Synthesis of [12-3H]-(±)-calanolide A

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 38, Issue 12, 1996, Pages 1077-1081

  Rehder, Ken S ^a   Hristova Kazmierski, Maria K ^a   Kepler, John A ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

Calanolide A; HIV 1; Reverse transcriptase inhibitor; Sodium borotritide

Indexed keywords

CERIUM COMPOUNDS; CHLORINE COMPOUNDS;

% REDUCTIONS; CALANOLIDE A; HIV-1; PHLOROGLUCINOL; REVERSE TRANSCRIPTASE INHIBITOR; REVERSE-TRANSCRIPTASE; SODIUM BOROTRITIDE; SPECIFIC ACTIVITY; STEREO-SELECTIVE; SYNTHESISED;

SODIUM;

CALANOLIDE A; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRITIUM;

ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REACTION ANALYSIS; STEREOCHEMISTRY;

HUMAN IMMUNODEFICIENCY VIRUS 1; TRITIUM;

EID: 0029847883     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1099-1344(199612)38:12<1077::aid-jlcr930>3.0.co;2-%23     Document Type: Article

References (10)

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3. Sethna S. and Phadke R. - Org. React. 7: 1 (1953).
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6. Gemal A.L. and Luche J.-L. - J. Am. Chem. Soc. 103: 5454 (1981).
7. The low yield is due to the considerable loss of material experienced during the purification process.
8. The specific activity is about 70% of the theoretical specific activity of 90 mCi/mmole. The lower than theoretical specific activity may be due to a tritium isotope effect.
9. All compounds gave spectral and physical data consistent with the proposed structures.
10. The specific activity is the average of three separate determinations by weighing and liquid scintillation counting.