Studies on the magnitude and the mechanism of cough potentiation by angiotensin-converting enzyme inhibitors in guinea-pigs: Involvement of bradykinin in the potentiation

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 10, 1996, Pages 1027-1033

  Takahama, Kazuo ^a   Araki, Tatsuya ^a   Fuchikami, Jun Ichi ^b   Kohjimoto, Yoshiro ^b   Miyata, Takeshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b Panapharm Laboratories Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ; CAPSAICIN; CAPTOPRIL; CITRIC ACID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENALAPRILAT; ICATIBANT; IMIDAPRIL; IMIDAPRILAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; COUGHING; DOSE RESPONSE; GUINEA PIG; HYPERTENSION; LOWER RESPIRATORY TRACT; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; TASTE DISORDER; VAGUS NERVE;

EID: 0029847598     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb05895.x     Document Type: Article

References (35)

1. Cascieri, M. A., Bull, H. G., Mumfort, R. A., Patchett, A., Thornberry, N. A., Liang, T. (1984) Carboxylterminal tripeptidyl hydrolysis of substance P by purified rabbit lung angiotensin converting enzyme and the potentiation of substance P activity in vivo by captopril and MK-422. Mol. Pharmacol. 25: 287-293
2. 2, bradykinin and histamine. Am. Rev. Respir. Dis. 140: 137-141
3. Choudry, N. B., Fuller, R. W., Anderson, N., Karlsson, J.-A. (1990) Separation of cough and reflex bronchoconstriction by inhaled local anaesthetics. Eur. Respir. J. 3: 579-583
4. Coulter, D. M., Edwards, J. R. (1987) Cough associated with captopril and enalapril. Br. Med. J. 294: 1521-1523
5. Cushman, D. W., Cheung, H. S. (1971) Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20: 1637-1648
6. Forsberg, K., Karlsson, J.-A. (1986) Cough induced by stimulation of capsaicin-sensitive sensory neurons in conscious guinea-pigs, Acta Physiol. Scand. 128: 319-320
7. Fox, A. J., Barnes, P. J., Urban, L., Dray, A. (1993) An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J. Physiol. 469: 21-35
8. Fuchikami, J. (1992) Pharmacological Studies on Principles for Development of New Antitussives: Peripheral Mechanism of Cough Response and the Effect of Mai-Meu-Dong-Tang, a Chinese Herbal Medicine. Ph.D. Thesis, Kumamoto University, Japan
9. Fuchikami, J., Takahama, K., Kai, H., Miyata, T. (1990) Comparative study of the antitussive activity of Mai-Meu-Dong-Tang and codeine in normal and bronchitic guinea-pigs. Pharmacodyn. Ther. (Life Sci. Adv.) 9: 37-43
10. Fuller, R. W., Dixon, C. M. S., Cuss, F. M. C., Barnes, P. J. (1987) Bradykinin-induced bronchoconstriction in humans: mode of action. Am. Rev. Respir. Dis. 135: 176-180
11. Galler, M., Backenroth, R., Folkert, V. W., Schlondorrf, D. (1982) Effect of converting enzyme inhibitors on prostaglandin synthesis by isolated glomeruli and aortic strips from rats. J. Pharmacol. Exp. Ther. 220: 23-28
12. Geppetti, P., Bianco, E. D., Tramontana, M., Vigano, T., Folco, G. C., Maggi, C. A., Manzini, S., Fanciullacce, M. (1991) Arachidonic acid and bradykinin share a common pathway to release neuropeptide from capsaicin-sensitive sensory nerve fibers of the guinea-pig heart. J. Pharmacol. Exp. Ther. 259: 759-765
13. Hood, S., Nicholls, M. G., Gilchrist, N. (1987) Cough with angiotensin converting-enzyme inhibitors. New Zealand Med. J. 100: 6-7
14. Ichinose, M., Barnes, P. J. (1990) The effect of peptidase inhibitors on bradykinin-induced bronchoconstriction in guinea-pigs in vivo. Br. J. Pharmacol. 101: 77-80
15. Jaspard, E., Wei. L., Alhenc-Gelas, F. (1993) Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (Kininase II). J. Biol. Chem. 268: 9495-9503
16. Kase, Y., Seo, H., Oyama, Y., Sakata, M., Tomoda, K., Takahama, K., Hitoshi, T., Okano, Y., Miyata, T. (1982) A new method for evaluating mucolytic expectorant activity and its application. I. Methodology. Arzn. Forsch. 32: 368-373
17. Kaufman, M. P., Coleridge, H. M., Coleridge, J. C. G., Baker, D. G. (1980) Bradykinin stimulates afferent vagal C-fibres in intrapulmonary airways of dogs. J. Appl. Physiol. 48: 511-517
18. Kawashima, K., Mizuuchi, H., Yamanaka, K., Maki, T., Banno, K., Sato, T., Miyata, T., Takahama, K. (1994) Pharmacokinetics of imidapril, a new angiotensin-converting enzyme inhibitor, in guinea-pigs. Pharmacometrics 48: 371-381
19. Matsumoto, Y., Murata, T., Kikura, K., Koshida, T., Kaminuma, O., Naito, K., Kikura, K., Tsuzurahara, K. (1995) The effect of ACE inhibitors on bradykinin-induced microvascular leakage in guineapig airways. Japan. J. Pharmacol. 67 (Suppl. I): 313p
20. McEwan, J. R., Choudry, N. B., Fuller, R. W. (1990) The effect of sulinduc on the abnormal cough reflex associated with dry cough. J. Pharmacol. Exp. Ther, 255: 161-164
21. Nakashima, M., Hashimoto, H., Hayase, K., Hamajima, K. (1984) Phase I trial of a single oral dose of MK-421, a new angiotensin I converting enzyme inhibitor, in healthy subjects. First report. Yakuri To Chiryo 12: 3357-3374
22. Okamura, T., Kitamura, Y., Kimura, T., Toda, N. (1993) Comparison of selective actions of imidaprilat and enalaprilat on the response to angiotensin I and bradykinin in isolated dog blood vessels. Pharmacometrics 46: 427-436
23. Oomura, I, Maki, E., Naruse, T., Chen, C-S., Ideda, N., Asami, T. (1985) Effect of single and repeated oral administration of MK-421 and captopril on blood pressure in normotensive and experimental hypertensive rats. Folia Pharmacol. Japon. 86: 293-302
24. 2. J. Appl. Physiol. 58: 1823-1831
25. 2-exposed guinea-pigs. Japan. J. Pharmacol. 61 (Suppl. I): 80p
26. Sana, A., Martling, C.-R., Yan, Z. (1988) Release of multiple tachykinins from capsaicin-sensitive sensory nerves in the lung by bradykinin, histatnine, dimethylphenylpiperazinium, and vagal nerve stimulation. Am. Rev. Respir. Dis. 137: 1330-1335
27. Sasaguri, M., Ideishi, M., Hiroki, T., Arakawa, K. (1994) Comparative preliminary test of imidapril and other ACE inhibitors on cough production. Shinyaku To Rinsho 43: 2467-2471
28. Skidgel, R. A., Erdos, E. G. (1987) The broad substrate specificity of human angiotensin I converting enzyme. Clin. Exp. Hypertens. A9: 243-259
29. Takahama, K., Fuchikami, J., Kai, H., Miyata, T. (1990) The effect of Mai-Meu-Dong-Tang, a Chinese herbal medicine, on the cough augmented by angiotensin-converting enzyme inhibitors. J. Med. Pharm. Soc. (Wakan-Yaku) 7: 310-311
30. Takahama, K., Fuchikami, J., Suzuki, A., Tabata, T., Kai, H., Miyata, T. (1993) Differences in the mode of cough augmentation by four angiotensin-converting enzyme inhibitors in guinea-pigs. J. Pharm. Pharmacol. 45: 1003-1005
31. Turner, A. J., Matsas, R., Kenny, A. J. (1985) Commentary. Are there neuropeptidase-specific peptidases? Biochem. Pharmacol. 34: 1347-1356
32. Wei, L., Alhenc-Gelas, F., Corvol, P., Clauser, E. (1990) The two homologous domains of human angiotensin I converting enzyme are both catalytic active. J. Biol. Chem. 266: 9002-9008
33. Wei, L., Clauser, E., Alhenc-Gelas, F., Corvol, P. (1992) The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors. J. Biol. Chem. 267: 13398-13405
34. Yang, H. Y. T., Erdos, E. G., Levin, Y. (1970) A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin. Biochem. Biophys. Acta. 214: 374-376
35. Yokosawa, H., Endo, S., Ohgaki, Y., Maeyama, J., Ishii, S. (1985) Hydrolysis of substance P and its analogs by angiotensin-converting enzyme from rat lung. Characterization of endopeptidase activity of the enzyme. J. Biochem. 98: 1293-1299