Pharmacological evaluation of prazosin- and doxazosin-related compounds with modified piperazine ring

Arzneimittel-Forschung/Drug Research

Volumn 46, Issue 11, 1996, Pages 1054-1059

  Giardinà, Dario ^a   Crucianelli, Mauro ^a   Marucci, Gabriella ^a   Melchiorre, Carlo ^b   Polidori, Carlo ^a   Pompei, Pierluigi ^a   Massi, Maurizio ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

1 adrenoceptor antagonists; antihypertensives; CAS 19216 56 9; CAS 74191 85 8; doxazosin analogues, antihypertensive effects, synthesis; prazosin analogues, antihypertensive effects, synthesis

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; COCAINE; DOXAZOSIN; DOXAZOSIN DERIVATIVE; NORADRENALIN; PIPERAZINE DERIVATIVE; PRAZOSIN; PRAZOSIN DERIVATIVE; PROPRANOLOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SYNTHESIS; INTRAGASTRIC DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; SMOOTH MUSCLE CONTRACTILITY; SPONTANEOUSLY HYPERTENSIVE RAT; STRUCTURE ACTIVITY RELATION; VAS DEFERENS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BLOOD PRESSURE; DOXAZOSIN; INJECTIONS, INTRAPERITONEAL; INTUBATION, GASTROINTESTINAL; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PRAZOSIN; RATS; RATS, INBRED SHR;

EID: 0029851139     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Cavero, I., Roach, A. G., Life Sci. 27, 1525 (1980)
2. Langer, S. Z., Cavero, I., Massingham, R., Hypertension (Dallas) 2, 372 (1980)
3. Davey, M. J., J. Cardiovasc. Pharmacol. 2, 287 (1980)
4. Campbell, S. F., Davey, M. J., Hardstone, J. D. et al., J. Med. Chem. 30, 49 (1987)
5. Alabaster, V. A., Davey, M. J., Br. J. Clin. Pharmacol. 21 (Suppl. 1), 9S (1986)
6. Stokes, G. S., in: Handbook of Hypertension. Clinical Pharmacology of Antihypertensive Drugs, A. E., Doyle, (e.d.), Vol. 11, pp. 382-409, Elsevier Science, Amsterdam-New York (1988)
7. Colucci, W. S., Ann. Intern. Med. 97, 67 (1982)
8. Young, R. A., Brogden, R. N., Drugs 35, 525 (1988)
9. Lund-Johansen, P., Hjermann, I., Iversen, B. M. et al., Cardiology 83, 150 (1993)
10. Smyth, P., Pringle, S., Jackson, G. et al., Eur. J. Clin. Pharmacol. 34, 613 (1988)
11. Humphreys, J. E., Waite, M. A., J. Clin. Pharm. Ther. 14, 263 (1989)
12. Talseth, T., Westlie, L., Daae, L., Am. Heart J. 121, 280 (1991)
13. Kowala, M. C., Nicolosi, R. J., J. Cardiovasc. Pharmacol. 13 (Suppl.), 45 (1989)
14. Kowala, M. C., Nunnari, J. J., Duham, S. K. et al., Atherosclerosis 91, 35 (1991)
15. Giardinà, D., Brasili, L., Gregori, M. et al., J. Med. Chem. 32, 50 (1989)
16. Giardinà, D., Gulini, U., Massi, M. et al., J. Med. Chem. 36, 690 (1993)
17. Babamoto, K. S., Hirokama, W. T., Clin. Pharm. 11, 415 (1992)
18. Chapleo, C. B., Davis, J. A., Myers, P. L. et al., J. Heterocyclic Chem. 21, 77 (1984)
19. Koo, J., Avakian, S., Martin, G. J., J. Am. Chem. Soc. 77, 5374 (1955)
20. Althuis, T. H., Hess, H. J., J. Med. Chem. 20, 146 (1977)
21. Melchiorre, C., Brasili, L., Giardinà, D. et al., J. Med. Chem. 27, 1535 (1984)
22. Furchgott, R. F., in: Handbook of Experimental Pharmacology, H., Blanschko, E., Muscholl (eds.), Vol. 33, pp. 283-335, Springer, Berlin (1972)
23. Arunlakshana, O., Schild, H. O., Br. J. Pharmacol. 14, 48 (1959)
24. Tallarida, R. J., Murray, R. B., Manual of Pharmacologic Calculations with Computer Programs, Springer-Verlag New York (1987)
25. Drew, G. M., Eur. J. Pharmacol. 42, 123 (1977)
26. Doxey, J. C., Smith, C. F. C., Walker, J. M., Br. J. Pharmacol. 60, 91 (1977)
27. van Rossum, J. M., Arch. Int. Pharmacodyn. 143, 299 (1963)
28. Vincent, J., Meredith, P. A., Reid, J. L. et al., Clin. Pharmacokinet. 10, 144 (1985)
29. Larochelle, P., Du Sonich, P., Hamet, P. et al., Hypertension 4, 93 (1982)