An efficient synthetic route to ethyl 2-aryl-4-hydroxy-1,3(2H,4H)-dioxoisoquinoline-4-carboxylates

Journal of Organic Chemistry

Volumn 61, Issue 22, 1996, Pages 7967-7972

  Semple, J Edward ^a   Rydzewski, Robert M ^b   Gardner, Gary ^c  

^a Dendreon   (United States)

^b Arris Pharmaceuticals   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOQUINOLINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0029848073     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo961135j     Document Type: Article

References (40)

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17. (a) Ethoxycarbonylation of homophthalic anhydride derivatives with this system is known. However, we are unaware of any reports describing the direct acylation of 1,3(2H, 4H)-dioxoisoquinolines (homophthalimides) 2 by this method, cf.:
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34. 2-Aryl-1,3,4-(2H)-trioxoisoquinolines, also known as phthalonimides, have been previously described; see: (a) Peterson, S.; Heitzer, H. Liebigs Ann. Chem. 1978, 283. (b) Buu-Hoi, N. P.; Saint-Ruf, G.; Bourgeade, J. C. J. Heterocycl. Chem. 1968, 5, 545. (c) Meyer, A.; Villenet, R. C. R. Hebd. Seances Acad. Sci. 1931, 193, 531, 1095.
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