N-(4-Hydroxyphenyl)-retinamide increases lecithin:retinol acyltransferase activity in rat liver

Journal of Nutrition

Volumn 126, Issue 10, 1996, Pages 2474-2480

  Matsuura, Tomokazu ^a   Zhao, Zirong ^a   Ross, A Catharine ^b  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

cellular retinol binding protein; rats; retinamide; retinoic acid; retinol esterification; vitamin A

Indexed keywords

FENRETINIDE; LECITHIN RETINOL ACYLTRANSFERASE; RETINOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; ENZYME ACTIVITY; FEMALE; LIVER METABOLISM; MALE; METABOLIC REGULATION; NONHUMAN; RAT; VITAMIN METABOLISM;

ANIMALIA;

EID: 0029848873     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.10.2474     Document Type: Article

References (29)

1. Adams, W. R., Smith, J. E. & Green, M. H. (1995) Effects of N-(4-hydroxyphenyl)-retinamide on vitamin A metabolism in rats. Proc. Soc. Exp. Biol. Med. 208: 178-185.
2. Allen, L. E., Green, M. H. & Green, J. B. (1994) Effects of pharmacological retinoids on several vitamin A-metabolizing enzymes (correspondence re: S. E. Dew et al.). Cancer Res. 54: 3319.
3. Ball, M. D., Furr, H. C. & Olson, J. A. (1985) Enhancement of acyl coenzyme A:retinol acyltransferase in rat liver and mammary tumor tissue by retinyl acetate and its competitive inhibition by N-(4-hydroxyphenyl)retinamide. Biochem. Biophys. Res. Commun. 128: 7-11.
4. Berni, R., Clerici, M., Malpeli, G., Cleris, L. & Formelli, F. (1993) Retinoids: in vitro interaction with retinol-binding protein and influence on plasma retinol. FASEB J. 7: 1179-1184.
5. Bowman, T. A., Goonwardene, M. I., Pasatiempo, A.M.G., Ross, A. C. & Taylor, C. E. (1990) Vitamin A deficiency decreases natural killer cell activity and interferon production in rats. J. Nutr. 120: 1264-1273.
6. Chiesa, F., Tradati, N., Marazza, M., Rossi, N., Boracchi, P., Mariani, L., Clerici, M., Formelli, F., Barzan, L., Carrassi, A., Pastorini, A., Camerini, R., Giardini, R., Zurrida, S., Minn, F.L., Costa, A., De Palo, G. & Veronesi, U. (1992) Prevention of local relapses and new localisations of oral leukoplakias with the synthetic retinoid fenretinide (4-HPR). Preliminary results. Eur. J. Cancer Clin. Oncol. 28B: 97-102.
7. Cobleigh, M. A. (1994) Breast cancer and fenretinide, an analogue of vitamin A. Leukemia 8: S59-S63.
8. Costa, A., Malone, W., Perloff, M., Buranelli, F., Campa, T., Dossena, G., Magni, A., Pizzichetta, M., Andreoli, C., Del Vecchio, M., Formelli, F. & Barbieri, A. (1989) Tolerability of the synthetic retinoid fenretinide (HPR). Eur. J. Cancer Clin. Oncol. 25: 805-808.
9. Decensi, A., Formelli, F., Torrisi, R. & Costa, A. (1993) Breast cancer chemoprevention: studies with 4-HPR alone and in combination with tamoxifen using circulating growth factors as potential surrogate endpoints. J. Cell Biol. 17G: 226-233.
10. Dew, S. E., Wardlaw, S. A. & Ong, D. E. (1993) Effects of pharmacological retinoids on several vitamin A-metabolizing enzymes. Cancer Res. 53: 2965-2969.
11. Formelli, F., Carsana, R., & Costa, A. (1987) N-(4-hydroxyphenyl)-retinamide (4-HPR) lowers plasma retinol levels in rats. Med. Sci. Res. 15: 843-844.
12. Formelli, F., Carsana, R., Costa, A., Buranelli, F., Campa, T., Dossena, G., Magli, A. & Pizzichetta, M. (1989) Plasma retinol level reduction by the synthetic retinoid Fenretinide: a one year follow-up study of breast cancer patients. Cancer Res. 49: 6149-6152.
13. Hill, D. L. & Grubbs, C. J. (1992) Retinoids and cancer prevention. Ann. Rev. Nutr. 12: 161-181.
14. Hultin, T. A., Filla, M. S. & McCormick, D. L. (1990) Distribution and metabolism of the retinoid, N-(4-methoxyphenyl)-all-trans-retinamide, the major metabolite of N-(4-hydroxyphyenyl)-all-tranas-retinamide, in female mice. Drug Metab. Dispos. 18: 175-179.
15. Hultin, T. A., McCormick, D. L., May, C. M. & Moon, R. C. (1988) Effects of pretreatment with the retinoid N-(4-hydroxyphenyl)-all-trans-retinamide and phenobarbital on the disposition and metabolism of N-(4-hydroxyphenyl)-all-trrans-retinamide in mice. Drug Metab. Dispos. 16: 783-788.
16. Lewis, K. C., Zech, L. A. & Phang, J. M. (1994) Effects of N-(4-hydroxphenyl) retinamide supplementation on vitamin A metabolism. Cancer Res. 54: 4112-4117.
17. Matsuura, T. & Ross, A. C. (1993) Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid. Arch. Biochem. Biophys. 301: 221-227.
18. Moon, R. C., Thompson, H. J., Becci, P. J., Grubbs, C. J., Gander, R. J., Newton, D. L., Smith, J. M., Phillips, S. L., Henderson, W. R., Mullen, L. T., Brown, C. G. & Sporn, M.B. (1979) N-(4-Hydroxyphenyl)-retinamide, a new retinoid for prevention of breast cancer in the rat. Cancer Res. 39: 1339-1346.
19. Randolph, R. K. & Ross, A. C. (1991) Vitamin A status regulates hepatic lecithin:retinol acyltransferase activity in rats. J. Biol. Chem. 266: 16453-16457.
20. Rigtrup, K. M., Kakkad, B. & Ong, D. E. (1994) Purification and partial characterization of a retinyl ester hydrolase from the brush border of rat small intestine mucosa: probable identity with brush border phospholipase B. Biochemistry 33: 2661-2666.
21. Ritter, S. J., Green, M. H., Adams, W. R., Kelley, S. K., Schaffer, E. M. & Smith, J. E. (1995) N-(4-hydroxyphenyl) retinamid (Fenretinide) and nephrectomy alter normal plasma retinol-binding protein metabolism. J. Nutr. Biochem. 6: 689-696.
22. Ross, A.C. (1982) Retinol esterification by mammary gland microsomes from the lactating rat. J. Lipid Res. 23: 133-144.
23. Ross, A.C. (1993a) Cellular metabolism and activation of reti-noids: roles of the cellular retinoid-binding proteins. FASEB J. 7: 317-327.
24. Ross, A.C. (1993b) Overview of retinoid metabolism. J. Nutr. 123: 346-350.
25. Schaffer, E.M., Ritter, S.J. & Smith, J.E. (1993) N-(4-Hydroxyphe-nyl)retinamide (Fenretinide) induces retinol-binding protein secretion from liver and accumulation in the kidneys in rats. J. Nutr. 123: 1497-1503.
26. Shih, T.-W., Shealy, F. & Hill, D. L. (1988) Enzymatic hydrolysis of retinamides. Drug Metab. Dispos. 16:337-340.
27. Smith, J. E., Lawless, D. C., Green, M. H. & Moon, R. C. (1992) Secretion of vitamin A and retinol-binding protein into plasma is depressed in rats by N-(4-hydroxyphenyl)retinamide (Fenretinide). J. Nutr. 122: 1999-2009.
28. Yost, R. W., Harrison, E. H. & Ross, A. C. (1988) Esterification by rat liver microsomes of retinol bound to cellular retinol-binding protein. J. Biol. Chem. 263: 18693-18701.
29. Zhao, Z., Matsuura, T., Popoff, K. & Ross, A.C. (1994) Effects of N-(4-hydroxyphenyl)-retinamide on the number and cytotoxicity of natural killer cells in vitamin A-sufficient and -deficient rats. Nat. Immun. 13: 280-288.