Idiopathic primary osteo-myelofibrosis: A clinico-pathological study on 208 patients with special emphasis on evolution of disease features, differentiation from essential thrombocythemia and variables of prognostic impact

Leukemia and Lymphoma

Volumn 22, Issue 3-4, 1996, Pages 303-317

  Thiele, Juergen ^a   Kvasnicka, Hans Michael ^a   Werden, Cordula ^a   Zankovich, Rudolf ^a   Diehl, Volker ^a   Fischer, Robert ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Differentiation from essential thrombocythemia; Dynamics of myelofibrosis; Follow up; Idiopathic myelofibrosis; Laboratory features; Survival

Indexed keywords

ADULT; AGED; APOPTOSIS; ARTICLE; BONE MARROW; BONE MARROW BIOPSY; CELL DIFFERENTIATION; CLINICAL FEATURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MEGAKARYOPOIESIS; MYELOFIBROSIS; PATHOLOGY; PRIORITY JOURNAL; PROGNOSIS; THROMBOCYTE COUNT; THROMBOCYTHEMIA;

EID: 0029846133     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199609051762     Document Type: Article

References (53)

1. Varki, A., Lottenberg, R., Griffith, R. and Reinhard, E. (1983) The syndrome of idiopathic myelofibrosis. A clinicopathologic review with emphasis on the prognosis variables predicting survival. Medicine, 62, 353-371.
2. Geary, C. G. (1985) Clinical and hematological aspects of chronic myelofibrosis. In Myelofibrosis, pathophysiology and clinical management, edited by S. M. Lewis, pp. 15-49. New York: Marcel Dekker.
3. Lewis, S. M. (1985) Myelofibrosis: historical perspective. In Myelofibrosis, pathophysiology and clinical management, edited by S. M. Lewis, pp. 1-13. New York: Marcel Dekker.
4. Anger, B., Seidler, R., Haug, U., Popp, C. and Heimpel, H. (1990) Idiopathic myelofibrosis: Retrospective study of 103 patients. Haematologica, 75, 228-234.
5. Visani, G., Finelli, C., Castelli, U., Petti, M. C., Ricci, P., Vianelli, N., Gianni, L., Zuffa, E., Aloe Spiriti, M. A., Latagliata, R., Pileri, S., Magrini, U., Gugliotta, L., Morra, E., Bernasconi, C., Mandelli, F. and Tura, S. (1990) Myelofibrosis with myeloid metaplasia: Clinical and haematological parameters predicting survival in a series of 133 patients. Br. J. Haematol., 75, 4-9.
6. Rupoli, S., Da Lio, L., Sisti, S., Campanati, G., Salvi, A., Brianzoni, M. F., D'Amico, S., Cinciripini, A. and Leoni, P. (1994) Primary myelofibrosis: A detailed statistical analysis of the clinicopathological variables influencing survival. Ann. Hematol., 68, 205-212.
7. Ward, H. P. and Block, M. H. (1971) The natural history of agnogenic myeloid metaplasia. Medicine, 50, 357-420.
8. Wolf, B. C. and Neiman, R. S. (1985) Myelofibrosis with myeloid metaplasia: Pathophysiologic implications of the correlation between bone marrow changes and progression of splenomegaly. Blood, 65, 803-809.
9. Barosi, G., Berzuini, C., Liberator, L. N., Costa, A., Polino, G. and Ascari, E. (1988) A prognostic classification of myelofibrosis with myeloid metaplasia. Br. J. Haematol., 70, 397-401.
10. Pitcock, J. A., Reinhard, E. H., Justus, B. W. and Mendelsohn, R. S. (1962) A clinical and pathological study of seventy cases of myelofibrosis. Ann. Int. Med., 57, 73-84.
11. Manoharan, A., Smart, R. C. and Pitney, W. R. (1982) Chemotherapy resolves symptoms and reverses fibrosis in myelofibrosis. Scand. J. Haematol., 33, 453-459.
12. Löfvenberg, E., Wahlin, A., Roos, G. and Öst, Å. (1990) Reversal of myelofibrosis by hydroxyurea. Eur. J. Haematol., 44, 33-38.
13. Hasselbalch, H. and Jensen, B. A. (1990) Prognostic factors in idiopathic myelofibrosis: A simple scoring system with prognostic significance. Eur. J. Haematol., 44, 172-178.
14. Hasselbalch, H. and Lisse, I. (1991) A sequential histological study of bone marrow fibrosis in idiopathic myelofibrosis. Eur. J. Haematol., 46, 285-289.
15. Thiele, J., Zankovich, R., Steinberg, T., Fischer, R. and Diehl, V. (1989) Agnogenic myeloid metaplasia (AMM) - correlation of bone marrow lesions with laboratory data: A longitudinal clinicopathological study on 114 patients. Hematol. Oncol., 7, 327-343.
16. Pereira, A., Cervantes, F., Brugues, R. and Rozman, C. (1990) Bone marrow histopathology in primary myelofibrosis: Clinical and haematologic correlations and prognostic evaluation. Eur. J. Haematol., 44, 94-98.
17. Njoku, O. S., Lewis, S. M., Catovsky, D. and Gordon-Smith, E. C. (1983) Anaemia in myelofibrosis: Its value in prognosis. Br. J. Haematol., 54, 79-89.
18. Burkhardt, R., Bartl, R., Jäger, K., Frisch, B., Kettner, B., Mahl, G. and Sund, M. (1984) Chronic myeloproliferative disorders (CMPD). Path. Res. Pract., 179, 131-186.
19. Thiele, J., Höppner, B., Zankovich, R. and Fischer, R. (1989) Histomorphometry of bone marrow biopsies in primary osteomyelofibrosis/-sclerosis (agnogenic myeoloid metaplasia) - correlations between laboratory and morphological features. Virchows Arch. A. Pathol. Anat., 415, 191-202.
20. Georgii, A., Vykoupil, K. F., Buhr, T., Choritz, H., Döhler, U., Kaloutsi, V. and Werner, M. (1990) Chronic myeloproliferative disorders in bone marrow biopsies. Pathol. Res. Pract., 186, 3-27.
21. Buhr, T., Georgii, A., Schuppan, O., Amor, A. and Kaloutsi, V. (1992) Histologic findings in bone marrow biopsies of patients with thrombocythemic cell counts. Ann. Hematol., 64, 286-291.
22. Buhr, T., Georgii, A. and Choritz, H. (1993) Myelofibrosis in chronic myeloproliferative disorders. Incidence among subtypes according to the Hannover Classification. Path. Res. Pract., 189, 121-132.
23. Bartl, R., Frisch, B. and Wilmanns, W. (1993) Potential of bone marrow biopsy in chronic myeloproliferative disorders (CMPD). Eur. J. Haematol., 50, 41-52.
24. Buss, D. H., O'Connor, M. L., Woodruff, R. D., Richards, F. II and Brockschmidt, J. K. (1991) Bone marrow and peripheral blood findings in patients with extreme thrombocytosis. Arch. Pathol. Lab. Med., 115, 475-480.
25. Chelloul, N., Jacquillat, P., Briere, J., Laval-Jeantet, J. P. and Vorhauer-Atlan, W. (1975) Valeur prognostique des lesions osteomedullaires de splenomegalie myeloide primitive. Nouv. Press. Med., 43, 3060-3062.
26. Manoharan, A., Smart, R. C. and Pitney, W. R. (1982) Prognostic factors in myelofibrosis. Pathology, 14, 455-61.
27. Rozman, C., Giralt, M., Feliu, R., Rubio, D. and Cortes, M. T. (1991) Life expectancy of patients with chronic nonleukemic myeloproliferative disorders. Cancer, 67, 2658-2663.
28. Thiele, J., Windecker, R., Kvasnicka, H. M., Titius, B. R., Zankovich, R. and Fischer, R. (1994) Erythropoiesis in primary (idiopathic) osteomyelofibrosis: Quantification, PCNA-reactivity, and prognostic impact. Am. J. Hematol., 46, 36-42.
29. Gustavsson, P., Holm, J., Wahlin, A. and Norberg, B. (1985) Staging of idiopathic myelofibrosis. Significance of haemoglobin value and reticulocyte count. Acta. Med Scand., 218, 487-91.
30. Lohmann, T. P. and Beckman, E. N. (1983) Progressive myelofibrosis in agnogenic myeloid metaplasia. Arch. Pathol. Lab. Med., 107, 593-594.
31. Schaefer, H. E. (1984) How to fix, decalcify and stain paraffin embedded bone marrow biopsies. In Pathology of the bone marrow, edited by K. Lennert and K. Huebner, pp. 6-9. New York: G. Fischer, Stuttgart.
32. Thiele, J., Zankovich, R., Schneider, G., Kremer, B., Fischer, R. and Diehl, V. (1988) Primary (essential) thrombocythemia versus polycythemia vera rubra. A histomorphometric analysis of bone marrow features in trephine biopsies. Analyt. Quant. Cytol. Histol., 10, 375-382.
33. Fisher, R. A. (1972) Statistical methods for research workers. Oliver and Boyd, Edinburgh.
34. Kaplan, E. L. and Meier, P. (1958) Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc., 53, 457-481.
35. Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J. and Smith, P. G. (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br. J. Cancer., 35, 1-39.
36. Hakulinen, T. (1982) Cancer survival corrected for heterogeneity in patient withdrawal. Biometrics, 32, 933-942.
37. Hakama, M. and Hakulinen, T. (1977) Estimating the expectation of life in cancer survival studies with incomplete follow-up information. J. Chron. Dis., 30, 585-597.
38. Iland, H. J., Laszlo, J., Case, D. C., Murphy, S., Reichert, T. A., Tso, C. Y. and Wasserman, L. R. (1987) Differentiation between essential thrombocythemia and polycythemia vera with marked thrombocytosis. Am. J. Hematol., 25, 191-201.
39. Murphy, S., Iland, H., Rosenthal, D. and Laszlo, J. (1986) Essential thrombocythemia: An interim report from the Polycythemia Vera Study Group. Semin. Hematol., 23, 177-182.
40. Cervantes, F., Tassies, D., Salgado, C., Rovira, M., Pereira, A. and Rozman, C. (1991) Acute transformation in nonleukemic chronic myeloproliferative disorders: Actuarial probability and main characteristics in a series of 218 patients. Acta. Haematol., 85, 124-127.
41. Hasselbalch, H. (1990) Idiopathic myelofibrosis: A clinical study of 80 patients. Am. J. Hematol., 34, 291-300.
42. Dickstein, J. I. and Vardiman, J. W. (1993) Issues in the pathology and diagnosis of the chronic myeloproliferative disorders and the myelodysplastic syndromes. Am. J. Clin. Pathol., 99, 513-525.
43. Howarth, J. E., Waters, H. M., Hyde, K. and Geary, C. G. (1989) Detection of erythroid hypoplasia in myelofibrosis using erythrokinetic studies. J. Clin. Pathol., 24, 1250-1252.
44. Hoffbrand, A. V., Chanarin, I., Kremenchuzky, S., Szur, L., Water, A. H. and Mollin, D. L. (1968) Megaloblastic anaemia in myelosclerosis. Q. J. Med., 37, 493-516.
45. Wolf, B. C. and Neiman, R. S. (1987) Hypothesis: Splenic filtration and the pathogenesis of extramedullary hematopoiesis in agnognic myeloid metaplasia. Hematol. Pathol., 1, 77-80.
46. Bellucci, S., Janvier, M., Tobelem, G., Flandrin, G., Charpak, Y., Berger, R. and Boiron, M. (1986) Essential thrombocythemias. Clinical evolutionary and biological data. Cancer, 58, 2440-2447.
47. Hehlmann, R., Jahn, M., Baumann, B. and Köpcke, W. (1988) Essential thrombocythemia. Clinical characteristics and course of 61 cases. Cancer, 61, 2487-2496.
48. Lahuerta-Palacios, J. J., Bornstein, R., Fernández-Debora F. Gutiérrez-Rivas, E., Ortiz, M. C., Larregla, S., Calandre, L. and Montero-Castillo, J. (1988) Controlled and uncontrolled thrombocytosis. Its clinical role in essential thrombocythemia. Cancer, 61, 1207-1212.
49. Dudley, J. M., Messinezy, M., Eridani, S., Holland, L. J., Lawrie, A., Nunan, T. O., Sawyer, B., Savidge, G. F. and Pearson, T. C. (1989) Primary thrombocythaemia: Diagnostic criteria and a simple scoring system for positive diagnosis. Br. J. Hematol., 71, 331-335.
50. Mitus, A. J. and Schafer, A. I. (1990) Thrombocytosis and thrombocythemia. Hematol./Oncol. Clin. N. Am., 4, 157-178.
51. Cortelazzo, S., Viero, P., Finazzi, G., D'Emilio, A., Rodeghiero, F. and Barbui, T. (1990) Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia. J. Clin. Oncol., 8, 556-562.
52. Fenaux, P., Simon, M., Caulier, M. T., Lai, J. L., Goudemmand, J. and Bauters, F. (1990) Clinical course of essential thrombocythemia in 147 cases. Cancer, 66, 549-556.
53. Colombi, M., Radaelli, F., Zocchi, L. and Maiolo, A. T. (1991) Thrombotic and hemorrhagic complications in essential thrombocythemia. A retrospective study of 103 patients. Cancer, 67, 2926-2930.