Differential expression of CD44v6 in adenocarcinoma of the pancreas: An immunohistochemical study

Virchows Archiv

Volumn 429, Issue 4-5, 1996, Pages 191-195

  Castella E M ^a   Ariza, A ^a   Ojanguren, I ^a   Mate, J L ^a   Roca, X ^a   Fernandez Vasalo A ^a   Navas Palacios, J J ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

CD44s; CD44v6; Immunohistochemistry; Metastasis; Pancreatic adenocarcinoma

Indexed keywords

HERMES ANTIGEN;

ADULT; AGED; ALTERNATIVE RNA SPLICING; ANTIGEN EXPRESSION; ARTICLE; CHRONIC PANCREATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; EXON; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MALE; METASTASIS; METASTASIS POTENTIAL; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN VARIANT;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD44; EXONS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PANCREAS; PANCREATIC NEOPLASMS;

EID: 0029849072     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Cubilla AL, Fortner J, Fitzgerald PJ (1978) Lymph node involvement of the head of the pancreas area. Cancer 41:880-887
2. Denning SM, Le PT, Singer KH, Haines BF (1990) Antibodies against the CD44 p80, lymphocyte homing receptor augment human peripheral blood T cell activation. J Immunol 144:7-15
3. Faasen AE, Schrager JA, Klein DJ, Oegema TR, Couchman JR, McCarty JB (1990) A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44 is involved in type 1 collagen melanoma cell motility and invasion. J Cell Biol 116:521-531
4. Fox SB, Fawcett J, Jackson DG, Collins I, Gatter KC, Harris AL Gearing A, Simmons DL (1994) Normal human tissues, in addition to some tumours, express multiple different CD44 isoforms. Cancer Res 54: 4539-4546
5. Gansauge F, Gansauge S, Zobywalsky A, Scharnweber C, Link KH, Nussler AK, Beger HG (1995) Differential expression of CD44 splice variants in human pancreatic adenocarcinoma and in normal pancreas. Cancer Res 55: 5499-5503
6. Günthert U, Hofmann M, Wolfgang R, Reber S, Zöller M, Haubmann I, Matzku S, Wenzel A, Ponta H, Herrlich P (1991) A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65:13-24
7. Heider KH, Dämmrich J, Skroh-Angel P, Müller-Hermelink JK, Vollmers HP, Herrlich P, Ponta H (1993) Differential expression of CD44 splice variants in intestinal and diffuse-type human gastric carcinomas and normal gastric mucosa. Cancer Res 53:4197-4203
8. Jalkanen S, Bargatze RF, Herron LR, Butcher EC (1986) A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man. Eur J Immunol 16:1195-1202
9. Lesley J, Hyman R, Kinkade PW (1993) CD44 and its interaction with extracellular matrix. Adv Immunol 54:271-335
10. Manabe T, Miyashita T, Ohshio G, Nonaka A, Suzuki T, Endo K, Takahashi M, Tobe T (1988) Small carcinoma of the pancreas: clinical and pathologic evaluation of 17 patients. Cancer 62:135-141
11. Pollard HM, Anderson WAD, Brooks FP, Cohn H, Murray M, Connelly RR, Fortner JG, Lemon MH, Palmer PES, Thomas LB, Webster PD, Carter S (1980) Staging of cancer of pancreas. Cancer 47:1631-1637
12. Rall JNC, Rustgi AK (1995) CD44 isoform expression in primary and metastatic pancreatic adenocarcinoma. Cancer Res 55:1831-1835
13. Ristamäki R, Joensuu H, Söderström KO, Jalkanen S (1995) CD44v6 expression in non-Hodgkin's lymphoma: an association with low histological grade and poor prognosis. J Pathol (Lond) 176:259-267
14. Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI (1992) Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci USA 89:12160-12164
15. Seiter S, Arch R, Reber S, Komitowski D, Hofmann M, Ponta H, Herrlich P, Matzku S, Zöller M (1993) Prevention of tumour metastasis formation by antivariant CD44. J Exp Med 177:433-455
16. Stamenkovic I, Aruffo A, Amiot M, Seed B (1991) The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate bearing cells. EMBO J 10:343-348
17. Takada M, Yamamoto M, Saitoh Y (1994) The significance of CD44 in human pancreatic cancer. I. High expression of CD44 in human pancreatic adenocarcinoma. Pancreas 9:748-752
18. Takada M, Yamamoto M, Saitoh Y (1994) The significance of CD44 in human pancreatic cancer. II. The role of CD44 in human pancreatic adenocarcinoma invasion. Pancreas 9:753-757
19. Taylor WT, Everthert GE (1994) Pancreatic cancer. In: Everhert EG (ed) Digestive diseases in the United States: epidemiology and impact. (NIH publication no 94-92270) USPAH, Bethesda
20. Tepper J, Ardi G, Suit H (1976) Carcinoma of the pancreas: review of MGH experience from 1963 to 1973: analysis of surgical failure and implications for radiation therapy. Cancer 37:1519-1524
21. Wielenga VJM, Heider KH, Offerhaus GJA, Adolf GR, Berg FM van den, Ponta H, Herrlich P, Pals ST (1993) Expression of CD44 variant proteins in human colorectal cancer is related to tumour progression. Cancer Res 53:4754-4756