocytic activity and expression of myeloid-associated cell-surface antigens by blast cells in acute lymphoblastic leukemia. Med Pediatr Oncol 14:12, 1986.
29. Stass SA, McGraw TP, Folds J, Odle B, Bollum FJ: Terminal transferase in acute lymphoblastic leukemia in remission. Am J Clin Pathol 75:838, 1981.
30. Muehleck SD, McKenna RW, Gale RP, Brunning RD: Terminal deoxynucleotidyl transferase (TdT) positive cells in bone marrow in the absence of hématologie malignancy. Am J Clin Pathol 97:277, 1983.
31. Longacre TA, Foucar K, Crago S: Hematogones: a multiparameter analysis of bone marrow precursor cells. Blood 73:543, 1989.
32. Hayhoe FGJ, Quaglino D: Hemalological Cytochemistry, 2nd ed. Churchill Livingstone, Edinburgh, 1988.
33. Tricot G, Broeckaert-Van Orshoven A, Van Hoof A, Verwilghen RI: Sudan Black B positivity in acute lymphoblastic leukemia. Br J Haematol 51:615, 1982.
34. Griffin JD, Mayer RJ, Weinstein HJ, Rosenthal DS, Coral FS, Beveridge RP, Schlossman SF: Surface marker analysis of acute myeloblastic leukemia: identification of differentiation-associated phenotypes. Blood 62:557, 1983.
35. Greaves MF: Differentiation-linked leukemogenesis in lymphocytes. Science 234:697, 1986.
36. Neame PB, Soamboonsrup P. Browman GP, Meyer RM. Benger A, Wilson WEDC, Walker IR, Saeed N, McBride JA: Classifying acute leukemia by immunophenotyping; a combined FAB-immunologic classification of AML. Blood 68:1355, 1986.
37. San Miguel JF, Gonzales M, Canizzo MC, Anta JP, Zola H, Lopez-Borrasca A: Surface marker analysis in acute myeloid leukemia and correlation with FAB classification. Br J Haematol 64:547, 1986.
38. Campos L, Guyotat D, Archimbaud E, Devaux Y, Treille D, Laise A, Maupas J, Gentilhomme O, Ehrsam A, Fiere D: Surface marker expression in adult acute myeloid leukaemia: correlations with initial characteristics, morphology and response to therapy. Br J Haematol 72:161. 1989.
39. Chan LC, Pegram SM, Greaves MF: Contribution of immunophenotype to the classification and differential diagnosis of acute leukemia. Lancet i:475, 1985.
40. Janossy G, Coustan-Smith E, Campana D: The reliability of cytoplasmic CD3 and CD22 antigen expression in the immunodiagnosis of acute leukemia: a study of 500 cases. Leukemia 3:170, 1989.
41. Buccheri V, Shetty V, Yoshida N, Morilla R, Matutes E, Catovsky D: The role of an anti-myeloperoxidase antibody in the diagnosis and classification of acute leukemia: a comparison with light and electron microscopy cytochemistry. Br J Haematol 80:62, 1992.
42. Rani S, Pombo de Oliveira MS, Catovsky D: Different expression of CD3 and CD22 in leukemic cells according to whether tested in suspension or fixed on slides. Hematol Pathol 2:72, 1988.
43. Pombo de Oliveira MS, Matutes E, Rani S, Morilla R, Catovsky D: Early expression of MCS2 (CD13) in the cytoplasm of blast cells from acute myeloid leukemia. Acta Haematol 80:61, 1988.
44. Van der School CE, Daams GM, Pinkster J, Vet R, Von dem Borne AEG: Monoclonal antibodies against myeloperoxidase are valuable immunological reagents for the diagnosis of acute myeloid leukemia. Br J Haematol 74:173, 1990.
45. Storr J, Dolan G, Coustan-Smith E, Barnett D, Reilly JT: Value of monoclonal antimyeloperoxidase (MPO7) for diagnosing acute leukemia. J Clin Pathol 43:847, 1990.
46. Foon KA, Todd RA: Immunologie classification of leukemia and lymphoma. Blood 68:1, 1986.
47. Hayhoe FGJ: Classification of acute leukemia. Blood Rev: 2, 1988.
48. Huh Yo, Kantarjian H, Childs CC, Stass SA: Classification of adult acute lymphoblastic leukemia by immunophenotype. Blood 76:282, 1990.
49. Lavabre-Bertrand T, Janossy G, Ivory K, Peters R, Seeker-Walker L, Porwit-MacDonald A: Leukemiaassociated changes identified by quantitative flow cytometry: I. CDIO expression. Cytometry 18:209,1994.
50. Koehler M, Behm FG, Shuster J, Crist W, Borowitz M, Look AT, Head D, Carroll AJ, Land V, Steuber P: Transitional pre-B-cell acute lymphoblastic leukemia of childhood is associated with favorable prognostic clinical features and an excellent outcome: a Pédiatrie Oncology Group Study. Leukemia 7:2064, 1993.
51. Reinherz EL, Kung PC, Goldstein G, Levey RH, Schlossman SF: Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci USA 77:1588, 1980.
52. Haynes BF, Martin ME, Kay HH, Kurtzberg J: Early events in human T-cell ontogeny. Phenotypic characterization and immunohistologic localization of T-cell precursor in early human fetal tissues. J Exp Med 168:1061, 1988.
53. Campana D, van Dongen JJM, Mehta A, Coustan-Smith E, Wolvers-Tettero ILM, Ganeshaguru K, Janossy G: Stages of T-cell receptor protein expression in T-cell acute lymphoblastic leukemia. Blood 77: 15461554, 1991.
54. Crist WM, Shuster JJ, Falletta J, Pullen DJ, Berard CW, Vietti TJ, Alvarado CS, Roper MA, Prasthofer E, Grossi CE: Clinical features and outcome in childhood T-cell leukemia-lymphoma according to the stage of thymocyte differentiation: a Pédiatrie Oncology Group Study. Blood 72:1891, 1988.
55. Greaves MF, Janossy G, Peto J: Immunologically defined subclasses of acute lymphoblastic leukemia in children: their relationship to presentation features and prognosis. Br J Haematol 48:179, 1981.
56. Borowitz MJ, Dowell BL, Boyett JM: Clinicopathologic aspects of E rosette negative T-cell acute lymphocytic leukemia: a Pédiatrie Oncology Group Study. J Clin Oncol 4:170, 1986.
57. Thiel E, Kranz BR, Raghavachar A, Bartram CR, Loffler H, Messerer D, Ganser A, Ludwig WD, Bchner T, Hoelzer D: Prethymic phenotype and genotype of pre-T (CD7+/ER-)-cell leukemia and its clinical significance within adult acute lymphoblastic leukemia. Blood 73:1247, 1989.
58. Kristensen JS, Ellegaard J, Hansen KB, Clausen N, Hokland P: First line diagnosis based on immunological phenotyping in suspected acute leukemia: a prospective study. Leuk Res 12:773, 1988.
59. Adriaansen HJ, te Boekhorst PAW, Hagemeijer AM, van der School CE, Deiwel HR, van Dongen JJM: Acute myeloid leukemia M4 with bone marrow eosinophilia (M4Eo) and inv(16)(p13q22) exhibits a specific immunophenotype with CD2 expression. Blood 81:3043, 1993.
60. Erber WN, Asbahr H, Rule SA, Scott CS: Unique immunophenotype of acute promyelocytic leukemia as denned by CD9 and CD68 antibodies. Br J Haematol 88:101, 1994.
61. Venditti A, Del Poeta G, Stasi R, Masi M, Bruno A, Buccisano F, Cox C, Coppetelli U, Aronica G, Simone MD, Papa G: Minimally differentiated acute myeloid leukemia (AML-MO): cytochemical, immunophenotypic and cytogenetic analysis of 19 cases. Br J Haematol 88:784, 1994.
62. Drexler HG: Classification of acute myeloid leukemias: a comparison of FAB and immunophenotyping. Leukemia 1:697, 1987.
63. Matutes E, Buccheri V, Morilla R, Shetty V, Dyer M, Catovsky D: Immunological, ultrastructural and molecular features of unclassifiable acute leukemia. Rec Res Cancer Res 131:41, 1993.
64. Matutes E, Pombo de Oliveira M, Foroni L, Morilla R, Catovsky D: The role of ultrastructural cytochemistry and monoclonal antibodies in clarifying the nature of undifferentiated cells in acute leukemia. Br J Haematol 69:205, 1988.
65. Robinson D, Tavares de Castro J, Polli N, O'Brien M, Catovsky D: Simultaneous demonstration of membrane antigens and cytochemistry at ultrastructural level: a study with the immunogold method, acid phosphatase and myeloperoxidase. Br J Haematol 56:617, 1984.
66. Polli N, O'Brien M, Tavares de Castro J, Matutes E, San Miguel JF, Catovsky D: Characterization of blast cells in chronic granulocytic leukemia in transformation, acute myelofibrosis, and undifferentiated leukemia. I. Ultrastructural morphology and cytochemistry. Br J Haematol 59:277, 1985.
67. LeMaistre A, Childs A, Hirsh-Ginsberg C, Reuben J, Cork A, Trujillo J, Andersson B, McCredie K, Freireich E, Stass S: Heterogeneity in acute undifferentiated leukemia. Hematol Pathol 2:79, 1988.
68. Furley AJW, Chan LC, Mizutani S, Ford AM, Weilbaeker K, Pegram SM, Greaves NF: Lineage specificity of rearrangement and expression of genes encoding the T-cell receptor-T3 complex and immunoglobulin heavy chain in leukemia. Leukemia 1:644, 1987.
69. Seeker-Walker LM, Craig JM, Hawkins JM, Hoffbrand AV: Philadelphia positive acute lymphoblastic leukemia in adults: age distribution, BCR breakpoint and prognostic significance. Leukemia 5:901, 1991.
70. Westbrook CA, Hooberman AL, Spino C, Dodge RK, Larson RA, Davey F, Wurster-Hill DH, Sobol RE, Schiffer C, Bloomfield CD: Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B study (8762). Blood 80:2983, 1992.
71. Privitera E, Kamps MP, Hayashi Y, Inaba T, Shapiro LH, Raimondi SC, Behm F, Hendershot L, Carroll AJ, Baltimore D: Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia. Blood 79:1781, 1992.
72. Izraeli S, Janssen JWG, Haas OA, Harbott J, Brok-Simoni F, Walther JU, Kovar H, Henn T, Ludwig WD, Reiter A: Detection and clinical relevance of genetic abnormalities in pédiatrie acute lymphoblastic leukemia: a comparison between cytogenetic and polymerase chain reaction analyses. Leukemia 7:671, 1993.
73. Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, Kamada N, Ohki M: Junctions of the AML1/ MTG8 (ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood 82:1270, 1993.
74. Borrow J, Goddard AD, Gibbons B, Katz F, Swirsky D, Fioretos T, Dube I, Winfield DA, Kingston J, Hagemeijer A: Diagnosis of acute promyelocytic leukemia by RT-PCR: detection of PML-RARa and RARa-PML fusion transcripts. Br J Haematol 82:529, 1992.
75. Neri A, Barriga F, Knowles DM: Different regions of the immunoglobulin heavy chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma. Proc Natl Acad Sci USA 85:2748, 1988.
76. Kurzrock R, Gutterman JU, Talpaz M: The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 319:990, 1988.
77. Pandolfi PP, Alcalay M, Fagioli M, Zangrilli D, Mencarelli A, Diverio D, Biondi A, Lo Coco F, Rambaldi A, Grignani F: Genomic variability and alternative splicing generate multiple PML/RARa transcripts that encode aberrant PML proteins and PML/RARa isoforms in acute promyelocytic leukemia. EMBO J 11:1397, 1992.
78. Miller WH, Heller G, Warrel RP: Implications of the PML/RARa isoform at presentation and detection of PML/RARa by reverse transcription polymerase chain reaction (RT-PCR) in remission of acute promyelocytic leukemia (APL). Blood 84:150la, 1994.
79. Breit TM, Mol EJ, Wolvers-Tettero ILM, Ludwig WD, van Wering ER, van Dongen JJ: Site-specific deletions involving the TAL-1 and SIL genes are restricted to cells of the T-cell receptor αβ lineage: T-cell receptor 8 gene deletion mechanism affects multiple genes. J Exp Med 177:965, 1993.
80. Von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G: CAN, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. Mol Cell Biol 12:3346, 1992.
81. Graninger WB, Wright JJ, Felix CA: Characterization of acute leukemia using lineage-associated molecular probes. In The Acute Leukemias: Biologic, Diagnostic, and Therapeutic Determinants. Edited by SA Stass. Marcel Dekker, New York, 1987, p 299.
82. Kitchingman GR, Rovigatti U, Mauer AM: Rearrangement of immunoglobulin heavy chain genes in T-cell acute lymphoblastic leukemia. Blood 65:725, 1985.
83. Knowles DM: Immunophenotypic and antigen receptor gene rearrangement analysis in T-cell neoplasia. Am J Clin Pathol 134:761, 1989.
84. Krowlewski JJ, Dalla Pavera R: Molecular genetic approaches in the diagnosis and classification of lymphoid malignancies. Hematol Pathol 3:45, 1989.
85. Rovigatti U, Mirro J, Kitchingman GR: Heavy-chain immunoglobulin gene rearrangement in acute nonlymphocytic leukemia. Blood 63:1023, 1984.
86. Seremetis SV, Pellicci PG, Tabilio A, Tabilio A, Ubriaco A, Grignani F, Cuttner J, Winchester RJ, Knowles DM, Dalla Favera R: High-frequency of clonal immunoglobulin or T-cell receptor gene rearrangements in acute myelogenous leukemia expressing deoxyribonucleotidyl transferase. J Exp Med 165:1703, 1987.
87. Zaki SR, Austin GE, Swan D, Srinivasan A, Ragab AH, Chan WC: Human myeloperoxidase gene expression in acute leukemia. Blood 74:2096, 1989.
88. Ferrari S, Mariano MT, Tagliafico E, Sarti M, Ceccherelli G, Selleri L, Merli F, Narni F, Donelli A, Torelli G: Myeloperoxidase gene expression in blast cells with a lymphoid phenotype in cases of acute lymphoblastic leukemia. Blood 72:873, 1988.
89. Zhou M, Findley HW, Zaki SR, Little F, Coffield LM, Ragab AH: Expression of myeloperoxidase and RNA by leukemic cells from childhood acute lymphoblastic leukemia. Leukemia 7:1180, 1993.
90. Nara N, Chen GJ, Murohashi I, Tohda S, Imai Y, Tomiyama J, Nagata K, Suzuki T, Tanikawa S, Shiina S: The in vitro growth patterns and drug sensitivities of leukemic blast progenitors among the subtypes of acute myelocytic leukemia. Exp Hematol 20:904.
91. Touw I, Donath J, Pouwels K, van Buitenen C, Schipper P, Santini V, Hagemeijer A, Löwenberg B, Deiwel R: Acute myeloid leukemias with chromosomal abnormalities involving the 21q22 region identified by their in vitro responsiveness to interleukin-5. Leukemia 5:687, 1991.
92. Curtis JE, Messner HA, Hasselback R, Elhakim TM, McCulloch EA: Contributions of host- and diseaserelated attributes to the outcome of patients with acute myelogenous leukemia (AML). J Clin Oncol 2:253, 1984.
93. Löwenberg B, van Putten WLJ, Touw IP, Delwel R, Santini V: Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia. N Engl J Med 328:614, 1993.
94. Veerman AJP, Pieters R: Drug sensitivity assays in leukaemia and lymphoma. Br J Haematol 74:381,1990.
95. Santini V, Bernabei PA, Silvestro R. In vitro chemosensitivity testing of leukemic cell: prediction of response to chemotherapy in patients with acute nonlymphoblastic leukemia. Hematol Oncol 7:287,1989.
96. Sargent JM, Taylor CG: Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukemia. Br J Cancer 60:206, 1989.
97. Pieters R, Huismans DR, Loonen AH: Relationship of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukemia. Lancet 338:399, 1991.
98. Veisenthal LM, Dill PL, Kurnick NB, Lippman ME: Comparison of dye exclusion assays with clonogenic assay in the determination of drug-induced cytotoxicity. Cancer Res 43:258, 1983.
99. Lee EJ, Pollak A, Leavitt RD, Testa JR, Schiffer CA: Minimally differentiated acute nonlymphocytic leukemia: a distinct entity. Blood 70:1400, 1987.
100. Stasi R, Del Poeta G, Venditti A, Masi M, Stipa E, Dentamaro T, Cox C, Dalla Piccola B, Papa G: analysis of treatment failure in patients with minimally differentiated acute myeloid leukemia (AML-MO). Blood 83:1619, 1994.
101. Yokose N, Ogata K, Ito T, Miyaké K, An E, Inokuchi K, Yamada T, Gomi S, Tanabe Y, Ohki I, Kuwabara T, Hasegawa S, Shinohara T, Dan K, Nomura T: Chemotherapy for minimally differentiated acute myeloid leukemia (AML-MO). A report on five cases and review of the literature. Ann Hematol 66:67, 1993.
102. Von Lindern M, Fornerod M, Soekerman N, van Baal S, Jaegle M, Hagemeijer A, Bootsma D, Grosveld G: Translocation t(6;9) in acute nonlymphocytic leukemia results in the formation of a DEK-CAN fusion gene. Baillere's Clin Hematol 5:857, 1992.
103. Von Lindern M, Poustca A, Lehrach H, Grossveld G: The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of target gene on 9q34. Mol Cell Biol 10:4016, 1990.
104. Cuneo A, Kerim S, Vanderberghe E, Van Orshoven A, Rodhain J, Bosly A, Zachee P, Louwagie A, Michaux JL, Dal Cin P: Translocation t(6;9) occurring in acute myelofibrosis, myelodysplastic syndromes, and acute nonlymphocytic leukemia suggests multipotent stem cell involvement. Cancer Genet Cytogenet 42:209, 1989.
105. Castoldi GL, Cuneo A, Tomasi P: Phenotype-related chromosome aberrations and stem cell involvement in acute myeloid leukemia. Haematologica 74:525, 1989.
106. Soekerman D, Von Lindern M, Daenen S, De Jong B, Fonatsch C, Heinze B, Bartram C, Hagemeier A, Grosveld G: The translocation t(6;9)(p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features. Blood 79:2990, 1992.
107. Lillington DM, MacCallum TK, Lister TA, Gibbons B: Translocation t(6;9)(p23;q34) in acute myeloid leukemia without myelodysplasia or basophilia: two cases and a review of the literature. Leukemia 7:527, 1993.
108. Daniel MT, Bernheim A, Flandrin G, Berger R: Acute myeloblastic leukemia (M2) with basophilic cell line involvement and abnormalities of the short arm of chromosome 12 (12p). C R Acad Sci [III] 301:299, 1985.
109. Peterson LC, Parkin JL, Arthur DC, Brunning RD: Acute basophilic leukemia: a clinical morphologic and cytogenetic study of eight cases. Am J Clin Pathol 96:160, 1991.
110. Bitter MA, Le Beau MM, Larson RA, Rowley JD, Golomb HM, Vardiman JW: A morphologic and cytochemical study of acute myelomonocytic leukemia with abnormal marrow eosinophils associated with inv(16)(p13q22). Am J Clin Pathol 81:733, 1984.
111. Leder LD: Akute myelo-monozytäre leukämie mit atypishcen Napthol-AS-D-Chloroacetat-EsterasePositiven Eosinophilen. Acta Haematol 44:52, 1970.
112. Liu P, Tarle SA, Hajra A, Claxton DF, Mariton P, Freedman M, Siciliano MJ, Collins FS: Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 261:1041, 1993.
113. Larson RA, Williams SF, Le Beau MM: Acute myelomonocytic leukemia with abnormal eosinophils and inv(lft) or t(16;!6) has a favorable prognosis. Blood 68:1242, 1986.
114. Hagihara M, Miyachi H, Kobayashi H, Ogawa T: Bone marrow eosinophilia as a prognostic indicator in acute myelogenous leukemia with 8;21 translocation. Intl J Hematol 55:173, 1992.
115. Hogan T. Acute lymphoblastic leukemia with chromosomal 5:14 translocation and hypereosinophilia: case report and literature review. J Clin Oncol 5:382, 1988.
116. Meeker TC, Hardy D, Willman C: Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia. Blood 76:285, 1990.
117. Fauci AS, Harley JB, Roberts WC, Ferrans VJ, Gralnick HR. Bjornson BH: The idiopathic hypereosinophilic syndrome. Ann Intl Med 97:78, 1982.
118. Kueck BD, Smith RE, Parkin J, Peterson LC, Hanson CA: Eosinophilic leukemia: a myeloproliferative disorder distinct from the hypereosinophilic syndrome. Hematol Pathol 5:195, 1991.
119. Keene P, Mendelow B, Pinto MR, Bezwoda W, MacDougall L, Falkson G, Ruff P, Bernstein R: Abnormalities of chromosome 12pl3 and malignant proliferation of eosinophils: a nonrandom association. Br J Haematol 67:;25, 1987.
120. Yates P, Potter MN: Eosinophilic leukemia with an abnormality of 5q31, the site of the IL-5 gene. Clin Lab Haematol 13:211, 1991.
121. Sato H, Danbara M, Tamura M, Morita M: Eosinophilic leukemia with a t(2;5)(p23;q35) translocation. Br J Haematol 87:404, 1994.
122. Scully RE, Mark EJ, McNeely BU: Case records of the Massachusetts General Hospital. N Engl J Med 308:1081, 1983.
123. Kowal-Vern A, Cotelingam J, Schumacher HR: The prognostic significance of proerythroblasts in acute erythroleukemia. Am J Clin Pathol 98:34, 1992.
124. Atkinson J, Hrisinko MA, Weil SC: Erythroleukemia: a review of 15 cases meeting 1985 FAB criteria and survey of the literature. Blood Rev 6:204, 1993.
125. Olopade OI, Thangavelu MT, Larson RA, Mick R. Kowal-Vern A, Schumacher HR, Le Beau MM, Vardiman JW, Rowley JD: Clinical, morphologic, and cytogenetic characteristics of 26 patients with acute erythroblastic leukemia. Blood 80:2873-2882, 1992.
126. Villeval JL, Cramer F, Lemoine A, Henri A, Bettaieb A, Bernaudin F, Beuzard Y, Berger R, Flandrin G, Breton-Gorius J, Vainchenker W: Phenotype of early erythroblastic leukemias. Blood: 1167. 1986.
127. Kocova N, Kowalczyk JR, Sandberg AA: Translocation 4:11 acute leukemia: three case reports and review of the literature. Cancer Genet Cytogenet 16:21, 1985.
128. Berger R, Bernheim A, Sigaux F, Daniel MT, Valensi F, Flandrin G: Acute monocytic leukemia; chromosome studies. Leuk Res 6:17, 1982.
129. Arthur DC, Bloomfield CD, Lindquist LL, Nesbit ME: Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance. Blood 59:96, 1982.
130. Parkin JL, Arthur DC, Abramson CS, McKenna RW, Kersey JH, Heideman RL, Brunning RD: Acute leukemia associated with the t(4;ll) chromosome rearrangement: ultrastructural and immunologie characteristics. Blood 60:1321, 1982.
131. Stong RC, Korsmeyer SJ, Parkin JL, Arthur DC, Kersey JH: Human acute leukemia cell line with the t(4;ll) chromosomal rearrangement exhibits B-lineage and monocytic characteristics. Blood 65:21, 1985.
132. Mirro J, Kitchingman G, Williams D, Lauzon GJ, Lin CC, Callihan T, Zipf TF: Clinical and laboratory characteristics of acute leukemia with the 4;11 translocation. Blood 67:689, 1986.
133. Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E: The t(4;ll) chromosome translocation of human acute leukemias fuses ALL-1 gene related to Drosophila trithorax, to the AF-4 gene. Cell 71:701, 1992.
134. Pui CH, Behm FG, Raimondi SC, Dodge RK, George SL, Rivera GK, Mirro J Jr, Kalwinsky DK, Dahl GV, Murphy SB, Crist WM, Williams DL: Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. N Engl J Med 321:136, 1989.
135. Archimbaud E, Charrin C, Guyotat D, Magaud JP, Gentilhomme O, Fiere D: Acute leukemia with t(4;l 1 ) in patients previously exposed to carcinogens. Br J Haematol 69:467, 1988.
136. Pittalluga S, Raffeld M, Lipford EH, Gosman J. 3A1/CD7 expression precedes Tβ gene rearrangement in precursor T (lymphoblastic) neoplasms. Blood 68:134, 1986.
137. Link M, Warnke R, Finlay J, Amylon M, Miller R, Dilley J, Levy R: A single monoclonal antibody identifies T-cell lineage of childhood lymphoid malignancies. Blood 62:722, 1983.
138. Sandrin MS, Vaughan HA, Levering KE, Kurnow K, Deacon NJ, McKenzie FC: Characterization of the gene coding for the human lymphocyte surface antigen HuLy-m2 (CD7). In Leucocyte Typing. III. White Cell Differentiation Antigens. Edited by AJ McMichael, PCL Beverley, S Cobold, MJ Crumpton, W Gilks, FM Gotch, C Millstain, D Spiegelhalter, H Waldmann. Oxford University Press, Oxford, 1987 p 216.
139. Zutter MM, Martin PJ, Hanke D, Kidd PG: CD7-acute nonlymphocytic leukemia: evidence for an early multipotential progenitor. Leuk Res 14:23, 1990.
140. Jensen AW, Hokland M, Jorgesen H, Justesen J, Ellegaard J, Hokland P: Solitary expression of CD7 among T-cell antigens in acute myeloid leukemia: identification of a group of patients with similar T-cell receptor and 5 rearrangements and course of disease suggestive of poor prognosis. Blood 78:1292, 1991.
141. Kita K, Miwa H, Nakase K, Kawakami K, Kobayashi T, Shirakawa S, Tanaka I, Ohta C, Tsutani H, Oguma S, Kyo T, Dohy H, Kamada N, Nasu K, Uchino H: Clinical importance of CD7 expression in acute myelocytic leukemia. Blood 81:2399, 1993.
142. Del Poeta G, Stasi R, Venditti A, Suppo G, Aronica G, Bruno A, Masi M, Tablio A, Papa G: Prognostic value of cell marker analysis in de novo acute myeloid leukemia. Leukemia 8:388, 1994.
143. Lo Coco F, De Rossi G, Pasqualetti D, Lopez M, Diverio D, Latagliata R, Fenu S, Mandelli F. CD7 positive acute myeloid leukemia: a subtype associated with cell immaturity. Br J Haematol 73:480, 1989.
144. Fenchel K, Bergmann L, Christ S, Weidmann E, Brieger J, Mitrou PS, Hoelzer D: Prognostic value of simultaneous expression of CD7 and CD33 on leukemic blasts in AML. Unfavourable outcome of patients with CD54+. Blood 82(suppl l):122a(abstract 473), 1993.
145. Del Poeta G, Stasi R, Venditti A, Cox C, Aronica G, Masi M, Bruno A, Simone MD, Buccisano F, Papa G: CD7 expression in acute myeloid leukemia: Leuk Lymph (in press).
146. Darbyshire PJ, Lilleyman JS: Granular acute lymphoblastic leukemia of childhood: a morphological phenomenon. J Clin Pathol 40:251, 1987.
147. Hay CRM, Barnett D, James V, Woodcock BW, Brown MJ, Lawrence ACK: Granular common acute lymphoblastic leukemia in adults: a morphological study. Eur J Haematol 39:299, 1987.
148. Takemori N, Saito N, Morioka M, Sakurada K, Miyazaki T: Peculiar cytoplasmic inclusions in acute lymphoblastic leukemia: cytochemical and electron microscopic observations. Am J Clin Pathol 83:527, 1985.
149. Takemori N, Saito N, Tachibana N, Miyazaki T: Peculiar cytoplasmic inclusions in cells of acute lymphoblastic leukemia. Am J Clin Pathol 86:262, 1986.
150. Invernizzi R, Rosanda C, Basso G, Conter V, Di Cataldo A, Fenu S, Forni M, Frappampina V, Granchi D, Locatelli F, Miano C, Santostasi T, Cantù-Rajnoldi A: Granular acute lymphoblastic leukemia in children. Haematologica 77:30, 1992.
151. Tauchi T, Ohyashiki K, Ohyashiki JH, Saito M, Nakazava S, Enomoto Y, Hosoda Y, Toyama K: Acute lymphoblastic leukemia with azurophilic granules that contain ultrastructural myeloperoxiadase activity. Am J Hematol 36:288, 1991.
152. Foà R, Baldini L, Cattoretti G, Foa P, Gobi L, Lauria F, Madon E, Masera G, Minière R, Paolucci P: Multimarker phenotypic characterization of adult and childhood acute lymphoblastic leukemia: an Italian multicenter study. Br J Haematol 61:251, 1985.
153. Cerezo L, Shuster JJ, Pullen DJ, Brock B, Borowitz MJ, Falletta JM, Crist WM, Head DR: Laboratory correlates and prognostic significance of granular acute lymphoblastic leukemia in children. A pédiatrie oncology group study. Am J Clin Pathol 95:526, 1991.
154. Schumacher HR, Perlin E, Miller WM, Stass SA: Hand-mirror-cell leukaemia. Lancet i:655, 1977.
155. Stass SA, Phillips TM, Weislow OS, Schumacher HR: Antigen-antibody complexes related to the baboon endogenous virus in humans with acute lymphoblastic leukemia-hand mirror variant (ALL-HMV). Blood 56:661, 1980.
156. Schumacher HR, Desai SN, McClain KL, Domenico DR, Dizikes GJ, Bird ML: Acute lymphoblastic leukemia-hand mirror variant. Analysis for endogenous retroviral antibodies in bone marrow plasma. Am J Clin Pathol 91:410, 1989.
157. Schumacher HR, Champion JE, Thomas WJ, Pitts LL, Stass SA: Acute lymphoblastic leukemia-hand mirror variant: an analysis of a large group of patients. Am J Hematol 7:11-17, 1979.
158. Schumacher HR, Rainey T, Davidson L, Champion JE, Thomas WJ, Pitts LL, Stass SA: American Burkitt's lymphoma-hand mirror variant. Am J Clin Pathol 70:937, 1978.
159. Kovarik P, Shrit MA, Yuen B, Radvany R, Schumacher HR: Hand mirror variant of acute lymphoblastic leukemia. Evidence of a mixed leukemia. Am J Clin Pathol 98:526, 1992.
160. Pui CH, Raimondi SC, Head DR, Schell MJ, Rivera GK, Mirro J Jr, Crist WM, Behm FG: Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and relapse. Blood 78:1327-1337, 1991.
161. Mazur EM, Wittels EG, Schiffman FJ, South K, Homer RJ: Hand mirror cell lymphoid leukemia in adults. A distinct clinicopathologic syndrome. Case report and literature review. Cancer 57:92, 1986.
162. Yumura-Yagi K, Hara J, Kurahashi H, Okamura J, Koizumi S, Toyoda Y, Murayama N, Inoue M, Ishihara S, Tawa A, Nishiura T, Kaneyama Y, Okada S, Kawa-Ha K: Clinical significance of CD7-positive stem cell leukemia. A distinct subtype of mixed-lineage leukemia. Cancer 68:2273, 1991.
163. Campana D, Hansen-Hagge TE, Matutes E, Coustan-Smith E, Yokota S, Shetty V, Bartram CR, Janossy G: Phenotypic, genotypic, cytochemical, and ultrastructural characterization of acute undifferentiated leukemia. Leukemia 4:620, 1990.
164. Buhring HJ, Ullrich A, Schaudt K, Muller CA, Busch FW: The product of the proto-oncogene c-Kit (p!45/{c-Kit}) is a human bone marrow surface antigen of hemopoietic precursor cells which is expressed on a subset of acute nonlymphoblastic leukemic cells. Leukemia 5:854, 1991.
165. Gale RP, Ben-Bassat I: Hybrid acute leukemia. Br J Haematol 65:261, 1987.
166. Lo Coco F: Hybrid phenotypes and lineage promiscuity in acute leukemia. Haematologica 76:215, 1991.
167. Stass SA, Mirro J Jr: Lineage heterogeneity in acute leukemia: acute mixed-lineage leukemia and lineage switch. Clin Haematol 15:811, 1986.
168. Greaves MF, Chan LC, Furley AJW, Watt SM, Molgaard HV: Lineage promiscuity in hemopoietic differentiation and leukemia. Blood 67:1, 1986.
169. Bradstock KF, Kirk J, Grimsley PG, Kabral A, Hughes WG: Unusual immunophenotypes in acute leukaemias: incidence and clinical correlations. Br J Haematol 75:512-518, 1989.
170. Lo Coco F, Pasqualetti D, Lopez M: Immunophenotyping of acute leukemia: relevance of analyzing different lineage-associated markers. Blut 58:235-239, 1989.
171. Terstappen LWMM, Stafford M, Konemann S: Flow cytometric characterization of acute myeloid leukemia. Part II. Phenotypic heterogeneity at diagnosis. Leukemia 5:757-764, 1991.
172. Del Vecchio L, Schiavone EM, Ferrara F, Pace E, Lo Pardo C, Pacetti M, Russo M, Cirillo D, Vacca C: Immunodiagnosis of acute leukemia displaying ectopic antigens: proposal for a classification of promiscous phenotypes. Am J Hematol 31:173, 1989.
173. Childs CC, Hirsh-Ginsberg C, Walters RS, Andersson BS, Reuben J, Trujillo JM, Cork A, Stass SA, Freireich Ei, Zipf TF: Myeloid surface antigen-positive acute lymphoblastic leukemia (My+ ALL): immunophenotypic, ultrastructural, cytogenetic, and molecular characteristics. Leukemia 3:777-786, 1989.
174. Sobol RE, Mick R, Royston I, Davey FR, Ellison RR, Newman R, Cuttner J, Griffin JD, Collins H, Nelson DA, Bloomfield CD: Clinical importance of myeloid antigen expression in adult lymphoblastic leukemia. N Engl J Med 316:1111-1115, 1987.
175. Hayashi Y, Sugita K, Nakazawa S, Abe T, Kojima S, Inaba T, Hanada R, Yamamoto K: Karyotypic patterns in acute mixed-lineage leukemia. Leukemia 4:121-127, 1990.
176. Westbrook CA, Keinanen MJ: Myeloid malignancies and chromosome 5 deletions. Bailliere's Clin Haematol 5:931-942, 1992.
177. Mirro J, Kitchingman GR: The morphology, cytochemistry, molecular characteristics and clinical significance of acute mixed-lineage leukemia. In Leukemia Cytochemistry: Principles and Practice. Edited by CS Scott. Ellis Horwood Chichester, 1989.
178. Catovsky D, Matutes E, Buccheri V, Shetty V, Hanslip J, Yoshida N, Morilla R: A classification of acute leukemia for the 1990s. Ann Hematol 62:16, 1991.
179. Catovsky D, Matutes E: The classification of acute leukemia. Leukemia 6 (suppl 2):1, 1992.
180. Buccheri V, Mihaljevic B, Matutes E, Dyer MJ, Mason DY, Catovsky D: mb-1 : a new marker for B-lineage lymphoblastic leukemia. Blood 82:853, 1993.
181. Hirsch-Ginsberg C, Childs C, Chang KS, Beran M, Cork A, Reuben J, Freireich EJ, Chang LC, Bollum FJ, Trujillo J, Stass S: Phenotypic and molecular heterogeneity in Philadelphia chromosome-positive acute leukemia. Blood 71:186, 1988.
182. Dotier H, Arthur DC, Ball ED, Sobel RE, Davey FR, Lawrence D, Gordon L, Patil SR, Surana RB, Testa JR, Verma RS, Schiffer CA, Wurster-Hill DH, Bloomfield CD: Trisomy 13: a new recurring chromosome abnormality in acute leukemia. Blood 76:1614, 1990.
183. Hayashi Y, Pui CH, Behm FG, Fuchs AH, Raimondi SC, Kitchingman GR, Mirro J Jr, Williams DL: 14q32 translocations are associated with mixed-lineage expression in childhood acute leukemia. Blood 76: 150-156, 1990.
184. Fohlmeister I, Fischer R, Modder B: Aplastic anemia and the hypocellular myelodysplasias: histomorphological diagnosis and prognostic features. J Clin Pathol 39:1218-1226, 1985.
185. Appelbaum FR, Barrall J, Storb R, Ramberg R, Doney K, Sale GE, Thomas DE: Clonal cytogenetic abnormalities in patients with otherwise typical aplastic anemia. Exp Hematol 15:1134, 1987.
186. Matloub YH, Brunning RD, Arthur DC, Ramsay NK: Severe aplastic anemia preceding acute lymphoblastic anemia. Cancer 71:264, 1993.
187. Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H: Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to drosophila segmentation, runt. Blood 80:1825, 1992.
188. Kakizuka A, Miller WH, Umesono K, Warrel RP Jr, Frankel SR, Murty VV, Dmitrovsky E, Evans RM: Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARot with a novel putative transcription factor cPML. Cell 66:663, 1991.
189. Chen SJ, Zelent A, Tong JH, Yu HQ, Wang ZY, Derre J, Berger R, Waxman S, Chen Z: Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(ll;17)(q23;q21) in a patient with acute promyelocytic leukemia. J Clin Invest 91:2260, 1993.
190. Lai JL, Zandecki M, Jouet JP, Savery JB, Lambiloutte A, Bauters F, Cosson A, Deminatti M: Three cases of translocation (8;16)(pll;p13) observed in acute myelomonocytic leukemia: a new specific subgroup? Cancer Gen Cytogenet 27:101, 1987.
191. Carrol A, Civin C, Schneider N, Dabi G, Pappo A, Bowman P, Emami A, Gross S, Alvarado C, Phillips C, Krischer J, Crist W, Head D, Gresik M, Ravindranath Y, Weinstein M: The t(1;22)(p13;q13) is nonrandom and restricted to infants with acute megakaryoblastic leukemia: a Pédiatrie Oncology Group Study. Blood 78:748, 1991.
192. Taub R, Kirsh I, Morton C: Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmocytoma cells. Proc Natl Acad Sci USA 79:7837, 1982.
193. Croce CM, Theirfelder W, Erikson J: Transcriptional activation of an unarranged and untranslocated c-myc oncogene by translocation of a CX locus in Burkitt's lymphoma cells. Proc Natl Acad Sci USA 80:6922, 1983.
194. Erikson J, Nishikura K, ar-Rushdi A: Translocation of an immunoglobulin K locus to a region 3' of an unarranged c-myc oncogene enhances c-myc transcription. Proc Natl Acad Sci USA 80:7581, 1983.
195. Withers DA, Harvey RC, Faust JB, Melnik O, Carey K, Meeker TC: Characterization of a candidate bcl-1 gene. Mol Cell Biol 11:4846, 1991.
196. Ohno H, Takimoto G, McKeithan TW: The candidate proto-oncogene bel-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 60:991, 1990.
197. Kamps MP, Murre C, Sun XH: A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60:547, 1990.
198. Nourse J, Mellentin D, Galili N: Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60:535, 1990.
199. Apian PD, Raimondi SC, Kirsh IR: Disruption of the SCL gene by a t(l;3) translocation in a patient with T-cell acute lymphoblastic leukemia. J Exp Med 176:1303, 1992.
200. Fitzgerald TJ, Neale GAM, Raimondi SC, Goorha RM: c-tal, a helix-loop-helix protein, is juxtaposed to the T-cell receptor- chain gene by a reciprocal chromosomal translocation: t(l;7)(p32;q35). Blood 78:2686, 1991.
201. Tycko B, Smith SD, Sklar J: Chromosomal translocations joining LCK and TCR loci in human T-cell leukemia. J Exp Med 174:867, 1991.
202. Apian PD, Lombardi DP, Kirsh IR: Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia. Mol Cell Biol 11:5462, 1991.
203. Brown L, Cheng JT, Cheng Q: Site-specific recombinations of the tal-I gene is a common occurrence in human T-cell leukemia. EMBO J 9:3343, 1990.
204. Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J: TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649, 1991.
205. Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH: HOX11, a homeobox containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci USA 88:8900, 1991.
206. Mellentin JD, Smith SD, Cleary ML: Lyl-1, a novel gene altered by chromosomal translocation in T-cell leukemia codes for a protein with a helix-loop-helix DNA-binding motif. Cell 58:77, 1989.
207. Erikson J, Finger L, Sun L: Deregulation of c-myc by translocation of the a-locus of the T-cell receptor in Tcell leukemias. Science 232:884, 1986.
208. Kasai M, Maziart RT, Aoki K, Macintyre E, Strominger JL: Molecular involvement of the pvt-I locus in a y/8 T-cell leukemia bearing a variant t(8;14)(ql4;qll) translocation. Mol Cell Biol 12:4751, 1992.
209. Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ: Deregulation of a homeobox gene, HOX1I, by the t(10;14) in T-cell leukemia. Science 253:79, 1991.
210. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH: The rhombotin family of cysteine-rich LIMdomain oncogenes: distinct members are involved in T-cell translocations to human chromosomes llplS and Ilpl3. Proc Natl Acad Sci USA 88:4367, 1991.
211. Royer-Pokora B, Loos U, Ludwig WD: TTG-2, a new gene encoding a cysteine-rich protein with LIM motif, is overexpressed in acute T-cell leukemia with the t(ll;14)(pl3;qll). Oncogene 6:1887, 1991.
212. McGuire EA, Hockett RD, Pollock KM: The t(ll;14)(pl5;qll) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol Cell Biol 9:2124, 1989.
213. De Klein A, van Vessel AG, Grosveld G: A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukemia. Nature 300:765, 1982.
214. Groffen J, Stephenson JR, Heisterkamp N: Philadelphia chromosomal breakpoints are clustered within a limited region, her. on chromosome 22. Cell 36:93. 1984.
215. Rubin CM, Larson RA, Anastasi J, Winter JN, Thangavelu M, Vardiman JW, Rowley JD, Le Beau MM: t(3;21)(q26;q22):a recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia. Blood 76:2594, 1990.
216. Nucifora G, Begy CR, Kobayashy H, Roulston D. Claxton D, Pedersen-Bjergaard J, Parganas E. Ihle JN, Rowley JD: Consistent intergenic splicing and production of multiple transcripts between AMU at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations. Proc Natl Acad Sci USA 91:4004, 1994.