Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. IV. Synthesis and pharmacological evaluation of the oxidation products of (-)-(R)-5-[(1- methyl-1H-indol-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride (YM060: Ramosetron)

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 9, 1996, Pages 1717-1722

  Ohta, Mitsuaki ^a   Suzuki, Takeshi ^a   Nagashima, Shinya ^a   Tokunaga, Tatsuhiro ^a   Miyata, Keiji ^a   Mase, Toshiyasu ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

4,5,6,7 tetrahydro 1H benzimidazole; 5 hydroxytryptamine receptor antagonist; degradation product; metabolite; YM060 (ramosetron)

Indexed keywords

4 HYDROXY 6 [(1 METHYL 1H INDOL 3 YL)CARBONYL] 4,5,6,7 TETRAHYDRO 1H BENZIMIDAZOLE; ONDANSETRON; RAMOSETRON; SEROTONIN; SEROTONIN 3 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; GUINEA PIG; INTESTINE MOTILITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NAUSEA; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; STEREOCHEMISTRY; VOMITING;

EID: 0029851014     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.1717     Document Type: Article

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