Co-transfer of B cells converts resistance into susceptibility in T cell-reconstituted, Leishmania major-resistant C.B-17 scid mice by a non-cognate mechanism

International Immunology

Volumn 8, Issue 10, 1996, Pages 1569-1575

  Hoerauf, Achim ^a,b   Röllinghoff, Martin ^a   Solbach, Werner ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

Antigen presentation; H 2 restriction; Leishmania major infection; T and B cell reconstitution; T cell priming

Indexed keywords

CD4 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; COMBINED IMMUNODEFICIENCY; FEMALE; H2 SYSTEM; INFECTION RESISTANCE; INFECTION SENSITIVITY; LEISHMANIA MAJOR; LEISHMANIASIS; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; DISEASE SUSCEPTIBILITY; FEMALE; IMMUNITY, NATURAL; IMMUNIZATION, PASSIVE; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LYMPHOCYTE TRANSFUSION; MICE; MICE, INBRED BALB C; MICE, SCID; T-LYMPHOCYTES;

EID: 0029850251     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.10.1569     Document Type: Article

References (30)

1. Locksley, R. M. and Scott, P. 1991. Helper T cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol. Today 12:58.
2. Poulter, L. W. and Pearce, M. T. 1980. Mechanisms of immunity to leishmaniasis: III. The development and decay of resistance during metastatic disease. Clin. Exp. Immunol. 42:211.
3. Mitchel, G. F., Anders, G. V., Brown, V., Handman, E., Roberts- Thomson, I. C., Chapman C. B., Forsyth, K. P., Kahl, L. P. and Cruise, K. M. 1982. Analysis of infection characteristics and antiparasite immune responses in resistant compared with susceptible hosts. Immunol. Rev. 61:137.
4. Howard, J. G., Liew, F. Y., Hale, C. and Nicklin, S. 1984. Prophylactic immunization against experimental leishmaniasis. II. Further characterization of the protective immune response against fatal L. tropica infection induced by irradiated promastigotes. J. Immunol. 132:450.
5. Sacks, D. L., Scott, P. A., Asofsky, R. and Sher, A. 1984. Cutaneous leishmaniasis in anti-IgM-treated mice: enhanced resistance due to functional depletion of a B cell-dependent T- cell involved in the suppressor pathway. J. Immunol. 132:2072.
6. Hoerauf, A., Solbach, W., Lohoff, M. and Röllinghoff, M. 1994. The Xid defect determines an improved clinical course of murine leishmaniasis in susceptible mice. Int. Immunol. 6:1117.
7. Varkila, K., Chatelain, R., Leal, L. M. C. C. and Coffman, R. L. 1993. Reconstitution of C. B-17 scid mice with BALB/c T cells initiates a T helper type-1 response and renders them capable of healing Leishmania major infection. Eur. J. Immunol. 23:262.
8. Solbach, W., Forberg, K. and Röllinghoff, M. 1986. Effect of T- lymphocyte suppression on the parasitic burden in Leishmania major infected, genetically susceptible BALB/c mice. Infect. Immun. 54:909.
9. Heinzel, F. P., Sadick, M. D., Holaday, B. J., Coffman, R. L. and Locksley, R. M. 1989 Reciprocal expression of interferon- γ or interleukin-4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59.
10. Aebischer, T., Moody, S. F. and Handman, E. 1993. Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host. Infect. Immun. 61:220.
11. Titus, R. G., Ceredig, R., Cerottini, J. C. and Louis, J. A. 1985. Therapeutic effect of anti-L3T4 monoclonal antibody GK1. 5 on cutaneous leishmaniasis in genetically susceptible BALB/c mice. J. Immunol. 135: 2108.
12. Howard, J. G., Hale, C. and Liew, F. Y. 1981. Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to Leishmania tropica. J. Exp. Med. 153: 557.
13. Solbach, W., Forberg, K., Kammerer, E., Bogdan, C. and Röllinghoff, M. 1986. Suppressive effect of cyclosporin A on the development of Leishmania tropica-induced lesions in genetically susceptible BALB/c mice. J. Immunol. 137: 702.
14. Mitchell, G. F., Curtis, J. M., Scollay, R. G. and Handman, E. 1981 Resistance and abrogation of resistance to cutaneous leishmaniasis in reconstituted BALB/c nude mice. Aust. J. Exp. Biol. Med. Sci. 59: 539.
15. Scott, P. A., Natovitz, P. and Sher, A. 1986. B lymphocytes are required for the generation of T cells that mediate heating of cutaneous leishmaniasis. J. Immunol. 137:1017.
16. Solbach, W., Lohoff, M., Streck, H., Rohwer, P, and Röllinghoff, M. 1987. Kinetics of cell-mediated immunity developing during the course of Leishmania major infection in healer and non- healer mice: progressive impairment of response and generation of interleukin-2. Immunology 62:485.
17. Taswell, C. 1987. Limiting dilution assays for the separation, characterization and quantitation of biologically active particles and their clonal progeny. In Pretlow, T. G. and Pretlow, T. P., eds, Cell Separation: Methods and Selected Applications 4, p. 109. Academic Press, Orlando, FL.
18. Mamula, M. J. and Janeway, C. A. 1993. Do B cells drive the diversification of immune responses? Immunol. Today 14:151.
19. Fuchs, E. and Matzinger, P. 1993. B cells drive diversification - but not directly. Immunol. Today 14:153.
20. Janeway, C. A., Ron, Y. and Katz, M. E. 1987. The B cell is the initiating antigen-presenting cell in peripheral lymph nodes. J. Immunol. 138:1051.
21. Ron, Y. and Sprent, J. 1987. T cell priming in vivo: a major role for B cells in presentation of antigen to T cells in lymph nodes. J. Immunol. 138:2848.
22. Kurt-Jones, E. A., Liano, D., Hay Glass, K. A., Benacerraf, B., Syms, M.-S. and Abbas, A. K. 1988. The role of antigen- presenting B cells in T cell priming in vivo: studies of B cell- deficient mice. J. Immunol. 140:3773.
23. Lin, R. H., Mamula, M. J., Hardin, J. A. and Janeway, C. A. 1991. Induction of autoreactive B cells allows priming of autoreactive T cells. J. Exp. Med. 173:1433.
24. Mamula, M. J., Lin, R. H., Janeway, C. A. and Hardin, J. A. 1992. Breaking T cell tolerance with foreign and self coimmunogens. J. Immunol. 149:789.
25. + T cells. J. Immunol. 154:4915.
26. Fuchs, E. J. and Matzinger, P. 1992. B cells turn off virgin but not memory T cells. Science 258:1156.
27. Ronchese, F. and Hausmann, B. 1993. B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes. J. Exp. Med. 177:679.
28. + T cells in experimental leishmaniasis. Infect. Immun. 54:2120.
29. Lanzavecchia, A. 1990. Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu. Rev. Immunol. 8:773.
30. + T cell subsets. Proc. Natl. Acad. Sci. USA 91:18.