Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer

American Journal of Human Genetics

Volumn 59, Issue 6, 1996, Pages 1243-1251

  Moisio, Anu Liisa ^b   Sistonen, Pertti ^b   Weissenbach, Jean ^b   De La Chapelle, Albert ^b   Peltomäki, Päivi ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; AGE; ALLELE; ARTICLE; CLINICAL ARTICLE; COLON CANCER; CONTROLLED STUDY; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENE MUTATION; GENETIC DISTANCE; GENOTYPE; HAPLOTYPE; HUMAN; PEDIGREE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADULT; AGE FACTORS; AGE OF ONSET; CHROMOSOME MAPPING; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA REPAIR; DNA, SATELLITE; FINLAND; GENETIC MARKERS; GENETICS, POPULATION; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MIDDLE AGED; PEDIGREE;

EID: 0029851496     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Aaltonen LA, Sankila R, Mecklin J-P, Järvinen H, Pukkala E, Peltomäki P, de la Chapelle A (1994) A novel approach to estimate the proportion of hereditary non-polyposis colorectal cancer of total colorectal cancer burden. Cancer Detect Prev 18:57-63
2. Aarnio M, Mecklin J-P, Aaltonen LA, Nyström-Lahti M, Järvinen H ( 1995) Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer 64:430-433
3. Boehnke M, Lange K, Cox DR (1991) Statistical methods for multipoint radiation hybrid mapping. Am J Hum Genet 49: 1174-1188
4. Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, Kane M, et al (1994) Mutation in the DNA mismatch repair gene homologue hMLHl is associated with hereditary non-polyposis colon cancer. Nature 368:258-261
5. Cox DR, Burmeister M, Price ER, Kim S, Myers RM (1990) Radiation hybrid mapping: A somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Science 250:245-250