Synthesis of 4-(4-guanidinobenzoyloxy)benzamides and 1-(4-guanidinobenzoyloxy)benzoyloxy acetamides as trypsin inhibitors

European Journal of Medicinal Chemistry

Volumn 31, Issue 11, 1996, Pages 895-899

  Zlatoidsky P ^a   Maliar, T ^a  

^a Drug Research Institute   (Slovakia)

Author keywords

4 guanidinobenzoic acid derivatives; Serine protease; Serine protease inhibitor; Trypsin

Indexed keywords

CAMOSTAT; GABEXATE MESILATE; PANCREATIC ELASTASE; THROMBIN; TRYPSIN; TRYPSIN INHIBITOR;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 0029849451     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(97)89852-2     Document Type: Article

References (23)

1. 1 Markwardt F, Walsmann P, Landmann H (1970) Pharmazie 25, 551-554
2. 2 Sturzebecher J, Markwardt F, Richter P, Wagner G, Walsmann P, Landmann H (1974) Pharmazie 29, 337-338
3. 3 Walsmann P, Horn H, Landmann H, Markwardt F, Sturzebecher J, Wagner G (1975) Pharmazie 30, 386-389
4. 4 Walsmann P, Griessmann R, Horn H et al (1976) Pharmazie 31, 410-411
5. 5 Sturzebecher J, Markwardt F, Richter P, Woigt B, Wagner G, Walsmann P (1976) Pharmazie 31, 458-461
6. 6 Walsmann P, Markwardt F, Sturzebecher J, Woigt B, Wagner G (1976) Pharmazie 31, 733-735
7. 7 Wagner G, Lischke I, Markwardt F et al (1976) Pharmazie 32, 761-764
8. 8 Labes D, Hagen V (1979) Pharmazie 34, 342-346
9. 9 Aoyama T, Okutome T, Nakayama T et al (1984) Chem Pharm Bull 32, 3968-3980
10. 10 Richter P, Wagner G (1978) Pharmazie 33, 39-42
11. 11 Henkel HJ, Labes D, Hagen V (1983) Pharmazie 38, 342-346
12. 12 Wagner G, Wunderlich I (1978) Pharmazie 33, 15-19
13. 13 Okamoto S, Kinjo K, Hijikata A et al (1980) J Med Chem 23, 827
14. 14 Gupta SP, Prabhakar YS, Handa A (1984) QSAR studies of thrombin inhibitors: derivatives of N-substituted L-arginines. In: QSAR in Design of Bioactive Compounds. (Kuchař M, ed) JR Prous International, New York, 175-187
15. 15 Fuji S, Okutome T, Nakayama T, Yaegashi T, Kurumi M (1980) German Pat 3, 005, 580; Chem Abstr (1981) 94, 6534x
16. 16 Adler G, Rausch U, Wiedenbach F, Arnold R, Kern HF (1984) Klin Wochenschr 62, 406-411
17. 17 Gabryelewicz A, Prokopowicz J, Bodzenta A, Bieleczki W, Rydzewska G (1988) Digestion 40, 19-28
18. 18 Hideki O, Hayakawa T (1980) Dig Dis Sci 35, 787-791
19. 19 Zlatoidský P, Maliar T (1996) Eur J Med Chem 31 (in press)
20. 20 Zlatoidský P (1994) PhD Thesis, Slowak Technical University, Bratislava, 70-76
21. 21 Neelakantan S, Padmasani J, Seskadri T (1965) Tetrahedron 21, 3531-3536
22. 22 Hummel BCW (1959) Can J Biochem Physiol 37, 1393-1399
23. 23 Nakajima K, Powers JC, Ashe BM, Zimmerman M (1979) J Biol Chem 254, 4027-4032