Propranolol and bepridil attenuating levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg2+-ATPase activity elevation

Acta Pharmacologica Sinica

Volumn 17, Issue 6, 1996, Pages 516-518

  Chen, Ding Ding ^a   Dai, De Zai ^a   Lu, Jian ^a   Zhang, Xin Kui ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

bepridil; Ca2+ Mg2+ ATPase; heart hypertrophy; heart mitochondria; levothyroxine; propranolol

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM MAGNESIUM); BEPRIDIL; LEVOTHYROXINE; MITOCHONDRIAL ENZYME; OUABAIN; PROPRANOLOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; FEMALE; HEART HYPERTROPHY; HEART LEFT VENTRICLE; HEART MITOCHONDRION; HEART MUSCLE ISCHEMIA; INTRAGASTRIC DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; RAT;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BEPRIDIL; CA(2+) MG(2+)-ATPASE; CALCIUM CHANNEL BLOCKERS; CARDIOMEGALY; FEMALE; MITOCHONDRIA, HEART; PROPRANOLOL; RATS; RATS, SPRAGUE-DAWLEY; THYROXINE;

EID: 0029850087     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Morgan HE, Gorden EE, Kira Y, Chua BHL, Russo LA, Peterson CJ, et al. Biochemical mechanisms of cardiac hypertrophy. Annu Rev Physiol 1987; 49: 537 - 43.
2. 2+ ATPase and decreasing phospholamban expression. J Mol Cell Cardiol 1994; 26: 1145 - 54.
3. Marchall RJ, Winslow E, Lamer JC. Bepridil. In: Scriabine A, editor. New drugs annual: cardiovascular drugs; vol 2. New York: Raven, 1984: 157 - 204.
4. 2+-ATPase: inhibition by calcium channel entry blockers. Biochem Pharmacol 1987; 36: 2455 - 9.
5. Sugden P, Fuller SJ. Regulation of protein turnover in skeletal and cardiac muscle. Biochem J 1991 ; 273: 21 - 37.
6. Reinila M, MacDonald E, Salem N, Linnoila M, Trams EG. Standardized method for the determination of human erythrocyte membrane adenosine triphosphatases. Anal Biochem 1982; 124: 19 - 26.
7. m in enzyme reactions. Science 1952; 116: 329 - 31.
8. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248 - 58.
9. 2+ -ATPase in the rat heart. J Biol Chem 1988; 263: 6941 - 4.
10. Saini R. Calcium antagonists. In: Antonaccio MJ, editor. Cardiovascular pharmacology. 2nd ed. New York : Raven, 1984: 415 - 54.