Intrapulmonary administration of insulin to healthy volunteers

Journal of Internal Medicine

Volumn 240, Issue 2, 1996, Pages 93-98

  Jendle, J H ^a,b   Karlberg, B E ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Aerosol; C peptide; Insulin; Nebulization; Oral inhalation

Indexed keywords

C PEPTIDE; GLUCOSE; HUMAN INSULIN; INSULIN; NEUTRAL INSULIN; PLACEBO; SODIUM CHLORIDE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; HUMAN; HUMAN EXPERIMENT; HYPOGLYCEMIA; INHALATIONAL DRUG ADMINISTRATION; INSULINEMIA; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOLUNTEER;

EID: 0029847551     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.1996.502836000.x     Document Type: Article

References (21)

1. Almér L-O, Wollmer P, Jonson B, Bäckström K, Dahlbäck M. Insulin inhalation - at last a break-through. Diabetes Res Clin Pract 1988; 5: 163.
2. Home PD. Non-invasive insulin therapy. Diabetes News 1994; 15: 4-6.
3. Wasnich RD. A high-frequency ultrasonic nebulizer system for radioaerosol delivery. J Nucl Med 1976; 17: 707-10.
4. Gänssien M. Über inhalation von insulin. Klin Wochenschrift 1925; 2: 71-2.
5. Anderson SD, Schoefel RE, Black JL, Daviskas E. Airway cooling as the stimulus to exercise-induced asthma - a re-evaluation. Eur J Respir Dis 1986; 67: 20-30.
6. Jendle JH, Karlberg BE, Persliden J, Franzén L, Arborelius M Jr. Delivery and retention of an insulin aerosol produced by a new jet nebulizer. J Aerosol Med 1995; 8: 243-54.
7. Arnquist H, Olsson P-O, von Schenck H. Free and total insulin as determined after precipitation with polyethylene glycol: analytical characteristics and effects of sample handling and storage. Clin Chem 1987; 33: 93-6.
8. Jørgensen KH, Larsen UD. Homogenous mono-125I-(Tyr A14)- and Mono-125I-(Tyr A19)-insulin. Diabetologia 1980; 19: 546-54.
9. Heding LG, Munkgaard-Rasmussen S. Determination of human C-peptide in serum. Diabetologia 1975; 11: 541-8.
10. Elliott RB, Edgar BW, Pilcher CC, Quested C, McMaster J. Parenteral absorption of insulin from the lung in diabetic children. Aust Paediatr J 1987; 23: 293-7.
11. Pontirolli AE, Alberetto M, Secchi A, Dossi G, Bosi I, Pozza G. Insulin given intranasally induces hypoglycaemia in normal and diabetic subjects. Br Med J 1982; 284: 303-6.
12. Salzman R, Manson JE, Griffing GT. Intranasal aerosolized insulin. N Engl J med 1985; 312: 1078-84.
13. Wigley FM, Londono JH, Wood SH, Shipp JC, Waldman RH. Insulin across respiratory mucosae by aerosol delivery. Diabetes 1971; 20: 552-6.
14. Laube BL, Georgopoulos A, Adams III GK. Preliminary study of the efficacy of insulin aerosol delivered by oral inhalation in diabetic patients. JAMA 1993; 269: 2106-9.
15. Newman SP, Moren F, Pavia DL F, Clarke SW. Deposition of pressurized suspension aerosols inhaled through extension devices. Am Rev Respir Dis 1981; 124: 317-20.
16. Galloway JA, Spradlin RL, Nelson RL, Wentworth SM, Davidson JA, Swarner JL. Factors influencing the absorption, serum insulin concentration, and blood glucose responses after injections of regular insulin and various insulin mixtures. Diabetes Care 1981; 4: 366-78.
17. Sluzky V, Tamada JA, Klibanov AM, Langer R. Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces. Proc Natl Acad Sci 1991; 88: 9377-81.
18. Schanker LS. Relation between molecular weight and pulmonary absorption rate of lipid insoluble compounds in neonatal and adult rats. Biochem Pharmac 1985; 32: 2599-601.
19. Polonsky KS, Rubenstein AH. C-peptide as a measure of the secretion and hepatic extraction of insulin. Diabetes 1983; 33: 486-94.
20. Faber OK, Hagen C, Binder C, Markussen J, Naithani VK, Blix PM et al. Kinetics of human connecting peptide in normal and diabetic subjects. J Clin Invest 1978; 62: 197-205.
21. Patton JS, Platz RM. Pulmonary delivery of peptides and proteins for systemic action. Adv Drug Delivery Rev 1992; 8: 179-96.