Identification, analysis, and evolutionary relationships of the putative murine cytomegalovirus homologs of the human cytomegalovirus UL82 (pp71) and UL83 (pp65) matrix phosphoproteins

Journal of Virology

Volumn 70, Issue 11, 1996, Pages 7929-7939

  Cranmer, Lee D ^a   Clark, Charles L ^a   Morello, Christopher S ^b   Farrell, Helen E ^c   Rawlinson, William D ^d   Spector, Deborah H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HYPERIMMUNE GLOBULIN; MATRIX PROTEIN; MESSENGER RNA; VIRUS PHOSPHOPROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; EVOLUTION; FEMALE; GENE EXPRESSION; HUMAN CYTOMEGALOVIRUS; HUMORAL IMMUNITY; MOUSE; NONHUMAN; NORTHERN BLOTTING; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE HOMOLOGY; VACCINIA VIRUS; VIRION; VIRUS GENOME; VIRUS RECOMBINANT;

EID: 0029846226     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.11.7929-7939.1996     Document Type: Article

References (72)

1. Beninga, J., B. Kropff, and M. Mach. 1995. Comparative analysis of fourteen individual human cytomegalovirus proteins for helper T cell response. J. Gen. Virol. 76:153-160.
2. Biegalke, B. J., and A. P. Geballe. 1990. Translational inhibition by cytomegalovirus transcript leaders. Virology 177:657-667.
3. Borysiewicz, L. K., J. K. Hickliog, S. Graham, J. Sinclair, M. P. Cranage, G. L Smith, and J. G. P. Sissons. 1988. Human cytomegalovirus-specific cytotoxic T cells. Relative frequency of stage-specific CTL recognizing the 72-kD immediate early protein and glycoprotein B expressed by recombinant vaccinia viruses. J. Exp. Med. 168:919-931.
4. Britt, W. J. 1991. Recent advances in the identification of significant human cytomegalovirus-encoded proteins. Transplant. Proc. 23(Suppl 3):64-69.
5. Bruggeman, C. A. 1993. Cytomegalovirus and latency: an overview. Virchows Arch. B 64:325-333.
6. Chakrabarti, S., K. Brechung, and B. Moss. 1985. Vaccinia virus expression vector: coexpression of β-galactosidase provides visual screening of recombinant virus plaques. Mol. Cell. Biol. 5:3403-3409.
7. Chee, M., S.-A. Rudolph, B. Plachter, B. Barrell, and G. Jahn. 1989. Identification of the major capsid protein gene of human cytomegalovirus. J. Virol. 63:1345-1353.
8. Chee, M. S., A. T. Bankier, S. Beck, R. Bohni, C. M. Brown, R. Cerny, T. Horsnell, C. A. Hutchison III, T. Kouzarides, J. A. Martignetti, E. Preddie, S. C. Satchwell, P. Tomlinson, K. M. Weston, and B. G. Barrell. 1990. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. Immunol. 154:125-169.
9. Cranmer, L. D., C. Clark, and D. H. Spector. 1994. Cloning, characterization, and expression of the murine cytomegalovirus homologue of the human cytomegalovirus 28-kDa matrix phosphoprotein (UL99). Virology 205:417-429.
10. Depto, A. S., and R. M. Stenberg. 1989. Regulated expression of the human cytomegalovirus pp65 gene: octamer sequence in the promoter is required for activation by viral gene products. J. Virol. 63:1232-1238.
11. Doolittle, R. F. 1987. Of URFs and ORFs. University Science Books, Mill Valley, Calif.
12. Elliott, R., C. Clark, D. Jaquish, and D. H. Speclor. 1991. Transcription analysis and sequence of the putative murine cytomegalovirus DNA polymerase gene. Virology 185:169-186.
13. Feng, D.-F., and R. F. Doolittle. 1987. Progressive sequence alignment as a prerequisite to correct phylogenetic trees. J. Mol. Evol. 25:351-360.
14. Feng, D.-F., and R. F. Doolittle. 1990. Progressive alignment and phylogenetic tree construction of protein sequences. Methods Enzymol. 183:375-387.
15. Fourney, R. M., K. D. Dietrich, R. A. Aubin, and M. C. Paterson. 1988. HindIII polymorphism in the human c-sis proto-oncogene. Nucleic Acids Res. 16:8197.
16. Geballe, A. P., F. S. Leach, and E. S. Mocarski. 1986. Regulation of cytomegalovirus late gene expression: γ genes are controlled by posttranscriptional events. J. Virol. 57:864-874.
17. Gilbert, M. J., S. R. Riddell, C.-R. Li, and P. D. Greenberg. 1993. Selective interference with class I major histocompatibility complex presentation of the major immediate-early protein following infection with human cytomegalovirus. J. Virol. 67:3461-3469.
18. Giugni, T. D., M. A. Churchill, H. Pande, K. Campo, M. Guha, and J. A. Zaia. 1992. Expression in insect cells and immune reactivity of a 28K tegument protein of human cytomegalovirus. J. Gen. Virol. 73:2367-2374.
19. Gompels, U. A., J. Nicholas, G. Lawrence, M. Jones, B. J. Thomson, M. E. D. Martin, S. Efstathiou, M. Craxton, and H. A. Macaulay. 1995. The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology 209:29-51.
20. Greenberg, P. D., P. Reusser, J. M. Goodrich, and S. R. Riddell. 1991. Development of a treatment regimen for human cytomegalovirus (CMV) infection in bone marrow transplantation recipients by adoptive transfer of donor-derived CMV-specific T cell clones expanded in vitro. Ann. N. Y. Acad. Sci. 636:184-195.
21. Guan, K. L., and J. E. Dixon. 1991. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem. 192:262-267.
22. Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N. Y.
23. He, Y. S., L. Xu, and E.-S. Huang. 1992. Characterization of human cytomegalovirus UL84 early gene and identification of its putative protein product. J. Virol. 66:1098-1108.
24. Ho, M. 1992. Cytomegalovirus biology and infection, 2nd ed. Plenum Medical Book Co., New York.
25. Iskenderian, A. C., L. Huang, A. Reilly, R. M. Stenberg, and D. G. Anders. 1996. Four of eleven loci required for transient complementation of human cytomegalovirus DNA replication cooperate to activate expression of replication genes. J. Virol. 70:383-392.
26. Jahn, G., T. Kouzarides, M. Mach, B.-C. Scholl, B. Plachter, B. Traupe, E. Preddie, S. C. Satchwell, B. Fleckenstein, and B. G. Barrell. 1987. Map position and nucleotide sequence of the gene for the large structural phosphoprotein of human cytomegalovirus. J. Virol. 61:1358-1367.
27. Jahn, G., B.-C. Scholl, B. Traupe, and B. Fleckenstein. 1987. The two major structural phosphoproteins (pp65 and pp150) of human cytomegalovirus and their antigenic properties. J. Gen. Virol. 68:1327-1337.
28. Jonjic, S., M. del Val, G. M. Keil, M. J. Reddehase, and U. H. Koszinowski. 1988. A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection. J. Virol. 62:1653-1658.
29. Koszinowski, U. H., G. M. Keil, H. Schwarz, J. Schickedanz, and M. J. Reddehase. 1987. A nonstructural polypeptide encoded by immediate-early transcription unit 1 of murine cytomegalovirus is recognized by cytolytic T lymphocytes. J. Exp. Med. 166:289-294.
30. Koszinowski, U. H., M. J. Reddehase, G. M. Keil, and J. Schickedanz. 1987. Host immune response to cytomegalovirus: products of transfected viral immediate-early genes are recognized by cloned cytolytic T lymphocytes. J. Virol. 61:2054-2058.
31. Koszinowski, U. H., M. J. Reddehase, G. M. Keil, H. Volkmer, S. Jonjic, M. Messerle, M. del Val, W. Mutter, K. Münch, and B. Bühler. 1987. Molecular analysis of herpesviral gene products recognized by protective cytolytic T lymphocytes. Immunol. Lett. 16:185-192.
32. Laemmli, U. K, 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
33. Landini, M.-P., and S. Michelson. 1988. Human cytomegalovirus proteins. Prog. Med. Virol. 35:152-185.
34. Landini, M. P., M. C. Re, G. Mirolo, B. Baldassarri, and M. La Placa. 1985. Human immune response to cytomegalovirus structural polypeptides studied by immunoblotting. J. Med. Virol. 17:303-311.
35. Landini, M. P., B. Severi, G. Furlini, and L. Badiali De Giorgi. 1987. Human cytomegalovirus structural components: intracellular and intraviral localization of p28 and p65-69 by immunoelectron microscopy. Virus Res. 8:15-23.
36. Lawrence, G. L., M. Chee, M. A. Craxton, U. A. Gompels, R. W. Honess, and B. G. Barrell. 1990. Human herpesvirus 6 is closely related to human cytomegalovirus. J. Virol. 64:287-299.
37. Leader, D. P., and M. Katan. 1988. Viral aspects of protein phosphorylation. J. Gen. Virol. 69:1441-1464.
38. + virus-specific cytotoxic T lymphocytes. J. Med. Virol. 43:103-110.
39. Mercer, J. A-, J. R. Marks, and D. H. Spector. 1983. Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith strain). Virology 129:94-106.
40. Meyer, H., A. T. Bankier, M. P. Landini, C. M. Brown, B. G. Barrell, B. Rüger, and M. Mach. 1988. Identification and procaryotic expression of the gene coding for the highly immunogenic 28-kilodalton structural phosphoprotein (pp28) of human cytomegalovirus. J. Virol. 62:2243-2250.
41. Mokarski, E. S. 1996. Cytomegaloviruses and their replication, p. 2447-2492. In B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick. T. P. Monath, B. Roizman, and S. E. Straus (ed.), Field's virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia.
42. Moss, B. 1990. Regulation of vaccinia virus transcription. Annu. Rev. Biochem. 59:661-688.
43. Moss, B. 1991. Vaccinia virus: a tool for research and vaccine development. Science 252:1662-1667.
44. Nowak, B., A. Gmeiner, P. Sarnow, A. J. Levine, and B. Fleckenstein. 1984. Physical mapping of human cytomegalovirus genes: identification of DNA sequences coding for a virion phosphoprotein of 71 kDa and a viral 65-kDa polypeptide. Virology 134:91-102.
45. Pande, H., K. Campo, B. Tanamachi, and J. A. Zaia. 1991. Human cytomegalovirus strain Towne pp28 gene: sequence comparison to pp28 of HCMV AD169 and stable expression in Chinese hamster ovary cells. Virology 184:762-767.
46. Pande, H., K. Campo, B. Tanamachi, and J. A. Zaia. 1991. Human cytomegalovirus strain Towne pp65 gene: nucleotide sequence and expression in Escherichia coli. Virology 182:220-228.
47. Pande, H., T. D. Lee, M. A. Churchill, and J. A. Zaia. 1990. Structural analysis of a 64-kDa major structural protein of human cytomegalovirus (Towne): identification of a phosphorylation site and comparison to pp65 of HCMV (AD169). Virology 178:6-14.
48. Pari, G. S., and D. G. Anders. 1993. Eleven loci encoding trans-acting factors are required for transient complementation of human cytomegalovirus ori-Lyt-dependent DNA replication. J. Virol. 67:6979-6988.
49. Pearson, W. R. 1990. Rapid and sensitive sequence comparison with FASTP and FASTA. Methods Enzymol. 183:63-98.
50. Pearson, W. R., and D. J. Lipman. 1988. Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA 85:2444-2448.
51. Pereira, L., M. Hoffman, and N, Cremer. 1982. Electrophoretic analysis of polypeptides immune precipitated from cytomegalovirus-infected cell extracts by human sera, Infect. Immun. 36:933-942.
52. Rawlinson, W. D., H. E. Farrell, and B. G. Barrell. Analysis of the complete DNA sequence of murine cytomegalovirus. Submitted for publication.
53. Reddehase, M. J., S. Jonjic, F. Weiland, W. Mutter, and U. H. Koszinowski. 1988. Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors. J. Virol. 62:1061-1065.
54. Reddehase, M. J., G. M. Keil, and U. H. Koszinowski. 1984. The cytolytic T lymphocyte response to the murine cylomegalovirus. II. Detection of virus replication stage-specific antigens by separate populations of in vivo active cytolytic T lymphocyte precursors. Eur. J. Immunol. 14:56-61.
55. Reddehase, M. J., and U. H. Koszinowski. 1984. Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection. Nature (London) 312:369-371.
56. Reddehase, M. J., W. Mutter, and U. H. Koszinowski. 1987. In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection. J. Exp. Med. 165:650-656.
57. Reddehase, M. J., W. Mutter, K. Münch, H.-J. Bühring, and U. H. Koszinowski. 1987. CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. J. Virol. 61: 3102-3108.
58. Reddehase, M. J., F. Weiland, K. Münch, S. Jonjic, A. Lüske, and U. H. Koszinowski. 1985. Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs. J. Virol. 55:264-273.
59. Riddel, S. R., M. Rabin, A. P. Geballe, W. J. Britt, and P. D. Greenberg. 1991. Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression. J. lmmunol. 146:2795-2804.
60. Riddell, S. R., K. S. Watanabe, J. M. Goodrich, C. R. Li, M. E. Agha, and P. D. Greenberg. 1992. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257:238-241.
61. Ripalti, A., Q. Ruan, M. C. Boccuni, F. Campanini, G. Bergamini, and M. P. Landini. 1994. Construction of polyepitope fusion antigens of human cytomegalovirus ppUL32: reactivity with human antibodies. J. Clin. Microbiol. 32:358-363.
62. Roby, C., and W. Gibson. 1986. Characterization of phosphoproteins and protein kinase activity of virions, noninfectious enveloped particles, and dense bodies of human cytomegalovirus. J. Virol. 59:714-727.
63. Rüger, B., S. Klages, B. Walla, J. Albrecht, B. Fleckenstein, P. Tomlinson, and B. Barrell. 1987. Primary structure and transcription of the genes coding for the two virion phosphoproteins pp65 and pp71 of human cytomegalovirus. J. Virol. 61:446-453.
64. Sanger, F., S. Nicklen, and A. R. Coulsun. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
65. Spector, D. H., L. Hock, and J. C. Tamashiro. 1982. Cleavage maps for human cytomegalovirus DNA strain AD169 for restriction endonucleases EcoRI, BglII, and HindIII. J. Virol. 42:558-582.
66. Spector, D. J., and M. J. Tevethia. 1994. Protein-protein interactions between human cytomegalovirus IE2-580aa and pUL84 in lytically infected cells. J. Virol. 68:7549-7553.
67. Staczek, J. 1990. Animal cytomegaloviruses. Microbiol. Rev. 54:247-265.
68. Tsutsui, Y. 1995. Developmental disorders of the mouse brain induced by murine cytomegalovirus: animal models for congenital cytomegalovirus infection. Pathol. Int. 45:91-102.
69. Volkmer, H., C. Bertholet, S. Jonjic, R. Wittek, and U. H. Koszinowski. 1987. Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus. J. Exp. Med. 166:668-677.
70. Walter, E. A., P. D. Greenberg, M. J. Gilbert, R. J. Finch, K. S. Watanabe, E. D. Thomas, and S. R. Riddell. 1995. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 333:1038-1044.
71. Wright, U. A., S. I. Staprans, and D. H. Spector. 1988. Four phosphoproteins with common amino termini are encoded by human cytomegalovirus AD169. J. Virol. 62:331-340.
72. Zaia, J. A., S. J. Forman, Y.-P. Ting, E. Vanderwal-Urbina, and K. G. Blume. 1986. Polypeptide-specific antibody response to human cytomegalovirus after infection in bone marrow transplant recipients. J. Infect. Dis. 153:780-787.