The effects of clonidine on blood pressure, catecholamine and growth hormone release in hypogonadal men is preserved and not influenced by testosterone replacement therapy

Journal of Endocrinological Investigation

Volumn 19, Issue 8, 1996, Pages 505-510

  Del Rio, G ^a   Carani, C ^a   Velardo, A ^a   Procopio, M ^b   Zizzo, G ^a   Savio, P ^b   Mantovani, R ^a   Marrama, P ^a   Ghigo, E ^b,c  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c Ospedale Mclinette   (Italy)

Author keywords

Blood pressure; Catecholamines; Clonidine; GH; Male hypogonadism; Testosterone therapy

Indexed keywords

ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; CATECHOLAMINE; CLONIDINE; GROWTH HORMONE; NORADRENALIN; SOMATOMEDIN C; TESTOSTERONE; TESTOSTERONE ENANTATE; TESTOSTERONE PROPIONATE;

ADULT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE MEASUREMENT; CASTRATION; CATECHOLAMINE RELEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; GROWTH HORMONE RELEASE; HORMONE SUBSTITUTION; HUMAN; HYPOGONADISM; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NORADRENERGIC SYSTEM; ORAL DRUG ADMINISTRATION; PULSE RATE; SYSTOLIC BLOOD PRESSURE;

EID: 0029850664     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03349008     Document Type: Article

References (39)

1. Goldfien A. Adrenal medulla. In: Greenspan F.S. (Ed.), Basic and clinical endocrinology. Appleton & Lange, Norwalk, 1991, p. 380.
2. Müller E.E., Nisticò G. Neurotransmitter regulation of the anterior pituitary. In: Müller E.E., Nisticò G. (Eds.), Brain Messengers and the Pituitary. Academic Press, San Diego, 1989, p. 404.
3. Ghigo E. Neurotransmitter control of growth hormone secretion. In: De la Cruz L.F. (Ed.), Regulation of growth hormone and somatic growth. Elsevier Science Publishers, Amsterdam, 1992, p.103.
4. Kobinger W. Central alpha-adrenergic systems as targets for hypotensive drugs. Rev. Physiol. Biochem. Pharmacol. 81: 39, 1978.
5. Starke K., Montel H. Involvement of alpha-receptors in clonidine-induced inhibition of transmitter release from central monoamine neurons. Neuropharmacology 12: 1073, 1973.
6. Wolf D.L., Mohrland J.S. Lateral reticular formation as a site for morphine and clonidine-induced hypotension. Eur. J. Pharmacol. 98: 93, 1984.
7. vanZwietien P.A.V. Overview of alpha2-adrenoreceptor agonists with a central action. Am. J. Cardiol. 57. 3E, 1986.
8. Agnati L.F., Fuxe K., Andersson K., Eneroth P., Gustafsson J.A. Estrogen induced increases of high affinity and especially low affinity 3-H-clonidine binding sites in the amygdaloid-entorinal cortex of the ovariectomized rat. Neuroendocrinol. Lett. 2: 249, 1980.
9. Johnson A.E., Nock B., Mc Ewen B.S., Feder H.H. Alpha1- and alpha2-noradrenergic receptor binding in guinea pig brain: sex differences and effects of ovarian steroids. Brain Res. 442: 205, 1988.
10. Fischer G.M., Swain M.L. Effect of sex hormones on blood pressure and vascular connective tissue in castrated and noncastrated male rat. Am. J. Physiol. 232: H617, 1977.
11. Jansson J.O., Eden S., Isaksson O. Sexual dimorphism in the control of growth hormone secretion. Endocr. Rev. 13: 128, 1985.
12. Conway S., Moherek R., Mauceri H., Richardson L. Sexually dimorphic characteristics of clonidine-induced growth hormone release and autofeedback. Endocrinology 125: 2475, 1989.
13. Jansson J.O., Eriksson E., Eden E., Modigh K. Effects of gonadectomy and testosterone replacement on growth hormone responses to alpha2-adrenergic stimulation in male rat. Psychoneuroendocrinology 7: 245, 1982.
14. Amiel S.A., Maran A., Powrie J.K., Umpleby A.M., Macdonald I.A. Gender differences in counterregulation to hypoglycemia. Diabetologia 36: 460, 1993.
15. Davidson L., Vandogen R., Rouse I.L., Beilin L.J., Tunney A. Sex-related differences in resting and stimulated plasma noradrenaline and adrenaline. Clin. Sci. 67: 347, 1984.
16. Gustafson A.B., Kalkhoff R.K. Influence of sex and obesity on plasma catecholamine response to isometric excercise. J. Clin. Endocrinol. Metab. 55: 703, 1982.
17. Del Rio G., Velardo A., Zizzo G., Marrama P., Della Casa L. Sex differences in catecholamine response to clonidine. Int. J. Obesity 17: 465, 1993.
18. Wehrenberg W.B., Giustina A. Basic counterpoint: Mechanisms and pathways of gonadal steroid modulation of growth hormone secretion. Endocr. Rev. 13: 299, 1992.
19. Kerrigan J.R., Rogol A.D. The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence. Endocr. Rev. 13: 281, 1992.
20. Del Rio G., Velardo A., Zizzo G., Avogaro A., Cipolli C., Della Casa L., Marrama P., Macdonald I.A. Effect of estradiol on the sympathoadrenal response to mental stress in normal men. J. Clin. Endocrinol. Metab. 79: 836, 1994.
21. Ho K.K.Y., Evans W.S., Blizzard R.M., Veldhuis J.D., Merriam G.R., Samojlik E., Furlanetto R., Rogol A.D., Kaiser D.L., Thorner M.O. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J. Clin. Endocrinol. Metab. 64: 51, 1987.
22. Peters J.R., Martin-Elliott J., Grahame-Smith D.G. Effect of oral contraceptives on platelet noradrenaline and 5-hydroxytryptamine receptors and aggregation. Lancet 2: 933, 1979.
23. Larsson B., Andersson K.E., Batra S., Mattiasson A., Sjogren C. Effects of estradiol on norepinephrine-induced contraction, alphaadrenoceptor number and norepinephrine content in the female rabbit urethra. J. Pharmacol. Exp. Ther. 229: 557, 1984.
24. Guan X., Dluzen D. Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats. Brain. Res. 598: 147, 1991.
25. Salt P.J. Inhibition of noradrenaline uptake in the isolated rat heart by steroids, clonidine and methoxylated phenylethylamines. Eur. J. Pharmacol. 20: 329, 1972.
26. Saulnier-Blache J.S., Bouloumie A., Valet P., Devedjian J.C., Lafontan M. Androgenic regulation of adipocyte 2-adrenoceptor expression in male and female syrian hamsters: proposed transcriptional mechanism. Endocrinology 130: 316, 1992.
27. Keenan B.S., Richards G.E., Ponder S.W., Dallas J.S., Nagamani M., Smith E.R. Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty. J. Clin. Endocrinol. Metab. 76: 996, 1993.
28. Weissberger A.J., Ho K.K.Y. Activation of the somatotropic axis by testosterone in adult males: Evidence for the role of aromatization. J. Clin. Endocrinol. Metab. 76: 1407, 1993.
29. Illig R., Prader A. Effect of testosterone on growth hormone secretion in patients with anorchia and delayed puberty. J. Clin. Endocrinol. Metab. 30: 615, 1970.
30. Cappa M., Loche S., Salvatori R., Faedda A., Borrelli P., Cella S.G., Pintor C., Müller E.E. The GH response to pyridostigmine plus GHRH is not influenced by pubertal maturation. J Endocrinol Invest 14: 41, 1991.
31. Ceda G.P., Ceresini G., Denti L., Cortellini P., Hoffman A.R., Valenti G. The GH response to GHRH alone or combined with PD does not vary in middle aged men after castration. Horm. Metab. Res. 21: 695, 1989,
32. Kiem D.T., Strark E., Fekete M.I.K. Loss of the effects of clonidine on the growth hormone release and hypotensive action in long-term castrated rats: the possible role of testosterone on alpha-2-adrenergic mechanisms of clonidine. Neuroendocrinology 51: 226, 1990.
33. Kiem D.T., Bartha L., Harsing L.G. Jr, Makara G.B. Reevaluation of the role of alpha2-adrenoreceptors in morphine-stimulated release of growth hormone. Neuroendocrinology 53: 516, 1991.
34. Simpkins J.W., Kalra P.S., Kalra S.P. Effect of testosterone on catecholamine turnover and LHRH contents in the basal hypothalamus and preoptic area. Neuroendocrinology 30: 94, 1980.
35. Roberts T.M., Insel P.A., Goldfien A. Regulation of myometral adrenoceptors and adrenergic response by sex steroids. Mol. Pharmacol. 20: 52, 1981.
36. 2- adrenoceptors in rabbit urethra. Am. J. Physiol. 252: F1124, 1987.
37. Friedl K.E., Hannan Jr C.J., Jones R.E., Plymate S.R. High-density lipoprotein cholesterol is not decreased if an aromatizable androgen is administered. Metabolism 39: 69, 1990.
38. Del Rio G., Carani C., Velardo A., Zizzo G., Procopio M., Coletta F., Marrama P., Ghigo E. Effect of testosterone replacement therapy on the somatotrope responsiveness to GHRH alone or combined with pyridostigmine and on sympathoadrenal activity in patients with hypogonadism. J. Endocrinol. Invest. 18: 690, 1995.
39. Hjemdal P. Physiological aspects of catecholamine sampling. Life Sci. 41: 841, 1987.