Systemic hematological effects of granulocyte colony-stimulating factor produced by irradiated gene-transfected fibroblasts

Human Gene Therapy

Volumn 7, Issue 17, 1996, Pages 2147-2156

  Rosenthal, Felicia M ^a   Kulmburg, Peter ^a   Früh, Reinhard ^a   Pfeifer, Carolin ^a   Veelken, Hendrik ^a   Mackensen, Andreas ^a   Köhler, Gabriele ^a   Lindemann, Albrecht ^a   Mertelsmann, Roland ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; EXPRESSION VECTOR; FIBROBLAST; GENE THERAPY; HEMATOPOIESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD STEM CELL; PLASMID; PROTEIN SECRETION; RECOMBINANT GENE; REGULATOR GENE;

ANIMALIA; MURINAE;

EID: 0029849259     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.17-2147     Document Type: Article

References (39)

1. AEBISCHER, P., WINN, S.R., and GALLETTI, P.M. (1988). Transplantation of neural tissue in polymer capsules. Brain Res. 448, 364-368.
2. AL-HENDY, A., HORTELANO, G., TANNENBAUM, G.S., and CHANG, P.L. (1995). Correction of the growth defect in dwarf mice with nonautologous microencapsulated myoblasts - an alternative approach to somatic gene therapy. Hum. Gene. Ther. 6, 165-175.
3. ANDERSON, W.F. (1984). Prospects for human gene therapy. Science 226, 401-409.
4. ANDREE, C., SWAIN, W.F., PAGE, C.P., MACKLIN, M.D., SLAMA, J., HATZIS, D., and ERIKSSON, E. (1994). In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair. Proc. Natl. Acad. Sci. USA 91, 12188-12192
5. ATKINSON, K., MATIAL, C., GUIFFRE, A., SEYMOUR, R., COOLEY, M., BIGGS, J., MUNRO, V., and GILLIS, S. (1991). In vivo administration of granulocyte colony-stimulating factor (G-CSF), granuolcyte-macrophage CSF, interleukein-1 (IL-1), and IL-4, alone and in combination, after allogeneic murine hematopoietic stem cell transplantation. Blood 77, 1376-1382.
6. BARR, E., and LEIDEN, J.M. (1991). Systemic delivery of recombinant proteins by genetically modified myoblasts. Science 254, 1507-1509.
7. BRANDT, S.J., PETERS, W.P., ATWATER, S.K., KURTZBERG, J., BOROWITZ, M.J., JONES, R.B., SHPALL, E.J., BAST, R.C., GILBERT, C.J., and OETTE, D.H. (1988). Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. New Engl. J. Med. 318, 869-876.
8. BRUGGER, W., HEIMFELD, S., BERENSON, R.J., MERTELSMANN, R., and KANZ, L. (1995). Reconstitution of hematopoiesis after high-dose chemotherapy by autologous progenitor cells generated ex vivo. New Engl. J. Med. 333, 283-287.
9. COLOMBO, M.P., FERRARI, G., STOPPACCIARO, A., PARENZA, M., RODOLFO, M., MAVILIO, F., and PARMIANI G. (1991). Granulocyte Colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J. Exp. Med. 173, 889-897.
10. DeVITA, V.T., JR. (1993). Principles of chemotherapy. In Cancer: Principles and Practice of Oncology. V.T. DeVita, Jr., S. Hellman, and S.A. Rosenberg, eds. (J.B. Lippincott Company, Philadelphia, PA) pp. 276-292.
11. DHAWAN, J., PAN, L.C., PAVLATH, G.K., TRAVIS, M.A., LANCTOT, A.M., and BLAU, H.M. (1991). Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science 254, 1509-1512.
12. DWARKI, V.J., BELLONI, P., NIJJAR, T., SMITH, J., COUTO, L., RABIER, M., CLIFT, S., BERNS, A., and COHEN, L.K. (1995). Gene therapy for hemophilia A: Production of therapeutic levels of human factor VIII in vivo in mice. Proc. Natl. Acad. Sci. USA 92, 1023-1027.
13. GABRILOVE, J.L., JACUBOWSKI, A., SCHER, H., STERNBERG, C., WONG, G., GRON, J., YAGODA, A. FAIN, K., MOORE, M.A.S., CLARKSON, B., OETTGEN, H.F., ALTON, K., WELTE, K., and SOUZA, L. (1988). Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy or transitional cell carcinoma of the urothelium. New Engl. J. Med. 318, 1414-1422.
14. 1-antitrypsin gene in vivo. Science 237, 762-764.
15. HEARTLEIN, M.W., ROMAN, V.A., JIANG, J.-L., SELLERS, J.W., ZULIANI, A.M., TRECO, D.A., and SELDEN, R. (1994). Long-term production and delivery of human growth hormone in vivo. Proc. Natl. Acad. Sci. USA 91, 10967-10971.
16. LIU, H.-W., OFOSU, F.A., and CHANG, P.L. (1993). Expression of human factor IX by microencapsulated recombinant fibroblasts. Hum. Gene Ther. 4, 291-301.
17. LORD, B.I., MOLINEUX, G., POJDA, Z., SOUZA, L.M., MERMOD, J.-J., and DEXTER, T.M. (1991). Myeloid cell kinetics in mice treated with recombinant interleukin-3, granulocyte colony-stimulating factor (G-CSF), or granulocyte-macrophage CSF in vivo. Blood 77, 2154-2159.
18. MOLINEUX, G., POJDA, Z., and DEXTER, T.M. (1990). A comparison of hematopoiesis in normal and splenectomized mice treated with granulocyte colony-stimulating factor. Blood 75, 563-569.
19. MORSTYN, G., CAMPBELL, L., SOUZA, L.M., ALTON, N.K., KEECH, J., GREEN, M., SHERIDAN, W., METCALF, D., and FOX, R. (1988). Effect of granulocyte colony-stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet 1, 667-672.
20. MOULLIER, P., BOHL, D., HEARD, J.M., and DANOS, O. (1993). Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts. Nature Genet. 4, 154-159.
21. NAFFAKH, N., HENRI, A., VILLEVAL, J.L., ROUYER-FESSARD, P., MOULLIER, P., BLUMENFELD, N., DANOS, O., VAINCHENKER, W., HERAD, J.M., and BEUZARD, Y. (1995). Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts. Proc. Natl. Acad. Sci. USA 92, 3194-3198.
22. NICOLA, N.A., BERGLEY, C.G., and METCALF, D. (1985). Identification of the human analogue of a regulator that induces differentiation in murine leukemia cells. Nature 314, 625-628.
23. PALMER, T.D., HOCK, R.A., OSBORNE, W.R.A., and MILLER, A.D. (1987). Efficient retrovirus-mediated transfer and expression of human adenosine deaminase gene in diploid skin fibroblasts from an adenosine deaminase-deficient human. Proc. Natl. Acad. Sci. USA 84, 1055-1059.
24. PALMER, T.D., THOMPSON, A.R., and MILLER, A.D. (1989). Production of human factor IX in animals by genetically modified skin fibroblasts: potential therapy for hemophilia B. Blood 73, 438-445.
25. ROBERTS, A.W., and METCALF, D. (1994). Granulocyte colony-stimulating factor induces selective elevations of progenitor cells in the peripheral blood of mice. Exp. Hematol. 22, 1156-1163.
26. ROSENTHAL, F.M., CRONIN, K., BANNERJI, R., GOLDE, D.W., and GANSBACHER, B. (1994a). Augmentation of antitumor immunity by tumor cells transduced with a retroviral vector carrying the interleukin-2 and interferon-γ cDNAs. Blood 83, 1289-1298.
27. ROSENTHAL, F.M., FRÜH, R., HENSCHLER, R., VEELKEN, H., KULMBURG, P., MACKENSEN, A., GANSBACHER, B., MERTELSMANN, R., and LINDEMANN, A. (1994b). Cytokine therapy with gene transfected cells: single injection of irradiated granulocyte-macrophage colony-stimulating factor-transduced cells accelerates hematopoietic recovery after cytotoxic chemotherapy in mice. Blood 84, 2960-2965.
28. SCHARFMANN, R., AXELROD, J.H., and VERMA, I.M. (1991). Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proc. Natl. Acad. Sci. USA 88, 4626-4630.
29. SCHMIDT, W., SCHWEIGHOFFER, T., HERBST, E., MAASS, G., BERGER, M., SCHILCHER, F., SCHAFFNER, G., and BIRNSTIEL, M.L. (1995). Cancer vaccines: The interleukin 2 dosage effect. Proc. Natl. Acad. Sci. USA 92, 4711-4714.
30. SELDEN, R.F., SKOSJIEWICZ, M.J., HOWIE, K.B., RUSSELL, P.S., and GOODMAN, H.W. (1987). Implantation of genetically engineered fibroblasts into mice. Science 236, 714-718.
31. SHERIDAN, W.P., WOLF, M., LUSK, J., LAYTON, J.E., SOUZA, L., MORSTYN, G., DODDS, A., MAHER, D., GREEN, M.D., and FOX, R.M. (1989). Granulocyte colony-stimulating factor and neutrophil recovery after high-dose chemotherapy and autologous bone marrow transplantation. Lancet 2, 891-895.
32. SRIVASTAVA, P.K., DELEO, A.B., and OLD, L.J. (1986). Tumor rejection antigens of chemically induced sarcomas of inbred mice. Proc. Natl. Acad. Sci. USA 83, 3407-3411.
33. ST. LOUIS, D., and VERMA, I.M. (1988). An alternative approach to somatic cell gene therapy. Proc. Natl. Acad. Sci. USA 85, 3150-3154.
34. TANI, K., OZAWA, K., OGURA, H., TAKAHASHI, T., OHANO, A., WATARI, K., MATSUDAIRA, T., TAJIKA, K., KARASUYAMA, H., NAGATA, S., ASANO, S., and TAKAKU, F. (1989). Implantation of fibroblasts transfected with human granulocyte colony-stimulating factor cDNA into mice as a model of cytokine supplement gene therapy. Blood 74, 1274-1280.
35. VEELKEN, H., JESUITER, H., MACKENSEN, A., KULMBURG, P., SCHULTZE, J., ROSENTHAL, F.M., MERTELSMANN, A., and LINDEMANN, A. (1994). Primary fibroblasts from human adults as target cells for ex vivo transfection and gene therapy. Hum. Gene Ther. 5, 1203-1209.
36. VEELKEN, H., RE, D., KULMBURG, P., ROSENTHAL, F.M., MACKENSEN, A., MERTELSMANN, R., and LINDEMANN, A. (1996). Systematic evaluation of chimeric marker genes on dicistronic transcription units for regulated expression of transgenes in vitro and in vivo. Hum. Gene Ther. (in press).
37. WEGNER, M., ZASTROW, G., KLAVINIUS, A., SCHWENDER, S., MÜULLER, P., LUKSZA, H., HOPPE, J., WIENBERG, J., and GRUMMT, F. (1989). Cis-acting sequences from mouse rDNA promote plasmid DNA amplification and persistence in mouse cells: Implication of HMG-I in their function. Nucl. Acids Res. 17, 9909-9932.
38. WILSON, J.M., BIRINYI, L.K., SALOMON, R.N., LIBBY, P., CALLOW, A.D., and MULLIGAN, R.C. (1989). Implantation of vascular grafts lined with genetically modified endothelial cells. Science 244, 1344-1346.
39. WILSON, J.M., CHOWDHURY, N.R., GROSSMAN, M., WAJSMAN, R., EPSTEIN, A., MULLIGAN, R.C., and CHOWDHURY, J.R. (1990). Temporary amelioration of hyperlipidemia in low densitiy lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes. Proc. Natl. Acad. Sci. USA 87, 8437-8441.