Identification and purification of a hemoglobin-binding outer membrane protein from Neisseria gonorrhoeae

Infection and Immunity

Volumn 64, Issue 12, 1996, Pages 5008-5014

  Chen, Ching Ju ^a   Sparling, P Frederick ^a   Lewis, Lisa A ^b   Dyer, David W ^b   Elkins, Christopher ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HAPTOGLOBIN; HEMOGLOBIN; IRON; OUTER MEMBRANE PROTEIN; RECEPTOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL OUTER MEMBRANE; NEISSERIA GONORRHOEAE; NEISSERIA MENINGITIDIS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PURIFICATION;

EID: 0029850699     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.12.5008-5014.1996     Document Type: Article

References (43)

1. Aplcella. M, A., M, Shero, G. A. Jarvis, J. M. Grifflss, R. E. Mandrell, and H. Schneider. 1987, Phenotypic variation in epitope expression of the Neisseria gunorrhoeae lipooligosaccharide. Infect. Immun. 55:1755-1761.
2. Beucher, M., and P. F. Sparling. 1995. Cloning, sequencing, and characterization of the gene encoding FrpB, a major iron-regulated, outer membrane protein of Neisseria gonorrhoeae. J. Bacteriol, 177:2041-2049.
3. Bezkorovalny. A., 1987. Iron proteins, p. 27-67. In J. J. Bullen and E. Griffiths (ed.), Iron and infection: molecular, physiological and clinical aspects. John Wiley & Sons, New York.
4. Blswas, G. D., T. Sox, E, Blackman, and P, F. Sparling. 1977. Factors affecting genetic transformation of Neisstria gonorrhoeae. J. Bacteriol. 129: 983-992.
5. Blswas, G. D., and P, F. Sparling. 1995, Characterization of IhpA, the structural gene for a lactoferrin receptor in Neisseria gonorrhoeae. Infect. Immun. 63:2958-2907.
6. Blunton. K. J., G. D, Biswas, J. Tsal, J, Adams, D. W. Dyer, S. M. Davis, G. G. Koch, P. K. Sen, and P. F. Sparllng. 1990. Genetic evidence that Neisseria gaiiurrlioeat produces specific receptors for transferrin and lactoferrin. J. Bacteriol. 172:5225-5235.
7. Brinlon, C. C, S, W. Wood, A. Brown, A. M. Labik, J. R. Bryan, W. Lee, S. E. Polen, E. C. Tramant, J. Sadoff, and W. Zollinger. 1982. The development of a neisscrial pilus vaceine for gonorrhea and meningococcal meningitidis, p. 140-159. In L. Weinstein and B. N. Fields (ed.). Seminars in infectious disease. thieme-Stralion, New York.
8. Cornelissen, C. N., G. U. Biswas, J. Tsai, D. K. Panichuri, S. A. Thompson, and P. F, Sparling. 1992. Gonococcal transferrin-hinding protein 1 is required for transferrin utilization and is homologous to TonB-dependent outer membrane receptors. J. Bacteriol. 174:5788-5797.
9. Cornelissen, C. N., and P. F. Sparling, 1994. Iron piracy: acquisition of iranslcrrin-bound iron by bacterial pathogens. Mol. Microbml. 14:843-850.
10. Danaber, R. J., J. C. Levin, D. Arklng, C, L. Burch, R, Sandlln, and D. C, Stein. 1995. Genetic basis of Neisseria gonorrhoeae lipooligosaceburide antigenie variation. J. Bacteriol. 177:7275-7279,
11. Desai, P. J., K. Nzeribe, and C. A. Genco, 1995, Binding and accumulation of hemin in Neisseria ganmrhaeae. Infect. Immun. 63:4634-4641.
12. Dyer, D. W., E. P. West, and P.F. Sparling, 1987. Effects of serum carrier proteins on the growth of pathogenic neisseriae with heme-bound iron. Infect. Immun. 55:2171-2175.
13. Elklns, C. 1995. Identification and purification of a conserved heme-regu- lated hemoglobin-binding outer membrane protein from Haenophilus du- crayi. Infect. Immun. 63:1241-1245.
14. Elklns. C., C. J. Chen. and C. E. Thomas. 1995. Characterization of the ligbA locus encoding a henoglohin receptor from Haemophilus ducreyi Infect. Immun. 63:2194-2200.
15. Gotschlich, E. C. 1994. Genetic locus for the biosynthesis of the variable portion of Neisseria gonorrhoeae lipoolignsaccharide. J. Fxp. Med. 180:2181-2190.
16. Hagblom, P., K. Segal, E. Billyard, and M. So. 1985. Inlragenie rccnmhination leads to pilus antigenic variation in Neisseria gonorrhoeae. Nature (London) 315:156-158.
17. Harlow. E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor. N.Y.
18. Jonssin, A. B., M. Rahman, and S. Normark. 1995. Pilus biogenesis gene. PilC, of Neisseria gonorrhoeae; pilC l and pilC 2 arc each pan of a larger duplication of the gonococcal genome and share upstream and downstream homologous sequences with opa and pit loci. Microbiology 141:2367-2377.
19. Kellogg, D. S., Jr., W. L. Peacock, Jr., W. E. Deacon, L. Brown, and C. I. Pirkle, 1963. Neisseria gonorrhoeae. 1. Virulence genetically linked to clonal variation. J. Bacteriol. 85:1274-1279.
20. Lee, B. C. 1992. Isolation of haemin-hinding proteins of Neisseria gonorrhtoeae, J. Med. Microbiol. 36:121-127.
21. Lee, B. C. 1995. Quelling the red menace: haem capture hy bacteria, Mol. Microbiol. 18:383-390),
22. Lee, B. C., and L. E, Bryan. 1989. Identification and comparative analysis of the lactoferrin and transferrin receptors among clinical isolates of gonocoeci. J, Med. Microbiol. 28:199-204.
23. Lee, B. C., and P, Hill, 1992. Identification of an outer-membrane haemoglobin-binding protein in Neisseria meningitidis. J. Gen. Microbiol. 138:2647-2656.
24. Lewis, L. A., and D, W, Dyer. 1993. Identification of an iron-regulated outer membrane protein of Neisseria menintgitidis involved in the utilization of hemoglobin complexed to haptoglobin. J. Bacleriol. 177:1299-1306.
25. Lewis, L. A., and D, W. Dyer. 1995. Personal communication.
26. Mayer, L. W, 1982. Rates of in vitro changes in gonococcal colony opacity phenotypes. Infect. Immun. 37:481-485.
27. McKenna, W. R., P. A. Mickelsen, P. F. Sparling, and D. W, Dyer. 1988. Iron uptake from lactoferrin and transferrir by Neisseria gonorrhoeae. Infect. Immun. 56:785-791.
28. Meyer, T. F., N. Mlawer, and M. So, 1982. Pilus expression in Neissseria gonorrhoeas involves chromosomal rearrangement. Cell 30:45-52.
29. Miekelsen, P. A., E. Blackman, and P. F. Sparling. I982. Ability of Neisseria gonorrhoeae, Neisseria meningitidis, and commensal Neisseria species to obtain iron from lactoferrin. Infect. Immun. 35:915-920.
30. Mickelsen, P. A., and P. F. Sparling. 1981. Ability of Neisseria gonorrhoeae, Neisseria meniaglidis, and commensal Neisseria species to obtain iron from transferrin and iron compounds. Infect. Immun. 33:555-564.
31. Muller-Eberhard, U 1970. Hemopexin. N. Engl. J. Med 283:1090-1094.
32. Nachamkln,I., J.G.Cannon, and R. S. Mittler. 1981. Monoclonal antibodies against Neisseria gonorrhoeae production of antibodies directed against a strain-specific cell surface antigen. Infect, immun. 33:555-564.
33. Otto, B. R., A. M. J. J. Verwell van Vught, and D. M. MacLaren, 1992 Trunferrins and heme-compounds as iron sources for pathogenic haeteria Crit. Rev. Microbiol. 18:217-233.
34. Rufe, J, M., T. Abdullah, S. P. Singh, V. I. Kalve, and P. E. Klebba. 1991 Evolution of the ferric enterohactin receptor in gram-negative bicteria J Bacteriol. 173:5964-5974.
35. Seifert, H. S., M. So, and F, Heffron. 1986. Shuttle mutagenesis: a method of introducing transposons into transformable organisms, p. 123-134. In A. Hollaender and J. K. Setlow (ed,). Gonelic engineering, principles and methods. Plenum, New York.
36. Stern, A., M. Bruwn, P. Nickel, and T. F. Meyer, 1986. Opacity genes in Neisseria gonorrhoeae. control of phase and antigenic variation. Cell 47:61-71.
37. Stojujkovle. I., V. Hwa, L. de Saint Martin, P. O'Gaora. X, Nasslf, F. Heffron, and M. So. 1995. The Neinaeria meningitidis hemoglobin receptor: its role in iron utilization and virulence. Mol. Microbiol. 15:531-541.
38. Stojiljkovic, I., J. Larson, V. Hwa, S. Anie, and M, So. 1996. HmbR outer membrane receptors of pathogenic Nelsseria spp.: iron-regulated, hemoglobin-binding protein with a high level of primary structure conservation. J. Bacteriol, 178:4670-4678.
39. Thompson, S, A., L. L. Wang, A. West, and P. F. Sparling. 1993. Neisseria meninllidis produces iron-regulated proteins related to the RTX family of exoproteins. J, Bacleriol. 175:811-818.
40. Trees, D., and J. G. Cannon. Unpublished data.
41. Weinberg, E. D. 1978. Iron and infection Microbiol. Rev. 42:45-66.
42. West, S. E. H., and P. F. Sparling. 1985. Response of Neisseria gonorrhoeae to iron limitation: alterations in expression of membrane proteins without apparent siderophore production. Infect. Immun. 47:388-394.
43. West, S. E. H., and P. F. Sparling. 1987. Acrobaction utilization by Neisseria gonorrhoeae and cloning of a genomic DNA fragment thal complements Eseherichua coli fluB mutations. J. Bactoriol, 169:3414-3421.