No Evidence for Linkage of Chromosome 22 Markers to Schizophrenia in Southern African Bantu-Speaking Families

American Journal of Medical Genetics - Seminars in Medical Genetics

Volumn 67, Issue 6, 1996, Pages 515-522

  Riley, Brien ^a   Mogudi Carter, Mphala ^b   Jenkins, Trefor ^c   Williamson, Robert ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Catechol O methyl transferase; Linkage analysis; Nonparametric; Parametric; South African

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ADOLESCENT; ADULT; ARTICLE; CHROMOSOME 22Q; CLINICAL ARTICLE; ETHNIC GROUP; FAMILY STUDY; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC PARAMETERS; HUMAN; MALE; PEDIGREE ANALYSIS; PRIORITY JOURNAL; SCHIZOPHRENIA; SOUTH AFRICA;

CATECHOL O-METHYLTRANSFERASE; CHROMOSOMES, HUMAN, PAIR 22; FEMALE; HUMANS; LINKAGE (GENETICS); MALE; PEDIGREE; PHENOTYPE; SCHIZOPHRENIA; SOUTH AFRICA;

EID: 0029848377     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1096-8628(19961122)67:6<515::aid-ajmg2>3.0.co;2-g     Document Type: Article

References (38)

1. American Psychiatric Association (1987): "Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition Revised (DSM-III-R)." Washington, DC: American Psychiatric Association.
2. Buetow KH, Duggan D, Yang B, Ludwigsen S, Puck J, Porter J, Budarf M, Spielman R, Emanuel BS (1993): A microsatellite-based multipoint index map of human chromosome 22. Genomics 18:329-339.
3. Coon H, Jensen S, Holik J, Hoff M, Myles-Worsley M, Reimherr F, Wender P, Waldo M, Freedman R, Leppert M, Byerley W (1994a): Genomic scan for genes predisposing to schizophrenia. Am J Med Genet 54:59-71.
4. Coon H, Holik J, Hoff M, Reimherr F, Wender P, Myles-Worsley M, Waldo M, Freedman R, Byerley W (1994b): Analysis of chromosome 22 markers in nine schizophrenia pedigrees. Am J Med Genet 54:72-79.
5. Cottingham RW Jr, Idury RM, Schaffer AA (1993): Faster sequential genetic linkage computations. Am J Hum Genet 53:252-263.
6. Daniels JK, Williams NM, Williams J, Jones LA, Cardno AG, Murphy KC, Scott L, Spurlock G, Riley B, Scambler P, Asherson P, McGuffin P, Owen MJ (1996): No evidence for allelic association between schizophrenia and alleles determining high or low catechol-O-methyltransferase activity. Am J Psychiatry 153:268-270.
7. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SCL, Jenkins SC, Palmer SM, Balfour KM, Rowe BR, Farrall M, Barnett AH, Bain SC, Todd JA (1994): A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371:130-136.
8. Dunham I, Collins J, Wadey R, Scambler P (1992): Possible role for COMT in psychosis associated with velo-cardio-facial syndrome. Lancet 340:1361-1362.
9. Farmer AE, McGuffin P, Gottesman II (1987): Twin concordance for DSM-III schizophrenia: Scrutinizing the validity of the definition. Arch Gen Psychiatry 44:634-641.
10. Gill M, Vallada H, Collier D, Sham P, Holmans P, Murray R, McGuffin P, Nanko S, Owen M, Lasseter VK, Pulver AE, Meyers D, Nestadt G, Antonarakis S, Housman D, Childs B, Straub R, Su Y, MacLean C, Murphy B, Wang S, Walsh D, Kendler K, Polymeropoulos M, Coon H, Byerley W, Gershon E, Golden L, Crow T, DeLisi L, Freedman R, Reimherr F, Wender P, Laurent C, Dumas J-B, d'Amato T, Jay M, Martinez M, Campion D, Mallet J, Wildenauer D, Hallmayer J, Lerer B, Maier W, Schwab SG, Ebstein RP, Gurling H, Curtis D, Blackwood D, Muir W, St. Clair D, He L, Maguire S, Moises H, Yang L, Wiese C, Kristbjarnason H, Levinson D, Mowry B (1996): A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12. Am J Med Genet 67:40-45.
11. Gottesman II, Shields J (1982): "Schizophrenia: The Epigenetic Puzzle." Cambridge: Cambridge University Press.
12. Gureje O (1991): Gender and schizophrenia: age at onset and sociodemographic attributes. Acta Psychiatr Scand 83:402-405.
13. Gyapay G, Morissette J, Vignal A, Dib C. Fitzames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J (1994): The 1993-94 Genethon human genetic linkage map. Nat Genet 7: 246-339.
14. Hashimoto L, Habita C, Beressi JP, Delepine M, Besse C, Cambon-Thompsen A, Deschamps I, Rotter JI, Djoulah S, James MR, Froguel P, Weissenbach J, Lathrop GM, Julier C (1994): Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus in chromosome 11q. Nature 371:161-164.
15. Kalsi G, Brynjolfsson J, Butler R, Sherrington R, Curtis D, Sigmundsson T, Read T, Murphy P, Sharma T, Petursson H, Gurling HMD (1995): Linkage analysis of chromosome 22q12-13 in a United Kingdom/Icelandic sample of 23 multiplex schizophrenia families. Am J Med Genet 60:298-301.
16. Kelly D, Goldberg R, Wilson D, Lindsay E, Carey A, Goodship J, Burn J, Cross I, Shprintzen RJ, Scambler PJ (1993): Confirmation that the velo-cardio-facial syndrome is associated with haplo-insufficiency of genes at chromosome 22q11. Am J Med Genet 45: 308-312.
17. Kendler KS, Diehl SR (1993): The genetics of schizophrenia: A current genetic-epidemiological perspective. Schizophr Bull 19:261-285.
18. Kendler KS, Gruneberg AM, Strauss JS (1981): An independent analysis of the Copenhagen sample of the Danish adoption study of schizophrenia II. The reliability between schizotypal personality disorder and schizophrenia. Arch Gen Psychiatry 38:982-984.
19. Lathrop GM, Lalouel J-M (1984): Easy calculations of lod scores and genetic risks on small computers. Am J Hum Genet 36:460-465.
20. Maziade M, Roy M-A, Fournier J-P, Cliche D, Mérette C, Caron C, Garneau Y, Montgrain N, Shriqui C, Dion C, Nicole L, Potvin A, Lavallée J-C, Pirés A, Raymond V (1992): Reliability of best-estimate diagnosis in genetic linkage studies of major psychoses: Results from the Quebec pedigree studies. Am J Psychiatry 149:1674-1686.
21. McGuffin P, Farmer AE, Gottesman II, Murray RM, Revely A (1984): Twin concordance for operationally defined schizophrenia: Confirmation of familiality and heritability. Arch Gen Psychiatry 41:541-545.
22. Miller SA, Dykes DD, Polesky HF (1988): A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215.
23. Murray JC, Buetow KH, Weber JL, Ludwigsen S, Scherpbier-Heddma T, Manion F, Quillen J, Sheffield VC, Sunden S, Duyk GM, Weissenbach J, Gyapay G, Dib C, Morrissette J, Lathrop GM, Vignal A, White R, Matsunami N, Gerken S, Melis R, Albertsen H, Plaetke R, Odelberg S, Ward D, Dausset J, Cohen D, Cann H (1994): A comprehensive human linkage map with centimorgan density. Science 265:2049-2070.
24. Nurse GT, Weiner JS, Jenkins T (1985): "The Peoples of Southern Africa and Their Affinities." Oxford: Clarendon, p 138.
25. Ott J (1991): "Analysis of Human Genetic Linkage, Revised Edition." Baltimore: Johns Hopkins University Press, p 205, p 218.
26. Polymeropoulos MH, Coon H, Byerley W, Gershon ES, Goldin L, Crow TJ, Rubenstein J, Hoff M, Holik J, Smith AM, Shields G, Bass NJ, Poulter M, Lofthouse R, Vita A, Morganti C, Merrill CR, DeLisi LE (1994): Search for a schizophrenia susceptibility locus on chromosome 22. Am J Med Genet 54:93-99.
27. Pulver AE, Karayiorgou M, Wolyniec PS, Lasseter VK, Kasch L, Nestadt G, Antonarakis S, Housman D, Kazazian HH, Meyers D, Ott J, Lamacz M, Liang K-Y, Hanfeldt J, Ullrich G, DeMarchi N, Ramu E, McHugh PR, Adler L, Thomas M, Carpenter WT, Manschreck T, Gordon CT, Kimberland M, Babb R, Puck J, Childs B (1994a): Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12-q13.1: Part 1. Am J Med Genet 54:36-43.
28. Pulver AE, Karayiorgou M, Lasseter VK, Wolyniec PS, Kasch L, Antonarakis S, Housman D, Kazazian HH, Meyers D, Nestadt G, Ott J, Liang K-Y, Lamacz M, Thomas M, Childs B, Diehl SR, Wang S, Murphy B, Sun C, O'Neill FA, Nie L, Sham P, Burke J, Duke BW, Duke F, Kipps BR, Bray J, Hunt W, Shinkwin R, Ni Nuallain M, Su Y, MacLean CJ, Walsh D, Kendler KS, Gill M, Vallada H, Mant R, Asherson P, Collier D, Parfitt E, Roberts E, Nanko S, Walsh C, Daniels J, Murray R, MeGuffin P, Owen M, Laurent C, Dumas J-B, d'Amato T, Jay M, Martinez M, Campion D, Mallet J (1994b): Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1: Part 2. Am J Med Genet 54:44-50.
29. Ramsay M, Jenkins T (1987): Globin gene-associated restriction-fragment-length polymorphisms in Southern African peoples. Am J Hum Genet 41:1132-1144.
30. Riley BP, Rajagopalan S, Mogudi-Carter M, Jenkins T, Williamson R (1996): No evidence for linkage of chromosome 6p markers to schizophrenia in southern African Bantu-speaking families. Psychiatr Genet 6: 41-50.
31. Scambler PJ, Kelly D, Lindsay E, Williamson R, Goldberg R, Shprintzen R, Wilson DI, Goodship JA, Cross IE, Burn J (1992): Velo-cardio-facial syndrome associated with chromosome 22 deletions encompassing the DiGeorge locus. Lancet 339:1138-1139.
32. Schaffer AA, Gupta SK, Shriram K, Cottingham RW Jr (1994): Avoiding recomputation in genetic linkage analysis. Hum Hered 44: 225-237.
33. Shprintzen RJ, Goldberg R, Golding-Kushner KJ, Marion RW (1992): Late-onset psychosis in the velo-cardio-facial syndrome. Am J Med Genet 42:141-142.
34. Spitzer RL, Williams JBW, Gibbon M, First MB (1990): "Structured Clinical Interview for DSM-III-R Patient (SCID-P) and Non-Patient (SCID-NP) Editions, Version 1.0." Washington DC: American Psychiatric Press, pp.
35. Tenhunen J, Salminen M, Lundstrom K, Kiviluoto T, Savolainen R, Ulmanen I (1994): Genomic organisation of the human catechol-O-methyltransferase gene and its expression from two distinct promoters. Eur J Biochem 223:1049-1059.
36. Vallada HP, Gill M, Sham P, Lim LCC, Nanko S, Asherson P, Murray RM, MeGuffin P, Owen M, Collier D (1995): Linkage studies on chromosome 22 in familial schizophrenia. Am J Med Genet 60: 139-146.
37. Weeks DE, Lange K (1988): The affected-pedigree-member method of linkage analysis. Am J Hum Genet 42:315-326.
38. Weinshilboum RM, Raymond FA (1977): Inheritance of low erythrocyte catechol-O-methyltransferase in man. Am J Med Genet 29: 125-135.