Lymphoma-selective antibody Lym-1 recognizes a discontinuous epitope on the light chain of HLA-DR10

Cancer Immunology Immunotherapy

Volumn 43, Issue 1, 1996, Pages 26-30

  Rose, Larry M ^a   Gunasekera, Angelo H ^a,c   DeNardo, Sally J ^b   DeNardo, Gerald L ^b   Meares, Claude F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ABBOTT DIAGNOSTICS   (United States)

Author keywords

B cell lymphocytic cancer antigen; HLA DR10; Lym 1; Radioimmunotherapy; Tumor selective antibodies

Indexed keywords

EPITOPE; HLA DR ANTIGEN; LYM 1 ANTIGEN; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; BLOTTING, WESTERN; BURKITT LYMPHOMA; EPITOPES; HAPLOTYPES; HLA-DR ANTIGENS; HUMANS; LYMPHOMA; MOLECULAR SEQUENCE DATA;

EID: 0029851182     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050299     Document Type: Article

References (19)

1. DeNardo GL (1995) The next generation of imaging and therapeutic agents for lymphoma and chronic lymphocytic leukemia. New Perspect Cancer Diagn Manage 3: 76
2. 131I-Lym-1. Cancer Res 50: 1014s
3. 131I Lym-1 monoclonal antibodies. Int J Cancer [Suppl] 3: 96s
4. Epstein AL, Marder RJ, Winter JN, Stathopoulos E, Chen FM, Parker JW, Taylor CR (1987) Two new monoclonal antibodies, Lym-1 and Lym-2, reactive with human B-lymphocytes and derived tumors, with immunodiagnostic and immunotherapeutic potential. Cancer Res 47: 830
5. Gorga JC, Horejsi V, Johnson DR, Raghupathy R, Strominger JL (1987) Purification and characterization of class II histocompatibility antigens from homozygous human B cell line. J Biol Chem 262: 16087
6. Gregersen PK, Silver J, Winchester RJ (1987) The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30: 1205
7. Greiner DP, Hughes KA, Gunasekera AH, Meares CF (1996) Binding of the sigma-70 protein to the core subunits of Escherichia coli RNA polymerase, studied by iron-EDTA protein footprinting. Proc Nat Acad Sci USA 93: 71
8. Gustafsson K, Wiman K, Emmoth E, Larhammar D, Bohme J, Hylig NJ, Ronne H, Peterson PA, Rask L (1984) Mutation and selection in the generation of class II histocompatibility antigen polymorphism. FMBO J 3: 1655
9. Hu E, Epstein AL, Naeve GS, Gill I, Martin S, Sherrod A, Nichols P, Chen D, Mazumder, Levine AM (1989) A phase 1a clinical trial of Lym-1 monoclonal antibody serotherapy in patients with refractory B cell malignancies. Hematol Oncol 7: 155
10. Lechler RI, Simpson E, Bach F (1995) Major and minor histocompatibility antigens: an introduction. In: Bach F, Auchincloss H (ed) Transplantation immunology. Wiley-Liss, New York, pp 1-34
11. Marsh SG, Bodmer JG (1989) HLA-DR and -DQ epitopes and monoclonal antibody specificity. Immunol Today 10: 305
12. Marsh SGE, Bodmer JG (1995) HLA class II region nucleotide sequences. Tissue Antigens 46: 258
13. 2 locus and as the probable site encoding a polymorphic MHC class II epitope. J Immunol 140: 2447
14. Merrynian P, Silver J, Gregersen PK, Solomon G, Winchester RA (1989) Novel association of DQα and DQβ genes in the DRw10 haplotype. Determination of a DQw1 specificity by the DQ β-chain. J Immunol 143: 2068
15. Ollier W, Thomson W (1992) Population genetics of rheumatoid arthritis. Rheum Dis Clin North Am 18: 741
16. Pistillo MP, Sun PF, Mantero S, Ferrara GB (1993) Shared epitopes of the HLA-DR10 molecule recognized by murine and human mAbs. Eur J Immunogenet 20: 111
17. So A (1993) Genetics, polymorphism and regulation of expression of HLA region genes. In: Lechler R (ed) HLA and disease. Academic Press, London, p 18
18. Towbin H, Staelhelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 79: 4350
19. Tsuji K, Aizawa M, Sasazuki T (eds) (1992) The proceedings of the 11th International Histocompatibility Workshop: HLA 1991. Oxford University Press, New York